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Prolonged Administration Enhances the Renoprotective Effect of Pentoxifylline via Anti-Inflammatory Activity in Streptozotocin-Induced Diabetic NephropathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigates whether prolonged administration of PTX (40 mg/kg, per oral) is effective in streptozotocin-induced diabetic nephropathy. The amount of urinary protein was higher in the diabetic rats than in the control rats. The amount remained unchanged after 4 weeks and decreased after 8 weeks of PTX treatment. Accumulation of monocyte chemoattractant peptide-1 (MCP-1) and mouse monoclonal anti-monocyte/macrophage antibody (ED-1) positive cells was higher in untreated diabetic rats than in the control rats. PTX administration ameliorated the urinary MCP-1 excretion and interstitial infiltrati...
Source: Inflammation - November 18, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Schisantherin A Exhibits Anti-inflammatory Properties by Down-Regulating NF-κB and MAPK Signaling Pathways in Lipopolysaccharide-Treated RAW 264.7 CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Schisantherin A, a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been used as an antitussive, tonic, and sedative agent under the name of Wuweizi in Chinese traditional medicine. In the present study, we carry out a screening program to identify the anti-inflammatory potentials of schisantherin A. We found that schisantherin A reduced lipopolysaccharide (LPS (1 mg/L))-induced levels of TNF-α, IL-6, NO, and PGE2 (p < 0.01 or p < 0.05), and also reduced levels of iNOS and COX-2 in RAW 264.7 macrophages in a concentration-dependent manner. We fu...
Source: Inflammation - November 13, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Characterization of ERK Activation in Human Mast Cells Stimulated by Contact with T CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Close physical proximity between mast cells and T cells has been demonstrated in several human conditions. We have identified and characterized a novel mast cell activation pathway initiated by contact with T cells, and showed that this pathway is associated with cytokine release. It has been shown recently that Ras is activated in this pathway. Thus, in the present study we further explore the downstream events associated with Ras activation and cytokine release in human mast cells stimulated by contact with T cells. ERK activation in human mast cells stimulated by either contact with T cells or by...
Source: Inflammation - November 11, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

