Tumor necrosis factor receptor-associated factor 5 protects against intimal hyperplasia by regulation of macrophage polarization via directly targeting PPAR γ
ConclusionsCollectively, this evidence reveals an important role of TRAF5 in the development of intimal hyperplasia through the regulation of macrophage polarization, which provides a promising target for arterial restenosis-related disease management. (Source: Inflammation Research)
Source: Inflammation Research - April 20, 2024 Category: Research Source Type: research
PLD2 deletion ameliorates sepsis-induced cardiomyopathy by suppressing cardiomyocyte pyroptosis via the NLRP3/caspase 1/GSDMD pathway
ConclusionPLD2 deletion is involved in SICM pathogenesis and is associated with the inhibition of the myocardial inflammatory response and pyroptosis through the NLRP3/caspase 1/GSDMD pathway. (Source: Inflammation Research)
Source: Inflammation Research - April 17, 2024 Category: Research Source Type: research
Viperin inhibits interferon- γ production to promote Mycobacterium tuberculosis survival by disrupting TBK1-IKKε-IRF3-axis and JAK-STAT signaling
ConclusionsThis study highlights the involvement of TBK1-IKK ε-IRF3 axis and JAK-STAT signaling pathways in Viperin-suppressed IFN-γ production in Mtb infected macrophages, and identifies a novel mechanism of Viperin on negatively regulating host immune response to Mtb infection. (Source: Inflammation Research)
Source: Inflammation Research - April 16, 2024 Category: Research Source Type: research
Integration of multiomics analyses reveals unique insights into CD24-mediated immunosuppressive tumor microenvironment of breast cancer
ConclusionThis study highlights the importance of CD24+breast cancer cells in clinical prognosis and immunosuppressive microenvironment, which may provide a new direction for improving patient outcomes. (Source: Inflammation Research)
Source: Inflammation Research - April 15, 2024 Category: Research Source Type: research
Impacts of liver macrophages, gut microbiota, and bile acid metabolism on the differences in iHFC diet-induced MASH progression between TSNO and TSOD mice
ConclusionsThe dynamics of liver macrophage subsets, and the compositions of the gut microbiota and bile acids at steady state and post-onset of MASH, had major impacts on MASH development. (Source: Inflammation Research)
Source: Inflammation Research - April 15, 2024 Category: Research Source Type: research
Acute lung injury: a view from the perspective of necroptosis
ConclusionNecroptosis plays an important role in the progression of ALI/ARDS. However, since ALI/ARDS is a clinical syndrome caused by a variety of mechanisms, we emphasize that while focusing on necroptosis, it may be more beneficial to treat ALI/ARDS by collaborating with other mechanisms. (Source: Inflammation Research)
Source: Inflammation Research - April 14, 2024 Category: Research Source Type: research
Macrophage-enriched novel functional long noncoding RNAs LRRC75A-AS1 and GAPLINC regulate polarization and innate immune responses
ConclusionOur results show that polarized M φs acquire a unique lncRNA repertoire and identified many previously unknown lncRNA sequences. LRRC75A-AS1 and GAPLINC, which are induced in periodontitis, regulate Mφ polarization and innate immune functions supporting their critical role in inflammation. (Source: Inflammation Research)
Source: Inflammation Research - April 9, 2024 Category: Research Source Type: research
Tryptophan catabolism via the kynurenine pathway regulates infection and inflammation: from mechanisms to biomarkers and therapies
AbstractBackgroundl-Tryptophan (l-Trp), an essential amino acid, is the only amino acid whose level is regulated specifically by immune signals. Most proportions of Trp are catabolized via the kynurenine (Kyn) pathway (KP) which has evolved to align the food availability and environmental stimulation with the host pathophysiology and behavior. Especially, the KP plays an indispensable role in balancing the immune activation and tolerance in response to pathogens.Scope of reviewIn this review, we elucidate the underlying immunological regulatory network of Trp and its KP-dependent catabolites in the pathophysiological condi...
Source: Inflammation Research - April 9, 2024 Category: Research Source Type: research
Consistent efficacy outcomes between phase 2 and phase 3 trials in Crohn’s disease or ulcerative colitis in adults: a meta-analysis
ConclusionsOur findings suggest that the main efficacy outcomes for CD and UC remain consistent between phase 2 and phase 3 trials, except for UC response rates. The efficacy data obtained from phase 2 trials can be considered reliable for the design of subsequent phase 3 trials.Registration: PROSPERO (CRD42023407947). (Source: Inflammation Research)
Source: Inflammation Research - April 8, 2024 Category: Research Source Type: research
Quercetin and Kaempferol inhibit HMC-1 activation via SOCE/NFATc2 signaling and suppress hippocampal mast cell activation in lipopolysaccharide-induced depressive mice
ConclusionsOur results indicated that suppression of SOCE/NFATc2 pathway-mediated by ORAI channels may be the mechanism of inhibitory effect of Que and Kae on MC activation, and also suggested Que and Kae may exert the antidepressant effect through suppressing hippocampal mast cell activation. (Source: Inflammation Research)
Source: Inflammation Research - April 8, 2024 Category: Research Source Type: research
Transcriptomic analysis reveals molecular characterization and immune landscape of PANoptosis-related genes in atherosclerosis
ConclusionsThis study evaluated the expression changes of PANoptosis-related genes in atherosclerosis, providing a reference direction for the study of PANoptosis in atherosclerosis and offering potential new avenues for further understanding the pathogenesis and treatment strategies of atherosclerosis. (Source: Inflammation Research)
Source: Inflammation Research - April 8, 2024 Category: Research Source Type: research
Recognition of Mycobacterium tuberculosis by macrophage Toll-like receptor and its role in autophagy
ConclusionsIn-depth understanding of the mechanisms by which macrophage autophagy interacts with intracellular Mycobacterium tuberculosis, as well as the study of potent and specific autophagy-regulating molecules, will lead to much-needed advances in drug discovery and vaccine design, which will improve the prevention and treatment of human tuberculosis. (Source: Inflammation Research)
Source: Inflammation Research - April 2, 2024 Category: Research Source Type: research
γδ T cells in oral diseases
ConclusionThis review focuses on the involvement of γδ T cells in oral diseases, with a particular emphasis on the main functions and underlying mechanisms by which γδ T cells influence the pathogenesis and progression of these conditions. This review underscores the potential of γδ T cells as therapeutic targets in managing oral health issues. (Source: Inflammation Research)
Source: Inflammation Research - April 2, 2024 Category: Research Source Type: research
Immunopathogenesis of urticaria: a clinical perspective on histamine and cytokine involvement
ConclusionThe recent progress in understanding urticaria can help to understand the intricate characteristics in the immunopathogenesis of urticaria and could play a beneficial role in the management of urticaria. (Source: Inflammation Research)
Source: Inflammation Research - March 31, 2024 Category: Research Source Type: research
Inflammation in heart failure: pathophysiology and therapeutic strategies
AbstractA role for inflammation in the development and progression of heart failure (HF) has been proposed for decades. Multiple studies have demonstrated the potential involvement of several groups of cytokines and chemokines in acute and chronic HF, though targeting these pathways in early therapeutic trials have produced mixed results. These studies served to highlight the complexity and nuances of how pro-inflammatory pathways contribute to the pathogenesis of HF. More recent investigations have highlighted how inflammation may play distinct roles based on HF syndrome phenotypes, findings that may guide the development...
Source: Inflammation Research - March 28, 2024 Category: Research Source Type: research
