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Table of ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: IEE Transactions on NanoBioscience - June 1, 2009 Category: Nanotechnology Source Type: journals

IEEE Transactions on NanoBioscience publication informationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: IEE Transactions on NanoBioscience - June 1, 2009 Category: Nanotechnology Source Type: journals

Improvement in Resolution of Laser Capture Microdissection Using Near-Field Probe to Capture NanoparticlesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The new LCM system successfully captures nanoparticles and improves resolution of microdissection to 400 nm. With this LCM system, the isolation of a single organelle or bacterium is possible.
Source: IEE Transactions on NanoBioscience - June 1, 2009 Category: Nanotechnology Source Type: journals

Optical Detection of Human Papillomavirus Type 16 and Type 18 by Sequence Sandwich Hybridization With Oligonucleotide-Functionalized Au NanoparticlesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The importance of detecting and subtyping human papillomaviruses (HPVs) in clinical and epidemiological studies has been well addressed. In detecting the most common types of HPV, type 16 (HPV-16) and type 18 (HPV-18), in the cervical mucous of patients in a simple and rapid manner, the assay of a label-free colorimetric DNA sensing method based on sequence sandwich hybridization with oligonucleotide-functionalized Au nanoparticles (AuNPs) was fabricated in this study. Specific oligonucleotide probes were designed for the sequence detection within the L1 gene of HPV-16 and HPV-18, and the probes were capped onto AuNPs, as ...
Source: IEE Transactions on NanoBioscience - June 1, 2009 Category: Nanotechnology Source Type: journals

A System for the Determination of Planar Lipid Bilayer Breakdown Voltage and Its ApplicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this paper, we focus on measurement principles used in electroporation studies on planar lipid bilayers. In particular, we point out the voltage-clamp measurement principle that has great importance when the breakdown voltage of a planar lipid bilayer is under consideration; however, it is also appropriate for the determination of other planar lipid bilayer electrical properties such as resistance and capacitance. A new experimental system that is based on the voltage-clamp measurement principle is described. With the use of a generator that can generate arbitrary-type signals, many specific shapes of a voltage signal c...
Source: IEE Transactions on NanoBioscience - June 1, 2009 Category: Nanotechnology Source Type: journals

A Parallel Pairwise Local Sequence Alignment AlgorithmEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers are compelled to use heuristic-based pairwise sequence alignment tools instead of Smith–Waterman (SW) algorithm due to space and time constraints, thereby losing significant amount of sensitivity. Parallelization is a possible solution, though, till date, the parallelization is restricted to database searching through database fragmentation. In this paper, the power of a cluster computer is utilized for developing a parallel algorithm, RPAlign, involving, first, the detection of regions that are potentially alignable, followed by their actual alignment. RPAlign is found to reduce the timing requirement b...
Source: IEE Transactions on NanoBioscience - June 1, 2009 Category: Nanotechnology Source Type: journals

Class Discovery From Gene Expression Data Based on Perturbation and Cluster EnsembleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Class discovery from gene expression data is an important task for cancer diagnosis. In this paper, we present a new framework for class discovery. The new framework integrates the perturbation technique, the cluster ensemble approach, and the cluster validity index. Specifically, it first generates a set of perturbed datasets from the original microarray data. Then, the Neural Gas, which serves as the basic clustering algorithm, is applied to obtain the partitions from the original dataset and the perturbed datasets. Finally, a new cluster validity index called disagreement/agreement (DA) index (DAI) is designed to identi...
Source: IEE Transactions on NanoBioscience - June 1, 2009 Category: Nanotechnology Source Type: journals

Growth Cone 3-D Morphology is Modified by Distinct Micropatterned Adhesion SubstratesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The development, connectivity, and structural plasticity of neuronal networks largely depend on the directional growth of axonal growth cones (GCs). The morphology and 3-D profile of axons and GCs of primary hippocampal neurons, grown onto glass surfaces coated with poly-D-lysine (PDL) and micropatterned with stripes of the adhesion molecule L1 by using the indirect microcontact printing, were investigated. Neurons were fixed at early stages (one to seven days) of in vitro development prior to synapse formation, and analyzed by fluorescence and atomic force microscopy. The latter technique allowed us to investigate the 3-D...
Source: IEE Transactions on NanoBioscience - June 1, 2009 Category: Nanotechnology Source Type: journals

