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Italian Guidelines for the Diagnosis and Infectious Disease Management of Osteomyelitis and Prosthetic Joint Infections in AdultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article presents the recommendations for the diagnosis and management of osteomyelitis and prosthetic joint infections in adults developed by Bone and Joint Infections Committee for the Italian Society of Infectious and Tropical Diseases. It contains data published through to November 2007. An evidence-based scoring system that is used by the Infectious Diseases Society of America was applied to treatment recommendations. Content Type Journal ArticleCategory ReviewDOI 10.1007/s15010-009-8269-2Authors S. Esposito, Seconda Università di Napoli Dipartimento Malattie Infettive Naples ItalyS. Leone, U.O.C. Malatti...
Source: Infection - November 11, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Clinical and Epidemiological Features of TularemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s15010-009-3609-9Authors C. Ruef Journal InfectionOnline ISSN 1439-0973Print ISSN 0300-8126 (Source: Infection)
Source: Infection - November 11, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Management of Hepatitis B Virus Reactivation in Patients with Hematological Malignancies Treated with ChemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Essential to the management of patients with hematological malignancies undergoing chemotherapy are surveillance and prophylaxis of HBV infection together with prompt administration of nucleoside/nucleotide analogs in cases of reactivation and/or seroreversion. Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s15010-009-9019-1Authors D. Francisci, University of Perugia Division of Infectious Diseases, Dept. of Experimental Medicine and Biochemical Science Ospedale “Santa Maria della Misericordia”, P.zzle Menghini 1 06132 Perugia ItalyF. Falcinelli, University of Perugia Sect...
Source: Infection - November 11, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Coverage and Predictors of Adherence to Influenza Vaccination among Spanish Children and Adults with AsthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The overall influenza vaccination coverage among subjects who suffer from asthma in Spain is very low. Special attention should be paid to children, younger adults, and smokers, since these subjects have the lowest adherence to vaccine recommendations. Strategies focused on health-care providers and patients must be urgently implemented to improve influenza vaccination coverage among asthma sufferers. Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s15010-009-9069-4Authors R. Jiménez-García, Rey Juan Carlos University Unity of Teaching and Research in Preventive Medicine an...
Source: Infection - November 11, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Herpes Zoster Meningoencephalitis: Not Only a Disease of the Immunocompromised?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s15010-009-9092-5Authors A. Douglas, University of Melbourne School of Medicine Parkville VIC 3010 AustraliaP. Harris, Townsville Hospital Pathology Queensland 100 Angus Smith Drive Douglas QLD 4814 AustraliaF. Francis, Townsville Hospital Pathology Queensland 100 Angus Smith Drive Douglas QLD 4814 AustraliaR. Norton, Townsville Hospital Pathology Queensland 100 Angus Smith Drive Douglas QLD 4814 Australia Journal InfectionOnline ISSN 1439-0973Print ISSN 0300-8126 (Source: Infection)
Source: Infection - November 11, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Impact of a Change in Antibiotic Prophylaxis on Total Antibiotic Use in a Surgical Intensive Care UnitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Change to single shot prophylaxis along with an ongoing antibiotic stewardship program resulted in a cut-back in total antibiotic use amounting to as much as 15%. It would therefore appear that targeting interventions aimed at reducing antibiotic prophylaxis in surgical ICUs may be very worthwhile. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-009-9115-2Authors E. Meyer, Charité University Medicine Institute of Hygiene and Environmental Medicine Hindenburgdamm 27 12203 Berlin GermanyF. Schwab, Charité University Medicine Institute of Hygiene and...
Source: Infection - November 11, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Streptococcus anginosus (Streptococcus milleri Group) Pyomyositis in a 50-Year-Old Man with Acquired Immunodeficiency Syndrome: Case Report and Review of LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the first reported case of bacterial pyomyositis of the right thigh caused by Streptococcus anginosus (S. milleri group) in an HIV-infected patient. The clinical presentation was complicated by multiple ring-enhancing lesions detected on magnetic resonance imaging of the brain. Evaluation for central nervous system toxoplasmosis, syphilis, and cryptococcal infection was negative. Aggressive antibiotic therapy directed against S. anginosus and surgical debridement were limb salvaging. Clinicians should consider S. anginosus as a causative pathogen in HIV-associated pyomyositis, particularly in complex presenta...
