A new, all-encompassing aetiology of type 1 diabetes
In conclusion, T1D is caused by a somatic mutation within the epitope-binding groove of an at-risk HLA gene that affects HLA-insulin-peptide-TCR complex binding affinity and initiates an autoimmune pathway. The nature of the peptide that binds to a mutated epitope-binding groove of an at-risk HLA gene determines the type of autoimmune disease that develops, that is, one at-risk HLA locus, multiple autoimmune diseases. Thus, T1D and AAIDs, and therefore common autoimmune diseases, share a similar somatic mutation-based aetiology.PMID:37772700 | DOI:10.1111/imm.13700 (Source: Immunology)
Source: Immunology - September 29, 2023 Category: Allergy & Immunology Authors: Piet C de Groen Source Type: research
A new, all-encompassing aetiology of type 1 diabetes
In conclusion, T1D is caused by a somatic mutation within the epitope-binding groove of an at-risk HLA gene that affects HLA-insulin-peptide-TCR complex binding affinity and initiates an autoimmune pathway. The nature of the peptide that binds to a mutated epitope-binding groove of an at-risk HLA gene determines the type of autoimmune disease that develops, that is, one at-risk HLA locus, multiple autoimmune diseases. Thus, T1D and AAIDs, and therefore common autoimmune diseases, share a similar somatic mutation-based aetiology.PMID:37772700 | DOI:10.1111/imm.13700 (Source: Immunology)
Source: Immunology - September 29, 2023 Category: Allergy & Immunology Authors: Piet C de Groen Source Type: research
A new, all-encompassing aetiology of type 1 diabetes
In conclusion, T1D is caused by a somatic mutation within the epitope-binding groove of an at-risk HLA gene that affects HLA-insulin-peptide-TCR complex binding affinity and initiates an autoimmune pathway. The nature of the peptide that binds to a mutated epitope-binding groove of an at-risk HLA gene determines the type of autoimmune disease that develops, that is, one at-risk HLA locus, multiple autoimmune diseases. Thus, T1D and AAIDs, and therefore common autoimmune diseases, share a similar somatic mutation-based aetiology.PMID:37772700 | DOI:10.1111/imm.13700 (Source: Immunology)
Source: Immunology - September 29, 2023 Category: Allergy & Immunology Authors: Piet C de Groen Source Type: research
A new, all-encompassing aetiology of type 1 diabetes
In conclusion, T1D is caused by a somatic mutation within the epitope-binding groove of an at-risk HLA gene that affects HLA-insulin-peptide-TCR complex binding affinity and initiates an autoimmune pathway. The nature of the peptide that binds to a mutated epitope-binding groove of an at-risk HLA gene determines the type of autoimmune disease that develops, that is, one at-risk HLA locus, multiple autoimmune diseases. Thus, T1D and AAIDs, and therefore common autoimmune diseases, share a similar somatic mutation-based aetiology.PMID:37772700 | DOI:10.1111/imm.13700 (Source: Immunology)
Source: Immunology - September 29, 2023 Category: Allergy & Immunology Authors: Piet C de Groen Source Type: research
Suppression of protein quality control system by TRIM30a sensitises tumour cells to NK cell-mediated immune surveillance
In this study, we find that overexpression of murine tripartite motif-containing protein 30a (TRIM30a) sensitises tumour cells to natural killer (NK) cells-mediated cytolysis. TRIM30a has no effect on tumour cell proliferation or apoptosis in vitro. However, TRIM30a-overexpressing tumour cells grow substantially slower than control tumour cells in immune-competent mice but not in NK-depleted mice. Mechanistically, TRIM30a overexpression impedes the clearance of misfolded protein and increases the production of reactive oxygen species induced by proteotoxic stress, implying that TRIM30a impairs protein quality control (PQC)...
Source: Immunology - September 27, 2023 Category: Allergy & Immunology Authors: Lukman O Afolabi Jiacheng Bi Liang Chen Xiaolu Yang Xiaochun Wan Source Type: research
Suppression of protein quality control system by TRIM30a sensitises tumour cells to NK cell-mediated immune surveillance
In this study, we find that overexpression of murine tripartite motif-containing protein 30a (TRIM30a) sensitises tumour cells to natural killer (NK) cells-mediated cytolysis. TRIM30a has no effect on tumour cell proliferation or apoptosis in vitro. However, TRIM30a-overexpressing tumour cells grow substantially slower than control tumour cells in immune-competent mice but not in NK-depleted mice. Mechanistically, TRIM30a overexpression impedes the clearance of misfolded protein and increases the production of reactive oxygen species induced by proteotoxic stress, implying that TRIM30a impairs protein quality control (PQC)...