Molecular Communication: Modeling Noise Effects on Information RateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Molecular communication is a new paradigm for communication between biological nanomachines over a nano- and microscale range. As biological nanomachines (or nanomachines in short) are too small and simple to communicate through traditional communication mechanisms (e.g., through sending and receiving of radio or infrared signals), molecular communication provides a mechanism for a nanomachine (i.e., a sender) to communicate information by propagating molecules (i.e., information molecules) that represent the information to a nanomachine (i.e., a receiver). This paper describes the design of an in vitro molecular communica...
Source: IEE Transactions on NanoBioscience - June 1, 2009 Category: Nanotechnology Source Type: journals

Decision Making With an Interpretive Structural Modeling Method Using a DNA-Based AlgorithmEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel method of interpretive structural modeling (ISM) using a DNA-based algorithm is proposed in this paper. ISM is commonly used when the current technology and its application to business administration, industrial and systems engineering, organizational behavior, etc., concern complicated or problematic issues, or situations among an element set of the given problem context for making decisions. When structuring a problem with a large number of elements in an ISM process, the crossings among elements should be minimized. This computationally complex minimization is NP-complete. The proposed algorithm describes how to...
Source: IEE Transactions on NanoBioscience - June 1, 2009 Category: Nanotechnology Source Type: journals

Biological and Magnetic Contrast Evaluation of Shape-Selective Mn–Fe NanowiresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One-dimensional composite Mn–Fe oxide nanostructures of different sizes (nanoneedles, nanorods, and nanowires) were prepared by a linker-induced organization of manganese-doped iron oxide nanoparticles. The nanostructures were obtained by the treatment of $hbox{MnFe}_{2}hbox{O}_{4}$ nanoparticles in the presence of cystamine. The average lengths of nanoneedle, nanorod, and nanowire are approximately 400, 800, and 1000 nm, respectively. High-resolution transmission electron microscopy (HR-TEM), energy-dispersive X-ray (EDX) spectroscopy, and inductively coupled plasma-optical emission spectroscopy (ICP–OES) we...
Source: IEE Transactions on NanoBioscience - June 1, 2009 Category: Nanotechnology Source Type: journals

Call for papers ISBI 2010Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: IEE Transactions on NanoBioscience - June 1, 2009 Category: Nanotechnology Source Type: journals

Leading the field since 1884Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: IEE Transactions on NanoBioscience - June 1, 2009 Category: Nanotechnology Source Type: journals

IEEE Transactions on NanoBioscience information for authorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: IEE Transactions on NanoBioscience - June 1, 2009 Category: Nanotechnology Source Type: journals

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Source: IEE Transactions on NanoBioscience - June 1, 2009 Category: Nanotechnology Source Type: journals

Table of ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

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Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

Introduction to the Special Section on Colloidal Quantum Dots for Biomedical ApplicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The overview paper in this special issue deals with the unique optical properties and biofunctionalization of quantum dots (QDs), and their use in biosensing and in vivo imaging. The remaining eight papers cover the synthesis and applications of QDs and, in four cases, QD-derived or non-QD nanostructures.
Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

Semiconductor Quantum Dots for Biosensing and In Vivo ImagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Semiconductor quantum dots (QDs) have captivated researchers in the biomedical field over the last decade. Compared to organic dyes and fluorescent proteins, QDs have unique optical properties such as tunable emission spectra, improved brightness, superior photostability, and simultaneous excitation of multiple fluorescence colors. Since the first successful reports on the biological use of QDs a decade ago, QDs and their bioconjugates have been successfully applied to various imaging applications including fixed cell labeling, live-cell imaging, in situ tissue profiling, fluorescence detection and sensing, and in vivo ani...
Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

