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Macrophage- and Dendritic-Cell-Derived Interleukin-15 Receptor Alpha Supports Homeostasis of Distinct CD8+ T Cell SubsetsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Erwan Mortier, Rommel Advincula, Leesun Kim, Stephen Chmura, Julio Barrera, Boris Reizis, Barbara A. Malynn, Averil Ma. Interleukin-15 receptor alpha (IL-15Rα) is a pleiotropically expressed molecule that chaperones and trans-presents IL-15 to NK and T cells. To investigate whether IL-15Rα presented by diffe.... (Source: Immunity)
Source: Immunity - November 13, 2009 Category: Allergy & Immunology Source Type: journals

Coactivation of Syk Kinase and MyD88 Adaptor Protein Pathways by Bacteria Promotes Regulatory Properties of NeutrophilsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Xiaoming Zhang, Laleh Majlessi, Edith Deriaud, Claude Leclerc, Richard Lo-Man. Neutrophils are one of the first lines of defense against microbial pathogens and are rapidly recruited at the infection site upon inflammatory conditions. We show here that after bacterial stimul.... (Source: Immunity)
Source: Immunity - November 13, 2009 Category: Allergy & Immunology Source Type: journals

Selective Expression of the Chemokine Receptor XCR1 on Cross-presenting Dendritic Cells Determines Cooperation with CD8+ T CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Brigitte G. Dorner, Martin B. Dorner, Xuefei Zhou, Corinna Opitz, Ahmed Mora, Steffen Güttler, Andreas Hutloff, Hans W. Mages, Katja Ranke, Michael Schaefer, Robert S. Jack, Volker Henn, Richard A. Kroczek. The expression of the chemokine receptor XCR1 and the function of its ligand XCL1 (otherwise referred to as ATAC, lymphotactin, or SCM-1) remained elusive to date. In the present report we demonst.... (Source: Immunity)
Source: Immunity - November 13, 2009 Category: Allergy & Immunology Source Type: journals

Decrease of Foxp3+ Treg Cell Number and Acquisition of Effector Cell Phenotype during Lethal InfectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Guillaume Oldenhove, Nicolas Bouladoux, Elizabeth A. Wohlfert, Jason A. Hall, David Chou, Liliane Dos santos, Shaun O'Brien, Rebecca Blank, Erika Lamb, Sundar Natarajan, Robin Kastenmayer, Christopher Hunter, Michael E. Grigg, Yasmine Belkaid. Using a model of lethal oral infection with Toxoplasma gondii, we examined the fate of both induced and natural regulatory T (Treg) cells in the face of strong inflammatory responses occurr.... (Source: Immunity)
Source: Immunity - November 6, 2009 Category: Allergy & Immunology Source Type: journals

Suppression of Phosphatidylinositol 3,4,5-Trisphosphate Production Is a Key Determinant of B Cell AnergyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cecille D. Browne, Christopher J. Del Nagro, Matthew H. Cato, Hart S. Dengler, Robert C. Rickert. Anergy is a critical physiologic mechanism to censor self-reactive B cells. However, a biochemical understanding of how anergy is achieved and maintained is lacking. Herein, we investigated the ro.... (Source: Immunity)
Source: Immunity - November 6, 2009 Category: Allergy & Immunology Source Type: journals

A Distinct Subset of Self-Renewing Human Memory CD8+ T Cells Survives Cytotoxic ChemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cameron J. Turtle, Hillary M. Swanson, Nobuharu Fujii, Elihu H. Estey, Stanley R. Riddell. The mechanisms that maintain human T cell memory during normal and perturbed homeostasis are not fully understood. The repeated induction of profound lymphocytopenia in patients undergoing multipl.... (Source: Immunity)
Source: Immunity - October 30, 2009 Category: Allergy & Immunology Source Type: journals

T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor ImmunityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Natalia Martin-Orozco, Pawel Muranski, Yeonseok Chung, Xuexian O. Yang, Tomohide Yamazaki, Sijie Lu, Patrick Hwu, Nicholas P. Restifo, Willem W. Overwijk, Chen Dong. Although T helper 17 (Th17) cells have been found in tumor tissues, their function in cancer immunity is unclear. We found that interleukin-17A (IL-17A)-deficient mice were more susceptible to dev.... (Source: Immunity)
Source: Immunity - October 30, 2009 Category: Allergy & Immunology Source Type: journals

