Novel ZBTB24 Mutation Associated with Immunodeficiency, Centromere Instability, and Facial Anomalies Type-2 Syndrome Identified in a Patient with Very Early Onset Inflammatory Bowel Disease
Conclusion:
This describes the first case of inflammatory bowel disease associated with immunodeficiency, centromere instability, and facial anomalies type-2 syndrome in a child with a novel disease-causing mutation in ZBTB24 found on whole-exome sequencing. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - December 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Real-world Experience of Anti–tumor Necrosis Factor Therapy for Internal Fistulas in Crohn's Disease: A Retrospective Multicenter Cohort Study
Conclusions:
In the present retrospective cohort study, approximately half of patients with internal fistulas avoided surgery for long periods. It may be reasonable to treat quiescent single internal fistulas with anti-TNF agents soon after the diagnosis of internal fistulas. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - December 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Impact of Histological and Endoscopic Remissions on Clinical Recurrence and Recurrence-free Time in Ulcerative Colitis
Conclusion:
The presence of histological activity represents an independent predictive factor of recurrence and time to recurrence, which was not verified with MSe 0 to 1. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - December 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Subcutaneous Golimumab in Pediatric Ulcerative Colitis: Pharmacokinetics and Clinical Benefit
We report a multicenter, open-label study of golimumab with a pharmacokinetics phase (week 0–14). Patients had moderately-to-severely active UC and were naive to anti-tumor necrosis factor treatment. At weeks 0 and 2, patients received golimumab induction dosed by weight ( (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - December 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Bone Mass Development from Childhood into Young Adulthood in Patients with Childhood-onset Inflammatory Bowel Disease
Conclusions:
Male patients with childhood-onset IBD seem to have an increased risk of compromised BMD in young adulthood. Both female and male patients with IBD seem to increase their BMD beyond the age for expected peak bone mass (see Video abstract, Supplemental Digital Content 1, http://links.lww.com/IBD/B648). (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - December 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Metronidazole or Rifaximin for Treatment of Clostridium difficile in Pediatric Patients with Inflammatory Bowel Disease: A Randomized Clinical Trial
Conclusions:
Metronidazole and rifaximin were similarly effective treatments for CDI in pediatric patients with IBD. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - December 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Antibodies Toward Vedolizumab Appear from the First Infusion Onward and Disappear Over Time
Conclusions:
AVA appear from the first VDZ infusion onward and disappear over time. The low prevalence of AVA suggests that immunogenicity does not influence response to treatment. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - December 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Surgical Outcomes in Vedolizumab-Treated Patients with Ulcerative Colitis
Conclusions:
Vedolizumab patients had significantly increased rates of superficial SSI, but not overall infectious complications. Among ileal pouch anal anastomosis patients, peripouch abscess rates were increased among vedolizumab-treated patients, but this did not reach statistical significance. Vedolizumab seems safe in the perioperative period for patients with UC. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - December 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Minority Pediatric Patients with Inflammatory Bowel Disease Demonstrate an Increased Length of Stay
Background:
Genetic and other biological factors may lead to differences in disease behavior among children with inflammatory bowel disease of different races, which may be further modified by disparities in care delivery. Using the Kids' Inpatient Database, we aimed to evaluate differences in the management of pediatric patients with inflammatory bowel disease by race, focusing on length of stay (LOS).
Methods:
We performed a cross-sectional analysis using 2000 to 2012 data from the Kids' Inpatient Database, a nationally representative database. We identified pediatric patients (≤18 years of age) with discharge dia...
Source: Inflammatory Bowel Diseases - December 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Lasting Impact of Clostridium difficile Infection in Inflammatory Bowel Disease: A Propensity Score Matched Analysis
Background:
Patients with inflammatory bowel disease are at an increased risk of Clostridium difficile infection (CDI), but the impact of CDI on disease severity is unclear. The aim of this study was to determine the effect of CDI on long-term disease outcome in a matched cohort of patients with inflammatory bowel disease.
Methods:
Patients who tested positive for infection formed the CDI-positive group. We generated a 1:2 propensity matched case to control cohort based on risk factors for CDI in the year before infection. Health care utilization data (emergency department use, hospitalizations, and telephone encounte...
Source: Inflammatory Bowel Diseases - December 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Tissue Drug Concentrations of Anti-tumor Necrosis Factor Agents Are Associated with the Long-term Outcome of Patients with Crohn's Disease
Conclusions:
Concentrations of anti-TNF agents in the noninflamed tissue can reflect sustained remission and may be a useful biomarker for monitoring therapeutic intensity in patients with Crohn's disease treated with anti-TNF agents (see Video Abstract, Supplemental Digital Content 1, http://links.lww.com/IBD/B623). (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - December 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Serum Hepcidin in Children with Inflammatory Bowel Disease
Conclusions:
In our study, serum hepcidin concentration was significantly decreased in IBD children compared with controls. Hepcidin correlated positively with ferritin, but not with any of inflammatory markers. It may suggest that in our cohort, hepcidin was regulated predominantly by iron storage level. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - December 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Phenotype and Management of Infantile-onset Inflammatory Bowel Disease: Experience from a Tertiary Care Center in China
Conclusions:
Patients with infantile-onset IBD had severe phenotype and early onset. Medical, surgical interventions with supportive care are essential. High-throughput sequencing ensures appropriate treatment. Hematopoietic stem cell transplantation can be performed in selected patients with IL10RA mutations (see Video Abstract, Supplemental Digital Content 1, http://links.lww.com/IBD/B657). (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - December 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Impact of Prostate Cancer and Its Treatment on the Outcomes of Ileal Pouch-Anal Anastomosis
Conclusions:
The risk of pouch failure may be increased after the diagnosis of prostate cancer with or without treatment. However, for those with retained pouches, their pouch function and QOL did not seem to be adversely affected. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - December 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Obese Patients Undergoing Ileal Pouch–Anal Anastomosis: Short-and Long-term Surgical Outcomes
Background:
Ileal pouch–anal anastomosis (IPAA) is the preferred surgical treatment for patients with chronic ulcerative colitis. Little is known about the impact of obesity on operative characteristics, short-term postoperative complications and long-term functional outcomes after IPAA.
Methods:
A retrospective review of all patients undergoing IPAA for chronic ulcerative colitis at a single tertiary referral center between January 2002 and August 2013 was performed. Thirty-day postoperative complications and long-term functional outcomes were analyzed according to body mass index.
Results:
Nine hundred nine IPA...
Source: Inflammatory Bowel Diseases - December 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
