IET NanobiotechnologyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

21 records returned

Effects of poly (lactic-co-glycolic acid) as a co-emulsifier on the preparation and hypoglycaemic activity of insulin-loaded solid lipid nanoparticlesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Poly (lactic-co-glycolic acid) (PLGA) was used as a co-emulsifier in the preparation of insulin-loaded solid lipid nanoparticles (SLN) with hydrogenated castor oil as lipid matrix and lecithin as surfactant by doubleemulsion technique. The effects of PLGA on the preparation and hypoglycaemic activity of insulin-loaded SLN were studied. The results showed that with the supplement of PLGA, the encapsulation efficiency and loading capacity were increased significantly from 79.08±1.62 to 85.57±3.21% and 1.58±0.03 to 1.71±0.06%, whereas the surface charge and particle size were changed insignific...
Source: IET Nanobiotechnology - November 19, 2009 Category: Nanotechnology Source Type: journals

Performance analysis and comparison of a minimum interconnections direct storage model with traditional neural bidirectional memoriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study proposes an efficient and improved model of a direct storage bidirectional memory, improved bidirectional associative memory (IBAM), and emphasises the use of nanotechnology for efficient implementation of such large-scale neural network structures at a considerable lower cost reduced complexity, and less area required for implementation. This memory model directly stores the X and Y associated sets of M bipolar binary vectors in the form of (M X Nx) and (M X Ny) memory matrices, requires O(N ) or about 30% of interconnections with weight strength ranging between ±1, and is computationally very efficient...
Source: IET Nanobiotechnology - November 19, 2009 Category: Nanotechnology Source Type: journals

Surface plasmon resonance imaging for biosensingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Surface plasmon resonance imaging (SPRI) is a useful tool for the study of surface biomolecular interactions allowing for label-free detection and elegant instrumentation. SPRI imaging system is described in this review with an emphasis on recent applications with examples of different biological interactions and high throughput analysis. Signal amplification in SPRI using nanoparticle and waveguide-based optical coupling is introduced. Finally the detection sensitivity of the SPRI system is examined in terms of other competitive methods. (Source: IET Nanobiotechnology)
Source: IET Nanobiotechnology - August 8, 2009 Category: Nanotechnology Source Type: journals

Nanoreactors for pH controlled sequential activity switching in multistep enzymatic processesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This theoretical model predicts that the activity of multiple enzymes may be controlled simultaneously with superior efficiency in nanosized reactors by adjusting pH. Multistep enzymatic processes employed for various purposes including organic biotransformation may require application of multiple reactions and isolation of intermediates. Sequential activity switching would offer substantial advantages. Nanoreactors would provide better option to fully appreciate the pH switching approach. (Source: IET Nanobiotechnology)
Source: IET Nanobiotechnology - August 8, 2009 Category: Nanotechnology Source Type: journals

Dynamics of capturing process of multiple magnetic nanoparticles in a flow through microfluidic bioseparation systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A mathematical model based on finite-element technique is developed for predicting the transport and capture of multiple magnetic nanoparticles in a microfluidic system that consists of a microfluidic channel enclosed by a permanent magnet. The trajectories and trapping efficiencies are calculated for multiple magnetic nanoparticles when released in the microsystem. It is demonstrated that not only the size but also the point of release of nanoparticles within the microchannel affects the capturing process. Influence of three important parameters, inlet velocities of fluid containing magnetic nanoparticles, diameter of mag...
Source: IET Nanobiotechnology - August 8, 2009 Category: Nanotechnology Source Type: journals

Localised heating of tumours utilising injectable magnetic nanoparticles for hyperthermia cancer therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study reports an investigation of hyperthermia cancer therapy utilising an alternating magnetic field to induce a localised temperature increase on tumours by using injectable magnetic nanoparticles. Invitro and in-vivo experiments represent the feasibility of hyperthermia cancer therapy. A feedback temperature control system was first developed to keep the nanoparticles at a constant temperature to prevent overheating in the tumours such that a safer and more precise cancer therapy becomes feasible. By using the feedback temperature control system, magnetic nanoparticles can be heated up to the specific constant temp...
Source: IET Nanobiotechnology - May 31, 2009 Category: Nanotechnology Source Type: journals

Dielectric and dielectrophoretic properties of DNAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The physical properties of DNA are quite important for molecular genetics as well as for its nanotechnological applications. Studying the interactions of alternating current (AC) electric fields with deoxyribonucleic acid (DNA) allows one to draw conclusions about these properties. These interactions are usually investigated in two different ways. In dielectric spectroscopy, a DNA solution is placed in a homogeneous AC field and electronic parameters are measured over several frequency decades in the Hz to GHz range. These electronic data are then interpreted on the basis of physico-chemical models as a result of certain p...
Source: IET Nanobiotechnology - May 31, 2009 Category: Nanotechnology Source Type: journals