Critical Role for Asparagine Endopeptidase in Endocytic Toll-like Receptor Signaling in Dendritic CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fernando E. Sepulveda, Sophia Maschalidi, Renaud Colisson, Lea Heslop, Cristina Ghirelli, Emna Sakka, Ana-Maria Lennon-Duménil, Sebastian Amigorena, Lucien Cabanie, Bénédicte Manoury. Intracellular Toll-like receptor 3 (TLR3), TLR7, and TLR9 localize in endosomes and recognize single-stranded RNA and nucleotides from viruses and bacteria. This interaction induces their conforma.... (Source: Immunity)
Source: Immunity - October 30, 2009 Category: Allergy & Immunology Source Type: journals

Interleukin-17 Is Required for T Helper 1 Cell Immunity and Host Resistance to the Intracellular Pathogen Francisella tularensisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Yinyao Lin, Shane Ritchea, Alison Logar, Samantha Slight, Michelle Messmer, Javier Rangel-Moreno, Lokesh Guglani, John F. Alcorn, Heather Strawbridge, Sang Mi Park, Reiko Onishi, Nikki Nyugen, Michael J. Walter, Derek Pociask, Troy D. Randall, Sarah L. Gaffen, Yoichiro Iwakura, Jay K. Kolls, Shabaana A. Khader. The importance of T helper type 1 (Th1) cell immunity in host resistance to the intracellular bacterium Francisella tularensis is well established. However, the relative roles of interleuki.... (Source: Immunity)
Source: Immunity - October 23, 2009 Category: Allergy & Immunology Source Type: journals

The Gut Immune Barrier and the Blood-Brain Barrier: Are They So Different?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Richard Daneman, Maria Rescigno. In order to protect itself from a diverse set of environmental pathogens and toxins, the body has developed a number of barrier mechanisms to limit the entry of potential hazards. Here, we compare.... (Source: Immunity)
Source: Immunity - October 16, 2009 Category: Allergy & Immunology Source Type: journals

Chemokines and Chemokine Receptors: Standing at the Crossroads of Immunobiology and NeurobiologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Richard M. Ransohoff. There are several molecular entities common to the immune and nervous systems. Salient among them are the chemokines and their receptors, which play remarkably varied and potent roles in immunobio.... (Source: Immunity)
Source: Immunity - October 16, 2009 Category: Allergy & Immunology Source Type: journals

Immune and Nervous Systems: More Than Just a Superficial Similarity?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dimitris Kioussis, Vassilis Pachnis. Strong evidence is emerging that the nervous and immune systems share mechanisms of gene regulation, signaling, cell communication, and supracellular organization. This brings to the fore many que.... (Source: Immunity)
Source: Immunity - October 16, 2009 Category: Allergy & Immunology Source Type: journals

A Recurrent Network Involving the Transcription Factors PU.1 and Gfi1 Orchestrates Innate and Adaptive Immune Cell FatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chauncey J. Spooner, Jason X. Cheng, Elisabet Pujadas, Peter Laslo, Harinder Singh. The transcription factor PU.1, encoded by the Sfpi1 gene, functions in a graded manner to regulate macrophage versus B cell generation; its higher concentration favors the macrophage fate. .... (Source: Immunity)
Source: Immunity - October 9, 2009 Category: Allergy & Immunology Source Type: journals

Differential Expression of Interleukin-17A and -17F Is Coupled to T Cell Receptor Signaling via Inducible T Cell KinaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Julio Gomez-Rodriguez, Nisebita Sahu, Robin Handon, Todd S. Davidson, Stacie M. Anderson, Martha R. Kirby, Avery August, Pamela L. Schwartzberg. T helper 17 (Th17) cells play major roles in autoimmunity and bacterial infections, yet how T cell receptor (TCR) signaling affects Th17 cell differentiation is relatively unknown. We demonstrate .... (Source: Immunity)
Source: Immunity - October 9, 2009 Category: Allergy & Immunology Source Type: journals

How Punctual Ablation of Regulatory T Cells Unleashes an Autoimmune Lesion within the Pancreatic IsletsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Markus Feuerer, Yuelei Shen, Dan R. Littman, Christophe Benoist, Diane Mathis. CD4+Foxp3+ regulatory T cells (Treg cells) are known to control the progression of autoimmune diabetes, but when, where, and how they exert their influence in this context ar.... (Source: Immunity)
Source: Immunity - October 9, 2009 Category: Allergy & Immunology Source Type: journals

