Immunology and Allergy Clinics of North America 
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Eosinophilic Gastrointestinal Diseases
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - April 3, 2024 Category: Allergy & Immunology Authors: Glenn T. Furuta, Dan Atkins Source Type: research
Copyright
ELSEVIER (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - April 3, 2024 Category: Allergy & Immunology Source Type: research
Contributors
ROHIT KATIAL, MD, FAAAAI, FACAAI, FACP (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - April 3, 2024 Category: Allergy & Immunology Source Type: research
Contents
Rohit Katial (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - April 3, 2024 Category: Allergy & Immunology Source Type: research
Forthcoming Issues
Updates in Urticaria/Angioedema (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - April 3, 2024 Category: Allergy & Immunology Source Type: research
Pathophysiology of Non-Esophageal Eosinophilic Gastrointestinal Disorders
Eosinophilic gastrointestinal disorder (EGID) is an umbrella term encompassing a group of chronic, immune-mediated disorders characterized by eosinophil-rich inflammation affecting one or more segments of the gastrointestinal tract. A recent consensus in nomenclature and emerging data made possible through multi-center consortia are beginning to unravel the molecular and cellular underpinnings of EGIDs below the esophagus. These emerging findings are revealing both overarching commonalities related to a food allergen-driven, chronic, Th2-mediated immune response as well as location-specific nuances in the pathophysiology o...
Source: Immunology and Allergy Clinics of North America - February 20, 2024 Category: Allergy & Immunology Authors: Julia L.M. Dunn, Lisa A. Spencer Source Type: research
Dietary Management of Eosinophilic Esophagitis
This article will focus on the rationale for dietary therapy in EoE and provide helpful tools for the implementation of dietary therapy in practice. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - February 19, 2024 Category: Allergy & Immunology Authors: Alfredo Lucendo, Marion Groetch, Nirmala Gonsalves Source Type: research
Embracing Diversity, Equity, Inclusion, and Accessibility in Eosinophilic Gastrointestinal Diseases
Eosinophilic gastrointestinal diseases (EGIDs) including eosinophilic esophagitis (EoE) are rare diseases in which eosinophils abnormally infiltrate the gastrointestinal tract. Because these are rare diseases, there is limited information regarding race and ethnicity in EGIDs and even less is known about the impact of socioeconomic factors. There is some evidence that access to care in rural settings may be affecting epidemiologic understanding of EGIDs in the pediatric populations. Future work should try to evaluate bias in research and strive for representation in clinical trials and medicine. (Source: Immunology and All...
Source: Immunology and Allergy Clinics of North America - February 19, 2024 Category: Allergy & Immunology Authors: Amanda B. Muir, Dominique D. Bailey, Pooja Mehta Source Type: research
Role of Mast Cells in Eosinophilic Gastrointestinal Diseases
Mast cells play a central role in the pathogenesis of eosinophilic gastrointestinal disorders (EGIDs), including eosinophilic esophagitis. Their interactions with immune and structural cells, involvement in tissue remodeling, and contribution to symptoms make them attractive targets for therapeutic intervention. More is being discovered regarding the intricate interplay of mast cells and eosinophils. Recent studies demonstrating that depletion of eosinophils is insufficient to improve symptoms of EGIDs have raised the question of whether other cells may play a role in symptomatology and pathogenesis of EGIDs. (Source: Immu...
Source: Immunology and Allergy Clinics of North America - February 19, 2024 Category: Allergy & Immunology Authors: Paneez Khoury, Joshua B. Wechsler Source Type: research
Associations of Eosinophilic Gastrointestinal Disorders with Other Gastrointestinal and Allergic Diseases
Eosinophilic gastrointestinal disorders (EGIDs) are becoming more common causing significant suffering and reduced quality of life. These conditions can affect different parts of the digestive system, either individually or in combination. Recognition of their link to allergic disorders or other gastrointestinal (GI) diseases has raised questions about their shared underlying mechanisms, which has had implications for diagnosis and management. The authors critically examine the current understanding of the connection between EGIDs and allergic conditions (ie, atopic dermatitis, allergic rhinitis, asthma, and food allergy) ...
