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Simultaneous RP-HPLC and HPTLC estimation of fluoxetine hydrochloride and olanzapine in tablet dosage formsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patel Sejal, Patel N JIndian Journal of Pharmaceutical Sciences 2009 71(4):477-480A binary mixture of fluoxetine HCl and olanzapine was determined by two different methods. The first method involved determination of fluoxetine HCl and olanzapine using reversed-phase liquid chromatography using acetonitrile:methanol:0.032 M ammonium acetate buffer (45:05:50, v/v/v) as the mobile phase at a flow rate of 1.5 ml/min. Quantitation was achieved with ultraviolet detection at 235 nm over concentration ranges of 0.2-4 and 0.1-2 &#956;g/ml; mean accuracies were 101.16&#177;0.59 and 99.79&#177;0.56&#x...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Patel Sejal, Patel N J Source Type: journals

Spectrophotometric and chromatographic simultaneous estimation of amitriptyline hydrochloride and chlordiazepoxide in tablet dosage formsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patel Sejal, Patel N JIndian Journal of Pharmaceutical Sciences 2009 71(4):472-476A binary mixture of amitriptyline HCl and chlordiazepoxide was determined by three different methods. The first method involved determination of amitriptyline HCl and chlordiazepoxide using the first derivative spectrophotometric technique at 219 and 230 nm over the concentration ranges of 1-20 and 2-24 &#956;g/ml with mean accuracies 100.9&#177;0.87 and 99.2&#177;1.0%, respectively. The second method was reversed-phase high performance liquid chromatography using methanol: acetonitrile: 0.065 M ammoniu...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Patel Sejal, Patel N J Source Type: journals

Simultaneous spectrophotometric estimation of imipramine hydrochloride and chlordiazepoxide in tabletsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patel Sejal, Patel N J, Patel S AIndian Journal of Pharmaceutical Sciences 2009 71(4):468-472A binary mixture of imipramine HCl and chlordiazepoxide was determined by three different spectrophotometric methods. The first method involved determination of imipramine HCl and chlordiazepoxide using the simultaneous equations and the second method involved absorbance ratio method. Imipramine has absorbance maxima at 251 nm, chlordiazepoxide has absorbance maxima at 264.5 nm and isoabsorptive point is at 220 nm in methanol. Linearity was obtained in the concentration ranges of 1-25 and 1-10 &#956;g/ml for Imipramine H...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Patel Sejal, Patel N J, Patel S A Source Type: journals

pH-sensitive mebeverine microspheres for colon deliveryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dandagi P M, Mastiholimath V S, Gadad A P, Kulkarni A R, Konnur B KIndian Journal of Pharmaceutical Sciences 2009 71(4):464-468Mebeverine hydrochloride is known to suffer from extensive first pass effect. In an attempt to improve its oral bioavailability and possibility to restrict its absorption only to the colon, mebeverine microspheres were prepared by emulsion solvent evaporation method. Four formulations were prepared with varying drug and polymer ratio. These formulations were subjected to various evaluation parameters like percent practical yield, entrapment efficiency, particle size, in vitro...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Dandagi P M, Mastiholimath V S, Gadad A P, Kulkarni A R, Konnur B K Source Type: journals

Evaluation of analgesic and antipyretic activities of Centratherum anthelminticum (L) kuntze seedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Purnima A, Koti B C, Tikare V P, Viswanathaswamy A.H.M, Thippeswamy A.H.M, Dabadi PIndian Journal of Pharmaceutical Sciences 2009 71(4):461-464The study was designed to investigate analgesic and antipyretic activities of petroleum ether and alcohol extracts of Centratherum anthelminticum (L) Kuntze (family: Asteraceae) seeds (100 and 200 mg/kg, p.o.) in brewer's yeast-induced fever model in rats, acetic acid-induced writhing and Eddy's hot plate methods in mice. Both petroleum ether and alcohol extracts showed significant decrease in number of writhes in acetic a...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Purnima A, Koti B C, Tikare V P, Viswanathaswamy A.H.M, Thippeswamy A.H.M, Dabadi P Source Type: journals

