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Pathophysiology of age-related diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
On April 7,8, 2009 a Symposium on Pathophysiology of Successful and Unsuccessful Ageing was held in Palermo, Italy. Here, the lectures of G. Campisi, L. Ginaldi and F. Licastro on Pathophysiology of age-related diseases are summarized. Ageing is a complex process that negatively impacts the development of the different systems and its ability to function. A long life in a healthy, vigorous, youthful body has always been one of humanity greatest dreams. So, a better understanding of pathophysiology of age-related diseases is urgently needed to maintain health state of elderly and to program possible therapeutic interventions.
Source: Immunity & Aging - September 8, 2009 Category: Geriatrics Authors: Giuseppina CampisiMartina ChiappelliMassimo De MartinisVito FrancoLia GinaldiRosario GuigliaFederico LicastroDomenico Lio Source Type: journals

Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The finding that the phenotype of CMV pp65-specific CD8 T cells in elderly individuals is similar to the predominant phenotype of CD8 T cells as a whole, suggests that CMV persistent infections contributes to the age-related changes observed in the CD8 T cell compartment, and that chronic stimulation by other persistent antigens also play a role in T cell immunosenescence. Differences in subset distribution in elderly individuals showing a decrease in naive and an increase in effector-memory CD8 T cells may be relevant in the age-associated defective immune response.
Source: Immunity & Aging - August 28, 2009 Category: Geriatrics Authors: Maria Luisa Pita-LopezInmaculada GayosoOlga DelaRosaJavier CasadoCorona AlonsoElisa Munoz-GomarizRaquel TarazonaRafael Solana Source Type: journals

Mechanisms of immunosenescenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
On April 7,8, 2009 a Symposium entitled "Pathophysiology of Successful and Unsuccessful Ageing" took place in Palermo, Italy. Here, the lectures of G. Pawelec, D. Dunn-Walters and. G. Colonna-Romano on T and B immunosenescence are summarized. In the elderly, many alterations of both innate and adaptive immunity have been described. Alterations to the immune system in the older person are generally viewed as a deterioration of immunity, leading to the use of the catch-all term immunosenescence. Indeed, many immunological parameters are often markedly different in elderly compared to young people, and some, mostly circumstan...
Source: Immunity & Aging - July 22, 2009 Category: Geriatrics Authors: Calogero CarusoSilvio BuffaGiuseppina CandoreGiuseppina Colonna-RomanoDeborah Dunn-WaltersDavid KiplingGraham Pawelec Source Type: journals

The immune system and the impact of zinc during agingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The trace element zinc is essential for the immune system, and zinc deficiency affects multiple aspects of innate and adaptive immunity. There are remarkable parallels in the immunological changes during aging and zinc deficiency, including a reduction in the activity of the thymus and thymic hormones, a shift of the T helper cell balance toward T helper type 2 cells, decreased response to vaccination, and impaired functions of innate immune cells. Many studies confirm a decline of zinc levels with age. Most of these studies do not classify the majority of elderly as zinc deficient, but even marginal zinc deprivation can a...
Source: Immunity & Aging - June 12, 2009 Category: Geriatrics Authors: Hajo HaaseLothar Rink Source Type: journals

Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We conclude that immunosenescence could alter arthritis susceptibility in a very complex manner: cumulative alterations in immunoregulatory functions, including both adaptive and innate immunity, which then lead to impaired regulation and eventually increase the chance of autoimmunity.
Source: Immunity & Aging - June 11, 2009 Category: Geriatrics Authors: Oktavia TarjanyiFerenc BoldizsarPeter NemethKatalin MikeczTibor Glant Source Type: journals

Adverse environmental conditions influence age-related innate immune responsivenessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We conclude that the decline in innate cytokine responses is an intrinsic ageing phenomenon, while pathogen exposure and/or selective survival drive pro-inflammatory responses under adverse living conditions.
Source: Immunity & Aging - May 30, 2009 Category: Geriatrics Authors: Linda MayAnita van den BiggelaarDavid van BodegomHans MeijAnton de CraenJoseph AmankwaMarijke FrolichMaris KuningasRudi Westendorp Source Type: journals

