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Effects of glycation of the model food allergen ovalbumin on antigen uptake and presentation by human dendritic cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Advanced glycation endproducts (AGEs) of food proteins resulting from the Maillard reaction after cooking or heating may have particular importance in food allergy. The underlying immunological mechanisms are only poorly understood. The aim of the study was to examine the effects of AGE derived from the model food allergen ovalbumin (AGE-OVA) on dendritic cells (DCs), their immunostimulatory capacity and the T-cell response compared with regular OVA. For this purpose, human immature DCs were exposed to fluorescein isothiocyanate (FITC)-labelled AGE-OVA and FITC-labelled regular OVA and uptake was analysed by flow cytom...
Source: Immunology - November 17, 2009 Category: Allergy & Immunology Authors: Hilmenyuk T, Bellinghausen I, Heydenreich B, Ilchman A, Toda M, Grabbe S, Saloga J Tags: Immunology Source Type: journals

Mesenteric lymph nodes are not required for an intestinal immunoglobulin A response to oral cholera toxin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stimulation of the adaptive immune system in the gut is thought to be mainly initiated in the Peyer's patches as well as in the mesenteric lymph nodes (mLNs) and results in immunoglobulin A (IgA) secretion by plasma cells in the lamina propria. However, the precise role of the mLNs in the development of IgA immune responses is poorly understood. Thus, cholera toxin (CT) was administered to mLN-resected and mLN-bearing animals and the IgA response to CT in the intestine and serum was examined. Levels of CT-specific IgA antibodies and the numbers of cells producing these antibodies in the intestine were increased in mLN-...
Source: Immunology - November 17, 2009 Category: Allergy & Immunology Authors: Hahn A, Thiessen N, Pabst R, Buettner M, Bode U Tags: Immunology Source Type: journals

Killer cell immunoglobulin-like receptor expression induction on neonatal CD8(+) T cells in vitro and following congenital infection with Trypanosoma cruzi.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Major histocompatibility complex (MHC) class I-specific inhibitory natural killer receptors (iNKRs) are expressed by subsets of T cells but the mechanisms inducing their expression are poorly understood, particularly for killer-cell immunoglobulin-like receptors (KIRs). The iNKRs are virtually absent from the surface of cord blood T cells but we found that KIR expression could be induced upon interleukin-2 stimulation in vitro. In addition, KIR expression was enhanced after treatment with 5-aza-2'-deoxycytidine, suggesting a role for DNA methylation. In vivo induction of KIR expression on cord blood T cells was also ob...
Source: Immunology - November 17, 2009 Category: Allergy & Immunology Authors: Hermann E, Berthe A, Truyens C, Alonso-Vega C, Parrado R, Torrico F, Carlier Y, Braud VM Tags: Immunology Source Type: journals

Dendritic cells activated by an anti-inflammatory agent induce CD4(+) T helper type 2 responses without impairing CD8( +) memory and effector cytotoxic T-lymphocyte responses.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prevalence of pro-inflammatory diseases is rising in developed country populations. The increase in these diseases has fuelled the search for new, immune suppressive, anti-inflammatory therapies, which do not impact, or minimally impact, CD4(+) and/or CD8(+) T-cell-mediated immunity. The goal of this study was to determine if antigen-presenting cells (APCs) activated by the anti-inflammatory oligosaccharide, lacto-N-fucopentaose III (LNFPIII), would have an impaired ability to drive CD4(+) T helper (Th) or CD8(+) memory and effector T-cell responses. To investigate this we activated splenic dendritic cells (SDCs) with ...
Source: Immunology - November 17, 2009 Category: Allergy & Immunology Authors: Wang Y, Da'dara AA, Thomas PG, Harn DA Tags: Immunology Source Type: journals