The Anti-Inflammatory Effects of a Methanolic Extract from Radix Isatidis in Murine Macrophages and MiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Radix Isatidis is the dried root of the plant Isatidis indigotica Fort (family Cruciferae) and traditionally used as an anti-viral, anti-bacterial, anti-endotoxic, and immune regulatory agent in the folk medicine of Korea and China. The aim of the present study was to determine the anti-inflammatory effects of methanolic extracts of Radix Isatidis (RIME) in lipopolysaccharide (LPS)-stimulated murine macrophages and in a TPA-induced ear edema animal model. Anti-inflammatory effects of RIME were examined in LPS-stimulated RAW 264.7 macrophages. In order to investigate the effects of RIME in vivo, act...
Source: Inflammation - November 3, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Effects of Protein-Energy Malnutrition on NF-KappaB Signalling in Murine Peritoneal MacrophagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Protein-energy malnutrition (PEM) is an important public health problem affecting millions of people worldwide. PEM decreases resistance to infection, impairing a number of physiological processes. In unstimulated cells, NF-κB is kept from binding to its consensus sequence by the inhibitor IκBα, which retains NF-κB in the cytoplasm. Upon various signals, such as lipopolysaccharide (LPS), IκBα is rapidly degraded and NF-κB is induced to translocate into the nucleus, where it activates expression of various genes that participate in the inflammatory response, including those involved in the syn...
Source: Inflammation - October 29, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Beneficial Effects of TLR-2/6 Ligation in Pulmonary Bacterial Infection and Immunization with Pseudomonas aeruginosaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, local immunostimulation at the appropriate time can enhance the host defense against bacteria in the lung. Content Type Journal ArticleDOI 10.1007/s10753-009-9158-7Authors Tanja Kerber-Momot, Medical School Hannover Institute of Functional and Applied Anatomy Carl-Neuberg Str. 1 30625 Hannover GermanyDamaris Leemhuis, Medical School Hannover Institute of Functional and Applied Anatomy Carl-Neuberg Str. 1 30625 Hannover GermanyAnke Lührmann, Medical School Hannover Institute of Functional and Applied Anatomy Carl-Neuberg Str. 1 30625 Hannover GermanyAntje Munder, Medical School Hannover Clinical Resear...
Source: Inflammation - October 21, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Association of Interleukin-8 Gene Polymorphisms and Haplotypes with Oral Lichen Planus in a Chinese PopulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Interleukin-8 (IL-8), a CXC chemokine with multiple biological functions, plays an important role in the pathogenesis of oral lichen planus (OLP). The aim of this study was to investigate the association of single nucleotide polymorphisms (SNPs) of IL-8 gene with OLP in a Chinese population. Four SNPs of the IL-8 gene at positions −845 T/C (rs2227532), −738 T/A, −251 A/T (rs4073) and +781 C/T (rs2227306) were analyzed in 109 patients with OLP and 101 normal controls using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method. The data revealed that the −251 A...
Source: Inflammation - October 20, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Gamma-Linolenic Acid Inhibits Inflammatory Responses by Regulating NF-κB and AP-1 Activation in Lipopolysaccharide-Induced RAW 264.7 MacrophagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we assessed the effect of GLA with that of LA on lipopolysaccharide (LPS)-induced inflammatory responses and further explored the molecular mechanism underlying the pharmacological properties of GLA in mouse RAW 264.7 macrophages. GLA significantly inhibited LPS-induced protein expression of inducible nitric oxide synthase, pro-interleukin-1β, and cyclooxygenase-2 as well as nitric oxide production and the intracellular glutathione level. LA was less potent than GLA in inhibiting LPS-induced inflammatory mediators. Both GLA and LA treatments dramatically inhibited LPS-induced IκB-α degradation, IκB-...
Source: Inflammation - October 20, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Carbon Monoxide Liberated from CO-Releasing Molecule (CORM-2) Attenuates Ischemia/Reperfusion (I/R)-Induced Inflammation in the Small IntestineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we assessed the effects and potential mechanisms of CORM-2-released CO in modulation of inflammatory response in the small intestine following I/R-challenge. To this end mice (C57Bl/6) small intestine were challenged with ischemia by occluding superior mesenteric artery (SMA) for 45 min. CORM-2 (8 mg/kg; i.v.) was administered immediately before SMA occlusion. Sham operated mice were injected with vehicle (0.25% DMSO). Inflammatory response in the small intestine (jejunum) was assessed 4 h following reperfusion by measuring tissue levels of TNF-α protein (ELISA), adhesion molecules E-sel...
Source: Inflammation - October 20, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