Mung Bean nuclease mapping of RNAs 3' endEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A method is described that allows an accurate mapping of 3' ends of RNAs. In this method a labelled DNA probe, containing the presumed 3' end of the RNA under analysis is allowed to anneals to the RNA itself. Mung-bean nuclease is then used to digest single strands of both RNA and DNA. Electrophoretic fractionation of "protected" undigested, labeled DNA is than performed using a sequence reaction of a known DNA as length marker. This procedure was applied to the analysis of both a poly A RNA (Interleukin 10 mRNA) and non polyA RNAs (sea urchin 18S and 26S rRNAs). This method might be potentially relevant for the evaluation...
Source: Immunity & Aging - May 21, 2009 Category: Geriatrics Authors: Daniele BellaviaGiorgia SisinoGiorgio PapadopoulosGiusi ForteRainer Barbieri Source Type: journals

Modulation of immunity in young-adult and aged squirrel, Funambulus pennanti by melatonin and p-chlorophenylalanineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: PCPA suppressed immune status more in aged than in adult by reducing melatonin level as it did chemical Px. Melatonin level decreased in control aged squirrels and so there was a decrease in immune parameters with a concomitant increase in free radical load of spleen. Decreased immune status can be restored following melatonin injection which decreased free radical load of spleen and suggest that immune organs of aged squirrels were sensitive to melatonin. Increased free radical load and decreased peripheral melatonin could be one of the reasons of immunosenescence.
Source: Immunity & Aging - April 23, 2009 Category: Geriatrics Authors: Seema Rai, Chandana Haldar and Rajesh Singh Source Type: journals

Molecular Ageing in Progeroid Syndromes: Hutchinson-Gilford Progeria Syndrome as a modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature ageing disorder that belongs to a group of conditions called laminopathies which affect nuclear lamins. Mutations in two genes, LMNA and ZMPSTE24, have been found in patients with HGPS. The p.G608G LMNA mutation is the most commonly reported mutation. The aim of this work was to compile a comprehensive literature review of the clinical features and genetic mutations and mechanisms of this syndrome as a contribution to health care workers. This review shows the necessity of a more detailed clinical identification of Hutchinson-Gilford progeria syndrome and the ...
Source: Immunity & Aging - April 20, 2009 Category: Geriatrics Authors: Henrique DM Coutinho, Vivyanne S Falcao-Silva, Raphael B Nobrega and Gregorio F Goncalves Source Type: journals

Ageing exacerbates damage of systemic and salivary neutrophils from patients presenting Candida-related denture stomatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The data suggests that the Candida related-denture stomatitis is associated to neutrophils function deficiency, and ageing drastically appears to alter important characteristics of such cells, facilitating the establishment of this infection.
Source: Immunity & Aging - March 28, 2009 Category: Geriatrics Authors: Thais HELENA Gasparoto, Narciso ALMEIDA Vieira, Vinicius CARVALHO Porto, Ana PAULA Campanelli and Vanessa SOARES Lara Source Type: journals

Alterations of T cell activation signalling and cytokine production by postmenopausal estrogen levelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Immunosenescence is an age-associated disorder occurring primarily in T cell compartments, including altered subset composition, functions, and activation. In women, evidence implicates diminished estrogen in the postmenopausal period as a contributing factor to diminished T cell responsiveness. Since hypoestrogenism is present in postmenopausal women, our objective focused on whether T cell activation, defined as signalling molecule expressions and activation, and function, identified as IL-2 production, were affected by low estrogen. Methods: Using Jurkat 6.1 T cells, consequences of 4pg/ml (corresponding to...
Source: Immunity & Aging - March 5, 2009 Category: Geriatrics Authors: Lowell T Ku, Cicek Gercel-Taylor, Steven T Nakajima and Douglas D Taylor Source Type: journals

The management of cancer in the elderly: targeted therapies in oncologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cancer is universally considered a disease of ageing. Today the management of elderly cancer patients poses many specific problems and it should be revisited in the light of the most recent advances in both diagnosis and treatment of human malignancies. In particular, the potential use of novel therapeutic options, based on therapeutic agents raised against molecular targets (the so called targeted therapy), appears to be promising in this clinical settings especially in view of the limited side-effects. The mainstays of cancer treatment during the twentieth century were surgery, radiation and chemotherapy. However, surger...
Source: Immunity & Aging - December 30, 2008 Category: Geriatrics Authors: Biagio Agostara, Giuseppe Carruba and Antonella Usset Source Type: journals

