Elongated particulate burden in an individual who died of mesothelioma and had an occupational history as a talc "mucker"
CONCLUSIONS: The correlation between the unique asbestos mineral/fibrous content of the talc to which he was exposed and findings of the same type of asbestos found in his lung is discussed. The type of asbestos found (tremolite) is a "non-commercial" type of asbestos that has been identified in some talc deposits. Tremolite, like all forms of asbestos is a causative agent for mesothelioma-the disease from which this individual suffered.PMID:38502172 | DOI:10.1080/08958378.2024.2329935 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - March 19, 2024 Category: Respiratory Medicine Authors: Ronald F Dodson Jacqueline Moline Carlos D Salinas Lee W Poye Source Type: research

Evaluation of neural reflex activation as a potential mode of action for respiratory and cardiovascular effects of fine particulate matter
CONCLUSIONS: Further studies are needed to determine whether neural reflex activation is the MoA by which PM2.5 could cause either respiratory or cardiovascular morbidities in humans, particularly at the ambient concentrations associated with total mortality in epidemiology studies.PMID:38488087 | DOI:10.1080/08958378.2024.2324033 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - March 15, 2024 Category: Respiratory Medicine Authors: Robyn L Prueitt Cassandra J Meakin Nicholas L Drury Julie E Goodman Source Type: research

Crystalline silica-induced pulmonary inflammation and autoimmunity in mature adult NZBW/f1 mice: age-related sensitivity and impact of omega-3 fatty acid intervention
CONCLUSION: These results highlight life-stage significance in this preclinical lupus model and underscore omega-3 fatty acids' therapeutic potential against toxicant-triggered autoimmune responses.PMID:38477125 | DOI:10.1080/08958378.2024.2318378 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - March 13, 2024 Category: Respiratory Medicine Authors: Lauren K Heine Tasha Scarlett James G Wagner Ryan P Lewandowski Abby D Benninghoff Ashleigh N Tindle Anna E Skedel Jack R Harkema James J Pestka Source Type: research

Biological effects of diesel exhaust inhalation. III cardiovascular function
CONCLUSIONS: Based on the results of this study, we suggest that exposure to DE generated by a Tier 2 compliant diesel engine generates acute effects on biomarkers indicative of cardiovascular dysfunction. Recovery occurs quickly with most measures of vascular/cardiovascular function returning to baseline levels by 7d following exposure.PMID:38466202 | DOI:10.1080/08958378.2024.2327364 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - March 11, 2024 Category: Respiratory Medicine Authors: Kristine Krajnak Hong Kan Janet A Thompson Walter McKinney Stacey Waugh Tim South Dru Burns Ryan Lebouf Jared Cumpston Theresa Boots Jeffrey S Fedan Source Type: research