Source: Infection - November 11, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Interferon-Gamma Release Assay in the Ascites: Early Hint for Diagnosis of Abdominal TuberculosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on a 20-year-old woman with abdominal tuberculosis. Standard microbiological examination of ascites showed no acid-fast bacilli (AFB), and analysis for the Mycobacterium tuberculosis (MTB)-complex DNA by PCR was negative. However, the interferon-γ release assay (IGRA) of the ascites was positive after specific stimulation with mycobacterial antigens (ESAT-6/CFP-10/TB7.7[p4]), indicating an infection with MTB. The diagnosis of tuberculosis was later confirmed by histology, MTB culture, and PCR analysis of MTB-complex DNA in tissue samples taken during laparoscopy. Thus, the IGRA of ascites may guide the decis...
Source: Infection - November 11, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Effective Treatment of Patients in a Deep Salvage Situation with “Non-Active HAART”: Experiences with the Expert Advice System RADATAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Despite extensive pre-treatment and multiple resistances against prescribed HAART, our patients demonstrated a decline in viral load and a stable CD4-cell count over the observation period. We conclude that the activity of antiretroviral regimens is not exclusively explained by the current algorithms used for estimating antiretroviral drug activity. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-009-9022-6Authors T. Lorenzen, Hospital St. George Ifi–Institute for Interdisciplinary Medicine Lohmuehlenstrasse 5 20099 Hamburg GermanyI. Walther, Hosp...
Source: Infection - October 14, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Water-Borne Outbreak of Oropharyngeal and Glandular Tularemia in Georgia: Investigation and Follow-upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We observed unique features of persistent neuropsychiatric symptoms and lymphadenopathy 5 months after tularemia infection which were associated with delayed diagnosis and the lack of prompt response to therapy. This outbreak of oropharyngeal tularemia emphasizes the importance of a rapid diagnostic and investigative response to tularemia. This type of response can prevent ongoing exposure, as well as provide expeditious treatment to mitigate persistent symptoms. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-009-8193-5Authors N. Chitadze, Na...
Source: Infection - October 14, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Effect of Procalcitonin-Guided Treatment in Patients with Infections: a Systematic Review and Meta-AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Based on the results of this meta-analysis, it would appear that an algorithm based on serial PCT measurements would allow a more judicious use of antibiotics than currently occurs during the traditional treatment of patients with infections. PCT-guided antibiotic treatment appears to be safe and may also improve clinical outcome. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-009-9034-2Authors H. Tang, Zhejiang University Intensive Care Unit, The Second Affiliated Hospital, School of Medicine Jiefang Road #88 310009 Hangzhou Zhejiang People’s R...
Source: Infection - October 14, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Against the New H1N1 Influenza (Swine Influenza): Vaccinate or Don’t Vaccinate (All)? That is Currently the Question!Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s15010-009-3509-zAuthors H. W. Doerr, Johann Wolfgang Goethe University Clinic Medical Institute for Virology Paul-Ehrlich-Str. 40 60596 Frankfurt/Main GermanyR. Allwinn, Johann Wolfgang Goethe University Clinic Medical Institute for Virology Paul-Ehrlich-Str. 40 60596 Frankfurt/Main GermanyJ. Cinatl, Johann Wolfgang Goethe University Clinic Medical Institute for Virology Paul-Ehrlich-Str. 40 60596 Frankfurt/Main Germany Journal InfectionOnline ISSN 1439-0973Print ISSN 0300-8126 (Source: Infection)
Source: Infection - September 19, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Carbapenem-Resistant Acinetobacter baumannii Producing the OXA-23 Enzyme: Dissemination in Southern BrazilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s15010-009-9003-9Authors A. F. Martins, Universidade Federal do Rio Grande do Sul, Coordenadoria de Vigilância em Saúde de Porto Alegre Medical Sciences Post-Graduate Program 372/3 Padre Cacique Avenue Porto Alegre RS 90000-000 BrazilR. Kuchenbecker, Hospital de Clínicas de Porto Alegre Hospital Infection Control Committee Porto Alegre BrazilT. Sukiennik, Complexo HospitalarSanta Casa Hospital Infection Control Committee Porto Alegre BrazilR. Boff, Centro Universitário IPA Metodista Porto Alegre BrazilK. C. Reiter, Universidade Federal do Rio Grande do ...
