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Translational research: an important integrated paradigm for transfusion medicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Translational research (TR) has many different potential definitions. There are two broad elements: one is research that serves as a bridge between basic science and the development/use of a therapeutic product/intervention; the second (also known as knowledge translation) explores why a clinically established product is not used more widely and/or further characterizes its optimal use. The first TR element has always been an integral part of transfusion medicine; it has previously been referred to as applied research or development. TR includes animal model research, and Phase I, II, and I/II clinical trials using human v...
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: S. Kleinman Tags: Papers Source Type: journals

Patient blood management – a new paradigm for transfusion medicine?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The saving of many lives in history has been duly credited to blood transfusions. What is frequently overlooked is the fact that, in light of a wealth of evidence as well as other management options, a therapy deemed suitable yesterday may no longer be the first choice today. Use of blood has not been based upon scientific evaluation of benefits, but mostly on anecdotal experience and a variety of factors are challenging current practice. Blood is a precious resource with an ever limiting supply due to the aging population. Costs have also continually increased due to advances (and complexities) in collection, testing, pro...
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: A. Thomson, S. Farmer, A. Hofmann, J. Isbister, A. Shander Tags: Papers Source Type: journals

Donor care, the change we needEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background Safe and adequate blood supply is the ultimate goal of blood transfusion services. Apparently, donor retention is more cost-effective than donor recruitment. Furthermore, repeated blood donors showed lower prevalence of transfusion transmitted infection than first time donors. At present, approximately 70% of blood donors at National Blood Centre, the Thai Red Cross Society were repeated blood donors. Therefore, donor retention is considered the key success of blood safety and adequacy.Aims To focus on "donor care, the change we need" by decreasing the number of two main adverse effects of blood donation, which ...
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: S. Phikulsod, D. Chiewsilp, K. Ongtilanont, T. Bhakbhumpong, W. Patanapongsak Tags: Papers Source Type: journals

Donor complications and donor careEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vasovagal reaction (VVR) is the most common adverse reaction associated with blood donation, and we have analysed risk factors and suggested preventive measures for VVR.Donor complications In Japan, there were 5 137 612 donations in 2008, and the incidence of all donor complications was 1·16% (male 0·87%, female 1·76%). The distribution of complications was: VVR 76·8%, hematoma 16·5%, local pain 2·3%, citrate reaction 0·9%, nerve injury 0·8% and others 2·8%.Risk factors of VVR The incidence of VVR with respect to donation types, sex and ages was evaluated. The incidence was significantly higher for donors aged 16[...
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: K. Nakajima Tags: Papers Source Type: journals

Research and development of Haemoglobin vesicle, a cellular type artificial oxygen carrierEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: H. Horinouchi, H. Sakai, Y. Izumi, M. Kohno, E. Tsuchida, K. Kobayashi Tags: Papers Source Type: journals

Historical views of bloodletting and transfusion from the beginning to the present status in JapanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: M. Shimizu, T. Mazda Tags: Papers Source Type: journals

The introduction of Western medicine and bloodletting in JapanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: P. J. Schmidt Tags: Papers Source Type: journals

Transfusion errors and their preventionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although the current risks of acquiring viral transmission through blood components and products are very small, mistransfusion, in which a blood unit is incorrectly administered to a non-designated recipient, remains the most common type of error in transfusion practice. ABO-incompatible blood transfusion attributable to the incorrect identification (ID) of the patient or the blood unit is one of the most serious transfusion hazards. Many studies revealed that transfusion errors occur frequently in clinical areas, with the most common error being failure to perform the final patient ID check at the bedside. Thus, the pret...
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: A. Ohsaka Tags: Papers Source Type: journals

In vitro production of transfusable red blood cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions To the best of our knowledge, this is the first report to show the feasibility of establishing erythroid cell lines ablility to produce mature RBCs. Considering the number of human ES cell lines that have been established so far and the number of induced pluripotent stem cell lines that will be established in future, the intensive testing of a number of these lines for erythroid potential may allow the establishment of human erythroid cell lines similar to the mouse erythroid cell lines. (Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: Y. Nakamura Tags: Papers Source Type: journals