Source: Immunology - September 27, 2023 Category: Allergy & Immunology Authors: Lukman O Afolabi Jiacheng Bi Liang Chen Xiaolu Yang Xiaochun Wan Source Type: research
NLRP2 in health and disease
Immunology. 2023 Sep 22. doi: 10.1111/imm.13699. Online ahead of print.ABSTRACTNLR family pyrin domain containing 2 (NLRP2) is a novel member of the Nod-like receptor (NLR) family. However, our understanding of NLRP2 has long been ambiguous. NLRP2 may have a role in the innate immune response, but its 'specific' functions remain controversial. Although NLRP2 can initiate inflammasome and promote inflammation, it can also downregulate inflammatory signals. Additionally, NLRP2 has been reported to function in the reproductive system and shows high expression in the placenta. However, the exact role of NLRP2 in the reproducti...
Source: Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Tongtong Zhang Fei Xing Mingcui Qu Zhihu Yang Yafei Liu Yongchao Yao Na Xing Source Type: research
NLRP2 in health and disease
Immunology. 2023 Sep 22. doi: 10.1111/imm.13699. Online ahead of print.ABSTRACTNLR family pyrin domain containing 2 (NLRP2) is a novel member of the Nod-like receptor (NLR) family. However, our understanding of NLRP2 has long been ambiguous. NLRP2 may have a role in the innate immune response, but its 'specific' functions remain controversial. Although NLRP2 can initiate inflammasome and promote inflammation, it can also downregulate inflammatory signals. Additionally, NLRP2 has been reported to function in the reproductive system and shows high expression in the placenta. However, the exact role of NLRP2 in the reproducti...
Source: Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Tongtong Zhang Fei Xing Mingcui Qu Zhihu Yang Yafei Liu Yongchao Yao Na Xing Source Type: research
NLRP2 in health and disease
Immunology. 2023 Sep 22. doi: 10.1111/imm.13699. Online ahead of print.ABSTRACTNLR family pyrin domain containing 2 (NLRP2) is a novel member of the Nod-like receptor (NLR) family. However, our understanding of NLRP2 has long been ambiguous. NLRP2 may have a role in the innate immune response, but its 'specific' functions remain controversial. Although NLRP2 can initiate inflammasome and promote inflammation, it can also downregulate inflammatory signals. Additionally, NLRP2 has been reported to function in the reproductive system and shows high expression in the placenta. However, the exact role of NLRP2 in the reproducti...
Source: Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Tongtong Zhang Fei Xing Mingcui Qu Zhihu Yang Yafei Liu Yongchao Yao Na Xing Source Type: research
NLRP2 in health and disease
Immunology. 2023 Sep 22. doi: 10.1111/imm.13699. Online ahead of print.ABSTRACTNLR family pyrin domain containing 2 (NLRP2) is a novel member of the Nod-like receptor (NLR) family. However, our understanding of NLRP2 has long been ambiguous. NLRP2 may have a role in the innate immune response, but its 'specific' functions remain controversial. Although NLRP2 can initiate inflammasome and promote inflammation, it can also downregulate inflammatory signals. Additionally, NLRP2 has been reported to function in the reproductive system and shows high expression in the placenta. However, the exact role of NLRP2 in the reproducti...
Source: Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Tongtong Zhang Fei Xing Mingcui Qu Zhihu Yang Yafei Liu Yongchao Yao Na Xing Source Type: research
NLRP2 in health and disease
Immunology. 2023 Sep 22. doi: 10.1111/imm.13699. Online ahead of print.ABSTRACTNLR family pyrin domain containing 2 (NLRP2) is a novel member of the Nod-like receptor (NLR) family. However, our understanding of NLRP2 has long been ambiguous. NLRP2 may have a role in the innate immune response, but its 'specific' functions remain controversial. Although NLRP2 can initiate inflammasome and promote inflammation, it can also downregulate inflammatory signals. Additionally, NLRP2 has been reported to function in the reproductive system and shows high expression in the placenta. However, the exact role of NLRP2 in the reproducti...