A comparison between isolated blood dendritic cells and monocyte-derived dendritic cells in pigs.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Various dendritic cell (DC) populations exist that differ in phenotype and ability to present antigen to T cells. For example, plasmacytoid DCs (pDCs) are less potent T cell activators compared with conventional DCs (cDCs). Here, we compared porcine blood DCs (BDCs), containing pDCs and cDCs, and monocyte-derived DCs (MoDC), consisting of cDCs, in their phenotype, ability to uptake antigen, activation and maturation and their ability to present antigen to autologous T cells. Pigs represent an important animal model, whose immune system in many respects closely resembles that of humans. For example, the distribution of ...
Source: Immunology - November 17, 2009 Category: Allergy & Immunology Authors: Facci MR, Auray G, Buchanan R, van Kessel J, Thompson DR, Mackenzie-Dyck S, Babiuk LA, Gerdts V Tags: Immunology Source Type: journals

Characterization of an human leucocyte antigen A2-restricted Epstein-Barr virus nuclear antigen-1-derived cytotoxic T-lymphocyte epitope.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on the characterization of the LQTHIFAEV (LQT) epitope. LQT-specific memory CTL responses were reactivated in three of 14 healthy EBV seropositive donors (21%) whereas responses to HLA-A2-restricted epitopes, two derived from LMP2 and one from EBNA3A, were detected in 93%, 71% and 42% of the donors, respectively. The LQT-specific CTL clones did not lyse EBV-carrying lymphoblastoid cell lines and Burkitt's lymphoma cell lines nor EBNA1-transfected Burkitt's lymphoma cells but specifically released interferon-gamma upon stimulation with HLA-matched EBNA1-expressing cells and this response was enhanced by deletion o...
Source: Immunology - November 17, 2009 Category: Allergy & Immunology Authors: Marescotti D, Destro F, Baldisserotto A, Marastoni M, Coppotelli G, Masucci M, Gavioli R Tags: Immunology Source Type: journals

Plasticity of T-cell phenotype and function: the T helper type 17 example.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mature T helper type 1 (Th1) and Th2 cells antagonize the development of the opposing subset to sustain lineage-specific responses. However, the recent identification of a third distinct subset of helper T cells - the Th17 lineage - collapses the established Th1/Th2 dichotomy and raises intriguing questions about T-cell fate. In this review, we discuss the Th17 subset in the context of the effector and regulatory T-cell lineages. Initial studies suggested reciprocal developmental pathways between Th17/Th1 subsets and between Th17/regulatory T-cell subsets, and identified multiple mechanisms by which Th1 and Th2 cells a...
Source: Immunology - November 17, 2009 Category: Allergy & Immunology Authors: Peck A, Mellins ED Tags: Immunology Source Type: journals

The ceramide-1-phosphate analogue PCERA-1 modulates tumour necrosis factor-alpha and interleukin-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to delineate the signalling pathway leading from PCERA-1 via cAMP to modulation of TNF-alpha and IL-10 production. We show here that PCERA-1 elevates intra-cellular cAMP level in a guanosine triphosphate-dependent manner in RAW264.7 macrophages. The cell-permeable dibutyryl cAMP was able to mimic the effects of PCERA-1 on cytokine production, whereas 8-chloro-phenylthio-methyladenosine-cAMP, which specifically activates the exchange protein directly activated by cAMP (EPAC) but not protein kinase A (PKA), failed to mimic PCERA-1 activities. Consistently, the PKA inhibitor H89 efficiently blo...
Source: Immunology - November 17, 2009 Category: Allergy & Immunology Authors: Avni D, Philosoph A, Meijler MM, Zor T Tags: Immunology Source Type: journals

Future Meetings SectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - November 11, 2009 Category: Allergy & Immunology Source Type: journals

T-bet-dependent regulation of CD8+ T-cell expansion during experimental Trypanosoma cruzi infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - November 11, 2009 Category: Allergy & Immunology Authors: Cobb, DustinGuo, SiqiLara, Ana M.Manque, PatricioBuck, GregorySmeltz, Ronald B. Source Type: journals

Human peripheral T cells possess regulatory potentialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - November 11, 2009 Category: Allergy & Immunology Authors: Kuhl, Anja A.Pawlowski, Nina N.Grollich, KatjaBlessenohl, MaikeWestermann, JurgenZeitz, MartinLoddenkemper, ChristophHoffmann, Jorg C. Source Type: journals