Source: Infection - September 18, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Disparities in Influenza Vaccination Coverage Rates by Target Group in Five European Countries: Trends Over Seven Consecutive SeasonsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The change in general influenza vaccination coverage in the 2007/2008 season compared to the previous season was small, but decreases were seen in some target groups. The underlying motivations for and against vaccination did not substantially change. An effort to activate those driving forces that would encourage vaccination as well as dealing with barriers that tend to prevent it may help enhance coverage rates in Europe in the future. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-009-8467-yAuthors P. R. Blank, University of Zurich Institute o...
Source: Infection - September 18, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

An influenza A H1N1 virus revival – pandemic H1N1/09 virusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract In April 2009, a novel H1N1 influenza A virus, the so-called pandemic H1N1/09 virus (former designations include swine influenza, novel influenza, swine-origin influenza A [H1N1] virus [S-OIV], Mexican flu, North American Flu) was identified in Mexico. The virus has since spread throughout the world and caused an influenza pandemic as defined by the criteria of the World Health Organization. This represents the first influenza A virus pandemic since the emergence of H3N2 (‘‘Hong Kong’’ Flu) in 1968. Vaccine production has started, and vaccines are expected to become available during the co...
Source: Infection - September 18, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Efficacy and Safety of Sequential Intravenous/Oral Moxifloxacin vs Intravenous/Oral Amoxicillin/Clavulanate for Complicated Skin and Skin Structure InfectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Treatment with sequential iv/po moxifloxacin monotherapy once daily is clinically comparable to that with iv/po amoxicillin/clavulanate three times daily in the management of cSSSIs. Moxifloxacin’s simple dose regimen offers an advantage over amoxicillin/clavulanate and represents a valuable addition to current antibiotic regimens used in the treatment of cSSSIs. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-009-8468-xAuthors R. Vick-Fragoso, Hospital General “Dr Manuel Gea González” Infectious Disease Dept. Calzada de Tlalpan Tlalpan, Mex...
Source: Infection - September 18, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

An Influenza A H1N1 Virus Revival – Pandemic H1N1/09 VirusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract In April 2009, a novel H1N1 influenza A virus, the so-called pandemic H1N1/09 virus (former designations include swine influenza, novel influenza, swine-origin influenza A [H1N1] virus [S-OIV], Mexican flu, North American Flu) was identified in Mexico. The virus has since spread throughout the world and caused an influenza pandemic as defined by the criteria of the World Health Organization. This represents the first influenza A virus pandemic since the emergence of H3N2 (“Hong Kong” Flu) in 1968. Vaccine production has started, and vaccines are expected to become available during the course of ...
Source: Infection - September 18, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Tobramycin Once- vs Thrice-Daily for Elective Intravenous Antipseudomonal Therapy in Pediatric Cystic Fibrosis PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We conclude that tobramycin given in a daily single dose (with the advantage of being more practical in a home environment) has an efficacy equal to that of three daily doses in terms of elective antipseudomonal therapy in clinically stable patients with CF. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-009-8117-4Authors J. Riethmueller, University Children’s Hospital Hoppe-Seyler-Str. 1 72076 Tübingen GermanyM. Ballmann, University of Hannover Pediatric Dept. Hannover GermanyT. W. Schroeter, University Children′s Hospital Kiel Kiel GermanyP....
Source: Infection - September 15, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Persistent Helicobacter canis Bacteremia in a Patient with Gastric LymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A 78-year-old man with gastric diffuse large B cell lymphoma presented with persistent Helicobacter canis bacteremia while receiving chemotherapy. An examination of his medical history revealed a close exposure to dogs. The patient recovered after 4 weeks of antibiotic therapy. Immunocompromised persons who maintain close contacts with dogs may be at risk for this infection. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s15010-009-9067-6Authors D. Alon, Meir Medical Center Infectious Diseases Unit 59 Tshernichovski St 44281 Kfar Saba IsraelY. Ben-Nissan, Meir Medical Center The...