Preparation of carboxyl-coated polystyrene nanoparticles using oleic acidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Novel carboxyl group-decorated crosslinked polystyrene nanoparticles were prepared via the soapless emulsion polymerisation of styrene and divinyl benzene with oleic acid as functional comonomer. The existence of the surface carboxyl group was verified by zeta potential analysis. Particle sizes of the functional nanoparticles prepared with the proposed method were found to be in the range of 60¿100 nm by transmission electron microscopy and dynamic light scattering analyses. Functionalised nanoparticles are proposed as carriers for biomolecules or drugs. (Source: IET Nanobiotechnology)
Source: IET Nanobiotechnology - May 31, 2009 Category: Nanotechnology Source Type: journals

Bacterial detection using a carbon nanotube gas sensor coupled with a microheater for ammonia synthesis by aerobic oxidisation of organic componentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the authors propose a new bacteria detection method using a carbon nanotube (CNT) gas sensor and a microheater, which were coupled into a Bio-MEMS (microelectromechanical systems)-type device. Bacteria were heated by the microheater in air so that ammonia (NH3) gas can be generated by the oxidation reaction of organic components of bacteria. Thus generated NH3 gas was detected by using the CNT gas sensor, which was fabricated by dielectrophoresis (DEP) and combined with the microheater to form a small chamber. Cyclic pulsed heating operation was employed so that the CNT response to elevated temperature did n...
Source: IET Nanobiotechnology - May 31, 2009 Category: Nanotechnology Source Type: journals

Preparation, structure and drug release behaviour of chitosan-based nanofibresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Biomimetic polymeric nanofibres are of great interest in tissue engineering and wound repair because of their structural similarity to extracellular matrix. In this work, biomimetic chitosan-based nanofibres with various diameters were prepared by ionically cross-linking with tripolyphosphate (TPP) in adipic acid medium and characterised using transmission electron microscopy, X-ray diffraction and Fourier-transform infrared spectroscopy. Using dexamethasone sodium phosphate (DMP) and bovine serum albumin (BSA) as low and high molecular-weight bioactive molecule models, respectively, drug loading and in vitro release behav...
Source: IET Nanobiotechnology - March 14, 2009 Category: Nanotechnology Source Type: journals

Inexpensive, universal serial bus-powered and fully portable lab-on-a-chip-based capillary electrophoresis instrumentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Capillary electrophoresis is a cornerstone of lab-on-a-chip (LOC) implementations for medical diagnostics. However, the infrastructure needed to operate electrophoretic LOC implementations tends to be large and expensive, hindering the development of portable or low-cost systems. A custom-designed and highly integrated microelectronic chip for high-voltage generation switching and interfacing is recently developed. Here, the authors integrate the microelectronic chip with a microfluidic chip, a solid-state laser, filter, lens and several dollars worth of electronic components to form an inexpensive and portable platform, w...
Source: IET Nanobiotechnology - March 14, 2009 Category: Nanotechnology Source Type: journals

High-yield electrofusion of biological cells based on field tailoring by microfabricated structuresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors present the use of electric-field constriction created by a microfabricated structure to realise high-yield electrofusion of biological cells. The method uses an orifice on an electrically insulating wall (orifice plate) whose diameter is as small as that of the cells. Owing to the field constriction created by the orifice, we can induce the controlled magnitude of membrane voltage selectively around the contact point, regardless of the cell size. The field constriction also ensures 1:1 fusion even when more than two cells are forming a chain at the orifice. A device for electrofusion has been made with a stand...
Source: IET Nanobiotechnology - November 21, 2008 Category: Nanotechnology Source Type: journals

Healing assessment of tile sets for error tolerance in DNA self-assemblyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An assessment of the effectiveness of healing for error tolerance in DNA self-assembly tile sets for algorithmic/nano-manufacturing applications is presented. Initially, the conditions for correct binding of a tile to an existing aggregate are analysed using a Markovian approach; based on this analysis, it is proved that correct aggregation (as identified with a so-called ideal tile set) is not always met for the existing tile sets for nano-manufacturing. A metric for assessing tile sets for healing by utilising punctures is proposed. Tile sets are investigated and assessed with respect to features such as error (mismatche...
Source: IET Nanobiotechnology - November 21, 2008 Category: Nanotechnology Source Type: journals