Haemostasis and ageingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related Diseases was held in Palermo, Italy. The lecture of D. Mari on Hemostasis and ageing is summarized herein. Physiological ageing is associated with increased plasma levels of many proteins of blood coagulation together with fibrinolysis impairment. This may be of great concern in view of the known association between vascular and thromboembolic diseases and ageing. On the other hand, centenarians are characterized by a state of hypercoagulability and possession of several high-risk alleles and well-known atherothrombotic risk markers but this appears...
Source: Immunity & Aging - October 23, 2008 Category: Geriatrics Authors: Daniela Mari, Giulia Ogliari, Davide Castaldi, Giovanni Vitale, Elisa M Bollini and Domenico Lio Source Type: journals

Hemostasis and ageingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related Diseases was held in Palermo, Italy. The lecture of D. Mari on Hemostasis and ageing is summarized herein. Physiological ageing is associated with increased plasma levels of many proteins of blood coagulation together with fibrinolysis impairment. This may be of great concern in view of the known association between vascular and thromboembolic diseases and ageing. On the other hand, centenarians are characterized by a state of hypercoagulability and possession of several high-risk alleles and well-known atherothrombotic risk markers but this appears...
Source: Immunity & Aging - October 23, 2008 Category: Geriatrics Authors: Daniela Mari, Giulia Ogliari, Davide Castaldi, Giovanni Vitale, Elisa Mariadele Bollini and Domenico Lio Source Type: journals

Immunity, Ageing and Cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Compromised immunity contributes to the decreased ability of the elderly to control infectious disease and to their generally poor response to vaccination. It is controversial as to how far this phenomenon contributes to the well-known age-associated increase in the occurrence of many cancers in the elderly. However, should the immune system be important in controlling cancer, for which there is a great deal of evidence, it is logical to propose that dysfunctional immunity in the elderly would contribute to compromised immunosurveillance and increased cancer occurrence. The chronological age at which immunosenescence becom...
Source: Immunity & Aging - September 24, 2008 Category: Geriatrics Authors: Evelyna Derhovanessian, Rafael Solana, Anis Larbi and Graham Pawelec Source Type: journals

Immunity, ageing and cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Compromised immunity contributes to the decreased ability of the elderly to control infectious disease and to their generally poor response to vaccination. It is controversial as to how far this phenomenon contributes to the well-known age-associated increase in the occurrence of many cancers in the elderly. However, should the immune system be important in controlling cancer, for which there is a great deal of evidence, it is logical to propose that dysfunctional immunity in the elderly would contribute to compromised immunosurveillance and increased cancer occurrence. The chronological age at which immunosenescence becom...
Source: Immunity & Aging - September 24, 2008 Category: Geriatrics Authors: Evelyna Derhovanessian, Rafael Solana, Anis Larbi and Graham Pawelec Source Type: journals

Smoking, health and agingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related diseases was held in Palermo, Italy. Here, the lecture of V. Nicita-Mauro on Smoking, health and ageing is summarized. Smoking represents an important ageing accelerator, both directly by triggering an inflammatory responses, and indirectly by favouring the occurrence of several diseases where smoking is a recognized risk factor. Hence, non-smokers can delay the appearance of diseases and of ageing process, so attaining longevity.
Source: Immunity & Aging - September 16, 2008 Category: Geriatrics Authors: Vittorio Nicita Mauro, Giorgio Basile, Giuseppe Maltese, Claudio Nicita Mauro, Sebastiano Gangemi and Calogero Caruso Source Type: journals

Understanding Ageing: Biomedical and Bioengineering Approaches, the immunologic viewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
During the past century, humans have gained more years of average life expectancy than in the last 10,000 years; we are now living in a rapidly ageing world. The sharp rise in life expectancy, coupled to a steady decline in birth rates in all developed countries, has led to an unprecedented demographic revolution characterized by an explosive growth in the number and proportion of older people. Ageing is a complex process that negatively impacts the development of the immune system and its ability to function. Progressive changes in the T and B cell systems over the life span have a major impact on the capacity to respond ...
Source: Immunity & Aging - September 3, 2008 Category: Geriatrics Authors: Matteo Bulati, Mariavaleria Pellicano, Sonya Vasto and Giuseppina Colonna-Romano Source Type: journals