Source: Infection - September 15, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Continuous vs Thrice-Daily Ceftazidime for Elective Intravenous Antipseudomonal Therapy in Cystic FibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We conclude that continuous or thrice-daily dosing of intravenous ceftazidime, both combined with once-daily tobramycin, are equally effective application regimens for elective antipseudomonal therapy in clinically stable patients with CF. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-009-8116-5Authors J. Riethmueller, University Children’s Hospital Hoppe-Seyler-Str. 1 72076 Tübingen GermanyS. Junge, University of Hannover Pediatric Department Hannover GermanyT. W. Schroeter, University Children’s Hospital Kiel Kiel GermanyK. Kuemmerer, Univer...
Source: Infection - September 15, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Disseminated Aspergillosis Following Resolution of Pneumocystis Pneumonia with Sustained Elevation of Beta-Glucan in an Intensive Care Unit: a Case ReportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Invasive aspergillosis is a major cause of morbidity and mortality in immunocompromised patients receiving intensive care. The double-sandwich ELISA for galactomannan is reported to have a high sensitivity (96.5%) for the detection of invasive aspergillosis when a cut-off value of 0.8 ng/ml is used. However, we have experienced a case of lethal disseminated aspergillosis in a patient that presented with a negative galactomannan (GM) test and persistent elevation of β-d glucan (BG) levels. A 63-year-old female was admitted to our Intensive Care Unit (ICU) in acute respiratory failure and elevate...
Source: Infection - September 15, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

First Case of Bacteremia Caused by Moellerella wisconsensis: Case Report and a Review of the LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here a case of M. wisconsensis infection in a 46-year-old cirrhotic patient with acute cholecystitis. This is the first reported case of a M. wisconsensis infection in Belgium and the first reported case of human bacteremia caused by this bacterium. Our case report is followed by a review of the literature. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s15010-009-8446-3Authors A. Cardentey-Reyes, Université Libre de Bruxelles–Erasme Hospital Dept. of Microbiology Route de Lennik, 808 1070 Brussels BelgiumF. Jacobs, Université Libre de Bruxelles–Erasme Hospital Dept. of Infectious Disease...
Source: Infection - September 15, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Surgical Site Infections in HIV-infected Patients: Results from an Italian Prospective Multicenter Observational StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Although 92.5% of our HIV-infected patients presented a NNIS score ≤ 1, the SSI rate was twofold higher than that reported in Italian and European studies for the general population, with more severe clinical presentations. This is the first report of an association between HCV–HIV co-infection and SSI occurrence. Additionally, the viro-immunological status of our patients was not related to SSI occurrence, which suggests the need for further research for other potential risk factors that may be implicated in the occurrence of SSI. Content Type Journal ArticleCategory Brief ReportDOI 10...
Source: Infection - September 15, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Femoral Osteomyelitis due to Cladophialophora arxii in a Patient with Chronic Granulomatous DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the first case of CGD with femoral osteomyelitis due to Cladophialophora arxii, which is a member of the dematiaceous group. The causative fungus was identified on the basis of its morphological characteristics, growth temperature profile, and nucleotide sequence on the internal transcribed space region of the ribosomal gene. The patient was successfully treated with surgical debridement, subsequent administration of itraconazolem and interferon-γ. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s15010-009-8238-9Authors T. Shigemura, Shinshu University School of Medicine Dept. of Pediatrics...
Source: Infection - August 9, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Diagnostic Value of Early Secreted Antigenic Target-6 for the Diagnosis of Tuberculous Meningitis PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The detection of ESAT-6 in the CSF of TBM patients by indirect ELISA is a promising method and can be used to develop an immunodiagnostic assay with increased sensitivity and specificity. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-009-8261-xAuthors R. S. Kashyap, Central India Institute of Medical Sciences Biochemistry Research Laboratory Nagpur 440010 IndiaS. S. Ramteke, Central India Institute of Medical Sciences Biochemistry Research Laboratory Nagpur 440010 IndiaS. H. Morey, Central India Institute of Medical Sciences Biochemistry Research L...