The Effect of Epigallocatechin Gallate on Lipopolysaccharide-Induced Acute Lung Injury in a Murine ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was performed to evaluate the effects of epigallocatechin 3 gallate (EGCG) on lipopolysaccharide (LPS)-induced acute lung injury in a murine model. In the present study, production of TNF-α and MIP-2 and activation of extracellular signal-regulated kinases (ERK)1/2, c-Jun amino terminal kinases (JNK) and p38 in RAW264.7 cells were measured. EGCG inhibited the production of TNF-α and MIP-2, and attenuated phosphorylation levels of ERK1/2 and JNK, but not p38 in RAW264.7 cells stimulated with LPS. Also, EGCG attenuated the production of TNF-α and MIP-2, and the phosphorylation of ERK1/2 and JNK in the lungs...
Source: Inflammation - October 16, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Maternal Protein Restriction During Early Lactation Induces Changes on Neutrophil Activation and TNF-α Production of Adult OffspringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Maternal nutritional environmental in early life has been often associated with long term effects on the immune response in adulthood. The effects of maternal protein deprivation during early lactation on neutrophil-mediated innate immunity were investigated in adult rats, offspring of dams fed with a protein-free diet during the first days of lactation (PD), and compared to controls (22% protein diet). Inflamed PD animals showed an inhibited neutrophil migration and an impaired recruitment of leukocytes from bone marrow pool to circulation. In resting conditions, blood neutrophils from PD present r...
Source: Inflammation - October 14, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Accumulation of DC in Lamina Propria Induced by FMS-Like Tyrosine Kinase 3 Ligand Aggravates the Intestinal Inflammatory Response During EndotoxemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract It is known that the loss of DC plays an important role for immune suppression during endotoxemia or sepsis. To verify our hypothesis that pre-enrichment of the lamina propria (LP) DC pool may improve protective immunity to bacterial translocation and outcome in endotoxemic mice, we pre-treated mice with Flt3L or normal saline, and then challenged them with or without LPS. Twelve hours later the population size and maturity of DC in the LP and circulation were analyzed by flow cytometry. Bacterial translocation to distant organs, inflammatory responses in the intestine and the survival rate of mice ...
Source: Inflammation - October 3, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Protective Effects of Isolated Polyphenolic and Alkaloid Fractions of Ruta graveolens L. on Acute and Chronic Models of InflammationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Ruta graveolens L. (Rutaceae) are traditionally used for the treatment of rheumatism, arthritis and other inflammatory conditions in the traditional medicine of India, were evaluated for their protective effect in acute and chronic models of inflammation. Carrageenan induced rat paw edema and adjuvant induced arthritis were employed as the experimental models of acute and chronic inflammation respectively. Isolated polyphenolic and alkaloid fraction (AFR) from Ruta graveolens and evaluated its anti inflammatory activity in carrageenan induced acute model. AFR with a dose 10 mg/kg showed higher...
Source: Inflammation - September 24, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Resistin Up-Regulates COX-2 Expression via TAK1-IKK-NF-κB Signaling PathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The hormone resistin, which was originally shown to induce insulin resistance, has been implicated in the regulation of inflammatory processes, but the molecular mechanism underlying such regulation has not been clearly defined. The goal of our study was to determine whether the expression of COX-2 can be induced by resistin and what the potential signaling pathway involved in this process is. Compared with controls, resistin significantly upregulated COX-2 expression in RAW264.7 macrophage cells. Administration of anti-resistin antibody could significantly reduce this effect. Induction of COX-2 by ...
Source: Inflammation - September 23, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Release of the Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) by Activated Neutrophils in Rheumatoid ArthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Soluble form of the urokinase-type plasminogen activator receptor (suPAR) is markedly increased in biological fluids during different inflammatory conditions. It has previously been observed that the highest suPAR concentrations in inflammatory exudates tend to be associated with the presence of high number of neutrophils. Guided by this observation and our recent finding that activated neutrophils release suPAR we investigated whether neutrophils can be a source of suPAR during the inflammatory response in vivo. To address this question we conducted the comparative analysis of neutrophils isolated ...
Source: Inflammation - September 16, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Decreased Proinflammatory Cytokines Production in Children with Complicated Parapneumonic Pleural Effusion after Intrapleural Fibrinolytic TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, intrapleural fibrinolytic treatment with urokinase could enhance fibrinolytic activity and decrease TIMP-2 and RANTES production. Content Type Journal ArticleDOI 10.1007/s10753-009-9150-2Authors Jieh-Neng Wang, National Cheng Kung University Medical College Institute of Clinical Medicine Tainan 70421 TaiwanJyh-Wei Shin, National Cheng Kung University Medical College Department of Parasitology Tainan 70421 TaiwanTsuey-Yu Chang, National Cheng Kung University Medical College Department of Parasitology Tainan 70421 TaiwanJiu-Yao Wang, National Cheng Kung University Hospital Department of Pediatrics 138 Sh...
Source: Inflammation - September 16, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Effect of Splenectomy and Autologous Spleen Transplantation on the Serum Platelet-Activating Factor Acetylhydrolase (PAF-AH) Activity and Acute Phase Response (APR) in a Porcine ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s10753-009-9143-1Authors Romana Turk, University of Zagreb Department of Pathophysiology, Faculty of Veterinary Medicine Heinzelova 55 10000 Zagreb CroatiaDražen Vnuk, University of Zagreb Surgery, Orthopedics and Ophthalmology Clinic, Faculty of Veterinary Medicine Zagreb CroatiaAnte Svetina, University of Zagreb Department of Pathophysiology, Faculty of Veterinary Medicine Heinzelova 55 10000 Zagreb CroatiaZlata Flegar-Meštrić, Institute of Clinical Chemistry, Clinical Hospital “Merkur” Zagreb CroatiaMirna Robić, University of Zagreb Department of Pathop...
Source: Inflammation - September 16, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Anti-inflammatory and Immunomodulatory Effects of Baccharis trimera Aqueous Extract on Induced Pleurisy in Rats and Lymphoproliferation In VitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Baccharis trimera is a widespread South American plant known as “carqueja”. Medicinal teas prepared from the aerial parts of this plant are used in folk medicine in cases of liver diseases and inflammatory processes. We evaluated the effects of aqueous extract of B. trimera in the experimental inflammatory model of carrageenan-induced pleurisy in rat. The injection of carrageenan into the pleural cavity induces an influx of cells and fluid accumulation with a large number of polymorphonuclear leukocytes and increase of protein levels. The inflammation parameters were attenuated when B. trimera...
Source: Inflammation - September 16, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Suppressive Effect on MDC and IP-10 Expression in Monocytes by Endocrine Disruptor ChemicalsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The expression of chemokines is critical in leukocyte recruitment and inflammation, but the regulatory mechanisms involved remain incompletely defined. While endocrine disrupter chemicals (EDCs) are known to be ubiquitous in the environment and often associated with altered inflammatory response, their potential impact on chemokine expression in monocytes is at present unknown. To this end, the effects of EDCs on the expression of Th1- and Th2-related chemokines in a human monocytic cell line, THP-1, were investigated. THP-1 cells were pre-treated with varying concentrations of EDCs (nonylphenol and...
Source: Inflammation - September 16, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Monocytes and Macrophages as Cellular Targets in Liver FibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Inflammation)
Source: Inflammation - September 14, 2009 Category: Allergy & Immunology Authors: Heymann, FelixTrautwein, ChristianTacke, Frank Tags: Articles Source Type: journals