Plasma cell toll-like receptor (TLR) expression differs from that of Bcells, and plasma cell TLR triggering enhances immunoglobulin productionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - November 11, 2009 Category: Allergy & Immunology Authors: Dorner, MarcusBrandt, SimoneTinguely, MarianneZucol, FranziskaBourquin, Jean-PierreZauner, LudwigBerger, ChristophBernasconi, MicheleSpeck, Roberto F.Nadal, David Source Type: journals

Cord blood mesenchymal stem cells propel human dendritic cells to an intermediate maturation state and boost interleukin-12 production by mature dendritic cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - November 11, 2009 Category: Allergy & Immunology Authors: van den Berk, Lieke C. J.Roelofs, HeleneHuijs, TonnieSiebers-Vermeulen, Kim G. C.Raymakers, Reinier A.Kogler, GesineFigdor, Carl G.Torensma, Ruurd Source Type: journals

Accelerated induction of mycobacterial antigen-specific CD8+ T cells in the Mycobacterium tuberculosis-infected lung by subcutaneous vaccination with Mycobacterium bovis bacille CalmetteGuerinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - November 11, 2009 Category: Allergy & Immunology Authors: Begum, DilaraUmemura, MasayukiYahagi, AyanoOkamoto, YukoHamada, SatoruOshiro, KiyotetsuMatsuzaki, Goro Source Type: journals

Leucocyte-associated immunoglobulin-like receptor-1 is an inhibitory regulator of contact hypersensitivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - November 11, 2009 Category: Allergy & Immunology Authors: Omiya, RyusukeTsushima, FumihikoNarazaki, HidehikoSakoda, YukimiKuramasu, AtsuoKim, YounXu, HaiyingTamura, HidetoZhu, GefengChen, LiepingTamada, Koji Source Type: journals

The role of protein tyrosine phosphatases in the regulation of allergic asthma: implication of TC-PTP and PTP-1B in the modulation of disease developmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - November 11, 2009 Category: Allergy & Immunology Authors: Pouliot, PhilippeBergeron, SebastienMarette, AndreOlivier, Martin Source Type: journals

Altered peptide ligands of myelin basic protein (MBP8799) conjugated to reduced mannan modulate immune responses in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - November 11, 2009 Category: Allergy & Immunology Authors: Katsara, MariaYuriev, ElizabethRamsland, Paul A.Tselios, TheodoreDeraos, GeorgeLourbopoulos, AthanasiosGrigoriadis, NikolaosMatsoukas, JohnApostolopoulos, Vasso Source Type: journals

Heat shock proteins and superantigenic properties of bacteria from the gastrointestinal tract of patients with Kawasaki diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - November 11, 2009 Category: Allergy & Immunology Authors: Nagata, SatoruYamashiro, YuichiroOhtsuka, YoshikazuShimizu, ToshiakiSakurai, YumikoMisawa, ShigekiIto, Teruyo Source Type: journals

A single amino acid defines cross-species reactivity of tree shrew (Tupaia belangeri) CD1d to human invariant natural killer T (iNKT) cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - November 11, 2009 Category: Allergy & Immunology Authors: Zhang, PingLi, DeminStewart-Jones, GuillaumeShao, XiaoliZhang, YuanxuChen, QiongyuLi, YijiangHe, You-WenXu, Xiao-NingZhang, Hua-Tang Source Type: journals

The contribution of Toll-like receptor 2 to the innate recognition of a Leishmania infantum silent information regulator 2 proteinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - November 11, 2009 Category: Allergy & Immunology Authors: Silvestre, RicardoSilva, Ana M.Cordeiro-da-Silva, AnabelaOuaissi, Ali Source Type: journals

Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar Typhimurium infection, but not for the initiation of bacterial clearanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - November 11, 2009 Category: Allergy & Immunology Authors: Talbot, SuzanneTotemeyer, SabineYamamoto, MasahiroAkira, ShizuoHughes, KatherineGray, DavidBarr, TomMastroeni, PietroMaskell, Duncan J.Bryant, Clare E. Source Type: journals

Characterization of CD4+ T-celldendritic cell interactions during secondary antigen exposure in tolerance and primingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - November 11, 2009 Category: Allergy & Immunology Authors: Rush, Catherine M.Millington, Owain R.Hutchison, SharonBryson, KarenBrewer, James M.Garside, Paul Source Type: journals

Visualizing recall immune responses with multi-photon microscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - November 11, 2009 Category: Allergy & Immunology Authors: Yates, Andrew Source Type: journals

Eosinophils infiltrate thyroids, but have no apparent role in induction or resolution of experimental autoimmune thyroiditis in interferon-gamma mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Granulomatous experimental autoimmune thyroiditis (G-EAT) is induced by mouse thyroglobulin (MTg)-sensitized splenocytes activated with MTg and interleukin (IL)-12. Our previous studies showed that, when used as donors and recipients, interferon (IFN)-gamma(-/-) and wild-type (WT) DBA/1 mice both develop severe G-EAT. Thyroid lesions in IFN-gamma(-/-) mice have many eosinophils and few neutrophils, while those in WT mice have extensive neutrophil infiltration and few eosinophils. Thyroid lesions in IFN-gamma(-/-) mice consistently resolve by day 40-50, whereas those in WT mice have ongoing inflammation and fibr...
Source: Immunology - October 20, 2009 Category: Allergy & Immunology Authors: Fang Y, Chen K, Jackson DA, Sharp GC, Braley-Mullen H Tags: Immunology Source Type: journals

Clonal relationships between thyroid-stimulating hormone receptor-stimulating antibodies illustrate the effect of hypermutation on antibody function.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the genetic analysis of two monoclonal antibodies (mAbs) with thyroid-stimulating activity (TSAb) obtained from a single mouse with experimental Graves' disease. The mAbs were class switched, but used the same rearrangement of immunoglobulin heavy chain, variable region (IGHV) and immunoglobulin light chain, variable region (IGLV) germline genes, implying a clonal relationship and derivation from a single precursor B-cell clone. The IGHV-region genes of the two mAbs underwent high degrees of somatic hypermutation by sharing numerous mutations before diverging, while the IGLV genes evolved separately. Interestin...
Source: Immunology - October 20, 2009 Category: Allergy & Immunology Authors: Padoa CJ, Larsen SL, Hampe CS, Gilbert JA, Dagdan E, Hegedus L, Dunn-Walters D, Banga JP Tags: Immunology Source Type: journals

The self-antigen, thyroglobulin, induces antigen-experienced CD4 T cells from healthy donors to proliferate and promote production of the regulatory cytokine, interleukin-10, by monocytes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Thyroglobulin (TG), as autoantigen, induces in vitro proliferation of T and B cells from normal individuals, but the cytokine production differs from that in patients with autoimmune thyroid disease. Here, we investigate whether normal T cells responding to TG are naive, or have previously encountered TG in vivo, using their responses to classic primary and secondary antigens, keyhole limpet haemocyanin (KLH) and tetanus toxoid (TT), respectively, for comparison. While TG elicited T-cell proliferation kinetics typical of a secondary response, the cytokine profile was distinct from that for TT. Whereas TT induce...
Source: Immunology - October 20, 2009 Category: Allergy & Immunology Authors: Nielsen CH, Galdiers MP, Hedegaard CJ, Leslie RG Tags: Immunology Source Type: journals

Migration of immature and mature B cells in the aged microenvironment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Studies in aged mice show that the architecture of B-cell areas appears disrupted and that newly made B cells fail to incorporate into the spleen. These observations may reflect altered migration of immature and mature B cells. Using adoptive transfer, we tested the effect of the aged microenvironment and the intrinsic ability of donor B cells from aged mice to migrate to spleens of intact hosts. Spleens of aged recipients were deficient in attracting young or old donor immature B cells. In contrast, immature and mature B cells maintained an intrinsic ability to migrate to young recipient spleens, except that a...
Source: Immunology - October 20, 2009 Category: Allergy & Immunology Authors: Minges Wols HA, Johnson KM, Ippolito JA, Birjandi SZ, Su Y, Le PT, Witte PL Tags: Immunology Source Type: journals