Source: Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Tongtong Zhang Fei Xing Mingcui Qu Zhihu Yang Yafei Liu Yongchao Yao Na Xing Source Type: research
Transforming growth factor- β, Interleukin-23 and interleukin-1β modulate TH22 response during active multidrug-resistant tuberculosis
Immunology. 2023 Sep 16. doi: 10.1111/imm.13698. Online ahead of print.ABSTRACTWe previously reported that patients with multidrug-resistant tuberculosis (MDR-TB) showed low systemic and Mtb-induced Th22 responses associated to high sputum bacillary load and severe lung lesions suggesting that Th22 response could influence the ability of these patients to control bacillary growth and tissue damage. In MDR-TB patients, the percentage of IL-22+ cells inversely correlates with the proportion of senescent PD-1+ T cells. Herein, we aimed to evaluate the pathways involved on the regulation of systemic and Mtb-induced Th22 respon...
Source: Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Bel én R Imperiale Ana Gamberale Noem í Yokobori Ana Garc ía Bruno Bartoletti Omar Aidar Beatriz L ópez Victor Cruz Pablo Gonz ález Montaner Domingo J Palmero Silvia de la Barrera Source Type: research
Transforming growth factor- β, Interleukin-23 and interleukin-1β modulate TH22 response during active multidrug-resistant tuberculosis
Immunology. 2023 Sep 16. doi: 10.1111/imm.13698. Online ahead of print.ABSTRACTWe previously reported that patients with multidrug-resistant tuberculosis (MDR-TB) showed low systemic and Mtb-induced Th22 responses associated to high sputum bacillary load and severe lung lesions suggesting that Th22 response could influence the ability of these patients to control bacillary growth and tissue damage. In MDR-TB patients, the percentage of IL-22+ cells inversely correlates with the proportion of senescent PD-1+ T cells. Herein, we aimed to evaluate the pathways involved on the regulation of systemic and Mtb-induced Th22 respon...
Source: Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Bel én R Imperiale Ana Gamberale Noem í Yokobori Ana Garc ía Bruno Bartoletti Omar Aidar Beatriz L ópez Victor Cruz Pablo Gonz ález Montaner Domingo J Palmero Silvia de la Barrera Source Type: research
Transforming growth factor- β, Interleukin-23 and interleukin-1β modulate TH22 response during active multidrug-resistant tuberculosis
Immunology. 2023 Sep 16. doi: 10.1111/imm.13698. Online ahead of print.ABSTRACTWe previously reported that patients with multidrug-resistant tuberculosis (MDR-TB) showed low systemic and Mtb-induced Th22 responses associated to high sputum bacillary load and severe lung lesions suggesting that Th22 response could influence the ability of these patients to control bacillary growth and tissue damage. In MDR-TB patients, the percentage of IL-22+ cells inversely correlates with the proportion of senescent PD-1+ T cells. Herein, we aimed to evaluate the pathways involved on the regulation of systemic and Mtb-induced Th22 respon...
Source: Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Bel én R Imperiale Ana Gamberale Noem í Yokobori Ana Garc ía Bruno Bartoletti Omar Aidar Beatriz L ópez Victor Cruz Pablo Gonz ález Montaner Domingo J Palmero Silvia de la Barrera Source Type: research
Transforming growth factor- β, Interleukin-23 and interleukin-1β modulate TH22 response during active multidrug-resistant tuberculosis
Immunology. 2023 Sep 16. doi: 10.1111/imm.13698. Online ahead of print.ABSTRACTWe previously reported that patients with multidrug-resistant tuberculosis (MDR-TB) showed low systemic and Mtb-induced Th22 responses associated to high sputum bacillary load and severe lung lesions suggesting that Th22 response could influence the ability of these patients to control bacillary growth and tissue damage. In MDR-TB patients, the percentage of IL-22+ cells inversely correlates with the proportion of senescent PD-1+ T cells. Herein, we aimed to evaluate the pathways involved on the regulation of systemic and Mtb-induced Th22 respon...
Source: Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Bel én R Imperiale Ana Gamberale Noem í Yokobori Ana Garc ía Bruno Bartoletti Omar Aidar Beatriz L ópez Victor Cruz Pablo Gonz ález Montaner Domingo J Palmero Silvia de la Barrera Source Type: research
