Outcome of Human Parainfluenza Virus infection in allogeneic stem cell transplantation recipients: possible impact of ribavirin therapy
ConclusionALC, corticosteroids, and fever increased the risk for progression to LRTD while ribavirin decreased the risk. However, mortality was associated with ALC and co-infections. This study supports further research of ribavirin therapy for hPIV in the allo-HSCT setting. (Source: Infection)
Source: Infection - April 24, 2024 Category: Infectious Diseases Source Type: research
Real-world application of nirmatrelvir/ritonavir in hospitalized COVID-19 patients with onset of symptoms beyond 5 days: a comparative study
ConclusionsThe application of Nirmatrelvir-ritonavir was associated with a significantly reduced risk of intubation or death in hospitalized COVID-19 patients who experienced symptoms for more than 5 days as compared to those who did not receive the treatment. (Source: Infection)
Source: Infection - April 23, 2024 Category: Infectious Diseases Source Type: research
Assessment of a novel BLOOMY score for predicting mortality in hospitalised adults with bloodstream infection
ConclusionThe BLOOMY 14-day and 6-month scores performed well in the estimations of mortality in our cohort and exceeded some established scores, but their adoption in clinical work remains to be seen. (Source: Infection)
Source: Infection - April 23, 2024 Category: Infectious Diseases Source Type: research
Anti-spike antibody level is associated with the risk of clinical progression among subjects hospitalized with COVID-19 pneumonia: results from a retrospective cohort study
ConclusionThis study suggests that levels of anti-S antibodies can predict critical or fatal outcomes in COVID-19 pneumonia patients, regardless of vaccination. Whether anti-S Ab could guide risk assessment and vaccination boosting merits further evaluation. (Source: Infection)
Source: Infection - April 23, 2024 Category: Infectious Diseases Source Type: research
High cure rates of Mycoplasma genitalium following empiric treatment with azithromycin alongside frequent detection of macrolide resistance in Austria
ConclusionsMycoplasma genitalium was readily detected in this Austrian observational study, affected predominantly MSM and often presented as asymptomatic disease. We observed a worryingly high prevalence of AZM resistance mutations; however, empiric AZM treatment cleared twice as many MG infections as expected. (Source: Infection)
Source: Infection - April 22, 2024 Category: Infectious Diseases Source Type: research
The U-shaped association between serum osmolality and 28-day mortality in patients with sepsis: a retrospective cohort study
ConclusionThere is a U-shaped relationship between serum osmolality and the 28-day mortality risk in patients with sepsis. Higher or lower serum osmolality is associated with an increased risk of mortality in patients with sepsis. Patients with sepsis have a lower risk of mortality when their osmolality is 285.80-296.29 mmol/L. (Source: Infection)
Source: Infection - April 22, 2024 Category: Infectious Diseases Source Type: research
Wide use of broad-spectrum antibiotics in very low birth weight infants with spontaneous focal intestinal perforation —is it really justified?
ConclusionThe use of carbapenems as broad-spectrum antimicrobials agents might not be justified in most VLBW infants with FIP. Knowledge on the development of the neonatal gut microbiota, local resistance patterns and individual microbiological findings should be taken into consideration when implementing antimicrobial stewardship programs (ASPs). (Source: Infection)
Source: Infection - April 18, 2024 Category: Infectious Diseases Source Type: research
Non-betahemolytic streptococcal bacteremia, cardiac implantable electronic device, endocarditis, extraction, and outcome; a population-based retrospective cohort study
ConclusionThe study did not find a high risk of IE in patients with NBHSB and CIED. Most cases of IE were in conjunction with a simultaneous HVP. A management algorithm is suggested. (Source: Infection)
Source: Infection - April 18, 2024 Category: Infectious Diseases Source Type: research
Significance of colonization by antibiotic-resistant organisms prior to congenital heart disease surgery in children from low- to middle-income countries sent by non-governmental organizations to Switzerland
ConclusionPrevalence of AMROs carriage is high in children from LMIC and has a limited impact on patients ’ outcome. However, ARMOs carriage leads to higher consumption of antibiotics. Screening may help saving use of broad-spectrum antibiotic in non-carrier patients. (Source: Infection)
Source: Infection - April 18, 2024 Category: Infectious Diseases Source Type: research
Wide use of broad-spectrum antibiotics in very low birth weight infants with spontaneous focal intestinal perforation —is it really justified?
ConclusionThe use of carbapenems as broad-spectrum antimicrobials agents might not be justified in most VLBW infants with FIP. Knowledge on the development of the neonatal gut microbiota, local resistance patterns and individual microbiological findings should be taken into consideration when implementing antimicrobial stewardship programs (ASPs). (Source: Infection)
Source: Infection - April 18, 2024 Category: Infectious Diseases Source Type: research
Non-betahemolytic streptococcal bacteremia, cardiac implantable electronic device, endocarditis, extraction, and outcome; a population-based retrospective cohort study
ConclusionThe study did not find a high risk of IE in patients with NBHSB and CIED. Most cases of IE were in conjunction with a simultaneous HVP. A management algorithm is suggested. (Source: Infection)
Source: Infection - April 18, 2024 Category: Infectious Diseases Source Type: research
Significance of colonization by antibiotic-resistant organisms prior to congenital heart disease surgery in children from low- to middle-income countries sent by non-governmental organizations to Switzerland
ConclusionPrevalence of AMROs carriage is high in children from LMIC and has a limited impact on patients ’ outcome. However, ARMOs carriage leads to higher consumption of antibiotics. Screening may help saving use of broad-spectrum antibiotic in non-carrier patients. (Source: Infection)
Source: Infection - April 18, 2024 Category: Infectious Diseases Source Type: research
Sepsis and case fatality rates and associations with deprivation, ethnicity, and clinical characteristics: population-based case –control study with linked primary care and hospital data in England
ConclusionGiven the variety of predictors and their level of associations for developing sepsis, there is a need for prediction models for risk of developing sepsis that can help to target preventative antibiotic therapy. (Source: Infection)
Source: Infection - April 16, 2024 Category: Infectious Diseases Source Type: research
Comprehensive risk factor predictions for 3-year survival among HIV-associated and disseminated cryptococcosis involving lungs and central nervous system
ConclusionsIL-1RA is a biomarker for predicting 3-year survival. Further investigations to explore the pathogenetic role of IL-1RA in HIV-associated disseminated cryptococcosis and as a potential therapeutic target are warranted. (Source: Infection)
Source: Infection - April 13, 2024 Category: Infectious Diseases Source Type: research