T Cell Islet Accumulation in Type 1 Diabetes Is a Tightly Regulated, Cell-Autonomous EventEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Greig P. Lennon, Maria Bettini, Amanda R. Burton, Erica Vincent, Paula Y. Arnold, Pere Santamaria, Dario A.A. Vignali. Type 1 diabetes is a T cell-mediated autoimmune disease, characterized by lymphocytic infiltration of the pancreatic islets. It is currently thought that islet antigen specificity is not a require.... (Source: Immunity)
Source: Immunity - October 9, 2009 Category: Allergy & Immunology Source Type: journals

Mast Cell-Mediated Antigen Presentation Regulates CD8+ T Cell Effector FunctionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Erietta Stelekati, Rajia Bahri, Orietta D'Orlando, Zane Orinska, Hans-Willi Mittrücker, Rabea Langenhaun, Markus Glatzel, Annalena Bollinger, Ralf Paus, Silvia Bulfone-Paus. The characteristics, importance, and molecular requirements for interactions between mast cells (MCs) and CD8+ T cells have not been elucidated. Here, we demonstrated that MCs in.... (Source: Immunity)
Source: Immunity - October 9, 2009 Category: Allergy & Immunology Source Type: journals

Distinct Conformations of Ly49 Natural Killer Cell Receptors Mediate MHC Class I Recognition in Trans and CisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Jonathan Back, Emilio L. Malchiodi, Sangwoo Cho, Léonardo Scarpellino, Pascal Schneider, Melissa C. Kerzic, Roy A. Mariuzza, Werner Held. Certain cell-surface receptors engage ligands expressed on juxtaposed cells and ligands on the same cell. The structural basis for trans versus cis binding is not known. Here, we sho.... (Source: Immunity)
Source: Immunity - October 9, 2009 Category: Allergy & Immunology Source Type: journals

CCCTC-Binding Factor and the Transcription Factor T-bet Orchestrate T Helper 1 Cell-Specific Structure and Function at the Interferon-γ LocusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Masayuki Sekimata, Mercedes Pérez-Melgosa, Sara A. Miller, Amy S. Weinmann, Peter J. Sabo, Richard Sandstrom, Michael O. Dorschner, John A. Stamatoyannopoulos, Christopher B. Wilson. How cell type-specific differences in chromatin conformation are achieved and their contribution to gene expression are incompletely understood. Here we identify a cryptic upstream orchestrator of.... (Source: Immunity)
Source: Immunity - October 9, 2009 Category: Allergy & Immunology Source Type: journals

Indispensable Role of the Runx1-Cbfβ Transcription Complex for In Vivo-Suppressive Function of FoxP3+ Regulatory T CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Akihiko Kitoh, Masahiro Ono, Yoshinori Naoe, Naganari Ohkura, Tomoyuki Yamaguchi, Hiroko Yaguchi, Issay Kitabayashi, Toshihiko Tsukada, Takashi Nomura, Yoshiki Miyachi, Ichiro Taniuchi, Shimon Sakaguchi. Naturally arising regulatory T (Treg) cells express the transcription factor FoxP3, which critically controls the development and function of Treg cells. FoxP3 interacts with another transcription.... (Source: Immunity)
Source: Immunity - October 2, 2009 Category: Allergy & Immunology Source Type: journals

Upregulation of CD4 Expression during MHC Class II-Specific Positive Selection Is Essential for Error-free Lineage ChoiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sophia D. Sarafova, Francois Van Laethem, Stanley Adoro, Terry Guinter, Susan O. Sharrow, Lionel Feigenbaum, Alfred Singer. The lineage fate of developing thymocytes is determined by the persistence or cessation of T cell receptor (TCR) signaling during positive selection, with persistent TCR signaling required for CD4.... (Source: Immunity)
Source: Immunity - September 11, 2009 Category: Allergy & Immunology Source Type: journals

Small, Mobile FcɛRI Receptor Aggregates Are Signaling CompetentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nicholas L. Andrews, Janet R. Pfeiffer, A. Marina Martinez, David M. Haaland, Ryan W. Davis, Toshiaki Kawakami, Janet M. Oliver, Bridget S. Wilson, Diane S. Lidke. Crosslinking of IgE-bound FcɛRI triggers mast cell degranulation. Previous fluorescence recovery after photobleaching (FRAP) and phosphorescent anisotropy studies suggested that FcɛRI must immobil.... (Source: Immunity)
Source: Immunity - September 11, 2009 Category: Allergy & Immunology Source Type: journals