Drug usage evaluation of dapsoneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kannan G, Vasantha J, Rani N Vanitha, Thennarasu P, Kousalya K, Anuradha P, Reddy C UmaMaheswaraIndian Journal of Pharmaceutical Sciences 2009 71(4):456-460Dapsone has been the principal drug in a multidrug regimen recommended by the World Health Organization for the treatment of leprosy. It is also widely used by dermatologists in varied skin conditions like dermatitis herpetiformis, bullous pemphigoid, Behcet's disease, lupus erythematous and a host of other skin diseases. Hence an attempt has been made to review the utilization and qualitative evaluation of dapsone over a period of 6 months in a tertiary care tea...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Kannan G, Vasantha J, Rani N Vanitha, Thennarasu P, Kousalya K, Anuradha P, Reddy C UmaMaheswara Source Type: journals

Antiinflammatory activity of Piper longum fruit oilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kumar A, Panghal S, Mallapur S S, Kumar M, Ram Veerma, Singh B KIndian Journal of Pharmaceutical Sciences 2009 71(4):454-456In the present study, antiinflammatory activity of the Piper longum dried fruit's oil was studied in rats using the carrageenan-induced right hind paw edema method. The activity was compared with that of standard drug ibuprofen. The dried fruit's oil inhibited carrageenan-induced rat paw edema. The results indicated that the dried fruit's oil produced significant (p< 0.001) anti...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Kumar A, Panghal S, Mallapur S S, Kumar M, Ram Veerma, Singh B K Source Type: journals

Development and validation of HPTLC method for the estimation of clotrimazole in bulk drug and tablet formulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Parmar Parul, Mehta AnkitaIndian Journal of Pharmaceutical Sciences 2009 71(4):451-454A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed and validated for the determination of clotrimazole in bulk drug and tablet dosage form. The stationary phase used was precoated silica gel 60F 254 . The mobile phase used was a mixture of cyclohexane:toluene:methanol:triethyleamine (8:2:0.5:0.2 v/v/v/v). The detection of spot was carried out at 262 nm. The method was validated in terms of linearity, accuracy, precision and specific...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Parmar Parul, Mehta Ankita Source Type: journals

Design of fast disintegrating tablets of prochlorperazine maleate by effervescence methodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Shirsand S B, Suresh Sarasija, Para M S, Swamy P VIndian Journal of Pharmaceutical Sciences 2009 71(4):447-451In the present work, fast disintegrating tablets of prochlorperazine maleate were designed with a view to enhance patient compliance by effervescent method. In this method, mixtures of sodium bicarbonate and anhydrous citric acid in different ratios along with crospovidone (2-10% w/w), croscarmellose sodium (2-10% w/w) were used as superdisintegrants. Estimation of prochlorperazine maleate in the prepared tablet formulations was carried out by extracting the drug with methanol and measuring the absorb...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Shirsand S B, Suresh Sarasija, Para M S, Swamy P V Source Type: journals

CNS depressant activity of ethanol extract of Sterculia guttata seeds in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Katade S R, Misar A V, Mujumdar A M, Phalgune U D, Wakharkar R D, Deshpande N RIndian Journal of Pharmaceutical Sciences 2009 71(4):445-447Shade dried, powdered seeds of Sterculia guttata were extracted using a Soxhlet extractor with ethanol. Ethanol was removed under reduced pressure and dried to obtained crude extract. This extract was evaluated for its effect on behavioral changes, exploratory activity and barbiturate-sleeping time, using appropriate standard methods in mice. The extract exhibited dose-dependent CNS depressant activity. (Source: Indian Journal of Pharmaceutical Sciences)
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Katade S R, Misar A V, Mujumdar A M, Phalgune U D, Wakharkar R D, Deshpande N R Source Type: journals

Analgesic and antiinflammatory activity of Amukkarac curanamEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Saraswathy A, Devi S Nandini, Pradeep Chandran R VIndian Journal of Pharmaceutical Sciences 2009 71(4):442-445Amukkarac curanam a polyherbal Siddha formulation was examined for its analgesic and antiinflammatory activity at a dose of 500 mg/kg, p.o. The experimental methods used were tail immersion and acetic acid induced writhing method for analgesic and cotton pellet induced granuloma formation for antiinflammatory activity. Pentazocine (10 mg/kg, intraperitoneally) and aspirin (150 mg/kg, orally) clinically used analgesics were used as standard analgesics. Indomethacin (10 ...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Saraswathy A, Devi S Nandini, Pradeep Chandran R V Source Type: journals

