The Role of Nrf2 and Inflammation on the Dissimilar Cardiotoxicity of Doxorubicin in Two-Time Points: a Cardio-Oncology In Vivo Study Through Time
AbstractDoxorubicin (DOX) is a topoisomerase II inhibitor used in cancer therapy. Despite its efficacy, DOX causes serious adverse effects, such as short- and long-term cardiotoxicity. This work aimed to assess the short- and long-term cardiotoxicity of DOX and the role of inflammation and antioxidant defenses on that cardiotoxicity in a mice model. Adult CD-1 male mice received a cumulative dose of 9.0  mg/kg of DOX (2 biweekly intraperitoneal injections (ip), for 3 weeks). One week (1W) or 5 months (5M) after the last DOX administration, the heart was collected. One week after DOX, a significant increase in p62, tumo...
Source: Inflammation - October 14, 2023 Category: Allergy & Immunology Source Type: research

hPMSCs Regulate the Level of TNF- α and IL-10 in Th1 Cells and Improve Hepatic Injury in a GVHD Mouse Model via CD73/ADO/Fyn/Nrf2 Axis
AbstractMesenchymal stem cells (MSCs) ameliorate graft-versus-host disease (GVHD)-induced tissue damage by exerting immunosuppressive effects. However, the related mechanism remains unclear. Here, we explored the therapeutic effect and mechanism of action of human placental-derived MSCs (hPMSCs) on GVHD-induced mouse liver tissue damage, which shows association with inflammatory responses, fibrosis accompanied by hepatocyte tight junction protein loss, the upregulation of Bax, and the downregulation of Bcl-2. It was observed in GVHD mice  and Th1 cell differentiation system that hPMSCs treatment increased IL-10 levels an...
Source: Inflammation - October 13, 2023 Category: Allergy & Immunology Source Type: research

Proteome Analysis for Inflammation Related to Acute and Convalescent Infection
In conclusion, we demonstrated that irrespective of the pathogen type, there are common immunoregulatory and proinflammatory signals. (Source: Inflammation)
Source: Inflammation - October 13, 2023 Category: Allergy & Immunology Source Type: research

SIRT6 Protects Against Lipopolysaccharide-Induced Inflammation in Human Pulmonary Lung Microvascular Endothelial Cells
AbstractInflammatory response in the pulmonary endothelium drives the pathogenesis of acute lung injury and sepsis. Sirtuin 6 (SIRT6), a member of class III NAD+-dependent deacetylases belonging to the sirtuin family, regulates senescence, metabolism, and inflammation and extends lifespan in mice and model organisms. However, the role of SIRT6 in pulmonary endothelial inflammation is unknown. Thus, we hypothesized that SIRT6 suppresses inflammatory response in human lung microvascular cells (HLMEC) and ensues monocyte adhesion to endothelial cells. Primary HLMECs were treated with control or SIRT6 adenovirus or SIRT6 agoni...
Source: Inflammation - October 11, 2023 Category: Allergy & Immunology Source Type: research

Manganese Exacerbates ConA-Induced Liver Inflammation via the cGAS-STING Signaling Pathway
AbstractThere is a potential association between the dysregulation of trace elements and impaired liver function. Elevated levels of manganese, an essential metal ion, have been observed in liver-related diseases, and excessive intake of manganese can worsen liver damage. However, the specific mechanisms underlying manganese-induced liver injury are not well understood. The aim of our study was to investigate the effects of excess manganese on autoimmune hepatitis  (AIH) and elucidate its mechanisms. Our findings revealed that manganese exacerbates liver damage under ConA-induced inflammatory conditions. Transcriptomic an...
Source: Inflammation - October 8, 2023 Category: Allergy & Immunology Source Type: research

Suppression of IRF9 Promotes Osteoclast Differentiation by Decreased Ferroptosis via STAT3 Activation
In conclusion, we identified an essential role of IRF9 in the regulation of osteoclastogenesis in osteoporosis and its underlying mechanism. (Source: Inflammation)
Source: Inflammation - October 7, 2023 Category: Allergy & Immunology Source Type: research

LIF Aggravates Pulpitis by Promoting Inflammatory Response in Macrophages
This study aimed to investigate the modulation of LIF in dental pulp inflammation. Experimental pulpitis was established in wild-type (WT) andLif-deficient (Lif−/−) mice. Histological and immunostaining analyses were conducted to assess the role of LIF in the progression of pulpitis. Mouse macrophage cell line (RAW264.7) was treated with LPS to simulate an inflammatory environment. Exogenous LIF was added to this system to examine its modulation in macrophage inflammatory responsein vitro. Primary bone marrow-derived macrophages (BMDMs) from WT andLif−/− mice were isolated and stimulated with LPS to confirm the eff...
Source: Inflammation - October 2, 2023 Category: Allergy & Immunology Source Type: research