Is the concentration of C-reactive protein in bacteraemia associated with age?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: C-reactive protein (CRP) is an indicator of inflammation, and is often used in the diagnosis of bacterial infections. It is poorly known whether CRP in bacterial infection is age-dependent. Methods: Adult patients with a positive blood culture with E. coli or S. pneumoniae during 1994-2004 were included. CRP measured on the same date as the blood cultures were drawn (CRP1), 2-3 days (CRP2) and 4-7 days later (CRP3), were retrieved. The patients were divided into three age groups, or = 85, respectively. We studied three cut-off values for CRP and produced age-specific receiver operating characteristics (ROC) cur...
Source: Immunity & Aging - August 15, 2008 Category: Geriatrics Authors: Astrid L Wester, Karl G Blaasaas and Torgeir B Wyller Source Type: journals

Alzheimer's disease;new diagnostic and therapeutic tools.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related diseases was held in Palermo, Italy. Here, the lectures of M. Racchi on History and future perspectives of Alzheimer Biomarkers and of G. Scapagnini on Cellular Stress Response and Brain Ageing are summarized. Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disease which in Western society mainly accounts for clinica dementia. AD prevention is an important goal of ongoing research. Two objectives must be accomplished to make prevention feasible: i) individuals at high risk of AD need to be identified before the earliest...
Source: Immunity & Aging - August 13, 2008 Category: Geriatrics Authors: Marco Racchi, Daniela Uberti, Stefano Govoni, Maurizio Memo, Cristina Lanni, Sonya Vasto, Giuseppina Candore, Calogero Caruso, Loriana Romeo and Giovanni Scapagnini Source Type: journals

Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old peopleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Overall, the results suggest that both differences in subset distribution and differences between subsets are responsible for age-related changes in CD8 cells but that differences within rather than between subsets are more prominent for CD4 cells.
Source: Immunity & Aging - July 25, 2008 Category: Geriatrics Authors: Sven Koch, Anis Larbi, Evelyna Derhovanessian, Dennis Ozcelik, Elissaveta Naumova and Graham Pawelec Source Type: journals

Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results are consistent with the view that constitutive activation of inflammatory pathways is a phenomenon prevalent in aged fibroblasts. It is possibly part of a cellular survival process in response to compromised mitochondrial function. Importantly, the inflammatory gene expression signature described here is cell autonomous, i.e. occurs in the absence of prototypical immune or pro-inflammatory cells, growth factors, or other inflammatory mediators.
Source: Immunity & Aging - July 16, 2008 Category: Geriatrics Authors: Andres Kriete, Kelli L. Mayo, Nirupama Yalamanchili, William Beggs, Patrick Bender, Csaba Kari and Ulrich Rodeck Source Type: journals

Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results are consistent with the view that constitutive activation of inflammatory pathways is a phenomenon prevalent in aged fibroblasts. It is possibly part of a cellular survival process in response to compromised mitochondrial function. Importantly, the inflammatory gene expression signature described here is cell autonomous, i.e. occurs in the absence of prototypical immune or pro-inflammatory cells, growth factors, or other inflammatory mediators.
Source: Immunity & Aging - July 16, 2008 Category: Geriatrics Authors: Andres Kriete, Kelli L Mayo, Nirupama Yalamanchili, William Beggs, Patrick Bender, Csaba Kari and Ulrich Rodeck Source Type: journals

Endothelial nitric oxide synthase gene polymorphisms and cardiovascular damage in hypertensive subjects: an Italian case-control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results seem to indicate a lack of association with eNOS variants and cardiovascular damage onset.
Source: Immunity & Aging - May 29, 2008 Category: Geriatrics Authors: Daniela Colomba, Giovanni Duro, Salvatore Corrao, Christiano Argano, Tiziana Di Chiara, Domenico Nuzzo, Federica Pizzo, Gaspare Parrinello, Rosario Scaglione and Giuseppe Licata Source Type: journals

The metal ion theory of ageing: dietary target hazard quotients beyond radicalsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Numerous theories of ageing exist and many are interconnected when viewed through a modern integrative biology perspective. Diet provides a link to a large number of the theories that prevail at the molecular levels. In particular, metal ions form key elements of the radical theory along with having established roles in several age-related neurodegenerative disorders. Lifetime exposure to metals has been linked to ageing by contributions to oxidative stress and neurodegenerative disorders. As many foodstuffs contain high levels and diverse profiles of metals, their cumulative effect on ageing warrants investigation. The cu...
Source: Immunity & Aging - May 20, 2008 Category: Geriatrics Authors: Declan P Naughton and Andrea Petroczi Source Type: journals