Origin of the Lamina Propria Dendritic Cell NetworkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Milena Bogunovic, Florent Ginhoux, Julie Helft, Limin Shang, Daigo Hashimoto, Melanie Greter, Kang Liu, Claudia Jakubzick, Molly A. Ingersoll, Marylene Leboeuf, E. Richard Stanley, Michel Nussenzweig, Sergio A. Lira, Gwendalyn J. Randolph, Miriam Merad. CX3CR1+ and CD103+ dendritic cells (DCs) in intestinal lamina propria play a key role in mucosal immunity. However, the origin and the developmental pathways that .... (Source: Immunity)
Source: Immunity - September 4, 2009 Category: Allergy & Immunology Source Type: journals

Type I Interferon Signaling in Dendritic Cells Stimulates the Development of Lymph-Node-Resident T Follicular Helper CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Helena Cucak, Ulf Yrlid, Boris Reizis, Ulrich Kalinke, Bengt Johansson-Lindbom. T follicular helper (Tfh) cells represent a recently defined CD4+ T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cell.... (Source: Immunity)
Source: Immunity - September 4, 2009 Category: Allergy & Immunology Source Type: journals

Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and FunctionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chen Varol, Alexandra Vallon-Eberhard, Eran Elinav, Tegest Aychek, Yami Shapira, Hervé Luche, Hans Jörg Fehling, Wolf-Dietrich Hardt, Guy Shakhar, Steffen Jung. The intestinal immune system discriminates between tolerance toward the commensal microflora and robust responses to pathogens. Maintenance of this critical balance is attributed to mucosal dendri.... (Source: Immunity)
Source: Immunity - September 4, 2009 Category: Allergy & Immunology Source Type: journals

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and AutoimmunityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Caroline E. Sutton, Stephen J. Lalor, Cheryl M. Sweeney, Corinna F. Brereton, Ed C. Lavelle, Kingston H.G. Mills. Th17 cells, CD4+ T cells that secrete interleukin-17 (IL-17), are pathogenic in autoimmune diseases and their development and expansion is driven by the cytokines IL-6, TGF-β, IL-21, IL.... (Source: Immunity)
Source: Immunity - August 14, 2009 Category: Allergy & Immunology Source Type: journals

Loss of the LAT Adaptor Converts Antigen-Responsive T Cells into Pathogenic Effectors that Function Independently of the T Cell ReceptorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Michael Mingueneau, Romain Roncagalli, Claude Grégoire, Adrien Kissenpfennig, Arkadiusz Miazek, Cristel Archambaud, Ying Wang, Pierre Perrin, Elodie Bertosio, Amandine Sansoni, Sylvie Richelme, Richard M. Locksley, Enrique Aguado, Marie Malissen, Bernard Malissen. Despite compromised T cell antigen receptor (TCR) signaling, mice in which tyrosine 136 of the adaptor linker for activation of T cells (LAT) was constitutively mutated (LatY136F.... (Source: Immunity)
Source: Immunity - August 14, 2009 Category: Allergy & Immunology Source Type: journals

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental SignalsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bruno Martin, Keiji Hirota, Daniel J. Cua, Brigitta Stockinger, Marc Veldhoen. γδ T cells are an innate source of interleukin-17 (IL-17), preceding the development of the adaptive T helper 17 (Th17) cell response. Here we show that IL-17-producing T cell receptor γδ (TCRγδ) .... (Source: Immunity)
Source: Immunity - August 14, 2009 Category: Allergy & Immunology Source Type: journals

Transcriptional Repressor Blimp-1 Promotes CD8+ T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell PropertiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rachel L. Rutishauser, Gislâine A. Martins, Sergey Kalachikov, Anmol Chandele, Ian A. Parish, Eric Meffre, Joshy Jacob, Kathryn Calame, Susan M. Kaech. During acute infections, a small population of effector CD8+ T cells evades terminal differentiation and survives as long-lived memory T cells. We demonstrate that the transcriptional r.... (Source: Immunity)
Source: Immunity - August 7, 2009 Category: Allergy & Immunology Source Type: journals