Source: Immunology and Allergy Clinics of North America - February 19, 2024 Category: Allergy & Immunology Authors: Salvatore Oliva, Emily Clarke McGowan Source Type: research
The Relationship Between Eosinophilic Esophagitis and Immunotherapy
Immunotherapy is a treatment approach based on the principle of incremental allergen exposure to achieve desensitization. Recently, oral immunotherapy has been introduced as a treatment of IgE-mediated food allergy. Some patients receiving oral immunotherapy for food allergy may develop eosinophilic esophagitis. Here, we summarize the literature examining this association, its treatment, and outcomes and discuss possible explanations for this clinical phenomenon. We further identify potential associations with aeroallergen sensitivity and other forms of immunotherapy including subcutaneous immunotherapy and sublingual immu...
Source: Immunology and Allergy Clinics of North America - February 14, 2024 Category: Allergy & Immunology Authors: Bridget E. Wilson, Maria A. Sacta, Benjamin L. Wright, Jonathan Spergel, Nicole Wolfset Source Type: research
Histopathology of Eosinophilic Gastrointestinal Diseases Beyond Eosinophilic Esophagitis
Eosinophilic gastrointestinal diseases (EGID), such as eosinophilic gastritis (EoG), eosinophilic enteritis, and eosinophilic colitis (EoC), are chronic inflammatory conditions characterized by persistent gastrointestinal symptoms and elevated levels of activated eosinophils in the gastrointestinal tract. EoG and eosinophilic duodenitis (EoD) are strongly associated with food allergen triggers and TH2 inflammation, whereas EoC shows minimal transcriptomic overlap with other EGIDs. The level of expression of certain genes associated with TH2 immune response is associated with certain histopathologic findings of EoG, EoD, an...
Source: Immunology and Allergy Clinics of North America - February 14, 2024 Category: Allergy & Immunology Authors: Nicoleta C. Arva, Anas Bernieh, Oscar Lopez-Nunez, Maria Pletneva, Guang-Yu Yang, Margaret H. Collins Source Type: research
Eosinophilic Gastrointestinal Diseases
It is with great pleasure that I introduce this comprehensive issue, edited by eminent leaders in the field, Drs Furuta and Atkins. This issue is a significant contribution to the understanding and management of Eosinophilic Gastrointestinal Diseases (EGIDs) as well as a testament to the dedication and expertise of luminaries in the field, who have meticulously compiled and analyzed the latest research and clinical practices related to EGIDs. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - February 14, 2024 Category: Allergy & Immunology Authors: Rohit Katial Tags: Foreword Source Type: research
Clinical Presentation of Patients with Eosinophilic Gastrointestinal Diseases beyond Eosinophilic Esophagitis
The clinical presentation of eosinophilic gastrointestinal diseases beyond eosinophilic esophagitis (non-EoE EGIDs) varies depending on the gastrointestinal segments affected by the eosinophilic inflammation, the extent of eosinophilic inflammation within the gastrointestinal tract and its depth through the bowel wall. Non-EoE EGIDs with mucosal involvement tend to present with diarrhea, malabsorption, and sometimes bleeding, those with muscular involvement may present with symptoms of obstruction or pseudo-obstruction, intussusception, and even perforation, whereas those with serosal involvement may present wit h eosino...
Source: Immunology and Allergy Clinics of North America - February 13, 2024 Category: Allergy & Immunology Authors: Alexandra Papadopoulou, Noam Zevit Source Type: research
Endoscopic Features of Eosinophilic Gastrointestinal Diseases
Endoscopic evaluation with biopsies is a mainstay of the diagnosis of eosinophilic esophagitis (EoE) and non-EoE eosinophilic gastrointestinal diseases (EGIDs). Increasing knowledge has resulted in the development of 2 standardized scoring systems: the Endoscopic REFerence Score (EREFS) for EoE and the EG-REFS for eosinophilic gastritis, although the latter has not been validated. In EGIDs, diagnosis and follow-up focus on eosinophil infiltration in biopsies. In this article, we will discuss the most commonly used endoscopic scores in EoE and non-EoE EGIDs, their validity for the diagnosis and follow-up of disease activity...
Source: Immunology and Allergy Clinics of North America - February 13, 2024 Category: Allergy & Immunology Authors: Thomas Greuter, David Katzka Source Type: research