Auxiliary role for d-alanylated wall teichoic acid in Toll-like receptor 2-mediated survival of Staphylococcus aureus in macrophages.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary We previously reported that Staphylococcus aureus avoids killing within macrophages by exploiting the action of Toll-like receptor 2 (TLR2), which leads to the c-Jun N-terminal kinase (JNK)-mediated inhibition of superoxide production. To search for bacterial components responsible for this event, a series of S. aureus mutants, in which the synthesis of the cell wall was interrupted, were screened for the level of JNK activation in macrophages. In addition to a mutant lacking the lipoproteins that have been suggested to act as a TLR2 ligand, two mutant strains were found to activate the phosphorylation of JNK t...
Source: Immunology - October 20, 2009 Category: Allergy & Immunology Authors: Shiratsuchi A, Shimizu K, Watanabe I, Hashimoto Y, Kurokawa K, Razanajatovo IM, Park KH, Park HK, Lee BL, Sekimizu K, Nakanishi Y Tags: Immunology Source Type: journals

Future Meetings SectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - October 12, 2009 Category: Allergy & Immunology Source Type: journals

ErratumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - October 12, 2009 Category: Allergy & Immunology Source Type: journals

Neutralization of LIGHT ameliorates acute dextran sodium sulphate-induced intestinal inflammationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - October 12, 2009 Category: Allergy & Immunology Authors: Jungbeck, MichaelaDaller, BarbaraFederhofer, JosefWege, Anja K.Wimmer, NadinMannel, Daniela N.Hehlgans, Thomas Source Type: journals

Tumour-derived prostaglandin E2 and transforming growth factor- synergize to inhibit plasmacytoid dendritic cell-derived interferon-Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - October 12, 2009 Category: Allergy & Immunology Authors: Bekeredjian-Ding, IsabelleSchafer, MeikeHartmann, EvelynPries, RalphParcina, MarijoSchneider, PhilipGiese, ThomasEndres, StefanWollenberg, BarbaraHartmann, Gunther Source Type: journals

MyD88 and interferon- are differentially required for dendritic cell maturation but dispensable for development of protective memory against ListeriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - October 12, 2009 Category: Allergy & Immunology Authors: Tam, Miguel A.Wick, Mary Jo Source Type: journals

Priming of immune responses against transporter associated with antigen processing (TAP)-deficient tumours: tumour direct primingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - October 12, 2009 Category: Allergy & Immunology Authors: Li, Xiao-LinZhang, DongqingKnight, DavidOdaka, YoshinobuGlass, JonathanMathis, J. MichaelZhang, Qian-Jin Source Type: journals

Ex vivo expanded cord blood CD4 T lymphocytes exhibit a distinct expression profile of cytokine-related genes from those of peripheral blood originEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - October 12, 2009 Category: Allergy & Immunology Authors: Miyagawa, YoshitakaKiyokawa, NobutakaOchiai, NakabaImadome, Ken-IchiHoriuchi, YasuomiOnda, KeikoYajima, MisakoNakamura, HiroyukiKatagiri, Yohko U.Okita, HajimeMorio, TomohiroShimizu, NorioFujimoto, JunichiroFujiwara, Shigeyoshi Source Type: journals

Immunological dysfunction in HIV-1-infected individuals caused by impairment of adenosine deaminase-induced costimulation of T-cell activationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - October 12, 2009 Category: Allergy & Immunology Authors: Martinez-Navio, Jose M.Climent, NuriaPacheco, RodrigoGarcia, FelipePlana, MontserratNomdedeu, MeritxellOliva, HaroldRovira, CristinaMiralles, LaiaGatell, Jose M.Gallart, TeresaMallol, JosefaLluis, CarmeFranco, Rafael Source Type: journals

