Correction to: Patchouli Alcohol: A Natural Sesquiterpene Against Both Inflammation and Intestinal Barrier Damage of Ulcerative Colitis
(Source: Inflammation)
Source: Inflammation - February 20, 2024 Category: Allergy & Immunology Source Type: research
PD-L1 Expression Is Increased in LPS-Induced Acute Respiratory Distress Syndrome by PI3K-AKT-Egr-1/C/EBP δ Signaling Pathway
Abstract The role of programmed death ligand 1 (PD-L1) has been extensively investigated in adaptive immune system. However, increasing data show that innate immune responses are also affected by the immune checkpoint molecule. It has been demonstrated that regulation of PD-L1 signaling in macrophages may be a potential therapeutic method for acute respiratory distress syndrome (ARDS). However, the PD-L1 expression pattern in local macrophages and whole lung tissues remains mysterious, hindering optimization of the potential treatment program. Therefore, we aim to determine the PD-L1 expression pattern during ARDS. Our fin...
Source: Inflammation - February 20, 2024 Category: Allergy & Immunology Source Type: research
Correction to: Patchouli Alcohol: A Natural Sesquiterpene Against Both Inflammation and Intestinal Barrier Damage of Ulcerative Colitis
(Source: Inflammation)
Source: Inflammation - February 20, 2024 Category: Allergy & Immunology Source Type: research
Dysbiosis of the Gut Microbiota in Patients with Psoriatic Arthritis is Closely Related to Lymphocyte Subsets and Cytokines
AbstractThe purpose of this research was to characterize the microbiota of patients with psoriatic arthritis (PsA) and to compare the relationship between the microbiota and peripheral lymphocyte subsets and cytokines. We collected stool samples from 13 PsA patients and 26 sex- and age-matched healthy controls (HCs) and researched the gut microbiota by sequencing the V3-V4 variable region of the bacterial 16S rRNA gene with the Illumina Miseq PE300 system. Flow cytometry was used to assess the peripheral lymphocyte subsets in these participants. Record measures of disease activity such as C-reactive protein (CRP) and eryth...
Source: Inflammation - February 15, 2024 Category: Allergy & Immunology Source Type: research
Retraction Note: Silencing of CREB Inhibits HDAC2/TLR4/NF- κB Cascade to Relieve Severe Acute Pancreatitis-Induced Myocardial Injury
(Source: Inflammation)
Source: Inflammation - February 15, 2024 Category: Allergy & Immunology Source Type: research
Dysbiosis of the Gut Microbiota in Patients with Psoriatic Arthritis is Closely Related to Lymphocyte Subsets and Cytokines
AbstractThe purpose of this research was to characterize the microbiota of patients with psoriatic arthritis (PsA) and to compare the relationship between the microbiota and peripheral lymphocyte subsets and cytokines. We collected stool samples from 13 PsA patients and 26 sex- and age-matched healthy controls (HCs) and researched the gut microbiota by sequencing the V3-V4 variable region of the bacterial 16S rRNA gene with the Illumina Miseq PE300 system. Flow cytometry was used to assess the peripheral lymphocyte subsets in these participants. Record measures of disease activity such as C-reactive protein (CRP) and eryth...
Source: Inflammation - February 15, 2024 Category: Allergy & Immunology Source Type: research
Retraction Note: Silencing of CREB Inhibits HDAC2/TLR4/NF- κB Cascade to Relieve Severe Acute Pancreatitis-Induced Myocardial Injury
(Source: Inflammation)
Source: Inflammation - February 15, 2024 Category: Allergy & Immunology Source Type: research
Albiflorin Attenuates Neuroinflammation and Improves Functional Recovery After Spinal Cord Injury Through Regulating LSD1-Mediated Microglial Activation and Ferroptosis
AbstractSpinal cord injury (SCI) is a serious, prolonged, and irreversible injury with few therapeutic options. Albiflorin (AF) possesses powerful pharmacodynamic properties and exerts protective effects against neuroinflammation. However, no research has examined the neuroprotective effect of AF following SCI. Rats were received laminectomy to establish SCI animal model and treated with AF (20 mg/kg and 40 mg/kg). Behavioral experiments were conducted to assess the impacts of AF on motor function after SCI in rats. Hematoxylin–eosin (HE) staining, Nissl staining, and Prussian Blue staining were perf ormed to observe...