Synthesis and Characterization of Double-layer Quantum-Dots-Tagged MicrospheresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Quantum-dots-tagged poly(styrene-acrylamide-acrylic acid) microspheres (QDsAAMs) were synthesized and modified with hydrazine hydrate through hydrazinolysis. Azidocarbonyl groups, which can be rapidly coupled with proteins under mild conditions, were introduced onto the surface of QDsAAM using azido reaction. Bovine serum albumin (BSA) was selected as model protein to be covalently immobilized on the azidocarbonyl QDsAAM. Instruments such as fluorescence microscope, optical microscope, confocal laser scanning microscope, UV-visible spectrometer, Fourier transform infrared spectrometer, size analyzer, and fluorescence spect...
Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

Nanoscintillators for Microscopic Diagnostics of Biological and Medical Objects and Medical TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The main focus of this paper is the description of qualitatively new facilities for diagnostics of biological and medical objects and medical therapy obtained by applications of nanocrystalline scintillators. These facilities are based on abilities of nanoscintillators to selective conjugation with various biomolecular objects and noticeable variations of their atomic structures, X-ray diffraction (XRD) patterns, and light-emission characteristics induced by modifications of conditions on their external surfaces. Experimental results presented in this paper provide development of detection in vivo just inside a living orga...
Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

Magnetically Responsive Nanoparticles for Drug Delivery Applications Using Low Magnetic Field StrengthsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study indicates that lower magnetic field strengths may be successfully utilized for drug delivery applications as a method for drug delivery transport enhancement and drug release switches.
Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

Chloroform- and Water-Soluble Sol–Gel Derived $hbox{Eu}^{+++}/hbox{Y}_{{rm 2}}hbox{O}_{{rm 3}}$ (Red) and $hbox{Tb}^{+++}/hbox{Y}_{{rm 2}}hbox{O}_{{rm 3}}$ (Green) Nanophosphors: Synthesis, Characterization, and Surface ModificationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
$hbox{Eu}^{+++}$ and $hbox{Tb}^{+++}$ ions have been incorporated into nanodimensional yttrium oxide host matrices via a sol–gel process using $hbox{Y}_{5}hbox{O}(hbox{OPr}^{bf i})_{bf 13}$ as precursor ($hbox{OPr}^{bf i} = hbox{isopropoxy}$ ). The as-synthesized white powders have been annealed at different temperatures. Photoluminescence (PL) spectroscopy and X-ray diffraction (XRD) have been used as tools for documenting the characteristics of these powders. For $hbox{Eu}^{+++}$-doped powders, a comparison of the $hbox{Eu}^{+++}$, $^{5}hbox{D}_{0}{rightarrow}^{7}hbox{F}_{1}$, and $^{5}hbox{D}_{0}{rightarrow}^{7}h...
Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

Immune Response Induced by Fluorescent Nanocrystal Quantum Dots In Vitro and In VivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigated the immune response and biological behavior of QDs in vitro and in vivo. The immune response to QDs by both lymphocytes and kinds of macrophages in vitro and in vivo was investigated. Co-culture of QDs with immune cells showed that apparently normal production of cytokines and chemokines in both mouse CD4+ lymphocytes and peritoneal F4/80+ macrophages (PM phi). In addition, the bionanocomplex of QDs with enhanced-green-fluorescent-protein (eGFP)-encoding nucleotides successfully induced the expression of eGFP protein by PMphi. However, direct injection of QD+nucleotides bionanocomplex aqueous soluti...
Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

Toxicity of CdTe Quantum Dots in Bacterial StrainsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we compare the cytotoxicity of CdTe quantum dots (QDs) to four very different environmental bacterial strains, giving quantitative models of the growth curves for exposed organisms. The mechanisms of toxicity are explored by measuring reactive oxygen species generation by the QDs alone and investigating the oxidative damage to mutant bacteria especially sensitive to ROS. Electron microscopic examination also reveals factors that may contribute to resistance to nanoparticles in some strains.
Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