Fight against TRALIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study revealed that female plasma, number of pregnancies in donors, number of donor units positive for anti-granulocyte antibodies and anti-HLA class II antibodies and concentration of lysophophatidylcholine in donor products are associated with developing TRALI. Our recent prospective study has revealed the predominance of male Fresh frozen plasma (FFP) FFP in post-transfusion respiratory function when comparing male only FFP and mixed FFP in surgical patients. The incidence of TRALI in the UK was successfully reduced by using preferentially male plasma. Although TRALI has a relatively better prognosis than ALI with ...
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: H. Okazaki Tags: Papers Source Type: journals

The molecular biology of blood groupsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The genes representing all but one of the 30 human blood group systems have been identified and sequenced, and the molecular bases to almost all of the blood group polymorphisms are known. Though most blood group polymorphisms result from single nucleotide polymorphisms, a variety of other mechanisms can also be involved. Some blood group variants result from mutations in genes independent of the blood group gene, such as the gene encoding a transcription factor. Some blood group proteins exist in the membrane as part of large protein complexes. Mutations in a gene encoding one of the proteins of the complex can affect ant...
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: G. Daniels Tags: Papers Source Type: journals

Epidemiology of dengue and chikungunya viruses and their potential impact on the blood supplyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dengue and chikungunya, transmitted by the Aedes mosquitoes, have caught worldwide attention because of increase in the frequency of major epidemics in recent years. Though transmitted by the same vectors, they are caused by different viruses (DENV and CHIKV) that belong to the genus Flavivirus and Alphavirus, respectively. There has been a worldwide resurgence of dengue in the last few decades. Today, it is estimated that it affects at least 50[ndash]100 million people every year. With more than 100 countries, between the 10°C isothermal lines, being endemic, 2·5 billion people are at risk of infection. Facilitated by r...
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: L. C. Ng, S. Lam, D. Teo Tags: Papers Source Type: journals

Epidemiology, clinical features and prevention of HTLV-I infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: K. Tajima Tags: Papers Source Type: journals

Occult hepatitis B infection: Incidence, detection and clinical implicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: C.-L. Lai, M.-F. Yuen Tags: Papers Source Type: journals

Washed/replaced (W/R)-plateletsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The preventive effect of plasma-reduction on transfusion-related adverse reaction caused by platelet concentrate (PC) is still controversial and a consensus about how much plasma should be removed is yet to be reached. However, according to previously reported papers and survey, widely various adverse reactions are preventable by plasma-reduced PC. Recently, a case series study of plasma-reduced PC (washed/replaced-PC, W/R-PC) using new platelet additive solution (M-sol), which can preserve platelet function longer than other additive solutions at as low as 5% plasma concentration, has been conducted in Hokkaido Red Cross ...
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: H. Azuma, H. Ikeda Tags: Papers Source Type: journals

Bacterial contamination: effect and limit of initial flow diversionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: M. Satake Tags: Papers Source Type: journals

Cost-effectiveness of blood programmes – the Asia Pacific Blood Network perspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Globally, cost management of blood programs is seen as a critical strategic issue. This needs to be balanced with other strategic priorities, including sustainability of the blood system and provision of sufficient, safe and appropriate products and services for patient care. Asia Pacific blood services seek improvement in cost efficiencies through both local initiatives, and through partnering with other countries via international networks such as the Asia Pacific Blood Network (APBN). Through the APBN, blood services participate in 2 key areas that have the potential to yield improved cost efficiencies. These are Compa...
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: C.-K. Lin, S. Thomas Tags: Papers Source Type: journals

Managing fractionated product in developing countriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: Y. Ayob Tags: Papers Source Type: journals

