Inflammation and Allergy Drug TargetsThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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124 records returned

Renoprotective potency of heme oxygenase-1 induction in rat renal ischemia-reperfusion.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: HO-1 decreased the degree and severity of tubular damage after IR, probably by attenuating the cytotoxic effects of inflammatory infiltrates and apoptosis. PMID: 19754408 [PubMed - in process] (Source: Inflammation and Allergy Drug Targets)
Source: Inflammation and Allergy Drug Targets - August 31, 2009 Category: Allergy & Immunology Authors: Chok MK, Ferlicot S, Conti M, Almolki A, Dürrbach A, Loric S, Benoît G, Droupy S, Eschwège P Tags: Inflamm Allergy Drug Targets Source Type: journals

General principles for the treatment of non-infectious uveitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ocular inflammatory disorders constitute a sight-threatening group of diseases that might be managed according to their severity. Their treatment guidelines experience constant changes with new agents that improve the results obtained with former drugs. Nowadays we can make use of a five step protocol in which topical, periocular and systemic corticosteroids remain as the main therapy for non infectious uveitis. In addition, immunosuppresive drugs can be added in order to enhance the anti-inflammatory effects and to develop the role of corticosteroid-saving agents. These can be organized in four other steps: Cyclospori...
Source: Inflammation and Allergy Drug Targets - August 31, 2009 Category: Allergy & Immunology Authors: Díaz-Llopis M, Gallego-Pinazo R, García-Delpech S, Salom-Alonso D Tags: Inflamm Allergy Drug Targets Source Type: journals

Anti-inflammatory drugs in psychiatry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article is supposed to give an overview over the current concepts and possibilities since hopefully these hypotheses lead to new therapeutical strategies for psychiatric patients in the future. PMID: 19754410 [PubMed - in process] (Source: Inflammation and Allergy Drug Targets)
Source: Inflammation and Allergy Drug Targets - August 31, 2009 Category: Allergy & Immunology Authors: Berthold-Losleben M, Heitmann S, Himmerich H Tags: Inflamm Allergy Drug Targets Source Type: journals

Possible roles of microglial cells for neurotoxicity in clinical neurodegenerative diseases and experimental animal models.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Microglia has been demonstrated to play critical roles in various neurodegenerative disorders, such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD) as well as neuroinflammatory disorders including AIDS encephalitis, multiple sclerosis. In this manuscript, we review the possible roles of microglial cells in animal models of these clinical disorders and human clinical cases. Activated microglia has been demonstrated in various brain regions, such as the hippocampus, substantia nigra and cortex in PD, AD and HD. The contribution of microglial cells to these neurodegenerative disorders is s...
Source: Inflammation and Allergy Drug Targets - August 31, 2009 Category: Allergy & Immunology Authors: Sugama S, Takenouchi T, Cho BP, Joh TH, Hashimoto M, Kitani H Tags: Inflamm Allergy Drug Targets Source Type: journals

Leptin in non-autoimmune inflammation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Leptin is an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine and pro-inflammatory immune responses. Several studies have implicated leptin in the pathogenesis of chronic autoimmune inflammatory conditions such as autoimmune encephalomyelitis, intestinal bowel inflammation and type-1 diabetes. This review focuses on the role of leptin in non-autoimmune inflammatory diseases that include renal, liver and lung inflammation, atherosclerosis and metabolic syndrome, Behçet's disease and endometriosis. PMID: 19754412 [PubMed - in process] (Source:...
Source: Inflammation and Allergy Drug Targets - August 31, 2009 Category: Allergy & Immunology Authors: Cai C, Hahn BH, Matarese G, La Cava A Tags: Inflamm Allergy Drug Targets Source Type: journals

Assessment of Airway Inflammation by Exhaled Breath Condensate and Impedance Due to Gastroesophageal Reflux Disease (GERD).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Avoiding oxidative stress in the airways is important for the treatment of respiratory disease associated with gastroesophageal reflux disease (GERD). It is often difficult to decide whether GERD is causing airway inflammation or whether an airway disease is complicated by GERD. Measurement of exhaled breath condensate (EBC) is performed by cooling and collecting the airway lining fluid contained in exhaled air. A decrease of pH and an increase of the 8-isoprostane concentration in EBC have been observed in patients with mild to moderate asthma accompanied by GERD. There are still problems to be overcome before EBC can...
Source: Inflammation and Allergy Drug Targets - August 31, 2009 Category: Allergy & Immunology Authors: Shimizu Y, Dobashi K, Nagoshi A, Kawamura O, Mori M Tags: Inflamm Allergy Drug Targets Source Type: journals

Targeting Leukotrienes for the Treatment of COPD?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New drugs and new approaches of the treatment of chronic obstructive pulmonary disease (COPD) are needed. Despite recent advances in medical therapeutics, treatment of patients with COPD remains largely symptomatic. Although inhaled corticosteroids are currently the drug of choice for anti-inflammatory therapy, the inflammatory process in COPD is essentially steroid resistant. By now, COPD has been increasingly recognized as an inflammatory disease characterized by sputum neutrophilia and, in some cases, eosinophilia. Moreover other cell types thought to play the predominant role in COPD, are cytotoxic T lymphocytes (C...
Source: Inflammation and Allergy Drug Targets - August 31, 2009 Category: Allergy & Immunology Authors: Drakatos P, Lykouras D, Sampsonas F, Karkoulias K, Spiropoulos K Tags: Inflamm Allergy Drug Targets Source Type: journals