Implementation of wireless power transfer and communications for an implantable ocular drug delivery systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A wireless power transfer and communication system based on near-field inductive coupling has been designed and implemented. The feasibility of using such a system to remotely control drug release from an implantable drug delivery system is addressed. The architecture of the wireless system is described and the signal attenuation over distance in both water and phosphate buffered saline is studied. Additionally, the health risk due to exposure to radio frequency (RF) radiation is examined using a biological model. The experimental results demonstrate that the system can trigger the release of drug within 5 s, and that such...
Source: IET Nanobiotechnology - October 25, 2008 Category: Nanotechnology Source Type: journals

Polarisation and membrane voltage of ellipsoidal particle with a constant membrane thickness: a series expansion approachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The estimation of the membrane voltage and the polarisation factor of biological cells provide a base for the study of bio-manipulation techniques, such as dielectrophoresis, electroporation or electrofusion. To model a biological cell, an ellipsoidal particle with an insulating membrane is sometimes employed, but due to the limitation of the confocal nature of the coordinate system, the membrane thickness is assumed to vary with the position, despite the fact that the lipid bilayer membrane has a uniform thickness. The authors present a method to rigorously treat the uniform-thickness condition in a system having an axial...
Source: IET Nanobiotechnology - October 25, 2008 Category: Nanotechnology Source Type: journals

Nanoelectronic interface for lab-on-a-chip devicesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Innovations in microfabricated analytical devices integrated with microelectronic circuits and biological cells show promising results in detection, diagnosis and analysis. Planar metallic microelectrodes are widely used for the electrical interface with the biological cells. Issues with the current microelectrode array design are the difficulty in selective integration with a cell, the size dependency of its impedance and the large amount of noise in the circuit due to this mismatch. It is quite evident that an approach utilising nanotechnology can solve some of these problems by yielding efficient electrical interconnect...
Source: IET Nanobiotechnology - October 25, 2008 Category: Nanotechnology Source Type: journals

Fluorescent resonance energy transfer based detection of biological contaminants through hybrid quantum dot-quencher interactionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A nanoscale sensor employing fluorescent resonance energy transfer interactions between fluorescent quantum dots (QDs) and organic quencher molecules can be used for the multiplexed detection of biological antigens in solution. Detection occurs when the antigens to be detected displace quencher-labelled inactivated (or dead) antigens of the same type attached to QD-antibody complexes through equilibrium reactions. This unquenches the QDs, allowing detection to take place through the observation of photoluminescence in solution or through the fluorescence imaging of unquenched QD complexes trapped on filter surfaces. Multip...
Source: IET Nanobiotechnology - June 10, 2008 Category: Nanotechnology Source Type: journals

Enhanced bio-molecular interactions through recirculating microflowsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A recirculating microfluidic platform has been developed for carrying out optical bio-detection. The present device can be used for passive mixing of the biological species with the microfluidic channel without immobilisation, through appropriate design and flow control. The feasibility of bio-detection using the present setup has been demonstrated through the method of fluorescence and the experiments were carried out with Antisheep Antibody (AB) tagged with Alexafluor 647 (AF647) fluorophore particles. By controlling the fluid flow, it was possible to isolate AB separately into a recirculation zone within the microfluidi...
Source: IET Nanobiotechnology - June 10, 2008 Category: Nanotechnology Source Type: journals

Dielectrophoretic assembly of insulinoma cells and fluorescent nanosensors into threedimensional pseudo-islet constructsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dielectrophoretic forces, generated by radio-frequency voltages applied to micromachined, transparent, indium tin oxide electrodes, have been used to condense suspensions of insulinoma cells (BETA-TC-6 and INS-1) into a 10times10 array of three-dimensional cell constructs. Some of these constructs, measuring ~150 mum in diameter, 120 mum in height and containing around 1000 cells, were of the same size and cell density as a typical islet of Langerhans. With the dielectrophoretic force maintained, these engineered cell constructs were able to withstand mechanical shock and fluid flow forces. Reproducibility of the process r...
Source: IET Nanobiotechnology - June 10, 2008 Category: Nanotechnology Source Type: journals

Interactions of electrical fields with fluids:laboratory-on-a-chip applicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: IET Nanobiotechnology)
Source: IET Nanobiotechnology - March 3, 2008 Category: Nanotechnology Source Type: journals

Recent advances in microparticle continuous separationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: IET Nanobiotechnology)
Source: IET Nanobiotechnology - March 3, 2008 Category: Nanotechnology Source Type: journals