Evidence-based transfusion: young versus old blood as a case studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Evidence-based decision-making provides a formal process to evaluate the information supporting individual clinical and national policy decisions in transfusion medicine. Application to the specific problem of whether to limit the use of older blood suggests that the level of available evidence does not yet justify changing clinical practice. Adequately powered randomized controlled trials are necessary to determine the relative safety of older blood compared with younger blood in transfusion practice. (Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: R. J. Benjamin Tags: Papers Source Type: journals

Unrelated haematopoietic stem cell transplantation and bankEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the recent tremendous progress focusing on unrelated HSCT and HLA matching. (Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: Y. Morishima Tags: Papers Source Type: journals

Advances in alloimmune thrombocytopenia laboratory investigationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, international workshop exercises are of importance for further improvement and quality assurance proficiency. (Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: C. Kaplan Tags: Papers Source Type: journals

From NAT/PI to NAS/PO: preparing for nucleic acid surveillance and product optimizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The transfusion-transmitted infection (TTI) risk of pathogens for which nucleic acid testing (NAT) has been implemented is now insubstantial compared to other hazards of transfusion. Minimizing the TTI risk of non-tested pathogens is a goal of pathogen inactivation (PI); in particular, the interdiction of emerging pathogens is a major selling point. Incidental to PI is the possibility of eliminating certain patient-oriented procedures, e.g. selectively screening for cytomegalovirus (CMV) or irradiating to prevent transfusion-associated graft-versus-host disease (TA-GVHD). Do NAT and PI introduce new hazards? Perhaps. The p...
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: K. E. Nollet Tags: Papers Source Type: journals

Challenge of donor recruitmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: S. Lin Tsai Tags: Papers Source Type: journals

Prevalence of Hepatitis E virus infection among Japanese blood donorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: H. Ikeda, K. Matsubayashi, H. Sakata, H. Takeda, S. Sato, T. Kato, S. Hino, K. Tadokoro Tags: Papers Source Type: journals

Blood supply management during an influenza pandemicEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: D. Teo Tags: Papers Source Type: journals

From human somatic stem cells to human iPS cells – State of the art and future needsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The term environmental epigenetics refers the alterations in phenotype influenced by environmental exposures with the elucidation of epigenetic mechanisms responsible for altered gene expression. Epigenome of a stem cell is sensitive to environmental exposures. This character would cause phenotypic instability during in vitro expansion of a stem cell and disease susceptibility originated from a somatic stem cell. Although a reprogramming technology is to erase these disease-inducing epigenetic marks, recent knowledge indicate the incompleteness of the artificial reprogramming and the physiological reprogramming. (Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: K. Sakurada Tags: Papers Source Type: journals

Quality assurance in blood banking: the basis for safetyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: V. A. Armstrong Tags: Papers Source Type: journals

Donor management: social marketing, maintenance and trustEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: C. Tan Tags: Papers Source Type: journals

Collaboration of stakeholders for promotion of voluntary non-remunerated blood donorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: K. Tadokoro Tags: Papers Source Type: journals

Extending platelet storage: safety and quality considerationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: H. Ohto, S. Ezuki, T. Kanno, K. E. Nollet Tags: Papers Source Type: journals

Cost-effectiveness in haemotherapies and transfusion medicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: A. Hofmann, S. Farmer, A. Shander Tags: Papers Source Type: journals

Provision of blood products for the highly immunized patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: S. J. Nance Tags: Papers Source Type: journals

Leucocyte antibody screening of donors for the prevention of TRALIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antibody-mediated TRALI reduction strategies include the exclusion of high plasma volume blood components from risk donors or testing of these donors for leucocyte antibodies, i.e. HLA class I, HLA class II, and HNA antibodies. Recommendations for the detection of leucocyte antibodies have been made by the ISBT Working Party on Granulocyte Immunobiology. (Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: J. Bux Tags: Papers Source Type: journals