Blimp-1 Transcription Factor Is Required for the Differentiation of Effector CD8+ T Cells and Memory ResponsesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Axel Kallies, Annie Xin, Gabrielle T. Belz, Stephen L. Nutt. In response to viral infection, naive CD8+ T cells proliferate and differentiate into cytotoxic and cytokine-producing effector cells. Here we showed that the transcription factor Blimp.... (Source: Immunity)
Source: Immunity - August 7, 2009 Category: Allergy & Immunology Source Type: journals

A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral InfectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Haina Shin, Shawn D. Blackburn, Andrew M. Intlekofer, Charlly Kao, Jill M. Angelosanto, Steven L. Reiner, E. John Wherry. T cell exhaustion is common during chronic infections and can prevent optimal immunity. Although recent studies have demonstrated the importance of inhibitory receptors and other pathways in T cel.... (Source: Immunity)
Source: Immunity - August 7, 2009 Category: Allergy & Immunology Source Type: journals

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXREmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Noelia A-Gonzalez, Steven J. Bensinger, Cynthia Hong, Susana Beceiro, Michelle N. Bradley, Noam Zelcer, Jose Deniz, Cristina Ramirez, Mercedes Díaz, German Gallardo, Carlos Ruiz de Galarreta, Jon Salazar, Felix Lopez, Peter Edwards, John Parks, Miguel Andujar, Peter Tontonoz, Antonio Castrillo. Effective clearance of apoptotic cells by macrophages is essential for immune homeostasis. The transcriptional pathways that allow macrophages to sense and respond to apoptotic cells are poorly de.... (Source: Immunity)
Source: Immunity - July 31, 2009 Category: Allergy & Immunology Source Type: journals

Interleukin-10 Production by Th1 Cells Requires Interleukin-12-Induced STAT4 Transcription Factor and ERK MAP Kinase Activation by High Antigen DoseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Margarida Saraiva, Jillian R. Christensen, Marc Veldhoen, Theresa L. Murphy, Kenneth M. Murphy, Anne O'Garra. CD4+ T cells producing interleukin-10 (IL-10) and interferon-γ (IFN-γ) are reported in chronic infections. However, the signals that direct the development of IL-10-producing T helper 1.... (Source: Immunity)
Source: Immunity - July 31, 2009 Category: Allergy & Immunology Source Type: journals

Altered NK Cell Development and Enhanced NK Cell-Mediated Resistance to Mouse Cytomegalovirus in NKG2D-Deficient MiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Biljana Zafirova, Sanja Mandarić, Ronald Antulov, Astrid Krmpotić, Helena Jonsson, Wayne M. Yokoyama, Stipan Jonjić, Bojan Polić. NKG2D is a potent activating receptor on natural killer (NK) cells and acts as a molecular sensor for stressed cells expressing NKG2D ligands such as infected or tumor-transformed cells. Although .... (Source: Immunity)
Source: Immunity - July 24, 2009 Category: Allergy & Immunology Source Type: journals

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage CommitmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Di Yu, Sudha Rao, Louis M. Tsai, Sau K. Lee, Yiqing He, Elissa L. Sutcliffe, Monika Srivastava, Michelle Linterman, Lei Zheng, Nicholas Simpson, Julia I. Ellyard, Ian A. Parish, Cindy S. Ma, Qi-Jing Li, Christopher R. Parish, Charles R. Mackay, Carola G. Vinuesa. Follicular helper T (Tfh) cells provide selection signals to germinal center B cells, which is essential for long-lived antibody responses. High CXCR5 and low CCR7 expression facilitates their hom.... (Source: Immunity)
Source: Immunity - July 24, 2009 Category: Allergy & Immunology Source Type: journals

Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune ResponsesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dominique Gatto, Didrik Paus, Antony Basten, Charles R. Mackay, Robert Brink. Humoral immunity depends on both rapid and long-term antibody production against invading pathogens. This is achieved by the generation of spatially distinct extrafollicular plasmablast and follic.... (Source: Immunity)
Source: Immunity - July 17, 2009 Category: Allergy & Immunology Source Type: journals

KLF2 Transcription-Factor Deficiency in T Cells Results in Unrestrained Cytokine Production and Upregulation of Bystander Chemokine ReceptorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Michael A. Weinreich, Kensuke Takada, Cara Skon, Steven L. Reiner, Stephen C. Jameson, Kristin A. Hogquist. The transcription factor KLF2 regulates T cell trafficking by promoting expression of the lipid-binding receptor S1P1 and the selectin CD62L. Recently, it was proposed that KLF2 also re.... (Source: Immunity)
Source: Immunity - July 10, 2009 Category: Allergy & Immunology Source Type: journals