Study of degradation profile and development of stability indicating methods for cefixime trihydrateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gandhi S P, Rajput S JIndian Journal of Pharmaceutical Sciences 2009 71(4):438-442The degradation behavior of cefixime trihydrate was investigated under different stress conditions of acidic hydrolysis, alkaline hydrolysis and oxidation using spectrophotometry. Stability indicating spectrophotometric methods were developed that could separate the drug from its degradation products formed under these stress conditions. The UV spectral characteristics of the drug and degraded products were quite different and zero and first order derivative ultraviolet spectrophotometric methods were used to study the extent of degradation. ...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Gandhi S P, Rajput S J Source Type: journals

Antibacterial activity of ethanol extract of Andrographis paniculataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mishra U S, Mishra A, Kumari R, Murthy P N, Naik B SIndian Journal of Pharmaceutical Sciences 2009 71(4):436-438In the present study the ethanol extract of the aerial part of Andrographis paniculata was prepared and evaluated for antimicrobial activity against eleven bacterial strains by determining minimum inhibitory concentration and zone of inhibition. Minimum inhibitory concentration values were compared with control and zone of inhibition values were compared with standard ciprofloxacin in concentration 100 and 200 &#956;g/ml. The results revealed that, the eth...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Mishra U S, Mishra A, Kumari R, Murthy P N, Naik B S Source Type: journals

Synthesis and antiviral studies of novel N-sulphonamidomethyl piperazinyl fluoroquinolonesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Selvam P, Rathore P, Karthikumar S, Velkumar K, Palanisamy P, Vijayalakhsmi S, Witvrouw MIndian Journal of Pharmaceutical Sciences 2009 71(4):432-436A series of novel N-Sulphonamidomethyl piperzinyl fluoroquinolones were synthesized and screened antiviral activity. Eight compounds were synthesized through modifying the N 4 -hydrogen of piperazine in fluoroquinolones with formaldehyde and sulphanomides by Mannich reactions. The structures of the synthesized compounds were characterized by means of their IR and 1 H-NMR spec...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Selvam P, Rathore P, Karthikumar S, Velkumar K, Palanisamy P, Vijayalakhsmi S, Witvrouw M Source Type: journals

Synthesis and pharmacological evaluation of schiff bases of 4-(2-aminophenyl)-morpholinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Panneerselvam P, Priya M Gnanarupa, Kumar N Ramesh, Saravanan GIndian Journal of Pharmaceutical Sciences 2009 71(4):428-432In the present study, a novel series of 4-(2-aminophenyl)morpholines were synthesized and characterized by IR, 1 H-NMR, 13 C NMR and mass spectral analysis. The synthesized compounds were screened for analgesic (100 and 200 mg/kg), antiinflammatory (200 and 400 mg/kg), antibacterial (Bacillus subtilis, Bacillus cereus, Staphylococcus epidermidis, Staphylococcus aureus, Klebsiel...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Panneerselvam P, Priya M Gnanarupa, Kumar N Ramesh, Saravanan G Source Type: journals

Formulation and evaluation of in situ gels containing clotrimazole for oral candidiasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Harish N M, Prabhu P, Charyulu R N, Gulzar M A, Subrahmanyam E.V.SIndian Journal of Pharmaceutical Sciences 2009 71(4):421-427Gel dosage forms are successfully used as drug delivery systems to control drug release and protect the medicaments from a hostile environment. The main objective is to formulate and evaluate in situ oral topical gels of clotrimazole based on the concept of pH triggered and ion activated systems. The system utilizes polymers that exhibit sol-to-gel phase transition due to change in specific physico-chemical parameters. A pH triggered system consisting o...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Harish N M, Prabhu P, Charyulu R N, Gulzar M A, Subrahmanyam E.V.S Source Type: journals

Solid dispersion matrix tablet comprising indomethacin-PEG-HPMC fabricated with fusion and mold techniqueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mesnukul A, Yodkhum K, Phaechamud TIndian Journal of Pharmaceutical Sciences 2009 71(4):413-420The purpose of this study is to fabricate the polyethylene glycol matrix tablet by mold technique. Indomethacin and hydroxypropylmethylcellulose were used as model drug and polymer, respectively, in PEG matrix system. The physical and drug release characteristics of developed matrix tablet were studied. This inert carrier system comprising 7:3 polyethylene glycol 4000: polyethylene glycol 400 could effectively enhance the solubility of indomethacin and an addition of hydroxypropylmethylcellulose could sustain the drug release. Sc...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Mesnukul A, Yodkhum K, Phaechamud T Source Type: journals