Source: Infection - August 9, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Laboratory-Based Assessment of Influenza in German Ambulant Patients from 1998 to 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions While PCR is the most sensitive assay for the diagnosis of influenza, the RCA can still be used for diagnosis and surveillance of this disease. Based on our findings and given the known fact that influenza antibodies reach a plateau 2–4 weeks after immunization, the optimal time for vaccination in Germany is from October through November. Kindergarten and school-aged children represent an important reservoir of infection. Consequently, routine immunization should be considered for this age group to prevent the spread of influenza. Content Type Journal ArticleCategory Clinical and Ep...
Source: Infection - August 9, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Outcomes of Invasive Infection due to Vancomycin-Resistant Enterococcus faecium during a Recent OutbreakEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Invasive VREF infection during this outbreak was confined to patients with severe underlying comorbidity. The mortality of VREF infection remained high, despite treatment with newer VREF-active antibiotics such as linezolid and quinupristin–dalfopristin. Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s15010-009-9023-5Authors C. Theilacker, University Hospital Center for Infectious Diseases and Travel Medicine, Dept. of Medicine Hugstetter Strasse 55 79106 Freiburg GermanyD. Jonas, University Hospital Institute for Environmental Health Sciences Freiburg GermanyJ. Huebner, Univ...
Source: Infection - August 9, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Cutaneous Vasculitis Associated with FluoroquinolonesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Cutaneous vasculitis is a clinical entity with a broad differential diagnosis, including an adverse drug reaction. It is defined as inflammation of skin blood vessel walls. During a 7-year-period, we observed three patients who developed isolated cutaneous vasculitis during antibiotic therapy of bacterial infection. All were treated with a fluoroquinolone (ciprofloxacin or levofloxacin) combined with rifampin (two cases) or flucloxacillin (three cases), respectively. In all three cases the lesions gradually resolved after treatment with the inciting fluoroquinolone had been stopped. In one patient, ...
Source: Infection - August 9, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

The Epidemiology of Intra-Abdominal Flora in Critically Ill Patients with Secondary and Tertiary Abdominal SepsisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The composition of the intra-abdominal flora found in critically ill patients with abdominal sepsis varies depending on the location of the perforation. The efficacy of combined surgical and antibiotic treatment was 87% in 4 weeks for AGNB. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-009-8249-6Authors J. de Ruiter, University Medical Center Groningen Dept. of Anesthesiology Groningen The NetherlandsJ. Weel, Streeklaboratorium Friesland Dept. of Medical Microbiology Leeuwarden The NetherlandsE. Manusama, Medical Center Leeuwarden Dept. of Sur...
Source: Infection - August 9, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Effectiveness of Antiretroviral Regimens Containing Abacavir with Tenofovir in Treatment-Experienced Patients: Predictors of Virological Response and Drug Resistance Evolution in a Multi-Cohort StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The virological response to ABC + TDF-containing regimens in this moderately-to-heavily treatment-experienced cohort was good. Higher viral load and the presence of M41L at baseline were associated with worse virological responses, while the concomitant prescription of drugs enhancing the genetic barrier of the regimen conveyed a reduced risk of virological failure. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-009-8237-xAuthors S. Di Giambenedetto, Catholic University Institute of Clinical Infectious Diseases Largo Gemelli 8 00168 Rome ...
Source: Infection - August 9, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Occult Hepatitis B Virus Infection in a Cohort of HIV-Positive Patients: Correlation with Hepatitis C Virus Coinfection, Virological and Immunological FeaturesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In relation to the high prevalence of occult HBV infection, particularly in HIV/HCV-coinfected individuals, it is necessary to clarify the clinical impact of this cryptic infection by monitoring HBV-DNA in plasma using the correct approach. Similarly to HBsAg-positive individuals of the Mediterranean area, HBV genotype D is invariably detected in this cohort of HIV-infected patients with occult HBV infection. Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s15010-008-8194-9Authors G. Morsica, S. Raffaele Scientific Institute Dept. of Infectious Diseases Via Stamira d’Ancona...