Safety and immunogenicity of an MF59(TM)-adjuvanted subunit influenza vaccine in elderly Chinese subjectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The safety and immunogenicity of an MF59(TM)-adjuvanted subunit influenza vaccine (Sub/MF59(TM); FLUAD(R), Novartis Vaccines) was evaluated among elderly Chinese subjects (>=60 years of age). After a preliminary Phase I, open-label study (n=25) to assess safety 1-14 days post-vaccination, a comparative observer-blind, randomised, controlled clinical trial (n=600) was performed to assess safety and immunogenicity versus a non-adjuvanted subunit influenza vaccine (Subunit; Agrippal(R), Novartis Vaccines). Subjects were randomised (2:1) to receive Sub/MF59(TM) or Subunit. Results: Both vaccines were well tolerate...
Source: Immunity & Aging - February 20, 2008 Category: Geriatrics Authors: Rongcheng Li, Hanhua Fang, Yanping Li, Youping Liu, Michele Pellegrini and Audino Podda Source Type: journals

Differential effects of age on circulating and splenic leukocyte populations in C57BL/6 and BALB/c male miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data provide important information on the principal differences, within the context of age, in T cell and professional APC populations between the prototypical Th1 mouse strain C57BL/6 and the prototypical Th2 strain BALB/c. Although the age-related changes that occur may be rather subtle, they may be very relevant in conditions of disease and stress. Importantly, our data indicate that age and strain should be considered in concert in the selection of appropriate mouse models for immunological research.
Source: Immunity & Aging - February 11, 2008 Category: Geriatrics Authors: Lesya M Pinchuk and Nikolay M Filipov Source Type: journals

Challeneges for vaccination in the elderlyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well-documented as the cause of increased infection rates in elderly people. Such immunosenescence is multi-factorial and incompletely understood. Immunosenescent changes include malfunctioning of innate immune system cellular receptors; involution of the thymus, with consequent reduction of the naive T cell population; alteration of the T cell population composition; modified phenotypes of individual T cells; and replicative senescence of memory cells expressing naive markers. Unfortunat...
Source: Immunity & Aging - December 11, 2007 Category: Geriatrics Authors: Richard Aspinall, Giuseppe Del Giudice, Rita B Effros, Beatrix Grubeck-Loebenstein and Suryaprakash Sambhara Source Type: journals

The effect of aging and caloric restriction on murine CD8+ T cell chemokine receptor gene expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings are consistent with the notion that aging exists in a state of low grade pro-inflammatory environment. In addition, our results provide a potential mechanism for the reported aging-associated impaired T cell lymphoid homing and allograft response, and reduced survival in sepsis.
Source: Immunity & Aging - November 14, 2007 Category: Geriatrics Authors: Raymond Yung, RuRan Mo, Annabelle Grolleau-Julius and Mark Hoeltzel Source Type: journals

Zinc-bound Metallothioneins and immune plasticity: lessons from very old mice and humansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, zinc-bound MT homeostasis is fundamental to confer the immune plasticity that is a condition "sine qua non" to achieve healthy ageing and longevity.
Source: Immunity & Aging - September 29, 2007 Category: Geriatrics Authors: Eugenio Mocchegiani, Robertina Giacconi, Elisa Muti, Catia Cipriano, Laura Costerelli, Silvia Tesei, Nazzarena Gasparini and Marco Malavolta Source Type: journals

Evidence of Accelerated Ageing in Clinical Drug Addiction from Immune, Hepatic and Metabolic BiomarkersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Drug addiction is associated with significant disease and death, but its impact on the ageing process has not been considered. The recent demonstration that many of the items available in routine clinical pathology have applicability as biomarkers of the ageing process implies that routine clinical laboratory parameters would be useful as an initial investigation of this possibility. Methods: 12,093 clinical laboratory results 1995-2006 were reviewed. To make the age ranges of the medical and addicted groups comparable the age range was restricted to 15-45 years. Results: 739 drug addicted (DA) and 5834 general...
Source: Immunity & Aging - September 24, 2007 Category: Geriatrics Authors: Albert S Reece Source Type: journals