Targeting Leukotrienes for the Treatment of COPD?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Inflammation)
Source: Inflammation - September 14, 2009 Category: Allergy & Immunology Authors: Drakatos, PanagisLykouras, DimosthenisSampsonas, FotisKarkoulias, KiriakosSpiropoulos, Kostas Tags: Articles Source Type: journals

Assessment of Airway Inflammation by Exhaled Breath Condensate and Impedance Due to Gastroesophageal Reflux Disease (GERD)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Inflammation)
Source: Inflammation - September 14, 2009 Category: Allergy & Immunology Authors: Shimizu, YasuoDobashi, KunioNagoshi, AtsutoKawamura, OsamuMori, Masatomo Tags: Articles Source Type: journals

Leptin in Non-Autoimmune InflammationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Inflammation)
Source: Inflammation - September 14, 2009 Category: Allergy & Immunology Authors: Cai, ChunlinHahn, Bevra H.Matarese, GiuseppeLa Cava, Antonio Tags: Articles Source Type: journals

Possible Roles of Microglial Cells for Neurotoxicity in Clinical Neurodegenerative Diseases and Experimental Animal ModelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Inflammation)
Source: Inflammation - September 14, 2009 Category: Allergy & Immunology Authors: Sugama, ShueiTakenouchi, TakatoCho, Byung P.Joh, Tong H.Hashimoto, MakotoKitani, Hiroshi Tags: Articles Source Type: journals

Anti-Inflammatory Drugs in PsychiatryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Inflammation)
Source: Inflammation - September 14, 2009 Category: Allergy & Immunology Authors: Berthold-Losleben, MarkHeitmann, SabineHimmerich, Hubertus Tags: Articles Source Type: journals

General Principles for the Treatment of Non-Infectious UveitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Inflammation)
Source: Inflammation - September 14, 2009 Category: Allergy & Immunology Authors: Diaz-Llopis, ManuelGallego-Pinazo, RobertoGarcia-Delpech, SalvadorSalom-Alonso, David Tags: Articles Source Type: journals

Renoprotective Potency of Heme Oxygenase-1 Induction in Rat Renal Ischemia-ReperfusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Inflammation)
Source: Inflammation - September 14, 2009 Category: Allergy & Immunology Authors: Chok, Mohammed K.Ferlicot, SophieConti, MarcAlmolki, AbdelhamidDurrbach, AntoineLoric, SylvainBenoit, GerardDroupy, StephaneEschwege, Pascal Tags: Articles Source Type: journals

The C-Reactive Protein Levels in Left Ventricular Dysfunction of Different EtiologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Inflammation)
Source: Inflammation - September 14, 2009 Category: Allergy & Immunology Authors: Anzulovic-Mirosevic, DinkoRazzolini, RenatoZaninotto, MartinaPlebani, MarioMion, Monica M.Rozga, AnteDalla-Volta, Sergio Tags: Articles Source Type: journals