Source: Inflammation - February 10, 2024 Category: Allergy & Immunology Source Type: research
Three Main SCFAs Mitigate Lung Inflammation and Tissue Remodeling Nlrp3-Dependent in Murine HDM-Induced Neutrophilic Asthma
The objective of this study is to analyze whether SCFAs can attenuate lung inflammation and tissue remodeling in murine neutrophilic asthma and NLRP3 contribution to this endotype. Wild-type (WT) C57BL6 mice orotracheally received 10 μg of HDM (house dust mite) in 80 μL of saline on days 0, 6–10. To explore SCFAs, each HDM group received 200 mM acetate, propionate, or butyrate. To explore NLRP3, Nlrp3 KO mice received the same protocol of HDM. On the 14th day, after euthanasia, bronchoalveolar lavage fluid (BALF) and lung s were collected to evaluate cellularity, inflammatory cytokines, and tissue remodeling. HDM gr...
Source: Inflammation - February 8, 2024 Category: Allergy & Immunology Source Type: research
The Angiotensin II Receptor Neprilysin Inhibitor LCZ696 Inhibits the NLRP3 Inflammasome By Reducing Mitochondrial Dysfunction in Macrophages and Alleviates Dextran Sulfate Sodium-induced Colitis in a Mouse Model
This study highlights LCZ696, an angiotensin receptor-neprilysin inhibitor, as an effective suppressor of NLRP3 inflammasome activation in macrophages stimulated by ATP, nigericin, and mo nosodium urate. LCZ696 also reduces caspase-11 and GSDMD activation, lactate dehydrogenase release, propidium iodide uptake, and the extracellular release of NLRP3 and apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) in ATP-activated macrophages, suggesting a pot ential mitigation of pyroptosis. Mechanistically, LCZ696 lowers mitochondrial reactive oxygen species and preserves mitochondrial integrity. ...
Source: Inflammation - February 6, 2024 Category: Allergy & Immunology Source Type: research
Mesenchymal Stromal Cell Therapy Alleviates Ovalbumin-Induced Chronic Airway Remodeling by Suppressing M2 Macrophage Polarization
In conclusion, these results demonstrated that MSCs treatment prevents OVA-induced chronic airway remodeling by suppressing macrophage M2 polarization, which may be associated with the dual inhibition of ER stress and oxidative stress. This discovery may provide a new theoretical basis for the future clinical application of MSCs. (Source: Inflammation)
Source: Inflammation - February 6, 2024 Category: Allergy & Immunology Source Type: research
FSTL1 Accelerates Nucleus Pulposus Cell Senescence and Intervertebral Disc Degeneration Through TLR4/NF- κB Pathway
In this study, we mainly utilized an acidosis-induced NPC degeneration model and a rabbit puncture IVDD model to investigate the role of FSTL1 in IVDD bothin vitro andin vivo. We confirmed that FSTL1 expression significantly increased in nucleus pulposus (NP) tissues from IVDD patients and rabbit puncture IVDD models. The expression levels of FSTL1 were significantly increased in all three models of NPC degeneration under harsh microenvironments. In addition, recombinant human FSTL1 (rh-FSTL1) was found to upregulate the expression of p16 and p21, increase the number of senescence-associated β-galactosidase (SA-β-gal)-po...
Source: Inflammation - February 6, 2024 Category: Allergy & Immunology Source Type: research
P53 Alleviates the Progression of Periodontitis by Reducing M1-type Macrophage Differentiation
AbstractOur objective is to explore the effect of P53 on the progression of periodontitis by regulating macrophages differentiation bothin vitro andin vivo. Eighteen normal and periodontitis gingival tissues were collected for detecting P53 expression and macrophages infiltration by immunofluorescence, real-time PCR (qPCR) and western-blot. The differentiation and the inflammatory cytokines (TNF- α and IL-6) expression of THP-1, RAW264.7 and bone marrow derived macrophage (BMDM) cells, treating with Pifithrin-α (P53 inhibitor) or Nutlin-3a (P53 activator) under lipopolysaccharide (LPS) stimulation, were observed by flow ...
Source: Inflammation - February 6, 2024 Category: Allergy & Immunology Source Type: research