Zinc and ageing: third ZincAge conferenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The importance of Zn for optimal functioning of the immune system and antioxidant stress response is well documented. Zn homeostasis influences development and function of immune cells, activity of stress-related and antioxidant proteins [metallothioneins (MT), chaperones, ApoJ, Poly(ADP-Ribose) polymerase-1 (PARP-1) and Methionione Sulfoxide Reductase (Msr), Superoxide Dismutase (SOD)], and helps to maintain genomic integrity and stability. During ageing, the intake of Zn decreases due to inadequate diet and/or intestinal malabsorption, contributing to frailty, general disability and increased incidence of age-related deg...
Source: Immunity & Aging - September 20, 2007 Category: Geriatrics Authors: Eugenio Mocchegiani Source Type: journals

Pathophysiology of ageing, longevity and age related diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report we summarize the most important issues. However, ageing must be considered an unavoidable end point of the life history of each individual, nevertheless the increasing knowledge on ageing mechanisms, allows envisaging many different strategies to cope with, and delay it. So, a better understanding of pathophysiology of ageing and age-related disease is essential for giving everybody a reasonable chance for living a long and enjoyable final part of the life.
Source: Immunity & Aging - August 2, 2007 Category: Geriatrics Authors: Alexander Burkle, Graziella Caselli, Claudio Franceschi, Erminia Mariani, Paolo Sansoni, Angela Santoni, Giancarlo Vecchio, Jacek M Witkowski and Calogero Caruso Source Type: journals

NK cell compartment in patients with coronary heart diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data indicate that CHD is associated with an impairment of NK cells compartment.
Source: Immunity & Aging - May 8, 2007 Category: Geriatrics Authors: Lukasz Hak, Jolanta Mysliwska, Joanna Wieckiewicz, Krzysztof Szyndler, Piotr Trzonkowski, Janusz Siebert and Andrzej Mysliwski Source Type: journals

Role of persistent CMV infection in configuring T cell immunity in the elderlyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ageing is associated with declines in many physiological parameters, including multiple immune system functions. The rate of acceleration of the frequency of death due to cardiovascular disease or cancer seems to increase with age from middle age up to around 80 years, plateauing thereafter. Mortality due to infectious disease, however, does not plateau, but continues to accelerate indefinitely. The elderly commonly possess oligoclonal expansions of T cells, especially of CD8 cells, which, surprisingly, are often associated with cytomegalovirus (CMV) seropositivity. This in turn is associated with many of the same phenotyp...
Source: Immunity & Aging - March 21, 2007 Category: Geriatrics Authors: Sonya Vasto, Giuseppina Colonna-Romano, Anis Larbi, Anders Wikby, Calogero Caruso and Graham Pawelec Source Type: journals

The Interleukin-6 inflammation pathway from cholesterol to aging - Role of statins, bisphosphonates and plant polyphenols in aging and age-related diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the inflammation pathway from Cholesterol to Aging. Interleukin 6 mediated inflammation is implicated in age-related disorders including Atherosclerosis, Peripheral Vascular Disease, Coronary Artery Disease, Osteoporosis, Type 2 Diabetes, Dementia and Alzheimers disease and some forms of Arthritis and Cancer. Statins and Bisphosphonates inhibit Interleukin 6 mediated inflammation indirectly through regulation of endogenous cholesterol synthesis and isoprenoid depletion. Polyphenolic compounds found in plants, fruits and vegetables inhibit Interleukin 6 mediated inflammation by direct inhibition of the signal tr...
Source: Immunity & Aging - March 20, 2007 Category: Geriatrics Authors: Sota Omoigui Source Type: journals

Is inflammaging an auto[innate]immunity subclinical syndrome ?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The low-grade, chronic, systemic inflammatory state that characterizes the aging process (Inflammaging)results from late evolutive-based expression of the Innate Immune System. Inflammaging is characterized by the complex set of five conditions which can be described as (1)low-grade, (2)controlled, (3)asymptomatic,(4)chronic,(5)systemic, inflammatory state, and fits with the antagonistic pleiotropy theory on the evolution of aging postulating that senescence is the late deleterious effect of genes (pro-inflammatory versus anti-inflammatory)that are beneficial in early life. Evolutionary programming of the Innate Immune Sys...
Source: Immunity & Aging - December 16, 2006 Category: Geriatrics Authors: Sergio Giunta Source Type: journals

