Imperative connotation of SODs in cancer: Emerging targets and multifactorial role of action
AbstractSuperoxide dismutase (SOD) is a crucial enzyme responsible for the redox homeostasis inside the cell. As a part of the antioxidant defense system, it plays a pivotal role in the dismutation of the superoxide radicals (O2 −$$ {{\mathrm{O}}_2}^{-} $$) generated mainly by the oxidative phosphorylation, which would otherwise bring out the redox dysregulation, leading to higher reactive oxygen species (ROS) generation and, ultimately, cell transformation, and malignancy. Several studies have shown the involvement of RO S in a wide range of human cancers. As SOD is the key enzyme in regulating ROS, any change, such as ...
Source: IUBMB Life - April 11, 2024 Category: Research Authors: Biswajit Panda,
Ankita Tripathy,
Srimanta Patra,
Bandana Kullu,
Shams Tabrez,
Mrutyunjay Jena Tags: CRITICAL REVIEW Source Type: research
IUBMB Life special issue: Mitochondrial biology and the yeast paradigm
(Source: IUBMB Life)
Source: IUBMB Life - April 10, 2024 Category: Research Authors: Flavia Fontanesi Tags: SPECIAL ISSUE Source Type: research
Characterization of Mitoribosomal Small Subunit unit genes related immune and pharmacogenomic landscapes in renal cell carcinoma
AbstractMitoribosomes are essential for the production of biological energy. The Human Mitoribosomal Small Subunit unit (MRPS) family, responsible for encoding mitochondrial ribosomal small subunits, is actively engaged in protein synthesis within the mitochondria. Intriguingly, MRPS family genes appear to play a role in cancer. A multistep process was employed to establish a risk model associated with MRPS genes, aiming to delineate the immune and pharmacogenomic landscapes in clear cell renal cell carcinoma (ccRCC). MRPScores were computed for individual patients to assess their responsiveness to various treatment modali...
Source: IUBMB Life - April 2, 2024 Category: Research Authors: Zhihao Wei,
Chenchen Liu,
Jiaqian Liang,
Xuan Zhou,
Kaming Xue,
Keshan Wang,
Xiaoping Zhang Tags: RESEARCH ARTICLE Source Type: research
Mitochondrial respiratory supercomplexes of the yeast Saccharomyces cerevisiae
AbstractThe functional and structural relationship among the individual components of the mitochondrial respiratory chain constitutes a central aspect of our understanding of aerobic catabolism. This interplay has been a subject of intense debate for over 50 years. It is well established that individual respiratory enzymes associate into higher-order structures known as respiratory supercomplexes, which represent the evolutionarily conserved organizing principle of the mitochondrial respiratory chain. In the yeastSaccharomyces cerevisiae, supercomplexes are formed by a complex III homodimer flanked by one or two complex...
Source: IUBMB Life - March 27, 2024 Category: Research Authors: Mazzen H. Eldeeb,
Lizeth J. Camacho Lopez,
Flavia Fontanesi Tags: CRITICAL REVIEW Source Type: research
Issue Information
(Source: IUBMB Life)
Source: IUBMB Life - March 20, 2024 Category: Research Tags: ISSUE INFORMATION Source Type: research
Cover Image
On the Cover: Underlying molecular mechanisms by which 1,25(OH)2D3 on inhibition of LLC cell migration by Chen et al.; Article first published: 3 Nov 2023;https://doi.org/10.1002/iub.2789 On the Cover: Underlying molecular mechanisms by which 1,25(OH)2D3 on inhibition of LLC cell migration by Chen et al.; Article first published: 3 Nov 2023;https://doi.org/10.1002/iub.2789 (Source: IUBMB Life)
Source: IUBMB Life - March 19, 2024 Category: Research Tags: COVER IMAGE Source Type: research
Issue Information
(Source: IUBMB Life)
Source: IUBMB Life - March 19, 2024 Category: Research Tags: ISSUE INFORMATION Source Type: research
Cover Image
On the Cover: Underlying molecular mechanisms by which 1,25(OH)2D3 on inhibition of LLC cell migration by Chen et al.; Article first published: 3 Nov 2023;https://doi.org/10.1002/iub.2789 On the Cover: Underlying molecular mechanisms by which 1,25(OH)2D3 on inhibition of LLC cell migration by Chen et al.; Article first published: 3 Nov 2023;https://doi.org/10.1002/iub.2789 (Source: IUBMB Life)
Source: IUBMB Life - March 19, 2024 Category: Research Tags: COVER IMAGE Source Type: research
Autophagy inhibition potentiates energy restriction ‐induced cell death in hepatocellular carcinoma cells
AbstractHepatocellular carcinoma (HCC) significantly contributes to cancer-related mortality due to the limited response of HCC to current anticancer therapies, thereby necessitating more effective treatment approaches. Energy restriction mimetic agents (ERMAs) have emerged as potential therapies in targeting the Warburg effect, a unique metabolic process in cancer cells. However, ERMAs exhibit limited efficacy when used as monotherapy. Additionally, ERMAs have been found to induce autophagy in cancer cells. The role of autophagy in cancer survival remains a subject of debate. Thus, it is crucial to ascertain whether ERMA-...
Source: IUBMB Life - March 19, 2024 Category: Research Authors: Sara M. Elgendy,
Dana M. Zaher,
Nadin H. Sarg,
Nour N. Abu Jayab,
Dima W. Alhamad,
Taleb H. Al ‐Tel,
Hany A. Omar Tags: RESEARCH ARTICLE Source Type: research
Retraction: miR ‐212/132 downregulates SMAD2 expression to suppress the G1/S phase transition of the cell cycle and the epithelial to mesenchymal transition in cervical cancer cells
Retraction: ‘miR-212/132 downregulates SMAD2 expression to suppress the G1/S phase transition of the cell cycle and the epithelial to mesenchymal transition in cervical cancer cells’ byJian-Li Zhao,Le Zhang, Xu Guo,Jing-Hua Wang,Wen Zhou,Min Liu,Xin Li andHua Tang,IUBMB Life2015,67,380–394
: The above article, published online on 15 May 2015 on Wiley Online Library (https://doi.org/10.1002/iub.1381) has been retracted by agreement between the journal's Editor in Chief, Dr. Efstathios S. Gonos, and Wiley Periodicals LLC. The retraction has been agreed following an investigation based on allegations raised by a third...
Source: IUBMB Life - March 15, 2024 Category: Research Tags: RETRACTION Source Type: research
Particulate matters 2.5 induce tumor progression in lung cancer by increasing the activity of hnRNPA2B1 resulting in retarding mRNA decay of oxidative phosphorylation
In conclusion, PM2.5 appears to drive lung cancer progression and migration by modulating the energy metabolism of lung cancer in a hnRNPA2B1-dependent manner. (Source: IUBMB Life)
Source: IUBMB Life - March 7, 2024 Category: Research Authors: Wen Bian,
Haifeng Yu,
Xiaofei Zhang,
Yuxuan Wang,
Bin Ni Tags: RESEARCH ARTICLE Source Type: research