The Role of Pro-inflammatory Molecules and Pharmacological Agents in Acute Pancreatitis and Sepsis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acute pancreatitis (AP) and sepsis are inflammatory disorder varying in magnitude of response to infection or inflammatory stimuli. The specific role of various causative factors in AP, septic shock, current pharmacological treatments, animal models, role of infiltrating cells and novel molecules that play an important role in the disease progression to sepsis are explored. AP is an inflammatory disease of the pancreas. Over the years accumulating evidence suggests numerous molecules as key regulators of the inflammatory signaling cascade such as selectins, chemokine signaling and expression of intergrins on leukocytes...
Source: Inflammation and Allergy Drug Targets - August 12, 2009 Category: Allergy & Immunology Authors: Shanmugam MK, Bhatia M Tags: Inflamm Allergy Drug Targets Source Type: journals

The C-reactive Protein Levels in Left Ventricular Dysfunction of Different Etiology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: as shown by increment of C-reactive protein values, the immune system is activated in patients with the chronic left ventricular dysfunction. The patients with the chronic left ventricular dysfunction of an ishemic origin have higher levels of C-reactive protein than those of a non-ischemic origin. This difference could depend on the atherosclerotic process present presumably only in the first group. PMID: 19534672 [PubMed - as supplied by publisher] (Source: Inflammation and Allergy Drug Targets)
Source: Inflammation and Allergy Drug Targets - June 27, 2009 Category: Allergy & Immunology Authors: Anzulović-Mirošević D Tags: Inflamm Allergy Drug Targets Source Type: journals

Monocytes and Macrophages as Cellular Targets in Liver Fibrosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although chronic liver disease has many etiologies, including chronic viral hepatitis, alcohol abuse, metabolic syndrome, and autoimmune disorders, the cellular and pathological mechanisms leading to hepatic fibrosis and - as an end-stage - cirrhosis are relatively common and uniform. Liver fibrosis is characterized by an accumulation of extracellular matrix proteins, and activated hepatic stellate cells (HSC), portal fibroblasts and myofibroblasts have been identified as major collagen-producing cells in the injured liver. Experimental models of liver fibrosis highlight the importance of hepatic macrophages, so-called...
Source: Inflammation and Allergy Drug Targets - June 27, 2009 Category: Allergy & Immunology Authors: Tacke F Tags: Inflamm Allergy Drug Targets Source Type: journals

Syk: a novel target for treatment of inflammation in lung disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Spleen Tyrosine Kinase (Syk) is widely expressed in the immune system and functions in the transmission of inflammatory signals via ITAM-bearing cell surface receptors. The broad expression pattern and importance of Syk in regulating innate immunity and the inflammatory response have led to significant interest from the pharmaceutical industry to developing anti-Syk therapeutics for the treatment of inflammatory disorders such as allergic rhinitis and rheumatoid arthritis. While the function and regulation of Syk has been well-described in leukocytes, where its primary role is an early transducer of signaling following...
Source: Inflammation and Allergy Drug Targets - May 31, 2009 Category: Allergy & Immunology Authors: Sanderson MP, Lau CW, Schnapp A, Chow CW Tags: Inflamm Allergy Drug Targets Source Type: journals

Update on the medical treatment of allergic rhinitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Allergic rhinitis is a global health problem affecting at least 10 to 25 % of the population. So far, numerous classifications and treatment modalities have been described. In the treatment of allergic disorders Pharmacotherapy is the most used therapeutic modality, especially in allergic rhinitis. The first step to successful management is the accurate diagnosis of the type of AR (intermittent or persistent) and assessment of its severity (mild or moderate to severe). Although objective measurements of the nasal airway have great value to evaluate and follow up the cases, in most centers they are not done in routine c...
Source: Inflammation and Allergy Drug Targets - May 31, 2009 Category: Allergy & Immunology Authors: Cingi C, Kayabasoglu G, Nacar A Tags: Inflamm Allergy Drug Targets Source Type: journals

Genetic engineering of allergens for immunotherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Allergen-specific immunotherapy was introduced into clinical practice at the beginning of the 20(th) century and its efficacy in the treatment of seasonal allergic rhinitis has been confirmed in many clinical studies which have shown that it can prevent the onset of new sensitizations to different allergens and reduces the development of asthma in patients with allergic rhinitis. Progress in molecular cloning and characterization of allergens have made it possible to produce single recombinant allergens whose immunological properties have been tested in vitro and in vivo and have demonstrated that they retain propertie...
Source: Inflammation and Allergy Drug Targets - May 31, 2009 Category: Allergy & Immunology Authors: Bonura A, Colombo P Tags: Inflamm Allergy Drug Targets Source Type: journals