Is inflammaging an auto[innate]immunity subclinical syndrome?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The low-grade, chronic, systemic inflammatory state that characterizes the aging process (inflammaging) results from late evolutive-based expression of the innate immune system. Inflammaging is characterized by the complex set of five conditions which can be described as 1. low-grade, 2. controlled, 3. asymptomatic, 4. chronic, 5. systemic, inflammatory state, and fits with the antagonistic pleiotropy theory on the evolution of aging postulating that senescence is the late deleterious effect of genes (pro-inflammatory versus anti-inflammatory)that are beneficial in early life. Evolutionary programming of the innate immune ...
Source: Immunity & Aging - December 16, 2006 Category: Geriatrics Authors: Sergio Giunta Source Type: journals

Large scale analysis of pediatric antiviral CD8+ T cell populations reveals sustained, functional and mature responsesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: CMV consistently elicits a very strong CD8+ T cell response in infants and large pools of CMV specific CD8+ T cells are maintained throughout childhood. The presence of CMV may considerably mould the CD8+ T cell compartment over time, but the relative frequencies of CMV-specific cells do not show the evidence of a population-level increase during childhood and adulthood. This contrast with the marked expansion (inflation) of such CD8+ T cells in older adults. This study indicates that large scale analysis of peptide specific T cell responses in infants is readily possible. The robust nature of the responses ob...
Source: Immunity & Aging - December 8, 2006 Category: Geriatrics Authors: Haruki Komatsu, Ayano Inui, Tsuyoshi Sogo, Tomoo Fujisawa, Hironori Nagasaka, Shigeaki Nonoyama, Sophie Sierro, John Northfield, Michaela Lucas, Anita Vargas and Paul Klenerman Source Type: journals

Ageing is associated with a decline in peripheral blood CD56brightNK cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The number of CD56bright NK cells within peripheral blood declines with age. As this population plays a central role in cytokine secretion during the innate immune response this decline may contribute to impaired immune regulation in elderly individuals
Source: Immunity & Aging - November 29, 2006 Category: Geriatrics Authors: Shivani M Chidrawar, Naeem Khan, Tracey YL Chan, Laxman Nayak and Paul AH Moss Source Type: journals

Flow-cytometric assessment of cellular poly(ADP-ribosyl)ation capacity in peripheral blood lymphocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The methodology described in this paper should be generally useful for the determination of cellular poly(ADP-ribosyl)ation capacity in a wide variety of settings, especially for the comparison of large sets of samples, such as population studies. In contrast to previously published radiometric or immuno-dot-blot assays, the new FACS-based method allows (i) selective analysis of mononuclear cells by gating and (ii) detection of a possible heterogeneity in poly(ADP-ribosyl)ation capacity between cells of the same type.
Source: Immunity & Aging - July 19, 2006 Category: Geriatrics Authors: Andrea Kunzmann, Dan Liu, Kathryn Annett, Muriel Malaise, Bastian Thaa, Paul Hyland, Yvonne Barnett and Alexander Burkle Source Type: journals

Electrophoresis of proteins and DNA on horizontal sodium dodecyl sulfate polyacrylamide gelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We developed an inexpensive Plexiglass apparatus which allows a simple and rapid preparation of horizontal polyacrylamide gels of different dimensions for different purposes. Preparation of these gels is as easy and rapid as agarose gel preparation, and polymerized polyacrylamide gels are used to fractionate both proteins and small DNA fragments using a common horizontal electrophoretic tank. We used this apparatus to electrophoretically fractionate proteins and DNA for immuno-blot analyses, for Southern-blot hybridizations and in the study of DNA polymorphisms.
Source: Immunity & Aging - July 12, 2006 Category: Geriatrics Authors: Vincenzo Izzo, Maria A Costa, Renata Di Fiore, Giovanni Duro, Daniele Bellavia, Eleonora Cascone, Paolo Colombo, Maria C Gioviale and Rainer Barbieri Source Type: journals