Vaccinia virus decreases major histocompatibility complex (MHC) class II antigen presentation, T-cell priming, and peptide association with MHC class IIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - October 12, 2009 Category: Allergy & Immunology Authors: Rehm, Kristina E.Connor, Ramsey F.Jones, Gwendolyn J. B.Yimbu, KennethMannie, Mark D.Roper, Rachel L. Source Type: journals

Antibodies to wounded tissue enhance cutaneous wound healingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - October 12, 2009 Category: Allergy & Immunology Authors: Nishio, NaomiIto, SachikoSuzuki, HaruhikoIsobe, Ken-Ichi Source Type: journals

Cell cycle arrest induced by engagement of B7-H4 on EpsteinBarr virus-positive B-cell lymphoma cell linesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - October 12, 2009 Category: Allergy & Immunology Authors: Park, Ga BinSong, HyunkeunKim, Yeong-SeokSung, MinjungRyu, Jeoung W.Lee, Hyun-KyungCho, Dae-HoKim, DaejinLee, Wang J.Hur, Dae Y. Source Type: journals

Production of interferon- by activated T-cell receptor- CD8 intestinal intraepithelial lymphocytes is required and sufficient for disruption of the intestinal barrier integrityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - October 12, 2009 Category: Allergy & Immunology Authors: Zufferey, ChristelErhart, DominikSaurer, LeslieMueller, Christoph Source Type: journals

Insulin-like growth factor I messenger RNA and protein are expressed in the human lymph node and distinctly confined to subtypes of macrophages, antigen-presenting cells, lymphocytes and endothelial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - October 12, 2009 Category: Allergy & Immunology Authors: Oberlin, DominiqueFellbaum, ChristianEppler, Elisabeth Source Type: journals

Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc receptors and costimulatory molecules on dendritic cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - October 12, 2009 Category: Allergy & Immunology Authors: Carreno, Leandro J.Pacheco, RodrigoGutierrez, Miguel A.Jacobelli, SergioKalergis, Alexis M. Source Type: journals

Rapid and reliable generation of invariant natural killer T-cell lines in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - October 12, 2009 Category: Allergy & Immunology Authors: Chiba, AsakoCohen, NadiaBrigl, ManfredBrennan, Patrick J.Besra, Gurdal S.Brenner, Michael B. Source Type: journals

Toll-like receptors sentries in the B-cell responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - October 12, 2009 Category: Allergy & Immunology Authors: Bekeredjian-Ding, IsabelleJego, Gaetan Source Type: journals

Efficiency of T-cell costimulation by CD80 and CD86 cross-linking correlates with calcium entry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Costimulation is a fundamental principle of T-cell activation. In addition to T-cell receptor engagement, the interaction between CD80 and/or CD86 with CD28 and/or cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptors is required to regulate T-cell activation and tolerance. While the importance of costimulation is clearly established, the exact molecular mechanism is unknown. We demonstrate that T-cell proliferation and the ability of CD8(+) T-effector cells to kill were enhanced slightly by CD80 but dramatically by CD86 costimulation. To further analyse the cellular process of costimulation, we developed a singl...
Source: Immunology - October 11, 2009 Category: Allergy & Immunology Authors: Thiel M, Wolfs MJ, Bauer S, Wenning AS, Burckhart T, Schwarz EC, Scott AM, Renner C, Hoth M Tags: Immunology Source Type: journals

Natural killer cells in infection and inflammation of the lung.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The lungs are a major site of entry of pathogens into the body and thus require rapid and effective innate responses to prevent pathogens establishing infection and to limit their spread. Additionally, the immune response in the lung must be tightly regulated such that pathogens are cleared, but immunopathology and chronic inflammation are prevented. In this review, I consider the role of natural killer (NK) cells in pulmonary infection and inflammation, specifically their contributions to influenza, tuberculosis, asthma and chronic obstructive pulmonary disease (COPD), which are major causes of morbidity and mortality...
Source: Immunology - September 11, 2009 Category: Allergy & Immunology Authors: Culley FJ Tags: Immunology Source Type: journals