Non-invasive detection of foetal RhD status and other genetic characteristics by circulating nucleic acids in maternal plasmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since the discovery of cell-free foetal DNA in maternal plasma in 1997, many circulating foetal DNA markers have been developed for the non-invasive prenatal assessment of foetal genetic status. Some of the diagnostic applications, such as foetal sex determination and foetal rhesus D blood group genotyping, have already been introduced as routine services in some clinical centres. To extend the spectrum of foetal traits in which circulating foetal DNA can be worked on, advanced molecular technologies, such as mass spectrometry, microfluidic system and digital polymerase chain reaction analysis, have been employed. These ne...
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: N. B. Y. Tsui, Y. M. D. Lo Tags: Papers Source Type: journals

Update on current issues of the immune responses related to transfusion medicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antibodies are friends and foes in transfusion medicine; friends as diagnostic tools and as naturally occurring antibodies in healthy individuals, foes as alloantibodies or autoantibodies. In order for antibodies to appear, a complex immune response must have taken place. This regularly involves cells and molecules belonging to the innate and adaptive immune systems. The border between the innate and adaptive immune systems is not obvious and the two cannot be regarded as separate systems, but rather as two sequences of the same response. There are few if any immune responses belonging to the field of transfusion medicine ...
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: A. Husebekk Tags: Papers Source Type: journals

Transfusion-associated graft-versus-host diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: T. Juji, M. Nishimura, Y. Watanabe, S. Uchida, H. Okazaki, K. Tadokoro Tags: Papers Source Type: journals

Transfusion-related immune reactions: pathogenesis and preventionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: N. Ahrens Tags: Papers Source Type: journals

Prevention of bacterial contamination, including initial flow diversionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: E. Wood Tags: Papers Source Type: journals

Transfusion errors and managementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: M. B. C. Koh, R. Alcantara Tags: Papers Source Type: journals

Blood transfusions in neonatal cardiac surgery and ECMOEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: A. Brand Tags: Papers Source Type: journals

Hospital Transfusion Commitee – The essentials for safe and proper transfusion medicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: K. Takahashi, N. H. Tsuno Tags: Papers Source Type: journals

Worldwide network for blood and marrow transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: Y. Kodera Tags: Papers Source Type: journals

Allogeneic haematopoietic stem cell transplantation: an Asian perspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: R. Liang Tags: Papers Source Type: journals

Stem cell harvesting and transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Allogeneic haematopoietic stem cell transplantation is an accepted treatment for a variety of malignant and non-malignant diseases. Today, peripheral blood progenitor cells (PBPC) are increasingly used instead of bone marrow (BM) as stem cell source. Additionally, umbilical cord blood (UCB) has been established as an alternative source of donor cells. Many differences between the distinct stem cell sources do exist. PBPC contain a higher amount of CD34 + cells compared with BM and UCB, leading to more rapid engraftment with the disadvantage of a higher incidence of chronic graft-versus-host disease. In contrast to adults, ...
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: N. Worel, W. R. Mayr Tags: Papers Source Type: journals

Changing concept of hepatitis B virusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: M. Mizokami Tags: Papers Source Type: journals

Emerging infections in Asia and its possible global effectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: P. Flanagan Tags: Papers Source Type: journals

Transfusion-transmitted vCJD and its consequences for the Asia-Pacific regionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: A. Keller Tags: Papers Source Type: journals

Thrombotic thrombocytopenic purpura: Results of the patients with thrombotic microangiopathies across Japan by ADAMTS13 analysis during 1998–2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Although TMAs are highly heterogeneous pathological conditions, one third of TMA patients have severe deficiency of ADAMTS13:AC. Platelet transfusions to such patients are contraindicated. Thus, rapid ADAMTS13:AC assays will be prerequisite in medical facilities where TMA patients are treated. (Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: Y. Fujimura, M. Matsumoto Tags: Papers Source Type: journals

Heparin-induced thrombocytopeniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: S. Miyata Tags: Papers Source Type: journals

Blood group serologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ISBT Science Series)
Source: ISBT Science Series - March 1, 2009 Category: Hematology Authors: H. Goubran Tags: XIXth Regional Congress of the ISBT, Eastern Mediterranean & amp; Europe Source Type: journals