Zinc, oxidative stress, genetic background and immunosenescence: implications for healthy ageingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The relevance of zinc for proper functioning of the entire immune system is already well documented. However, the identification of individuals who really need zinc supplementation is still debated in view of the fact that excessive zinc may also be toxic. The risk of developing zinc deficiency in people from industrialized countries is relatively low, except for elderly subjects where zinc intake may be suboptimal and inflammation is chronic. Thus, the role of zinc on the immune system and on the health of European elderly people is becoming of paramount importance, considering also that the elderly population is rapidly ...
Source: Immunity & Aging - June 26, 2006 Category: Geriatrics Authors: Eugenio Mocchegiani, Marco Malavolta, Fiorella Marcellini and Graham Pawelec Source Type: journals

A paradox of immunodeficiency and inflammation in human aging: Lessons learned from apoptosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aging is associated with a paradox of immunodeficiency and inflammation (an evidence of hyperactive immune system). Apoptosis is associated with cellular depletion and suppression of inflammatory response. In this brief review, we will present evidence for the role of increased apoptosis in immunodeficiency and paradoxical increased inflammation associated with human aging. In particular, a role of apoptotic antibodies in failure to generate anti-inflammatory responses in dendritic cells will be discussed.
Source: Immunity & Aging - May 19, 2006 Category: Geriatrics Authors: Sudhir Gupta, Agrawal Anshu, Agrawal Sudhanshu, Houfen Su and Sastry Gollapudi Source Type: journals

Iterleukin 1 alpha is a marker of endothelial cellular senescentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results indicate that a dysfunction of the cytokine network associates with aging and point to a specific role of IL-1a in endothelial senescence.
Source: Immunity & Aging - April 6, 2006 Category: Geriatrics Authors: Massimo Mariotti, Sara Castiglioni, Daniela Bernardini and Jeanette AM Maier Source Type: journals

Systemic inflammatory response in erderly patients following hernioplastical operationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The number of old and oldest old patients undergoing surgery of varying severity is increasing. Ageing is a process that changes the performances of most physiological systems and increases susceptibility to diseases and death; accordingly, host responses to surgical stress are altered with ageing and the occurrence of age-related increase in susceptibility to post-operative complications has been claimed. Twenty-four male patients undergoing Lichtenstein (LH) hernioplasty for unilateral inguinal hernia were included in this study and divided in two groups (Young and Old respectively), according to their age. As an express...
Source: Immunity & Aging - March 29, 2006 Category: Geriatrics Authors: Gaetano Di Vita, Carmela Rita Balistreri, Francesco Arcoleo, Salvatore Buscemi, Enrico Cillari, Marcello Donati, Maria Garofalo, Florinda Listi, Maria Paola Grimaldi, Rosalia Patti and Giuseppina Candore Source Type: journals

Age and immunityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Longitudinal studies are defining progressive alterations to the immune system associated with increased mortality in the very elderly. Many of these changes are exacerbated by or even caused by chronic T cell stimulation by persistent antigen, particularly from Cytomegalovirus. The composition of T cell subsets, their functional integrity and representation in the repertoire are all markedly influenced by age and by CMV. How these findings relate to epidemiological, functional, genetic, genomic and proteomic studies of human T cell immunosenescence was the subject of intense debate at an international conference held just...
Source: Immunity & Aging - February 24, 2006 Category: Geriatrics Authors: Sonya Vasto, Marco Malavolta and Graham Pawelec Source Type: journals

A Need to Study the Immune Status of Frail Older AdultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Review
Source: Immunity & Aging - January 19, 2006 Category: Geriatrics Authors: Steven C Castle, Koichi Uyemura, Tamas Fulop, Katsuiku Hirokawa and Takashi Makinodan Source Type: journals

Melatonin, immune function and agingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aging is associated with a decline in immune function (immunosenescence), a situation known to correlate with increased incidence of cancer, infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased deterioration with age. A decrease in functional competence of individual natural killer (NK) cells is found with advancing age. Macrophages and granulocytes show functional decline in aging as evidenced by their diminished phagocytic activity and impairment of superoxide generation. There is also marked shift in cytokine profile as age advances, e.g., CD3+ and CD4+ cells decline in numbe...
Source: Immunity & Aging - November 29, 2005 Category: Geriatrics Authors: V Srinivasan, GJM Maestroni, DP Cardinali, AI Esquifino, SR Pandi Perumal and SC Miller Source Type: journals

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