Primary immune regulatory disorders (PIRD): expanding the mutation spectrum in Turkey and identification of sixteen novel variants
In this study, we report the identification of 38 disease-causing variants, including 16 novel ones, detected in 40 patients across 15 distinct PIRD genes. The application of next-gene ration sequencing enabled rapid and precise diagnosis of patients with PIRDs. (Source: Immunologic Research)
Source: Immunologic Research - April 22, 2024 Category: Allergy & Immunology Source Type: research
β-Indole-3-acetic acid attenuated collagen-induced arthritis through reducing the ubiquitination of Foxp3 via the AhR-TAZ-Tip60 pathway
In this study, the collagen-induced arthritis (CIA) rat model was established. Based on metabolomics analysis, the contents of β-indole-3-acetic acid (IAA), indolylpropionic acid, and indole-3-β-acrylic acid in the sera of CIA rats were significantly less compared with those of the normal rats. Under the condition of Treg or Th17 cell differentiation, IAA significantly promoted the differentiation and activation of Treg c ells instead of Th17 cells. Intestinal tryptophan metabolites are well-known endogenic ligands of aryl hydrocarbon receptor (AhR). Not surprisingly, IAA increased the level of Foxp3 through activating t...
Source: Immunologic Research - April 17, 2024 Category: Allergy & Immunology Source Type: research
Cluster analysis of long COVID symptoms for deciphering a syndrome and its long-term consequence
AbstractThe long-term symptoms of COVID-19 are the subject of public and scientific discussions. Understanding how those long COVID symptoms co-occur in clusters of syndromes may indicate the pathogenic mechanisms of long COVID. Our study objective was to cluster the different long COVID symptoms. We included persons who had a COVID-19 and assessed long-term symptoms (at least 4 weeks after first symptoms). Hierarchical clustering was applied to the symptoms as well as to the participants based on the Euclidean distanceh of the log-values of the answers on symptom severity. The distribution of clusters within our cohort ...
Source: Immunologic Research - April 16, 2024 Category: Allergy & Immunology Source Type: research
Low C4A copy numbers and higher HERV gene insertion contributes to increased risk of SLE, with absence of association with disease phenotype and disease activity
In conclusion, our data show that, lowC4A copy number and higher insertion ofHERV-K inC4A increases the risk for SLE.C4 andC4-HERV CNs did not correlate with serum complements, autoantibodies, disease phenotypes and activity in SLE. Further validation in a larger homogenous SLE cohort is needed. (Source: Immunologic Research)
Source: Immunologic Research - April 10, 2024 Category: Allergy & Immunology Source Type: research
Hormone and reproductive factors and risk of systemic lupus erythematosus: a Mendelian randomized study
AbstractSystemic lupus erythematosus (SLE) is an autoimmune and inflammatory disease with a risk associated with hormonal and reproductive factors. However, the potential causal effects between these factors and SLE remain unclear. A two-sample Mendelian randomization study was conducted using the published summary data from the genome-wide association study database. Five independent genetic variants associated with hormonal and reproductive factors were selected as instrumental variables: age at menarche, age at natural menopause, estradiol, testosterone, and follistatin. To estimate the causal relationship between these...
Source: Immunologic Research - April 6, 2024 Category: Allergy & Immunology Source Type: research
Exploring the causal relationship between Takayasu arteritis and inflammatory bowel disease using Mendelian randomization
This study represents one of the initial investigations into the potential causal association between TA and IBD. With three MR methods, including the primary IVW approach, indicating a notable effect on TA on CD, our analysis findings offer some indication that TA could be a contributing risk factor for CD. (Source: Immunologic Research)
Source: Immunologic Research - March 27, 2024 Category: Allergy & Immunology Source Type: research
Polyethylene glycol and immunology: aspects of allergic reactions and their mechanisms, as well as ways to prevent them in clinical practice
AbstractIn modern medical practice, where polyethylene glycol is widely used as a component of various drugs, such as vaccines, chemotherapy drugs, and antibiotics, including vaccines, the issue of allergic reactions to this substance is becoming increasingly important. The purpose of this study is to review and systematise data on various aspects of allergic reactions to polyethylene glycol with the aim of better understanding their pathogenesis, clinical manifestations, diagnostic methods, and possible treatment approaches. The study analysed literature data in modern databases, such as MEDLINE, PubMed, and Scopus, on al...
Source: Immunologic Research - March 19, 2024 Category: Allergy & Immunology Source Type: research
mTOR-mediated differentiation and maintenance of suppressive T cells at the center stage of IPEX treatment
(Source: Immunologic Research)
Source: Immunologic Research - March 11, 2024 Category: Allergy & Immunology Source Type: research
Assessing the steroid-sparing effect of biological agents in randomized controlled trials for lupus: a scoping review
AbstractPrompt disease control of flares in patients with systemic lupus erythematosus (SLE) is a priority in treatment strategy planning. However, the long-term dosage-related collateral effects of glucocorticoids (GCs) have pushed researchers towards the identification and utilization of novel biological agents that could both induce and maintain low disease activity and remission, especially in the context of lupus nephritis (LN). This scoping review aims at assessing the current evidence of the potential steroid-sparing effect of biologic therapies by reviewing phase II and phase III randomized, placebo-controlled tria...
Source: Immunologic Research - March 9, 2024 Category: Allergy & Immunology Source Type: research
Involvement of gut microbiota in multiple sclerosis —review of a new pathophysiological hypothesis and potential treatment target
AbstractMultiple sclerosis (MS) is a chronic inflammatory disease that leads to demyelination and damage to the central nervous system. It is well known, the significance of the involvement and influence of the immune system in the development and course of MS. Nowadays, more and more studies are demonstrating that an important factor that affects the action of the immune system is the gut microbiota. Changes in the composition and interrelationships in the gut microbiota have a significant impact on the course of MS. Dysbiosis affects the disease course mainly by influencing the immune system directly but also by modifyin...
Source: Immunologic Research - March 6, 2024 Category: Allergy & Immunology Source Type: research
Correction to: Characteristics of splenic PD-1+ γδT cells in Plasmodium yoelii nigeriensis infection
(Source: Immunologic Research)
Source: Immunologic Research - February 29, 2024 Category: Allergy & Immunology Source Type: research
Correction to: The immune regulatory function of B7-H3 in malignancy: spotlight on the IFN-STAT1 axis and regulation of tumor-associated macrophages
(Source: Immunologic Research)
Source: Immunologic Research - February 22, 2024 Category: Allergy & Immunology Source Type: research
Monophosphoryl lipid A as a co-adjuvant in methicillin-resistant Staphylococcus aureus vaccine development: improvement of immune responses in a mouse model of infection
AbstractTo increase the effectiveness of methicillin-resistantStaphylococcus aureus vaccines (MRSA), a new generation of immune system stimulating adjuvants is necessary, along with other adjuvants. In some vaccines, monophosphoryl lipid A (MPLA) as a toll-like receptor 4 agonist is currently used as an adjuvant or co-adjuvant. MPLA could increase the immune response and vaccine immunogenicity. The current investigation assessed the immunogenicity and anti-MRSA efficacy of recombinant autolysin formulated in MPLA and Alum as co-adjuvant/adjuvant. r-Autolysin was expressed and purified by Ni –NTA affinity chromatography a...
Source: Immunologic Research - February 21, 2024 Category: Allergy & Immunology Source Type: research