Anti-Inflammatory Activity of Ghrelin in Human Carotid Artery CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Receptors for eicosanoids such as prostaglandin E2, prostacyclin and thromboxane A2, as well as the ghrelin receptor polypeptide (GHS-R1b), can all regulate ghrelin (GHS-R1a) receptor activity, by the process of hetero-oligomerization, when heterologously expressed in human embryonic kidney (HEK 293) cells. To determine if such regulation might occur in inflammatory diseases of the vasculature, we incubated human coronary artery endothelial cells and human coronary artery smooth muscle cells with lipopolysaccharide and determined mRNA expression levels of these proteins using real-time PCR. Acute in...
Source: Inflammation - September 3, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Procaterol Inhibits Lung Fibroblast MigrationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Fibroblasts are important cells that are involved in modulation of fibrosis after injuries. In some uncontrollable inflammatory processes, excess fibroblasts migrate around the small airway. The pathogenesis of chronic obstructive pulmonary disease is related to fibrosis around the small airways. The aim of the current study was to investigate the effect of procaterol, a second-generation beta (2)-agonist, on migration of human fetal lung fibroblasts (HFL-1) induced by human plasma fibronectin (HFn). Using the blindwell chamber technique, 10−8 M procaterol inhibited migration of HFL-1 (contro...
Source: Inflammation - September 3, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Association of Ang-2 with Integrin β2 Controls Ang-2/PDGF-BB-Dependent Upregulation of Human Peripheral Blood Monocyte FibrinolysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study Ang-2 was found to bind to integrin β2, and functional inhibition of integrin β2 eliminated Ang-2/PDGF-BB-mediated upregulation of monocyte fibrin invasion. Additionally, integrin β2 blockade significantly inhibited the Ang-2/PDGF-BB based increase in matrix metalloproteinase-9 (MMP-9) and membrane type-1-MMP (MT1-MMP). Furthermore, Ang-2/PDGF-BB-upregulated urokinase plasminogen-activator receptor (uPAR) was shown to be associated in complexes with integrin β2. In addition, Ang-2 was shown to upregulate PDGFR-β expression in monocytes. Therefore several components of the mechanism via which the nove...
Source: Inflammation - September 3, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Nod2 Mutation Enhances NF-kappaB Activity and Bacterial Killing Activity of MacrophagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is to examine the role of NOD2 in the innate response of macrophages to bacterial challenge. First, peritoneal macrophages and alveolar macrophages were harvested from WT, Nod22939iC, as well as TLR4−/− mice and incubated with E. coli or P. aeruginosa. Bacterial killing activity; IL-1β and TLR4 protein expression; NF-κB DNA binding activity assay; as well as IL-1β, TNFα, TLR2, TLR4 and TLR9 mRNA expression of macrophages were examined. We found that alveolar macrophages and peritoneal macrophages of Nod22939iC mice but not WT mice or TLR4−/− mice demonstrated a significant increase of E. coli kil...
Source: Inflammation - September 3, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Evaluation of Anti-colitic Effect of Lactic Acid Bacteria in Mice by cDNA Microarray AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To evaluate the anti-colitic effect of lactic acid bacteria by cDNA microarray analysis, a lactic acid bacteria mixture (LM) consisting of Lactobacillus brevis HY7401, L. suntoryeus HY7801 and Bifidobacterium longum HY8004 was orally administered to dextran sulfate (DSS)-induced colitic mice and the expression profile of numerous genes was assessed. DSS treatment caused colitic outcomes such as inflammation and colon shortening. DSS also up-regulated the expression of inflammation-related genes: pro-inflammatory and chemotactic cytokines, including IL-1β, TNF-α, IL-6, CCL2, CCL4, CCL7, CCL24, CXCL...
Source: Inflammation - August 27, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Activation of PPAR-γ by Carbon Monoxide from CORM-2 Leads to the Inhibition of iNOS but not COX-2 Expression in LPS-Stimulated MacrophagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The effect of CO on the expression of iNOS and COX-2 was investigated by using a CO-releasing molecule (CORM)-2 in LPS-activated RAW 264.7 cells in vitro. Interestingly, CORM-2 significantly inhibited iNOS (NO) but not COX-2 (PGE2) expression. PPAR-γ activators such as troglitazone, GW1929, and 15-deoxy-Δ12, 14- prostaglandin J2 showed preferential inhibitory effect on iNOS over COX-2 expression in LPS-activated macrophages. The same effect was shown in lung tissues (iNOS, COX-2) and serum (NO, PGE2) when administered of CORM-2 in LPS-induced septic mice, indicating that CO derived from CORM-2 diffe...
Source: Inflammation - August 24, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Experimental Periodontitis Induces a cAMP-dependent Increase in Amylase Activity in Parotid Glands from Male RatsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present evidence that periodontitis induces an increase in resting amylase activity and release without changes in isoproterenol-induced amylase secretion. Changes in amylase were reverted by the inhibition of the adenylyl cyclase by SQ 22536, the cyclooxygenase type 1 by FR 122047 and by blocking the vasoactive intestinal peptide (VIP) receptor with VIP 6–28. Parotid glands from rats with periodontitis showed an increase in cAMP levels that was also reverted in the presence of SQ 22536, FR 122047 and VIP 6–28. We concluded that both PGE2 and VIP are produced in parotid glands from rats with periodontitis and, ...
Source: Inflammation - August 11, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Expression of Renin–Angiotensin System on Dendritic Cells of Patients with Coronary Artery DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Dendirtic cells (DCs) and renin–angiotensin system (RAS) have both been reported to contribute to the pathogenesis of atherosclerosis. Recently researches find the RAS expression on DCs and its effect on DCs’ differentiation and proinflammatory function. The pattern of RAS expression on DCs derived from normal monocytes vs that on DCs derived from cornoary artery diease was investigated. In 82 coronary artery disease (CAD) patients and healthy controls (CTL), expressions of angiotensin I-converting enzyme (ACE), angiotensin AT1 receptor and DC-specific ICAM-3-grabbing nonintegrin (DC-SIGN) on DC...
Source: Inflammation - August 9, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