Determination of antibacterial and antioxidant potential of some medicinal plants from Saurashtra Region, IndiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kaneria M, Baravalia Y, Vaghasiya Y, Chanda SIndian Journal of Pharmaceutical Sciences 2009 71(4):406-412Many plants used in Saurashtra folk medicine have been reported to exhibit high antibacterial and antioxidant activities. In the present study, some parts of five plants, Guazuma ulmifolia L., Manilkara zapota L., Melia azedarach L., Syzygium cumini L. and Wrightia tomentosa R.&...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Kaneria M, Baravalia Y, Vaghasiya Y, Chanda S Source Type: journals

Stabilization of quinapril by incorporating hydrogen bonding interactionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Roy B N, Singh G P, Godbole H M, Nehate S PIndian Journal of Pharmaceutical Sciences 2009 71(4):395-405In the present study stability of various known solvates of quinapril hydrochloride has been compared with nitromethane solvate. Nitromethane solvate was found to be more stable compared to other known solvates. Single crystal X-ray diffraction analysis of quinapril nitromethane solvate shows intermolecular hydrogen bonding between quinapril molecule and nitromethane. Stabilization of quinapril by forming strong hydrogen bonding network as in case of co-crystals was further studied by forming co-crystal with tris(hydroxym...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Roy B N, Singh G P, Godbole H M, Nehate S P Source Type: journals

Formulation and optimization of sustained release tablets of venlafaxine resinates using response surface methodologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Madgulkar Ashwini R, Bhalekar M R, Kolhe V J, Kenjale Y DIndian Journal of Pharmaceutical Sciences 2009 71(4):387-394The aim of the current study was to design sustained release matrix tablets of venlafaxine hydrochloride using ion exchange resin with the incorporation of hydrophilic and hydrophobic polymer combinations. Venlafaxine HCl was loaded onto Indion 244 by batch method and then resinate were wet granulated with ethyl cellulose and blended with hydroxypropylmethylcellulose and compressed. A central composite design for 2 factors at 3 levels each was employed to system...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Madgulkar Ashwini R, Bhalekar M R, Kolhe V J, Kenjale Y D Source Type: journals

Development of a RP-HPLC method for analysis of Triphala curna and its applicability to test variations in Triphala curna preparationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pawar V, Lahorkar P, Anantha Narayana D BIndian Journal of Pharmaceutical Sciences 2009 71(4):382-386A sensitive, rapid, reverse phase HPLC method is reported for analysis of Triphala Curna using gallic acid, chebulagic acid and chebulinic acid as markers. Validation data for the method has been provided. Unlike methods of recovery testing adopted for synthetic chemicals, a modified approach has been presented here for a formulation like Triphala Curna having three myrobalans in its composition. Data has been provided to demonstra...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Pawar V, Lahorkar P, Anantha Narayana D B Source Type: journals

Cefoperazone sodium impregnated polycaprolactone composite implant for osteomyelitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anand A, Pundir R, Pandian C S, Saraf S, Gupta HIndian Journal of Pharmaceutical Sciences 2009 71(4):377-381The use of local antibiotics from a biodegradable implant for chronic osteomyelitis is an attractive alternative. The implant delivers high antibiotic concentration at tissue levels, obliterates dead space, aids bone repair and does not need to be removed. The purpose of this paper is to develop and evaluate a calcium sulphate and polycaprolactone based composite biodegradable implantable delivery system of cefoperazone sodium. Implants were prepared by modified fabrication technique to avoid solvent use. Interaction...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Anand A, Pundir R, Pandian C S, Saraf S, Gupta H Source Type: journals

Synthesis and evaluation of chitosan-Vitamin C complexEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tian X L, Tian D F, Wang Z Y, Mo F KIndian Journal of Pharmaceutical Sciences 2009 71(4):371-376Chitosan is a biocompatible, biodegradable and non-toxic polysaccharide polymer. It dissolves in water only if the pH is lower than 6.5. To extend its range of application, many water-soluble derivatives have therefore been prepared. In this research, chitosan-vitamin C complex was synthesized and characterized with Fourier transformed infrared spectroscopy, differential scanning calorimetry and 1 H-NMR. The solubility of chitosan-vitamin C complex in distilled water was greatl...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Tian X L, Tian D F, Wang Z Y, Mo F K Source Type: journals