Source: Infection - August 9, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Nurses and Physicians’ Perceptions of the Importance and Impact of Healthcare-Associated Infections and Hand Hygiene: a Multi-Center Exploratory Study in Hong KongEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These results could be used as a tool to create goal-specific strategies for motivating hand hygiene amongst nurses and physicians in Hong Kong, with appropriate promotional interventions delivered to the different professional groups and specialties. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-009-8245-xAuthors J. W. M. Tai, Queen Mary Hospital Infection Control Unit Pokfulam Road Hong Kong Special Administrative Region of ChinaE. S. B. Mok, The Hong Kong Polytechnic University School of Nursing Kowloon, Hong Kong Special Administrative Region o...
Source: Infection - July 27, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Virological and Epitope Evolution of HCV Infection from Acute Hepatitis C to Subsequent Episodes of HCV-Related Acute Liver Cell NecrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Episodes of HCV-related acute liver cell necrosis after AHC may be associated to different virological patterns, such as the establishment of a chronic HCV infection, a reactivation of an occult virus, or a reinfection by a different HCV genotype. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-008-8197-6Authors E. Sagnelli, Second University of Naples Dept. of Public Medicine, Section of Infectious Diseases c/o Ospedale Gesù e Maria, Via D. Cotugno 1 80135 Naples ItalyC. Argentini, Istituto Superiore di Sanità Dept. of Infectious, Parasitic and...
Source: Infection - July 27, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Impact of Hepatitis B Vaccination in Children Born to HBsAg-Positive Mothers: a 20-year Retrospective StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Our data, while confirming the effectiveness of anti hepatitis B vaccination, highlight the need for post-vaccination follow-up, particularly in high-risk categories, to prolong protection, through booster doses if necessary. We show, moreover, the importance of maintaining active surveillance in the territory to improve follow-up to chronic carriers and to sensitize families. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-008-8252-3Authors L. Bracciale, Siena University Infectious Diseases Clinic, Dept. of Molecular Biology Siena ItalyM. Fabbiani,...
Source: Infection - July 25, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Hand Hygiene: Adherence Influenced by Knowledge and Subjective NormsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s15010-009-3409-2Authors C. Ruef Journal InfectionOnline ISSN 1439-0973Print ISSN 0300-8126 (Source: Infection)
Source: Infection - July 25, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

A Long Journey from Minimum Inhibitory Concentration Testing to Clinically Predictive Breakpoints: Deterministic and Probabilistic Approaches in Deriving BreakpointsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Since the origin of an “International Collaborative Study on Antibiotic Sensitivity Testing” in 1971, considerable advancement has been made to standardize clinical susceptibility testing procedures of antimicrobial agents. However, a consensus on the methods to be used and interpretive criteria was not reached, so the results of susceptibility testing were discrepant. Recently, the European Committee on Antimicrobial Susceptibility Testing achieved a harmonization of existing methods for susceptibility testing and now co-ordinates the process for setting breakpoints. Previously, breakpoints ...
Source: Infection - July 25, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

A Risk Profile for Invasive Aspergillosis in Liver Transplant RecipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The rate of IA found in this investigation is within the range reported in published studies. Based on our data, extended antifungal prophylaxis should be given to liver transplant patients with specific risk factors, such as renal insufficiency, requirement for dialysis, CMV infection, or thrombocytopenia. Additional focus should be on the prevention of CMV infections. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-008-8124-xAuthors M. Rosenhagen, University Hospital of Heidelberg Pharmacy Dept. INF 670 69120 Heidelberg GermanyR. Feldhues, Univers...
Source: Infection - July 25, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Risk Factors and Clinical Characteristics Associated with Hospitalization for Community-Acquired Bacterial Pneumonia in HIV-Positive Patients According to the Presence of Liver CirrhosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The diagnosis of CABP can be difficult in cirrhotic HIV-positive patients because clinical presentation is milder. However, CABP needs to be promptly recognized because mortality is higher in these patients. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-009-8140-5Authors D. Manno, University of Brescia Dept. of Infectious and Tropical Diseases P.zzle Spedali Civili 1 25123 Brescia ItalyM. Puoti, University of Brescia Dept. of Infectious and Tropical Diseases P.zzle Spedali Civili 1 25123 Brescia ItalyL. Signorini, University of Brescia Dept. of In...
