Methane-Rich Saline Suppresses ER-Mitochondria Contact and Activation of the NLRP3 Inflammasome by Regulating the PERK Signaling Pathway to Ameliorate Intestinal Ischemia ‒Reperfusion Injury
In conclusion, we believe that MS suppresses MAMs and activation of the NLRP3 inflammasome by regulating the PERK signaling pathway to ameliorate intestinal I/R injury. (Source: Inflammation)
Source: Inflammation - October 29, 2023 Category: Allergy & Immunology Source Type: research
EGR1 Mediated Reduction of Fibroblast Secreted-TGF- β1 Exacerbated CD8+ T Cell Inflammation and Migration in Vitiligo
AbstractVitiligo is a T cell-mediated depigment skin disease caused by the complex interplay between melanocyte dysfunction, environmental stimulation, and dysregulated immune signals. Transforming growth factor- β1 (TGF-β1), which typically derives from regulatory T cells, has long been identified at low levels in the peripheral system of vitiligo patients. Here, through RNA-sequencing and transcription factor enrichment, we revealed that in response to CD8+ T cell-secreted interferon-gamma (IFN- γ), stromal fibroblast downregulates early growth response 1 (EGR1) activity, leading to TGF-β1 deficiency. The defective i...
Source: Inflammation - October 26, 2023 Category: Allergy & Immunology Source Type: research
Preventive Anti-inflammatory Effects of Apocynin on Acetic Acid –Induced Colitis in Rats
This study shows that apocynin protects rats from acetic acid–induced colonic inflammation and suggests that apocynin may have a promising beneficial effect in the prevention of ul cerative colitis. (Source: Inflammation)
Source: Inflammation - October 26, 2023 Category: Allergy & Immunology Source Type: research
EGR1 Mediated Reduction of Fibroblast Secreted-TGF- β1 Exacerbated CD8+ T Cell Inflammation and Migration in Vitiligo
AbstractVitiligo is a T cell-mediated depigment skin disease caused by the complex interplay between melanocyte dysfunction, environmental stimulation, and dysregulated immune signals. Transforming growth factor- β1 (TGF-β1), which typically derives from regulatory T cells, has long been identified at low levels in the peripheral system of vitiligo patients. Here, through RNA-sequencing and transcription factor enrichment, we revealed that in response to CD8+ T cell-secreted interferon-gamma (IFN- γ), stromal fibroblast downregulates early growth response 1 (EGR1) activity, leading to TGF-β1 deficiency. The defective i...
Source: Inflammation - October 26, 2023 Category: Allergy & Immunology Source Type: research
Preventive Anti-inflammatory Effects of Apocynin on Acetic Acid –Induced Colitis in Rats
This study shows that apocynin protects rats from acetic acid–induced colonic inflammation and suggests that apocynin may have a promising beneficial effect in the prevention of ul cerative colitis. (Source: Inflammation)
Source: Inflammation - October 26, 2023 Category: Allergy & Immunology Source Type: research
Fibroblast Growth Factor 21 Relieves Lipopolysaccharide-Induced Acute Lung Injury by Suppressing JAK2/STAT3 Signaling Pathway
In this study, it was found that the expression of FGF21 was markedly increased in lung tissue under lipopolysaccharide (LPS) stimulationin vivo, whereas it was decreased in lung epithelial cells under LPS stimulationin vitro. Therefore, our research aimed to elucidate the potential role of FGF21 in LPS-induced ALI and to detect possible underlying mechanisms. The results revealed that the deficiency of FGF21 aggravated pathological damage, inflammatory infiltration, and pulmonary function in LPS-induced ALI, while exogenous administration of FGF21 improved these manifestations. Moreover, through RNA sequencing and enrichm...
Source: Inflammation - October 21, 2023 Category: Allergy & Immunology Source Type: research
The Role of Nrf2 and Inflammation on the Dissimilar Cardiotoxicity of Doxorubicin in Two-Time Points: a Cardio-Oncology In Vivo Study Through Time
AbstractDoxorubicin (DOX) is a topoisomerase II inhibitor used in cancer therapy. Despite its efficacy, DOX causes serious adverse effects, such as short- and long-term cardiotoxicity. This work aimed to assess the short- and long-term cardiotoxicity of DOX and the role of inflammation and antioxidant defenses on that cardiotoxicity in a mice model. Adult CD-1 male mice received a cumulative dose of 9.0 mg/kg of DOX (2 biweekly intraperitoneal injections (ip), for 3 weeks). One week (1W) or 5 months (5M) after the last DOX administration, the heart was collected. One week after DOX, a significant increase in p62, tumo...
Source: Inflammation - October 14, 2023 Category: Allergy & Immunology Source Type: research
hPMSCs Regulate the Level of TNF- α and IL-10 in Th1 Cells and Improve Hepatic Injury in a GVHD Mouse Model via CD73/ADO/Fyn/Nrf2 Axis
AbstractMesenchymal stem cells (MSCs) ameliorate graft-versus-host disease (GVHD)-induced tissue damage by exerting immunosuppressive effects. However, the related mechanism remains unclear. Here, we explored the therapeutic effect and mechanism of action of human placental-derived MSCs (hPMSCs) on GVHD-induced mouse liver tissue damage, which shows association with inflammatory responses, fibrosis accompanied by hepatocyte tight junction protein loss, the upregulation of Bax, and the downregulation of Bcl-2. It was observed in GVHD mice and Th1 cell differentiation system that hPMSCs treatment increased IL-10 levels an...
Source: Inflammation - October 13, 2023 Category: Allergy & Immunology Source Type: research
Proteome Analysis for Inflammation Related to Acute and Convalescent Infection
In conclusion, we demonstrated that irrespective of the pathogen type, there are common immunoregulatory and proinflammatory signals. (Source: Inflammation)
Source: Inflammation - October 13, 2023 Category: Allergy & Immunology Source Type: research
SIRT6 Protects Against Lipopolysaccharide-Induced Inflammation in Human Pulmonary Lung Microvascular Endothelial Cells
AbstractInflammatory response in the pulmonary endothelium drives the pathogenesis of acute lung injury and sepsis. Sirtuin 6 (SIRT6), a member of class III NAD+-dependent deacetylases belonging to the sirtuin family, regulates senescence, metabolism, and inflammation and extends lifespan in mice and model organisms. However, the role of SIRT6 in pulmonary endothelial inflammation is unknown. Thus, we hypothesized that SIRT6 suppresses inflammatory response in human lung microvascular cells (HLMEC) and ensues monocyte adhesion to endothelial cells. Primary HLMECs were treated with control or SIRT6 adenovirus or SIRT6 agoni...
Source: Inflammation - October 11, 2023 Category: Allergy & Immunology Source Type: research