Tumor-Targeted Quantum Dots Can Help Surgeons Find Tumor BoundariesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we show that quantum dots (QDs) coupled to epidermal growth factor (EGF) or anti-EGF receptor (EGFR, Her1) specifically and sensitively label glial tumor cells in cell culture, glioma mouse models, and human brain-tumor biopsies. A clear demarcation between brain and tumor tissue at the macroscopic as well as the cellular level is provided by the fluorescence emission of the QDs.
Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

Fabrication and Characterization of Silk-Fibroin-Coated Quantum DotsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a novel technique of directly coating colloidal CdSe/ZnS core/shell quantum dots (QDs) with silk fibroin (SF), a protein derived from the Bombyx mori silk worm. The approach results in protein-modified QDs with little or no particle aggregation, and mitigates the issue of biocompatibility. QDs have desirable optical properties, such as narrow-band emission, broadband absorption, high quantum yield, and high resistance to photobleaching. SF is a fibrous protein polymer with a biomimetic peptide sequence, water and oxygen permeability, low inflammatory response, no thrombogenecity, and cellular biocompatibility, wh...
Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

Differences in DNA Damage Pathways Induced by Two Ceramic NanoparticlesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In our prophase studies, it has been proved that hydroxyapatite (HAP) and tricalcium phosphate (TCP) nanoparticles (NPs) had obvious cytotoxicity on rat macrophages. So, mechanisms of DNA damage induced by HAP and TCP NPs would be discussed in these studies. Rat peritoneal macrophages were cultured and induced by NPs in vitro. Then, the expressions of P53, P21, growth arrest and DNA damage 45 (Gadd45), and heat shock protein 70 (HSP70) were examined by reverse transcription polymerase chain reaction. The results showed that the expressions of P53, P21, and HSP70 increased with increasing concentrations of HAP NPs. The expr...
Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

Switching Light With Light in Chlorophyll-A Molecules Based on Excited-State AbsorptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We analyze all-optical switching in chlorophyll-A (Chl-A) molecules for different combinations of pump-probe wavelengths, based on nonlinear intensity-induced excited-state absorption. It is shown that for a pulsed pump beam at 672 nm with peak pump intensity of 5 kW/cm2 and Chl-A concentration of 1.5 mM, the transmission of a continuous-wave probe beam at 476 nm can be completely switched off (100% modulation) with switch on-off time of 0.58 and 0.18 mus, respectively. It is also shown that the switching characteristics can be inverted by changing the probe beam wavelength. The effect of various parameters, such as concen...
Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

Protein Superfamily Classification Using Fuzzy Rule-Based ClassifierEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this paper, we have proposed a fuzzy rule-based classifier for assigning amino acid sequences into different superfamilies of proteins. While the most popular methods for protein classification rely on sequence alignment, our approach is alignment-free and so more human readable. It accounts for the distribution of contiguous patterns of n amino acids ( n-grams) in the sequences as features, alike other alignment-independent methods. Our approach, first extracts a plenty of features from a set of training sequences, then selects only some best of them, using a proposed feature ranking method. Thereafter, using these fea...
Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

Prediction of Protein Folds: Extraction of New Features, Dimensionality Reduction, and Fusion of Heterogeneous ClassifiersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Here, we consider a two-level (four classes in level 1 and 27 folds in level 2) protein fold determination problem. We propose several new features and use some existing features including frequencies of adjacent residues, frequencies of residues separated by one residue, and triplets (trio) of amino acid compositions (AACs). The dimensionality of the trio AAC features is drastically reduced using a neural network based novel online feature selection scheme. We also propose new sets of features called trio potential computed using the hydrophobicity values considering only the selected trio AACs. We demonstrate that the pr...
Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

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Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

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Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

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Source: IEE Transactions on NanoBioscience - March 1, 2009 Category: Nanotechnology Source Type: journals

The 4th International IEEE EMBS Conference on Neural EngineeringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: IEE Transactions on NanoBioscience - February 3, 2009 Category: Nanotechnology Source Type: journals

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Source: IEE Transactions on NanoBioscience - December 1, 2008 Category: Nanotechnology Source Type: journals

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Source: IEE Transactions on NanoBioscience - December 1, 2008 Category: Nanotechnology Source Type: journals