Source: Infection - July 25, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Legionella-induced Sudden Hearing Loss: a Rare ComplicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s15010-009-9016-4Authors J. E. Nolte, Sheba Medical Center Dept. of Medicine B Tel-Hashomer 52621 IsraelA. Altman, Sheba Medical Center Dept. of Medicine B Tel-Hashomer 52621 IsraelM. Szyper-Kravitz, Sheba Medical Center Dept. of Medicine B Tel-Hashomer 52621 IsraelY. Shoenfeld, Sheba Medical Center Dept. of Medicine B Tel-Hashomer 52621 IsraelE. Zimlichman, Sheba Medical Center Dept. of Medicine B Tel-Hashomer 52621 Israel Journal InfectionOnline ISSN 1439-0973Print ISSN 0300-8126 (Source: Infection)
Source: Infection - July 25, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

New Insights into the Epidemiology and Etiology of Fournier’s Gangrene: A Review of 33 PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Fournier’s gangrene remains a major challenge with a high mortality. Our results suggest that women are more commonly affected than has generally been assumed. Contrary to published reports, we found that anorectal sources appear to account for more cases of Fournier’s gangrene than urological sources. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-008-8169-xAuthors R. Czymek, University of Lübeck Medical School Department of Surgery Ratzeburger Allee 160 23538 Lübeck GermanyP. Hildebrand, University of Lübeck Medical School Department of Su...
Source: Infection - July 25, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Effectiveness and Safety of Colistin for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa InfectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Colistin is a safe option for the treatment of MDRP infections, with acceptable clinical outcomes. However, bacteriological eradication is difficult to achieve, especially in COPD patients. Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s15010-009-8342-xAuthors M. Montero, Autonomous University of Barcelona Dept. of Internal Medicine and Infectious Diseases, Hospital del Mar Paseo Marítimo 25-29 08003 Barcelona SpainJ. P. Horcajada, Autonomous University of Barcelona Dept. of Internal Medicine and Infectious Diseases, Hospital del Mar Paseo Marítimo 25-29 08003 Barcelona Spa...
Source: Infection - June 5, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Correlation Between Antibiotic Use and Resistance in a Hospital: Temporary and Ward-Specific ObservationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion At the level of individual medical specialties within one hospital, a higher prevalence of antimicrobial use among patients was associated with a significantly higher observed antimicrobial resistance. The use of CIP was associated with a stronger increase in resistance than the use of beta-lactams. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-009-8325-yAuthors I. Willemsen, Amphia Hospital Laboratory for Microbiology and Infection Control PO Box 90158 4800 RK Breda The NetherlandsD. Bogaers-Hofman, Amphia Hospital Laboratory for Microbiology and...
Source: Infection - June 5, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Disseminated Toxoplasmosis in a Patient with Non-Hodgkin LymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a patient with a history of chemotherapy for non-Hodgkin lymphoma who developed pain and progressive paresthesia of the right arm 6 weeks after remission. Relapsing lymphoma was suspected, and steroid and radiation treatment were initiated, but the patient died 5 days later due to multiple organ failure. Autopsy revealed disseminated toxoplasmosis. This case illustrates that toxoplasmosis should be suspected in patients with neoplastic disease, especially lymphomas, who present with unexplained neurologic, pulmonary, or febrile symptoms during or after chemotherapy. Content Type Journal Arti...
Source: Infection - June 5, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Neurotoxicity Associated with Standard Doses of Piperacillin in an Elderly Patient with Renal FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s15010-009-8373-3Authors W.-T. Huang, Zuoying Armed Forces General Hospital Dept. of Medicine Kaohsiung Taiwan, ROCY.-J. Hsu, National Defense Medical Center Division of Nephrology, Dept. of Medicine, Tri-Service General Hospital Number 325, Section 2, Cheng-Kung Road Neihu 114, Taipei Taiwan, ROCP.-L. Chu, National Defense Medical Center Division of Nephrology, Dept. of Medicine, Tri-Service General Hospital Number 325, Section 2, Cheng-Kung Road Neihu 114, Taipei Taiwan, ROCS.-H. Lin, National Defense Medical Center Division of Nephrology, Dept. of Medi...