T-cell reconstitution without T-cell immunopathology in two models of T-cell-mediated tissue destruction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we investigated whether it is possible to destroy specific unwanted antigen-specific T cells by incubating polyclonal T-cell populations with major histocompatibility complex (MHC) tetramers that are conjugated to the ribosomal-inactivating toxin, saporin. This strategy resulted in a dramatic reduction in the number of targeted antigen (Ag)-specific CD8 T cells with no observable bystander toxicity in vitro. Moreover, in a model of transferable T-cell-dependent neurological disease induced by intracerebral (i.c.) lymphocytic choriomeningitis virus (LCMV) infection, the targeted killing of LCMV-specific CD8 T ...
Source: Immunology - September 11, 2009 Category: Allergy & Immunology Authors: Penaloza-MacMaster P, Masopust D, Ahmed R Tags: Immunology Source Type: journals

Discrimination between the main activating and inhibitory killer cell immunoglobulin-like receptor positive natural killer cell subsets using newly characterized monoclonal antibodies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we report on the generation of KIR-specific antibodies allowing for discrimination between activating and inhibitory KIR. For this purpose, BALB/c mice were immunized with human KIR2DS2 recombinant protein. The precise specificity of KIR2DS2-specific clones was determined on KIR-transfected BW cells and KIR-genotyped NK cells. When used in combination with EB6 (KIR2DL1/2DS1) or GL183 (KIR2DL2/2DL3/2DS2), two KIR-specific monoclonal antibodies (mAbs), 8C11 (specific for KIR2DL1/2DL2/2DL3/2DS2) and 1F12 (specific for KIR2DL3/2DS2), discriminated activating KIR2DS1 (8C11(-) EB6(+)) from inhibitory KIR2DL1 (8C11...
Source: Immunology - September 11, 2009 Category: Allergy & Immunology Authors: David G, Morvan M, Gagne K, Kerdudou N, Willem C, Devys A, Bonneville M, Folléa G, Bignon JD, Retière C Tags: Immunology Source Type: journals

Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we performed a detailed analysis of the expression of mouse TREM-1 and its ligand(s). Our results demonstrate that TREM-1 is expressed on bone-marrow-derived dendritic cells (BMDC). On bone-marrow-derived macrophages (BMM) its expression is induced in vitro after stimulation by granulocyte-macrophage colony-stimulating factor, interleukin-3 or by myeloid differentiation primary response gene 88 (MyD88)-dependent Toll-like receptor (TLR) ligands. Under steady-state conditions mouse TREM-1 is detectable on a Gr-1(-) F4/80(+) monocyte subpopulation bearing markers of resident monocytes, but not on Gr-1(+) F4/80...
Source: Immunology - September 11, 2009 Category: Allergy & Immunology Authors: Zanzinger K, Schellack C, Nausch N, Cerwenka A Tags: Immunology Source Type: journals

Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Junctional adhesion molecule-A (JAM-A), JAM-B and JAM-C have been implicated in leucocyte transmigration. As JAM-B binds to very late activation antigen (VLA)-4, a leucocyte integrin that contributes to rolling and firm adhesion of lymphocytes to endothelial cells through binding to vascular cell adhesion molecule (VCAM)-1, we hypothesized that JAM-B is also involved in leucocyte rolling and firm adhesion. To test this hypothesis, intravital microscopy of murine skin microvasculature was performed. Rolling interactions of murine leucocytes were significantly affected by blockade of JAM-B [which reduced rolling interact...
Source: Immunology - September 11, 2009 Category: Allergy & Immunology Authors: Ludwig RJ, Hardt K, Hatting M, Bistrian R, Diehl S, Radeke HH, Podda M, Schön MP, Kaufmann R, Henschler R, Pfeilschifter JM, Santoso S, Boehncke WH Tags: Immunology Source Type: journals