Bioelectronic Imaging Array Based on Bacteriorhodopsin FilmEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A photoreceptor array that exploits the light sensitive bacteriorhodopsin (bR) films has been manufactured on a flexible indium-tin-oxide (ITO) coated plastic film using electrophoretic sedimentation technique (EPS). The effective sensing area of each photoreceptor is 2 times 2 mm2, separated by 1 mm and arranged in a 4 times 4 array. A switched integrator with gain on the order of 1010 is used to amplify the signal to a suitable level. When exposed to light, the differential response characteristic is attributed to charge displacement and recombination within bR molecules, as well as loading effects of the attached amplif...
Source: IEE Transactions on NanoBioscience - December 1, 2008 Category: Nanotechnology Source Type: journals

Mechanical Modeling of Biological Cells in MicroinjectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Microinjection is an effective technique to introduce foreign materials into a biological cell. Although some semi-automatic and fully-automatic microinjection systems have been developed, a full understanding of the mechanical response of biological cells to injection operation remains deficient. In this paper, a new mechanical model based on membrane theory is proposed. This model establishes a relationship between the injection force and the deformation of biological cells with the quasi-static equilibrium equations, which are solved by the Runge-Kutta numerical method. Based on this model, other mechanical responses ca...
Source: IEE Transactions on NanoBioscience - December 1, 2008 Category: Nanotechnology Source Type: journals

Numerical Study on the Multi-Region Bio-Heat Equation to Model Magnetic Fluid Hyperthermia (MFH) Using Low Curie Temperature NanoparticlesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study develops and solves two-dimensional convective-conductive coupled partial differential equations based on Pennes' bio-heat transfer model using low Curie temperature nanoparticles (LCTNPs) to illustrate thermal behavior quantitatively within tumor-normal composite tissue by establishing a multi-region finite difference algorithm. The model combines Neel relaxation and temperature-variant saturation magnetization derived from Brillouin Equation and Curie-Weiss Law. The numerical results indicate that different deposition patterns of LCTNP and boundary conditions directly effect the steady state temperature distri...
Source: IEE Transactions on NanoBioscience - December 1, 2008 Category: Nanotechnology Source Type: journals

Immunonanogold-Catalytic Cu $_{2}$O-Enhanced Assay for Trace Penicillin G With Resonance Scattering SpectrometryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel immunonanogold-catalytic Cu2O-enhanced resonance scattering (RS) spectral assay is reported, based on nanogold modified rabbit anti-penicillin G (RAPG) antibody, its catalytic enhanced effect on the slow particle reaction between Cu(II) and glucose, and the RS effect of (Au)nucleus(Cu2O)shell complex particle at 608 nm. As a model, we used nanogold in size of 9 nm to label RAPG to obtain an immunonanogold probe (AuRAPG) for penicillin G (PG). The immunoreactions between the probe and PG took place in phosphate-citric acid buffer solutions. After centrifugation, the excess AuRAPG in the supernatant was used to catal...
Source: IEE Transactions on NanoBioscience - December 1, 2008 Category: Nanotechnology Source Type: journals

Estimating Locations of Quantum-Dot-Encoded Microparticles From Ultra-High Density 3-D MicroarraysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We develop a maximum likelihood (ML)-based parametric image deconvolution technique to locate quantum-dot (q-dot) encoded microparticles from three-dimensional (3-D) images of an ultra-high density 3-D microarray. A potential application of the proposed microarray imaging is assay analysis of gene, protein, antigen, and antibody targets. This imaging is performed using a wide-field fluorescence microscope. We first describe our problem of interest and the pertinent measurement model by assuming additive Gaussian noise. We use a 3-D Gaussian point-spread-function (PSF) model to represent the blurring of the widefield micros...
Source: IEE Transactions on NanoBioscience - December 1, 2008 Category: Nanotechnology Source Type: journals