T Cell Receptor CDR2β and CDR3β Loops Collaborate Functionally to Shape the iNKT Cell RepertoireEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thierry Mallevaey, James P. Scott-Browne, Jennifer L. Matsuda, Mary H. Young, Daniel G. Pellicci, Onisha Patel, Meena Thakur, Lars Kjer-Nielsen, Stewart K. Richardson, Vincenzo Cerundolo, Amy R. Howell, James McCluskey, Dale I. Godfrey, Jamie Rossjohn, Philippa Marrack, Laurent Gapin. Mouse type I natural killer T cell receptors (iNKT TCRs) use a single Vα14-Jα18 sequence and Vβs that are almost always Vβ8.2, Vβ7, or Vβ2, although the basis of this differential usage is unclear.... (Source: Immunity)
Source: Immunity - July 10, 2009 Category: Allergy & Immunology Source Type: journals

Integrin-Dependent Organization and Bidirectional Vesicular Traffic at Cytotoxic Immune SynapsesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dongfang Liu, Yenan T. Bryceson, Tobias Meckel, Gaia Vasiliver-Shamis, Michael L. Dustin, Eric O. Long. Cytotoxic lymphocytes kill target cells by releasing the content of secretory lysosomes at the immune synapse. To understand the dynamics and control of cytotoxic immune synapses, we imaged human .... (Source: Immunity)
Source: Immunity - July 10, 2009 Category: Allergy & Immunology Source Type: journals

Differential Recognition of CD1d-α-Galactosyl Ceramide by the Vβ8.2 and Vβ7 Semi-invariant NKT T Cell ReceptorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Daniel G. Pellicci, Onisha Patel, Lars Kjer-Nielsen, Siew Siew Pang, Lucy C. Sullivan, Konstantinos Kyparissoudis, Andrew G. Brooks, Hugh H. Reid, Stephanie Gras, Isabelle S. Lucet, Ruide Koh, Mark J. Smyth, Thierry Mallevaey, Jennifer L. Matsuda, Laurent Gapin, James McCluskey, Dale I. Godfrey, Jamie Rossjohn. The semi-invariant natural killer T cell receptor (NKT TCR) recognizes CD1d-lipid antigens. Although the TCRα chain is typically invariant, the β chain expression is more diverse, where three Vβ c.... (Source: Immunity)
Source: Immunity - July 10, 2009 Category: Allergy & Immunology Source Type: journals

Deltex1 Is a Target of the Transcription Factor NFAT that Promotes T Cell AnergyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Huey-Wen Hsiao, Wen-Hsien Liu, Chen-Jhe Wang, Yu-Hsun Lo, Yung-Hsuan Wu, Si-Tse Jiang, Ming-Zong Lai. The molecular process underlying T cell anergy is incompletely understood. Deltex1 (DTX1) is a Notch target with unknown physiological function. Here we show that Dtx1 was a transcription t.... (Source: Immunity)
Source: Immunity - July 10, 2009 Category: Allergy & Immunology Source Type: journals

Human Dendritic Cells Induce the Differentiation of Interleukin-21-Producing T Follicular Helper-like Cells through Interleukin-12Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nathalie Schmitt, Rimpei Morita, Laure Bourdery, Salah Eddine Bentebibel, Sandra M. Zurawski, Jacques Banchereau, Hideki Ueno. T follicular helper (Tfh) cells help development of antibody responses via interleukin-21 (IL-21). Here we show that activated human dendritic cells (DCs) induced naive CD4+ T cells to .... (Source: Immunity)
Source: Immunity - July 10, 2009 Category: Allergy & Immunology Source Type: journals

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic CaspasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alexander U. Lüthi, Sean P. Cullen, Edel A. McNeela, Patrick J. Duriez, Inna S. Afonina, Clare Sheridan, Gabriela Brumatti, Rebecca C. Taylor, Kristof Kersse, Peter Vandenabeele, Ed C. Lavelle, Seamus J. Martin. Interleukin-33 (IL-33) is a member of the IL-1 family and is involved in polarization of T cells toward a T helper 2 (Th2) cell phenotype. IL-33 is thought to be activated via caspase-1-dependent .... (Source: Immunity)
Source: Immunity - July 3, 2009 Category: Allergy & Immunology Source Type: journals