Co-crystals: A novel approach to modify physicochemical properties of active pharmaceutical ingredientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article covers the advantages of co-crystals over salts, solvates (hydrates), solid dispersions and polymorphs, mechanism of formation of co-crystals, methods of preparation of co-crystals and application of co-crystals to modify physicochemical characteristics of active pharmaceutical ingredients along with the case studies. The intellectual property implications of creating co-crystals are also highly relevant. (Source: Indian Journal of Pharmaceutical Sciences)
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Yadav A V, Shete A S, Dabke A P, Kulkarni P V, Sakhare S S Source Type: journals

Solid lipid nanoparticles: A modern formulation approach in drug delivery systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mukherjee S, Ray S, Thakur R SIndian Journal of Pharmaceutical Sciences 2009 71(4):349-358Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research, as well as in other varied sciences. Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could be used for secondary and tertiary levels of drug targeting. Hence, solid lipid nanoparticles hold g...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Mukherjee S, Ray S, Thakur R S Source Type: journals

The antimicrobial activity of essential oil from Perovskia abrotanoides karel and its main componentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mahboubi M, Kazempour NIndian Journal of Pharmaceutical Sciences 2009 71(3):343-347In Iranian folk medicine, Perovskia abrotanoides is used for treatment of leishmaniasis. These patients may develop secondary infections with opportunistic microorganisms. Therefore, the antimicrobial activity of essential oil from aerial part of P. abrotanoides and its main components was evaluated against different microorganisms. Disc diffusion and broth micro dilution assays were used for in vitro a...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Mahboubi M, Kazempour N Source Type: journals

Anticandidal activity of Asparagus racemosusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Uma B, Prabhakar K, Rajendran SIndian Journal of Pharmaceutical Sciences 2009 71(3):342-343The in vitro anticandidal activity of Asparagus racemosus roots and tubers extract was investigated against Candida albicans, Candida tropicalis, Candida krusei, Candida guillermondii, Candida parapsilosis and Candida stellatoida, which are isolated from vaginal thrush patients. The extract of Asparagus racemosus showed high degree of activity again...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Uma B, Prabhakar K, Rajendran S Source Type: journals

A pharmacovigilance study of antihypertensive medicines at a South Delhi hospitalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hussain A, Aqil M, Alam M S, Khan M R, Kapur P, Pillai K KIndian Journal of Pharmaceutical Sciences 2009 71(3):338-341The aim of the present study was to monitor adverse drug reactions associated with antihypertensive drugs. The study was conducted in medicine out patient department of 150-bed Majeedia Hospital at Hamdard University Campus in New Delhi. The study was conducted by way of one to one patient interview by a registered pharmacist using a questionnaire-based Adverse Drug Reaction Monitoring Form drafted according to the World Health Organisation Monitoring Guidelines. A total of 34 adverse drug reactions were ob...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Hussain A, Aqil M, Alam M S, Khan M R, Kapur P, Pillai K K Source Type: journals

Quantitative estimation of naproxen in tablets using ibuprofen sodium as hydrotropic agentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Maheshwari R K, Wanare G, Chahar Nitika, Joshi Prajakta, Nayak NishiIndian Journal of Pharmaceutical Sciences 2009 71(3):335-337In the present investigation 0.5 M ibuprofen sodium solution has been used as hydrotropic solubilizing agent for naproxen, a poorly water-soluble drug and in it there was more than 350 fold enhancement in the solubility of naproxen as compared to the solubility in distilled water. Therefore, this hydrotropic solution was employed to extract out the drug from its tablet dosage form for quantitative estimation by titrimetry. The naproxen has been successfully analyzed in tablets. The results of anal...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Maheshwari R K, Wanare G, Chahar Nitika, Joshi Prajakta, Nayak Nishi Source Type: journals

Spectrophotometric quantitation of metformin in bulk drug and pharmaceutical formulations using multivariate techniqueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Arayne M S, Sultana Najma, Zuberi M H, Siddiqui F AIndian Journal of Pharmaceutical Sciences 2009 71(3):331-335A sensitive and accurate UV spectrophotometric method with multivariate calibration technique for the determination of metformin hydrochloride in bulk drug and different pharmaceutical formulations has been described. This technique is based on the use of the linear regression equations by using relationship between concentration and absorbance at five different wavelength. The results were treated statistically and were found highly accurate, precise and reproducible. The method is accurate, precise (% rec...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Arayne M S, Sultana Najma, Zuberi M H, Siddiqui F A Source Type: journals