Treatment of inflammatory diseases with mesenchymal stem cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human mesenchymal stem cells (hMSCs) are rare progenitor cells present in adult bone marrow that have the capacity to differentiate into a variety of tissue types, including bone, cartilage, tendon, fat, and muscle. In addition to multilineage differentiation capacity, MSCs regulate immune and inflammatory responses, providing therapeutic potential for treating diseases characterized by the presence of an inflammatory component. The availability of bone marrow and the ability to isolate and expand hMSCs ex vivo make these cells an attractive candidate for drug development. The low immunogenicity of these cells suggests...
Source: Inflammation and Allergy Drug Targets - May 31, 2009 Category: Allergy & Immunology Authors: Newman RE, Yoo D, LeRoux MA, Danilkovitch-Miagkova A Tags: Inflamm Allergy Drug Targets Source Type: journals

Modulation of regulatory T cells in health and disease: role of toll-like receptors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Naturally arising regulatory T cells (Tregs) originate from the thymus and are characterised by the expression of Foxp3 as a key control gene for their development and function. Their pivotal role is maintaining immunological self tolerance. Recently, Tregs have been shown to express Toll-like receptors (TLRs), which are essential components of the innate immune system for the detection of microbial infections and the activation of dendritic cells (DC) maturation programs to induce adaptive immune responses. TLRs are type 1 transmembrane receptors characterised by a highly variable extracellular region containing a leu...
Source: Inflammation and Allergy Drug Targets - May 31, 2009 Category: Allergy & Immunology Authors: Nyirenda MH, O'Brien K, Sanvito L, Constantinescu CS, Gran B Tags: Inflamm Allergy Drug Targets Source Type: journals

Are B cells a potential target for therapeutic intervention in the classical T cell-mediated autoimmune disease type 1 diabetes?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Incidence of autoimmune diseases is rising rapidly in the developed world and treatment of such diseases will be a major burden on Government health resources of the future. Whether systemic or organ-specific, immune cell destruction of the target tissue normally requires co-operative interaction of a many distinct immune cells. Detailed knowledge of the cells and signal pathways involved in tissue destruction is paramount to the design of novel therapeutics. Several organ-specific autoimmune diseases e.g. multiple sclerosis, rheumatoid arthritis and type 1 diabetes have long been attributed to T cell-mediated destruct...
Source: Inflammation and Allergy Drug Targets - May 31, 2009 Category: Allergy & Immunology Authors: Wållberg M, Green EA Tags: Inflamm Allergy Drug Targets Source Type: journals

Damage-associated molecular patterns--emerging targets for biologic therapy of childhood arthritides.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Juvenile idiopathic arthritis (JIA) is a group of chronic childhood arthritides of unknown origin. Although the use of glucocorticoids and immunosuppressants brought a substantial improvement in treatment, the present therapeutic regime could not be considered satisfactory. As inflammation seems to be an essential part of pathogenesis of JIA, efforts have been made to develop pharmaceutical means to mitigate the innate immune system. Emerging targets for treatment are alarmins, a family of multifunctional intracellular proteins with strong pro-inflammatory activity. In the context of JIA, particularly interesting are h...
Source: Inflammation and Allergy Drug Targets - May 31, 2009 Category: Allergy & Immunology Authors: Lukić IK, Jelusić-Drazić M, Kovacić N, Grcević D Tags: Inflamm Allergy Drug Targets Source Type: journals

The CLCA gene family: putative therapeutic target for respiratory diseases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The CLCA proteins were first shown to exist in bovine trachea and named as chloride channels calcium activated (CLCA) due to the calcium-dependent chloride conductance that appeared to be activated on expression of these proteins in trachea and other secretory epithelial cells. Since their initial discovery the CLCA gene family has grown extensively and family members have been identified in bovine, human, murine, equine and porcine tissues. The CLCA proteins appear to have a role to play in chloride conductance across epithelial cells and hence epithelial fluid secretion; cell-cell adhesion, apoptosis, cell cycle cont...
Source: Inflammation and Allergy Drug Targets - May 31, 2009 Category: Allergy & Immunology Authors: Winpenny JP, Marsey LL, Sexton DW Tags: Inflamm Allergy Drug Targets Source Type: journals

Vitamin D and the adaptive immune system with special emphasis to allergic reactions and allograft rejection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article summarizes present knowledge on vitamin D and the adaptive immune system. Experimental and clinical studies support the assumption that calcitriol can decrease the risk of allograft rejection. Prospective randomized clinical trials are however needed to clarify whether administration of calcitriol, some of its analogues, or simple vitamin D supplementation is able to prevent rejection in solid organ transplanted patients. With respect to allergic reactions, human data are inconsistent at present. Some argue that vitamin D deficiency may cause allergic reactions whereas others argue that vitamin D excess leads ...
Source: Inflammation and Allergy Drug Targets - May 31, 2009 Category: Allergy & Immunology Authors: Zittermann A, Tenderich G, Koerfer R Tags: Inflamm Allergy Drug Targets Source Type: journals