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand VirusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Martin Schlee, Andreas Roth, Veit Hornung, Cristina Amparo Hagmann, Vera Wimmenauer, Winfried Barchet, Christoph Coch, Markus Janke, Aleksandra Mihailovic, Greg Wardle, Stefan Juranek, Hiroki Kato, Taro Kawai, Hendrik Poeck, Katherine A. Fitzgerald, Osamu Takeuchi, Shizuo Akira, Thomas Tuschl, Eicke Latz, Janos Ludwig, Gunther Hartmann. Antiviral immunity is triggered by immunorecognition of viral nucleic acids. The cytosolic helicase RIG-I is a key sensor of viral infections and is activated by RNA containing a triphosphate at t.... (Source: Immunity)
Source: Immunity - July 3, 2009 Category: Allergy & Immunology Source Type: journals

Virus Binding to a Plasma Membrane Receptor Triggers Interleukin-1α-Mediated Proinflammatory Macrophage Response In VivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nelson C. Di Paolo, Edward A. Miao, Yoichiro Iwakura, Kaja Murali-Krishna, Alan Aderem, Richard A. Flavell, Thalia Papayannopoulou, Dmitry M. Shayakhmetov. The recognition of viral components by host pattern-recognition receptors triggers the induction of the antiviral innate immune response. Toll-like receptor 9 (TLR9) and NLRP3 inflammasome were sh.... (Source: Immunity)
Source: Immunity - July 3, 2009 Category: Allergy & Immunology Source Type: journals

Initial Clonal Expansion of Germinal Center B Cells Takes Place at the Perimeter of FolliclesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Francis Coffey, Boris Alabyev, Tim Manser. Current models of the germinal center (GC) response propose that after stimulation at the edges of T cell zones, pre-GC B cells directly migrate to the center of follicles and proliferate to form .... (Source: Immunity)
Source: Immunity - April 10, 2009 Category: Allergy & Immunology Source Type: journals

The Small GTPase Rac2 Controls Phagosomal Alkalinization and Antigen Crosspresentation Selectively in CD8+ Dendritic CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ariel Savina, Audrey Peres, Ignacio Cebrian, Nuno Carmo, Catarina Moita, Nir Hacohen, Luis F. Moita, Sebastian Amigorena. A unique subpopulation of spleen dendritic cells (DCs) that express the CD8 surface marker efficiently present phagocytosed antigens to CD8+ T lymphocytes in a process called “crosspres.... (Source: Immunity)
Source: Immunity - April 10, 2009 Category: Allergy & Immunology Source Type: journals

Genome-wide Lineage-Specific Transcriptional Networks Underscore Ikaros-Dependent Lymphoid Priming in Hematopoietic Stem CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Samuel Yao-Ming Ng, Toshimi Yoshida, Jiangwen Zhang, Katia Georgopoulos. The mechanisms regulating lineage potential during early hematopoiesis were investigated. First, a cascade of lineage-affiliated gene expression signatures, primed in hematopoietic stem cells (HSC.... (Source: Immunity)
Source: Immunity - April 10, 2009 Category: Allergy & Immunology Source Type: journals

Stepwise Activation of Enhancer and Promoter Regions of the B Cell Commitment Gene Pax5 in Early LymphopoiesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thorsten Decker, Marina Pasca di Magliano, Shane McManus, Qiong Sun, Constanze Bonifer, Hiromi Tagoh, Meinrad Busslinger. Pax5 is an essential regulator of B cell identity and function. Here, we used transgenesis and deletion mapping to identify a potent enhancer in intron 5 of the Pax5 locus. This enhancer in.... (Source: Immunity)
Source: Immunity - April 10, 2009 Category: Allergy & Immunology Source Type: journals

Autophagy Is an Essential Component of Drosophila Immunity against Vesicular Stomatitis VirusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Spencer Shelly, Nina Lukinova, Shelly Bambina, Allison Berman, Sara Cherry. Intrinsic innate immune mechanisms are the first line of defense against pathogens and exist to control infection autonomously in infected cells. Here, we showed that autophagy, an intrinsic mecha.... (Source: Immunity)
Source: Immunity - April 10, 2009 Category: Allergy & Immunology Source Type: journals