Antimicrobial evaluation of mangiferin analoguesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Singh S K, Kumar Y, Kumar S Sadish, Sharma V K, Dua K, Samad AIndian Journal of Pharmaceutical Sciences 2009 71(3):328-331The naturally occurring xanthone glycoside mangiferin has been isolated by column chromatography from the ethanol extract of stem bark of Mangifera indica. Mangiferin was further converted to 5-(N-phenylaminomethyleno)mangiferin, 5-(N-p-chlorophenylaminomethyleno) mangiferin, 5-(N-2-methylphenylaminomethyleno) mangiferin, 5-(N-p-methoxyphenylaminomethyleno) mangiferin, 5-(N,N-diphenylaminomethyleno) mangiferin, 5-(N--napthylaminomethyleno) mangiferin and 5-...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Singh S K, Kumar Y, Kumar S Sadish, Sharma V K, Dua K, Samad A Source Type: journals

Simultaneous spectrophotometric estimation of norfloxacin and ornidazole in tablet dosage formEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
W.hede S B, Prakash A, Kumari B, Chitlange S SIndian Journal of Pharmaceutical Sciences 2009 71(3):325-328Three simple, accurate and economical methods have been developed for the estimation of norfloxacin and ornidazole in tablet dosage form. First method is based on the simultaneous equations, wavelengths selected for analysis were 273.0 nm (&#955;max of norfloxacin) and 318.5 nm (&#955;max of ornidazole), respectively, in 0.1N NaOH. Second method is Q-analysis method, based on absorbance ratio at t...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Wankhede S B, Prakash A, Kumari B, Chitlange S S Source Type: journals

Antistress, adoptogenic activity of Sida cordifolia roots in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sumanth Meera, Mustafa S SIndian Journal of Pharmaceutical Sciences 2009 71(3):323-324Ethanol extract of roots of Sida cordifolia was evaluated for antistress, adaptogenic activity using cold restraint stress and swim endurance in mice. Mice pretreated with extract of Sida cordifolia showed significant improvement in the swim duration and reduced the elevated WBC, blood glucose and plasma cortisone. (Source: Indian Journal of Pharmaceutical Sciences)
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Sumanth Meera, Mustafa S S Source Type: journals

Investigation of hydrogel isolated from seeds of Ocimum basilicum as binderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bhosale A V, Hardikar S, Pathak A A, Sable R VIndian Journal of Pharmaceutical Sciences 2009 71(3):320-322Ayurvedic powders are widely used as therapeutic agents but most of them have unpleasant taste and large doses. One of the possible approach to overcome these drawbacks is to represent them in unit dosage form i.e. tablet dosage form. The purpose of this study is to elucidate and quantify the compressibility and compactibility of herbal granules prepared by using hydrogel isolated from whole seeds of Ocimum basilicum as a nove...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Bhosale A V, Hardikar S, Pathak A A, Sable R V Source Type: journals

HPLC method for estimation of metformin hydrochloride in formulated microspheres and tablet dosage formEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kar Mousumi, Choudhury P KIndian Journal of Pharmaceutical Sciences 2009 71(3):318-320A simple, accurate, economical and reproducible HPLC method has been developed for quantitative estimation of metformin hydrochloride from tablet dosage form and formulated microspheres. The developed HPLC method is a reverse phase chromatographic method using phenomenex C 18 column and acetonitrile:phosphate buffer (65:35) pH adjusted to 5.75 with o-phosphoric acid as mobile phase and glipizide as internal standard. The linearity was observed in concentration range of 0-25 &#...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Kar Mousumi, Choudhury P K Source Type: journals

Characterization of gelatin-sodium alginate complex coacervation systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Shinde Ujwala A, Nagarsenker Mangal SIndian Journal of Pharmaceutical Sciences 2009 71(3):313-317A gelatin and sodium alginate complex coacervation system was studied and an effect of pH and colloid mixing ratios on coacervation was investigated. A colloid mixing ratio at which optimum coacervation occurred varied with the coacervation pH. Viscometric, turbidity and coacervate dry yield investigations were used to investigate optimum conditions for complex coacervation. Optimum coacervation occurred at pH 3.5 at a gelatin sodium alginate ratio 4:1. Coacervate and equilibrium fluid was analyzed for gelatin and sodium algina...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Shinde Ujwala A, Nagarsenker Mangal S Source Type: journals