Development of Superparamagnetic Iron Oxide Nanoparticles (SPIONS) for Translation to Clinical ApplicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Superparamagnetic iron oxide nanoparticles (SPIONs) have attract a great deal of interest in biomedical research and clinical applications over the past decades. Taking advantage the fact that SPIONs only exhibit magnetic properties in the presence of an applied magnetic field, they have been used in both in vitro magnetic separation and in vivo applications such as hyperthermia (HT), magnetic drug targeting (MDT), magnetic resonance imaging (MRI), gene delivery (GD) and nanomedicine. Successful applications of SPIONs rely on precise control of the particle's shape, size, and size distribution and several synthetic routes ...
Source: IEE Transactions on NanoBioscience - December 1, 2008 Category: Nanotechnology Source Type: journals

2008 Index IEEE Transactions on NanoBioscience Vol. 7Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: IEE Transactions on NanoBioscience - December 1, 2008 Category: Nanotechnology Source Type: journals

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Source: IEE Transactions on NanoBioscience - December 1, 2008 Category: Nanotechnology Source Type: journals

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Source: IEE Transactions on NanoBioscience - December 1, 2008 Category: Nanotechnology Source Type: journals

Magnetically Targeted Viral Envelopes: A PET Investigation of Initial BiodistributionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the biodistribution of a viral envelope commonly used as a nanoscale gene delivery vehicle using positron emission tomography (PET) and investigated the magnetic alteration of its biodistribution. Iron oxide nanoparticles and 18F-fluoride were encapsulated by hemagglutinating virus of Japan envelopes (HVJ-Es). HVJ-Es were then injected intravenously in the rat and imaged dynamically using high-resolution PET. Control subjects received injections of encapsulated materials alone. For magnetic targeting, permanent magnets were fixed on the head during the scan. Based on the quantitative analysis of PET images, HVJ...
Source: IEE Transactions on NanoBioscience - October 26, 2008 Category: Nanotechnology Source Type: journals

Molecular Delivery to Cells Facilitated by Corona Ion DepositionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel method of inducing the delivery of nonpermeant molecules to the cytosol of cells is presented in this paper. Corona discharge in air was utilized to produce ions that in turn were deposited onto the liquid surface of media containing cultured cells. Murine B16 melanoma cells were used to demonstrate the molecular delivery of fluorescent dye calcein, the drug bleomycin, and a nucleic acid stain SYTOX-green. None of these molecules penetrate cells with intact membranes. Following the corona treatment, cells were observed to admit significant quantities of these molecules from the culture media, relative to control sa...
Source: IEE Transactions on NanoBioscience - October 26, 2008 Category: Nanotechnology Source Type: journals

The Effects of Cell Sizes, Environmental Conditions, and Growth Phases on the Strength of Individual W303 Yeast Cells Inside ESEMEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We performed in situ measurements of mechanical properties of individual W303 wild-type yeast cells by using an integrated environmental scanning electron microscope (ESEM)-nanomanipulator system. Compression experiments to penetrate the cell walls of single cells of different cell sizes (about 3-6 mu m diameter), environmental conditions (600 Pa and 3 mPa), and growth phases (early log, mid log, late log and saturation) were conducted. The compression experiments were performed inside ESEM, embedded with a 7 DOF nanomanipulator with a sharp pyramidal end effector and a cooling stage, i.e., a temperature controller. ESEM i...
Source: IEE Transactions on NanoBioscience - October 26, 2008 Category: Nanotechnology Source Type: journals

Use of Auricular Chondrocytes for Lining Artificial Surfaces: A Mathematical ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Auricular elastic cartilage is a potential source for lining of luminal surfaces of implantable vascular devices, such as stents and left ventricular assist devices with the purpose to improve their biocompatibility. Auricular chondrocytes are easily accessible, harvested, and isolated, and they have been shown to provide a strong adherent cell lining for left ventricular assist devices. Additionally, Dr. Rosenstrauch et al. have shown that it is possible to genetically engineer auricular chondrocytes to produce antithrombogenic factors. Thus, implantable vascular devices, such as coronary stents covered with genetically e...
Source: IEE Transactions on NanoBioscience - October 26, 2008 Category: Nanotechnology Source Type: journals