A Role for Forkhead Box A1 in Acute Lung InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, an in vivo model was employed whereby rats were administered an intravenous injection of oleic acid (OA, 0.1 ml/kg), and alveolar type II epithelial cells (AT-2 cells) injury was induced by hydrogen peroxide (H2O2) in vitro. OA injection resulted in lung injury and AT-2 cells apoptosis in vivo. OA injection and H2O2 upregulated FoxA1 mRNA and protein in lung tissue of the in vivo ALI model and in H2O2 challenged AT-2 cells. Overexpression of FoxA1 promoted apoptosis, whereas FoxA1 deficiency, induced by antisense oligonucleotides, decreased AT-2 cells apoptosis induced by H2O2, as shown by flow cytome...
Source: Inflammation - July 31, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Salicylate Inhibits Macrophage-Secreted Factors Induced Adipocyte Inflammation and Changes of Adipokines in 3T3-L1 AdipocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the effects of salicylate on inflammation-related changes in gene or/and protein expressions of several adipokines in 3T3-L1 adipocytes and of LPS-induced inflammatory factors in RAW 264.7 cell. Especially, we focused our attention on the cross-talk between the macrophages and adipocytes. Exposure to RAW-CM medium resulted in an increase in the gene expression or/and protein secretion of TNF-α, IL-6 and resistin, and at the same time, a decrease in the gene expression of PPARγ and adiponectin in 3T3-L1 adipocytes. Salicylate effectively reversed these changes, and up-regulated glucose consumption in adip...
Source: Inflammation - July 18, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Cyclooxygenase-2 is Upregulated in Copper-Deficient RatsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Copper deficiency inactivates Cu/Zn-SOD and promotes accumulation of reactive oxygen species. This process likely impairs nitric oxide (NO)-mediated relaxation as well as triggers vascular inflammation. The current study was designed to determine whether COX-2, a proinflammatory protein, expression and activity are upregulated in the oxidative environment associated with inadequate Cu. Weanling male Sprague Dawley rats were fed purified diets which were either Cu-adequate (Cu-A); Cu-marginal (Cu-M), Cu-deficient (Cu-D), or the Cu-D diet combined with the SOD mimetic Tempol (Cu-D/T; 1 mM in drin...
Source: Inflammation - July 18, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Effects of Endotoxin and Catecholamines on Hepatic Mitochondrial RespirationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Catecholamines are frequently used in sepsis, but their interaction with mitochondrial function is controversial. We incubated isolated native and endotoxin-exposed swine liver mitochondria with either dopamine, dobutamine, noradrenaline or placebo for 1 h. Mitochondrial State 3 and 4 respiration and their ratio (RCR) were determined for respiratory chain complexes I, II and IV. All catecholamines impaired glutamate-dependent RCR (p = 0.046), predominantly in native mitochondria. Endotoxin incubation alone induced a decrease in glutamate-dependent RCR compared to control samples (p = 0....
Source: Inflammation - July 15, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