Ion pair-HPLC method for the simultaneous estimation of quinapril and hydrochlorothiazide in tabletsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gandhimathi M, Ravi T KIndian Journal of Pharmaceutical Sciences 2009 71(3):311-313A simple, precise and rapid HPLC method has been developed and validated for the estimation of quinapril and hydrochlorothiazide simultaneously in combined dosage form. The mobile phase used was a mixture of 0.1% v/v triethylamine (pH 3.5), containing 1 mM of hexane sulphonic acid: acetonitrile (30:70% v/v). The detection of quinapril and hydrochlorothiazide was carried out on photo diode array detector at 220 nm. Results of the analysis were validated statistically and by recovery studies. The proposed method can be successful...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Gandhimathi M, Ravi T K Source Type: journals

Antioxidant activity of Passiflora edulis sims leavesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sunitha M, Devaki KIndian Journal of Pharmaceutical Sciences 2009 71(3):310-311Ethanol extract of Passiflora edulis Sims was analyzed for its antioxidant (1,1-diphenyl-2-picryl hydrazyl radical reducing power methods) and phytochemical analysis. The extract was found effective against the antioxidant test models exhibiting an IC 50 value of 875&#897;87.83 &#901;g/ml and showed strong potential antioxidant activity in both assays. (Source: Indian Journal of Pharmaceutical Sciences)
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Sunitha M, Devaki K Source Type: journals

Prescription writing trends of antihistamines at the university health centreEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kumar Anil, BeentaIndian Journal of Pharmaceutical Sciences 2009 71(3):307-310The aim of the present study was to establish antihistamines drug prescribing pattern in order to improve the rational prescribing of antihistamines by physicians at Panjab University Health Centre. The study was performed in between the months of November 2005 to April 2006. Five hundred out patients were monitored and data was collected on WHO-based prescription-auditing performa. Demographic analysis of this prospective study revealed that out of the 500 patients, 293 (58.6 %) were male and 207 (41.4 %) were female and maximum pa...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Kumar Anil, Beenta Source Type: journals

Free radical scavenging activity of leaves of Alocasia indica (Linn)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mulla W A, Salunkhe V R, Kuchekar S B, Qureshi M NIndian Journal of Pharmaceutical Sciences 2009 71(3):303-307The free radical scavenging potential of the plant Alocasia indica (Linn.) was studied by using different antioxidant models of screening like scavenging of 1,1-diphenyl-2-picryl hydrazyl radical, nitric oxide radical, superoxide anion radical, hydroxyl radical, iron chelating activity, total antioxidant capacity, non-enzymatic glycosylation of haemoglobin, rapid screening for antioxidant compounds by thin layer chromatography. The hydroalcoholic extract at 1000 ...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Mulla W A, Salunkhe V R, Kuchekar S B, Qureshi M N Source Type: journals

Formulation and evaluation of once daily minocycline hydrochloride extended release matrix tabletsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Keny R V, Mankame S A, Lourenco C FIndian Journal of Pharmaceutical Sciences 2009 71(3):295-302The present study was aimed to develop once daily extended release matrix tablets of minocycline hydrochloride, using hydroxypropylmethylcellulose either alone or in combination with ethyl cellulose as the matrix material in different proportions. The formulated tablets were also compared with a marketed product. The results of the dissolution study indicate that formulations FC-IV, FC-V and FC-VI showed maximum drug release upto 24 h, whereas the marketed product was found to extend the release only up to 14 h. Incase of formula...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Keny R V, Mankame S A, Lourenco C F Source Type: journals

Development of buccal adhesive tablet with prolonged antifungal activity: Optimization and ex vivo deposition studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Madgulkar A, Kadam S, Pokharkar VIndian Journal of Pharmaceutical Sciences 2009 71(3):290-294The purpose of the present work was to prepare buccal adhesive tablets of miconazole nitrate. The simplex centroid experimental design was used to arrive at optimum ratio of carbopol 934P, hydroxypropylmethylcellulose K4M and polyvinylpyrollidone, which will provide desired drug release and mucoadhesion. Swelling index, mucoadhesive strength and in vitro drug release of the prepared tablet was determined. The drug release and bioadhesion was dependent on type and relative amounts of th...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Madgulkar A, Kadam S, Pokharkar V Source Type: journals

Attitudes and behaviors of practicing community pharmacists towards patient counsellingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Adepu R, Nagavi B GIndian Journal of Pharmaceutical Sciences 2009 71(3):285-289The present study was conducted to assess the attitudes and behaviors of practicing community pharmacists towards patient counselling and use of patient information leaflets in the state of Karnataka. Convenient sampling method was adopted to collect the responses with the help of self-completion questionnaires. A total of 258 practicing community pharmacists in the age group of 22-60 y of both gender with practicing experience of 2-30 y participated in the study. Majority of respondents (80%) agreed that, patient counselling is their pro...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Adepu R, Nagavi B G Source Type: journals