Journal of Inflammation & Allergy - Drug Targets.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Inflammation & Allergy - Drug Targets. Inflamm Allergy Drug Targets. 2009 Mar;8(1):1 Authors: Zaenker KS PMID: 19275686 [PubMed - in process] (Source: Inflammation and Allergy Drug Targets)
Source: Inflammation and Allergy Drug Targets - March 1, 2009 Category: Allergy & Immunology Authors: Zaenker KS Tags: Inflamm Allergy Drug Targets Source Type: journals

A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Amongst these useful herbs, some like Cinnamon, Silybum marianum, Garlic, Nigella, and Echium seem potential targets of future effective drugs for diseases in which free radical damage play a pathogenical role. PMID: 19275687 [PubMed - in process] (Source: Inflammation and Allergy Drug Targets)
Source: Inflammation and Allergy Drug Targets - March 1, 2009 Category: Allergy & Immunology Authors: Hasani-Ranjbar S, Larijani B, Abdollahi M Tags: Inflamm Allergy Drug Targets Source Type: journals

Kounis syndrome following beta-lactam antibiotic use: review of literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Patients with anaphylaxis can present with acute coronary syndrome secondary to either vasospasm or acute plaque rupture and thrombus formation. The typical patient is a man with cutaneous, respiratory and cardiac symptoms and with ST segment elevation in inferior leads. The pathogenesis involves histamine and other mast cell mediators. Management should include therapy for anaphylaxis and vasospasmolytics. The use of epinephrine requires caution. PMID: 19275688 [PubMed - in process] (Source: Inflammation and Allergy Drug Targets)
Source: Inflammation and Allergy Drug Targets - March 1, 2009 Category: Allergy & Immunology Authors: Ridella M, Bagdure S, Nugent K, Cevik C Tags: Inflamm Allergy Drug Targets Source Type: journals

Adverse reactions to iodinated contrast media administered at the time of endoscopic retrograde cholangiopancreatography (ERCP).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Adverse reactions after intravascular administration of iodine contrast media are common and prophylactic regiments consisting of the use of steroids and low osmolality contrast media are highly effective in significantly decreasing the adverse reactions rate. The same type of contrast media are also used for opacification of the biliary tree and the pancreatic duct at the time of endoscopic retrograde cholangiopancreatography (ERCP). Systemic absorption of contrast media after ERCP routinely occurs. Although the adverse reaction rate appears to be very low the exact incidence remains unknown due to the retrospective n...
Source: Inflammation and Allergy Drug Targets - March 1, 2009 Category: Allergy & Immunology Authors: Pan JJ, Draganov PV Tags: Inflamm Allergy Drug Targets Source Type: journals

Interaction between arsenic trioxide and human primary cells: emphasis on human cells of myeloid origin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Arsenic trioxide (As(2)O(3); ATO) is considered to be one of the most potent drugs in cancer chemotherapy and is highly effective in the treatment of acute promyelocytic leukemia (APL). It is well established that treatment of APL patients with ATO is associated with the disappearance of the PML-RARalpha fusion transcript, the characteristic APL gene product of the chromosomal translocation t(15;17). Although its mode of action is still not fully understood, ATO is known to induce cell apoptosis via generation of reactive oxygen species and activation of caspases. Several reports have indicated that ATO acts principall...
Source: Inflammation and Allergy Drug Targets - March 1, 2009 Category: Allergy & Immunology Authors: Binet F, Antoine F, Girard D Tags: Inflamm Allergy Drug Targets Source Type: journals

Molecular basis of the anti-inflammatory effects of terpenoids.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Natural products play a significant role in human health in relation to the prevention and treatment of inflammatory conditions. Among them, terpenoids (also referred to as terpenes), are the largest and most widespread class of secondary metabolites. They are found in higher plants, mosses, liverworts, algae and lichens, and also in insects, microbes or marine organisms. Some terpenoids have been used for therapeutic purposes for centuries as antibacterial, anti-inflammatory, antitumoral agents, and in recent decades research activity into the clinical potential of this class of compounds has increased continuously as...
Source: Inflammation and Allergy Drug Targets - March 1, 2009 Category: Allergy & Immunology Authors: Heras Bde L, Hortelano S Tags: Inflamm Allergy Drug Targets Source Type: journals

The IL-12 family of cytokines in infection, inflammation and autoimmune disorders.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cytokines are critical coordinators of the immune response necessary for resolving bacterial and viral assaults on the immune system. In particular, the IL-12 family of cytokines are key players in the regulation of T cell responses. These responses are orchestrated by monocytes, macrophages, and dendritic cells which produce the members of the IL-12 family of cytokines in response to infection. IL-27 and IL-23 are two cytokines that are related to IL-12; these cytokines share homology at the subunit, receptor, and signalling levels. IL-12 is composed of p35 and p40 subunits, which, when combined together form the bioa...
Source: Inflammation and Allergy Drug Targets - March 1, 2009 Category: Allergy & Immunology Authors: Gee K, Guzzo C, Che Mat NF, Ma W, Kumar A Tags: Inflamm Allergy Drug Targets Source Type: journals