The Analysis of Tryptase in Serum of Sarcoidosis PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Sarcoidosis is a systemic granulomatous disease of unknown etiology characterized by activation of macrophages and T lymphocytes. Relatively little is known about the role of mast cells and their mediators in the pathogenesis of sarcoidosis. Tryptase is an enzyme produced by activated mast cells, regarded as a marker of mast cell activation. To analyse tryptase concentrations in serum of sarcoidosis patients in an attempt to define the role of tryptase and mast cells in the pathogenesis of sarcoidosis and to evaluate the potential of tryptase as marker of disease severity. Quantitative analysis of t...
Source: Inflammation - July 7, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

An Experimental Study of the Neurogenic and the Immunological Contribution to “Tennis Elbow” in RatsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Retraction NoteDOI 10.1007/s10753-009-9134-2Authors Eva Haker, Department of Physical Therapy Stockholm SwedenElvar Theodorsson, University Hospital Department of Clinical Chemistry Linkoping SwedenThomas Lundeberg, Karolinska Institutet Physiology and Pharmacology Stockholm Sweden Journal InflammationOnline ISSN 1573-2576Print ISSN 0360-3997 (Source: Inflammation)
Source: Inflammation - July 6, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

The Role of Anaphylatoxins C3a and C5a in Regulating Innate and Adaptive Immune ResponsesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Inflammation)
Source: Inflammation - July 5, 2009 Category: Allergy & Immunology Authors: Peng, QiLi, KeSacks, Steven H.Zhou, Wuding Tags: Articles Source Type: journals

Mechanism of Action of Flavonoids as Anti-inflammatory Agents: A ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Inflammation)
Source: Inflammation - July 5, 2009 Category: Allergy & Immunology Authors: Rathee, PermenderChaudhary, HemaRathee, SushilaRathee, DharmenderKumar, VikashKohli, Kanchan Tags: Articles Source Type: journals

Migration and Function of Th17 CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Inflammation)
Source: Inflammation - July 5, 2009 Category: Allergy & Immunology Authors: Kim, Chang H. Tags: Articles Source Type: journals

CD44 and its Role in Inflammation and Inflammatory DiseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Inflammation)
Source: Inflammation - July 5, 2009 Category: Allergy & Immunology Authors: Johnson, PaulineRuffell, Brian Tags: Articles Source Type: journals

Respiratory Syncytial Virus Bronchiolitis and Asthma - Insights from Recent Studies and Implications for TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Inflammation)
Source: Inflammation - July 5, 2009 Category: Allergy & Immunology Authors: Mailaparambil, BeenaGrychtol, RuthHeinzmann, Andrea Tags: Articles Source Type: journals

Toll-Like Receptors and Kidney DiseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Inflammation)
Source: Inflammation - July 5, 2009 Category: Allergy & Immunology Authors: Eleftheriadis, TheodorosLawson, Brian R. Tags: Articles Source Type: journals

Platelet Activating Factor/Platelet Activating Factor Receptor Pathway as a Potential Therapeutic Target in Autoimmune DiseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Inflammation)
Source: Inflammation - July 5, 2009 Category: Allergy & Immunology Authors: Edwards, Laura J.Constantinescu, Cris S. Tags: Articles Source Type: journals

The Airway Neurogenic Inflammation: Clinical and Pharmacological ImplicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Inflammation)
Source: Inflammation - July 5, 2009 Category: Allergy & Immunology Authors: Pisi, GiovannaOlivieri, DarioChetta, Alfredo Tags: Articles Source Type: journals