Preparation and evaluation of microencapsulated fast melt tablets of ambroxol hydrochlorideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrated that pectin could be a right choice in developing patient favored formulations for bitter drugs and can be utilized in fast disintegrating dosage forms as well. (Source: Indian Journal of Pharmaceutical Sciences)
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Jacob S, Shirwaikar A Source Type: journals

Effect of folic acid on hematological changes in methionine-induced hyperhomocysteinemia in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ansari M N, Nigam G K, Bhandari UmaIndian Journal of Pharmaceutical Sciences 2009 71(3):270-275The present study was designed to investigate the effect of folic acid on homocysteine, lipid profile and hematological changes in methionine-induced hyperhomocysteinemic rats. Hyperhomocysteinemia was induced by methionine (1 g/kg, p.o.) administration for 30 days. Biochemical and hematological observations were further substantiated with histopathological examination. The increase in homocysteine, total cholesterol, low density lipoprotein-cholesterol, very low density lipoprotein-cholesterol and triglycerides levels with reduc...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Ansari M N, Nigam G K, Bhandari Uma Source Type: journals

Transcranial route of brain targeted delivery of methadone in oilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pathirana W, Abhayawardhana P, Kariyawasam H, Ratnasooriya W DIndian Journal of Pharmaceutical Sciences 2009 71(3):264-269The unique anatomical arrangement of blood vessels and sinuses in the human skull and the brain, the prevalence of a high density of skin appendages in the scalp, extracranial vessels of the scalp communicating with the brain via emissary veins and most importantly, the way that the scalp is used in Ayurvedic medical system in treating diseases associated with the brain show that a drug could be transcranially ...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Pathirana W, Abhayawardhana P, Kariyawasam H, Ratnasooriya W D Source Type: journals

Synthesis, antiinflammatory and HIV-1 integrase inhibitory activities of 1,2-bis[5-thiazolyl]ethane-1,2-dione derivativesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Franklin P X, Yerande S, Thakar H M, Inamdar G S, Giri R S, Padh H, Sudarsanam V, Vasu Kamala KIndian Journal of Pharmaceutical Sciences 2009 71(3):259-263Based on principles of pharmacophore delineation and drug designing, compounds containing diketofunctionallity namely 1,2-bis[5-thiazolyl]ethane-1,2-diones were designed and synthesized as antiinflammatory agents. The compounds were evaluated in carrageenan-induced rat-paw edema method. G-3, G-6, G-17, G-20, G-23, G-22, L-708 and 906 showed good antiinflammatory activity. In addition as diketo functionality containing compounds are reported to have HIV-1 integrase inhibi...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Franklin P X, Yerande S, Thakar H M, Inamdar G S, Giri R S, Padh H, Sudarsanam V, Vasu Kamala K Source Type: journals

Formulation and in vitro evaluation of alfuzosin extended release tablets using directly compressible eudragitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Roni M A, Kibria G, Jalil RIndian Journal of Pharmaceutical Sciences 2009 71(3):252-258The aim of the present study was the determination of formulation factors and the in vitro evaluation of an extended release dosage form of a freely soluble weakly basic drug (alfuzosin hydrochloride). Binary mixer of one hydrophilic polymer (hydroxypropylmethylcellulose) and one directly compressible Eudragit (RS PO) was used in tablets prepared by direct compression. The amounts of both polymers were taken as independent variables for the 3 2</sup&...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Roni M A, Kibria G, Jalil R Source Type: journals

In situ forming polymeric drug delivery systemsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Madan M, Bajaj A, Lewis S, Udupa N, Baig J AIndian Journal of Pharmaceutical Sciences 2009 71(3):242-251In situ forming polymeric formulations are drug delivery systems that are in sol form before administration in the body, but once administered, undergo gelation in situ, to form a gel. The formation of gels depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation, from which the drug gets released in a sustained and controlled manner. Various polymers that are used for the formulat...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Madan M, Bajaj A, Lewis S, Udupa N, Baig J A Source Type: journals

Terahertz technology: A boon to tablet analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article demonstrates the potential of terahertz pulse imaging for the analysis of tablet coating thickness by illustrating the technique on tablets. (Source: Indian Journal of Pharmaceutical Sciences)
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Wagh M P, Sonawane Y H, Joshi O U Source Type: journals