TNF-alpha in tuberculosis: a cytokine with a split personality.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report aims to review the pivotal role of TNF-alpha in controlling the mycobacterial infection, with a particular emphasis on its influence on chemokine expression and cell movement during granuloma formation, and the issues surrounding the use of TNF-alpha inhibitors for therapeutic use in inflammatory diseases. PMID: 19275693 [PubMed - in process] (Source: Inflammation and Allergy Drug Targets)
Source: Inflammation and Allergy Drug Targets - March 1, 2009 Category: Allergy & Immunology Authors: Mootoo A, Stylianou E, Arias MA, Reljic R Tags: Inflamm Allergy Drug Targets Source Type: journals

Inflammatory mediators in smoke inhalation injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Smoke inhalation occurs in 10% to 30% of patients admitted to burn centers, and increases mortality by a maximum of 20% over that predicted by age and extent of cutaneous burn alone. Pneumonia in these patients then further increases mortality by a maximum of 40%. While one estimate suggested that 75% of deaths following burn injury may be accounted for by inhalation injury, more recent cohort studies have suggested there is a decreasing mortality attributable to inhalation injury. As part of understanding and improving outcomes from burn injuries, the pathophysiology and inflammatory processes involved in smoke inhala...
Source: Inflammation and Allergy Drug Targets - March 1, 2009 Category: Allergy & Immunology Authors: Sterner JB, Zanders TB, Morris MJ, Cancio LC Tags: Inflamm Allergy Drug Targets Source Type: journals

Renal & ocular targets for therapy in Wegener's granulomatosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Renal & ocular targets for therapy in Wegener's granulomatosis. Inflamm Allergy Drug Targets. 2009 Mar;8(1):70-9 Authors: Joshi L, Hamour S, Salama AD, Pusey CD, Lightman S, Taylor SR Wegener's granulomatosis (WG) is a multisystem small-vessel vasculitis which is characterised by granulomatous inflammation. Respiratory tract involvement is most commonly seen, affecting up to 85% of patients, closely followed by the renal system in up to 75% of patients; ocular involvement in WG is estimated to occur in 50-60% of patients. The purpose of this review is to provide an overview of the renal and ocular manifesta...
Source: Inflammation and Allergy Drug Targets - March 1, 2009 Category: Allergy & Immunology Authors: Joshi L, Hamour S, Salama AD, Pusey CD, Lightman S, Taylor SR Tags: Inflamm Allergy Drug Targets Source Type: journals

Role of Fc Receptors as a therapeutic target.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It has been forty years since the discovery of Fc Receptors and their function. Fc Receptors include the IgG receptors (FcgammaR), high-affinity IgE receptor (FcepsilonRI), IgA and IgA/IgM receptors, and neonatal Fc receptor for IgG (FcRn). In particular, the FcgammaRs have been well known to play an important role in many biologic processes including those associated with the response to infection and cancer as well as in the pathogenesis of immune-mediated diseases. Both positive and negative regulatory function has ascribed to Fc receptors and FcgammaRs in particular which serve to establish a threshold for immune c...
Source: Inflammation and Allergy Drug Targets - March 1, 2009 Category: Allergy & Immunology Authors: Masuda A, Yoshida M, Shiomi H, Morita Y, Kutsumi H, Inokuchi H, Mizuno S, Nakamura A, Takai T, Blumberg RS, Azuma T Tags: Inflamm Allergy Drug Targets Source Type: journals

Influence of Toll-like-receptor ligands on the dendritic cell-T cell interactions: therapeutic options for allergic diseases? Mini-review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dendritic cells (DC) exert important functions both in the induction of protective T cell immunity, as well as in the induction of tolerance. The latter is essential in protection against the development of allergy. Exposure to pathogen-associated molecular patterns (PAMPs), that signal through different Toll-like receptor (TLR)s, modulates production by DC of several Interleukin(IL)-12 family members: IL-12p70, IL-23, IL-27 and IL-35. The production of those cytokines in turn differentially influences both T cell differentiation and effector T cell activation. We focus in this review on myeloid and plasmacytoid DC and...
Source: Inflammation and Allergy Drug Targets - December 1, 2008 Category: Allergy & Immunology Authors: Bullens DM, Ceuppens JL Tags: Inflamm Allergy Drug Targets Source Type: journals

Influence of toll-like-receptor ligands on the dendritic cell - T cell interactions: therapeutic options for allergic diseases? Mini-review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dendritic cells (DC) exert important functions both in the induction of protective T cell immunity, as well as in the induction of tolerance. The latter is essential in protection against the development of allergy. Exposure to pathogen-associated molecular patterns (PAMPs), that signal through different Toll-like receptor (TLR)s, modulates production by DC of several Interleukin(IL)-12 family members: IL-12p70, IL-23, IL-27 and IL-35. The production of those cytokines in turn differentially influences both T cell differentiation and effector T cell activation. We focus in this review on myeloid and plasmacytoid DC and...
Source: Inflammation and Allergy Drug Targets - December 1, 2008 Category: Allergy & Immunology Authors: Bullens DM, Ceuppens JL Tags: Inflamm Allergy Drug Targets Source Type: journals

Regulatory T cells as targets for immunotherapy of autoimmunity and inflammation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Regulatory T (Treg) cells are emerging as key players in the regulation of different immune responses, thereby representing potential candidates for therapeutic interventions in a broad variety of immunological disorders. While the reduction or loss in function would be of benefit during the treatment of cancer, induction and/or expansion of Treg cell function might be helpful to interfere with unwanted immune responses in transplantation medicine, during autoimmunity, allergy and inflammation. However, a better understanding of Treg cell biology is a prerequisite to specifically modulate its function during immune res...
Source: Inflammation and Allergy Drug Targets - December 1, 2008 Category: Allergy & Immunology Authors: Hansen W, Westendorf AM, Buer J Tags: Inflamm Allergy Drug Targets Source Type: journals

TGF-beta, Eosinophils and IL-13 in Allergic Airway Remodeling: A Critical Appraisal with Therapeutic Considerations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Airway remodeling is a characteristic feature of allergic asthma that is now thought to contribute to airway dysfunction and, ultimately, to clinical symptoms. A prevalent hypothesis holds that eosinophil-derived transforming growth factor-beta (TGF-beta) is a predominant underlying mechanism driving the development of remodeling and thus, represent promising targets for therapeutic intervention. This notion is supported by in vivo evidence from loss of function experiments conducted in animal models employing the surrogate allergen ovalbumin (OVA), and by indirect evidence from studies in human asthmatics. However, it...
Source: Inflammation and Allergy Drug Targets - December 1, 2008 Category: Allergy & Immunology Authors: Fattouh R, Jordana M Tags: Inflamm Allergy Drug Targets Source Type: journals

Regulatory T cells and allergic disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Allergic diseases such as asthma, rhinitis, and eczema are increasing in prevalence and affect about 15% of the population in countries such as the UK or USA. Regulatory T cells (T(Regs)) have been shown to be critical in the maintenance of immune responses and T cell homeostasis. For example, depletion of CD4(+)CD25(+) T(Regs) from mice resulted in the development of multiorgan autoimmune diseases. So-called 'natural' CD4(+)CD25(+) T(Regs) and/or IL-10-producing Tr-1 cells are capable of suppressing Th2 responses to allergens in health, whereas such inhibition is attenuated in allergic conditions. In this context, bot...
Source: Inflammation and Allergy Drug Targets - December 1, 2008 Category: Allergy & Immunology Authors: Nouri-Aria KT, Durham SR Tags: Inflamm Allergy Drug Targets Source Type: journals

Tuning immune suppression in systemic autoimmunity with self-derived peptides.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A central pathologic mechanism in systemic autoimmune diseases with chronic inflammation such as systemic lupus erythematosus (SLE) is the aberrant production of antibodies against self-components produced by abnormal B cells with the help of hyperactive CD4(+)T cells. One goal for better control of the disease is the limitation of the number of abnormal and hyperactive cells, to prevent and/or attenuate the damaging effects of the pathogenic antibodies on target tissues. Recently, a role of regulatory T cells in the suppression of autoimmune reactivity in diseases including SLE has been recognized. CD4(+)CD25(+) regul...
Source: Inflammation and Allergy Drug Targets - December 1, 2008 Category: Allergy & Immunology Authors: Singh RP, Hahn BH, La Cava A Tags: Inflamm Allergy Drug Targets Source Type: journals

Design and modifications of allergens for improving specific immunotherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Specific immunotherapy is a clinically effective causative treatment for allergic conditions. However, the reagents used for immunotherapy are crude extracts, prepared from natural sources, and as such may cause potential life-threatening anaphylactic side effects. Our increasing knowledge of mechanisms that lead to allergy and of the mechanisms of successful immunotherapy have introduced new ideas for the treatment of allergic diseases. Techniques of biochemistry and molecular biology have made it feasible to design novel therapeutic approaches for improved and safer forms of allergen-specific immunotherapy. The purpo...
Source: Inflammation and Allergy Drug Targets - December 1, 2008 Category: Allergy & Immunology Authors: Velickovic TC, Jankov RM Tags: Inflamm Allergy Drug Targets Source Type: journals

Macrolide therapy targets a specific phenotype in respiratory medicine: from clinical experience to basic science and back.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For centuries a quest has been going on for the "holy grail" in respiratory medicine: a treatment for numerous devastating chronic lung disorders. Yet, it is only a decade ago that pharmacological interference with the activation of the innate immune system by a macrolide antibiotic silently moved into everyday clinical practice. Macrolides, with their unique molecular structure built around a lactone ring, are now known to target harmful exaggerated innate immune responses. However, not all chronic lung conditions benefit from macrolide therapy and interestingly, neither do all patients with an apparently identical ch...
Source: Inflammation and Allergy Drug Targets - December 1, 2008 Category: Allergy & Immunology Authors: Vanaudenaerde BM, Vos R, Meyts I, De Vleeschauwer SI, Verleden SE, Widyastuti-Willems A, Wuyts WA, Van Raemdonck DE, Hoet PH, Dupont LJ, Nemery B, Verleden GM Tags: Inflamm Allergy Drug Targets Source Type: journals

Should we Target Allergen Protease Activity to Decrease the Burden of Allergic Airway Inflammation?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The prevalence of allergy and asthma has been increasing steadily in the developed world. Despite the growing health problems associated with these conditions few new therapeutic options are becoming available. Relatively recent developments have identified a role for proteases in promoting allergic sensitisation and allergic airway inflammation. It is also known that most major allergens have associated protease activity that is closely related to their efficacy to induce sensitization and inflammation. Here we review the evidence for the significance of protease activity in allergic airway disease and offer suggestio...
Source: Inflammation and Allergy Drug Targets - December 1, 2008 Category: Allergy & Immunology Authors: Vliagoftis H, Forsythe P Tags: Inflamm Allergy Drug Targets Source Type: journals

Pulmonary arterial hypertension: need to treat.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pulmonary Arterial Hypertension (PAH) is defined by a persistent elevation in pulmonary artery pressure with normal left-sided pressures. It is characterized by increased pulmonary vascular resistance due to increased vascular tone and structural remodeling of pulmonary vessels. PAH is a quite rare condition, thus considering the rarity, subtle presentation, and diagnostic dilemma commonly posed by this disease, underdiagnosis and underreporting are probably widespread. In order to reach a diagnosis the use of echocardiography, right-heart catheterization and the six-minute walk test is essential. As far as therapy is ...
Source: Inflammation and Allergy Drug Targets - December 1, 2008 Category: Allergy & Immunology Authors: Lykouras D, Sampsonas F, Kaparianos A, Efremidis G, Karkoulias K, Tsoukalas G, Spiropoulos K Tags: Inflamm Allergy Drug Targets Source Type: journals

Potassium Channel Openers and Improvement of Toxic Stress: Do they have Role in the Management of Inflammatory Bowel Disease?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inflammatory bowel disease (IBD) is a progressive condition in gastrointestinal tract, which refers to two idiopathic diseases; ulcerative colitis and Crohn's disease. Although certain etiology of these conditions is not known, it seems that an abnormality in reaction and regulation of the immune system plays an important role in adventure of the disease. According to the investigations, it is likely that oxidative and nitrosative stress have etiologic roles in IBD. Their destructive effects may contribute to the initiation or progression of the disease. Nowadays, the effectiveness of different medicines in the treatme...
Source: Inflammation and Allergy Drug Targets - September 1, 2008 Category: Allergy & Immunology Authors: Hosseini-Tabatabaei A, Abdollahi M Tags: Inflamm Allergy Drug Targets Source Type: journals

The role of inflammation and allergy in acute coronary syndromes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is well known that inflammatory mechanisms play a crucial role in the pathogenesis of atherosclerosis and coronary artery disease. In recent years, allergic episodes have been shown to be associated with acute coronary syndromes. Mast cells release certain inflammatory mediators including histamine and neutral proteases during an allergic episode and these inflammatory mediators are implied to induce coronary artery spasm and/or atheromatous plaque erosion or rupture. As the inflammatory component of acute coronary syndromes is a potential therapeutic target, drugs that stabilize mast cell membrane and monoclonal an...
Source: Inflammation and Allergy Drug Targets - September 1, 2008 Category: Allergy & Immunology Authors: Ozben B, Erdogan O Tags: Inflamm Allergy Drug Targets Source Type: journals

Metal allergens of growing significance: epidemiology, immunotoxicology, strategies for testing and prevention.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Metal-induced allergic contact dermatitis (ACD) is expressed in a wide range of cutaneous reactions following dermal and systemic exposure to products such as cosmetics and tattoos, detergents, jewellery and piercing, leather tanning, articular prostheses and dental implants. Apart from the well known significance of nickel in developing ACD, other metals such as aluminium, beryllium, chromium, cobalt, copper, gold, iridium, mercury, palladium, platinum, rhodium and titanium represented emerging causes of skin hypersensitivity. Despite the European Union directives that limit the total nickel content in jewellery alloy...
Source: Inflammation and Allergy Drug Targets - September 1, 2008 Category: Allergy & Immunology Authors: Forte G, Petrucci F, Bocca B Tags: Inflamm Allergy Drug Targets Source Type: journals

Proteomic Screening Points to the Potential Importance of Ara h 3 Basic Subunit in Allergenicity of Peanut.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Peanuts are complex storage proteins with high contents and have been identified as one of the most allergenic foods. In this review, we summarize some of the latest findings and the potential importance of the Ara h 3 basic subunit, which has been overlooked as an allergen in early literature. Some recent studies indicate that Ara h 3 basic subunit may be as significant as or even a more important allergen than the acidic subunit. For example, one clinical study found a group of children with peanut allergy who were specifically sensitized to the basic subunit of Ara h 3. Although, proteomic analysis of total peanut s...
Source: Inflammation and Allergy Drug Targets - September 1, 2008 Category: Allergy & Immunology Authors: Guo B, Liang X, Chung SY, Maleki SJ Tags: Inflamm Allergy Drug Targets Source Type: journals

Effects of sublingual immunotherapy on allergic inflammation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The clinical expression of the most common allergic diseases reflects allergic inflammation and underlines that inflammation is the main target of anti-allergic therapies. Allergen specific immunotherapy (AIT) has a recognized impact on allergic inflammation, which persists after its discontinuation, and is the only therapy able to modify the natural history of allergic march. The traditional, subcutaneous route of administration is effective in altering the phenotype of allergen-specific T cells, switching from a Th2-type response, characterized by the production of IL-4, IL-5, IL-13, IL-17, and IL-32 cytokines to a T...
Source: Inflammation and Allergy Drug Targets - September 1, 2008 Category: Allergy & Immunology Authors: Incorvaia C, Frati F, Puccinelli P, Marcucci F, Di Cara G, Sensi L, Scurati S, Yacoub MR, Moingeon P Tags: Inflamm Allergy Drug Targets Source Type: journals

Non-IgE Mediated Food Allergy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Adverse reactions to dietary proteins (DPs) can impose a significant impact on one's daily life and can even affect the 'life style' of an entire family. Adverse reactions to DPs may or may not be immune-mediated. The immune-mediated adverse reaction to food is defined as food allergy (FA) which is roughly divided into IgE mediated or non-IgE mediated FA (NFA). As opposed to IgE mediated FA, NFA primarily affects the GI mucosa. In addition, there is far less of an understanding of NFA than IgE-mediated FA and its clinical relevance is likely under-estimated in most cases. This is partly due to delayed onset of symptoms...
Source: Inflammation and Allergy Drug Targets - September 1, 2008 Category: Allergy & Immunology Authors: Jyonouchi H Tags: Inflamm Allergy Drug Targets Source Type: journals

Innovative Therapeutic Strategies for Restoring Lymphocyte Functions in Septic Patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Septic syndromes still remain a major but largely under-recognized healthcare problem worldwide accounting for thousands of deaths every year. Despite numerous clinical trials, therapies have failed to mitigate the devastating effects of these conditions. It is now agreed that the initial hypotheses for sepsis pathophysiology have been misconstrued. Sepsis deeply perturbs immune homeostasis by concomitantly inducing a strong inflammatory response and a major anti-inflammatory process, acting as a negative feedback. Several lines of evidences indicate that this inhibitory response secondly may be deleterious in patients...
Source: Inflammation and Allergy Drug Targets - September 1, 2008 Category: Allergy & Immunology Authors: Turrel1 F, Guignant C, Venet F, Lepape A, Monneret G Tags: Inflamm Allergy Drug Targets Source Type: journals

Cytokines in colitis associated cancer: potential drug targets?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In inflammatory bowel disease (IBD), such as UC and CD, the development of colorectal carcinoma can be initiated through chronic inflammation, depending on the duration and severity of the disease. Growing evidence supports a role for various cytokines, released by epithelial and immune cells, in the pathogenesis of colitis associated cancer (CAC). For instance, TNF-alpha has been recently shown to promote tumor development in experimental colitis. Due to its role in the pathogenesis of IBD, TNF-alpha blockade has become one of the cornerstones of IBD therapy. Thus, anti-TNF-alpha strategies could also provide effectiv...
Source: Inflammation and Allergy Drug Targets - September 1, 2008 Category: Allergy & Immunology Authors: Waldner MJ, Neurath MF Tags: Inflamm Allergy Drug Targets Source Type: journals

Lead Compounds for Anti-inflammatory Drugs Isolated from the Plants of the Traditional Oriental Medicine in Korea.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Effects of compounds isolated from medicinal plants in Korea on prostaglandin E(2) (PGE(2)) production in rat peritoneal macrophages were examined, and mechanism of action of the active constituents was analyzed. The active constituents were as follows; tectorigenin and tectoridin isolated from the rhizomes of Belamcanda chinensis, platycodin D isolated from the roots of Platycodon grandiflorum, imperatorin isolated from the roots of Angelica dahurica, and hyperin isolated from the roots of Acanthopanax chiisanensis. These compounds inhibit the induction of cyclooxygenase-2 (COX-2), thus inhibiting PGE(2) production. T...
Source: Inflammation and Allergy Drug Targets - September 1, 2008 Category: Allergy & Immunology Authors: Hong J, Shin KH, Lim SS, Kwak JH, Zee O, Ishihara K, Hirasawa N, Seyama T, Ohuchi K Tags: Inflamm Allergy Drug Targets Source Type: journals

Therapeutic benefits of regulating inflammation in autoimmunity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Autoimmunity results from the dysregulation of the immune system leading to tissue damage. Th1 and Th17 cells are known to be cellular mediators of inflammation in autoimmune diseases. The specific cytokine milieu within the site of inflammation or within secondary lymphatic tissues is important during the priming and effector phases of T cell response. In this review, we will address the nature of the inflammatory response in the context of autoimmune disease, specifically we will discuss the role of dendritic cells following stimulation of their innate pathogen recognition receptors in directing the development of T ...
Source: Inflammation and Allergy Drug Targets - September 1, 2008 Category: Allergy & Immunology Authors: Nikoopour E, Schwartz JA, Singh B Tags: Inflamm Allergy Drug Targets Source Type: journals