Source: Infection - June 5, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Italian Consensus Statement on Management of HIV-Infected Individuals with Advanced Disease Naïve to Antiretroviral TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The principals of antiretroviral treatment in asymptomatic naïve patients with advanced HIV infection are the same as those applicable to the general population with asymptomatic HIV infection. Naïve patients with advanced HIV infection and a history of AIDS-defining illnesses urgently need antiretroviral treatment, with the choice of antiretroviral regimen and timetable based on such factors as concomitant treatment and prophylaxis, drug interactions, and potential concomitant drug toxicity. Finally, an adequate counseling program – both before and after HIV-testing – that includes aspects...
Source: Infection - May 29, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Influenza Moves to the Front of Public Health ConcernsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s15010-009-3309-5Authors C. Ruef Journal InfectionOnline ISSN 1439-0973Print ISSN 0300-8126 (Source: Infection)
Source: Infection - May 29, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Efficacy and Safety of Atazanavir in Patients with End-Stage Liver DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Unboosted ATV treatment did not worsen liver disease and was able to maintain or gain immuno-virological eligibility for OLTx in all patients, with a limited effect on unconjugated bilirubin. These results suggest that ATV is an easy-to-use drug in patients with ESLD. Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s15010-008-8025-zAuthors G. Guaraldi, University of Modena and Reggio Emilia Dept. of Internal Medicine and Medical Specialties, Clinic of Infectious Diseases Via del Pozzo 71 41100 Modena ItalyS. Cocchi, University of Modena and Reggio Emilia Dept. of Internal Medic...
Source: Infection - May 27, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Reducing the Burden of Influenza-Associated Complications with Antiviral TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Influenza complications place a large burden on healthcare providers and society. Neuraminidase inhibitors can reduce the incidence of such complications, particularly in high-risk groups. Content Type Journal ArticleCategory ReviewDOI 10.1007/s15010-009-8241-1Authors B. R. Ruf, Klinikum Sankt Georg Leipzig 2nd Dept. of Internal Medicine, Division of Infectious Diseases and Tropical Medicine Leipzig GermanyT. Szucs, University of Zurich Institute of Social and Preventive Medicine Zurich Switzerland Journal InfectionOnline ISSN 1439-0973Print ISSN 0300-8126 (Source: Infection)
Source: Infection - May 27, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Hyperbilirubinemia during Atazanavir Treatment in 2,404 Patients in the Italian Atazanavir Expanded Access Program and MASTER CohortsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Hyperbilrubinemia is a common side effect of an ATV pharmacotherapeutic regimen. However, grade IV increase in bilirubin was rarely found. In most cases, ATV hyperbilirubinemia appeared to be an innocent phenomenon as far as the risk of a subsequent increase in liver enzyme level is concerned. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-008-8010-6Authors C. Torti, University of Brescia School of Medicine, Institute of Infectious and Tropical Diseases P.le Spedali Civili, 1 25123 Brescia ItalyG. Lapadula, University of Brescia School of Medicine...
Source: Infection - May 27, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Prospective Population-based Study of RSV-related Intermediate Care and Intensive Care Unit Admissions in Switzerland over a 4-Year Period (2001–2005)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In Switzerland, RSV infections lead to the IMC/ICU admission of approximately 1%–2% of each annual birth cohort. Although prematurity, BPD, and CHD are significant risk factors, non-pharmacological preventive strategies should not be restricted to these high-risk patients but also target young NT/FT infants since they constitute 77% of infants requiring IMC/ICU admission. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-008-8130-zAuthors T. M. Berger, Children’s Hospital of Lucerne Neonatal and Pediatric Intensive Care Unit Spitalstrasse 6000...
Source: Infection - May 2, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals