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PTX3 as a potential biomarker of acute lung injury: supporting evidence from animal experimentationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  These results support the clinical finding that PTX3 may be a useful biomarker to the reflect severity of lung injury and provide effective therapies. The interplay between PTX3 and TF could be a potential mechanism that mediates lung injury. Content Type Journal ArticleCategory ExperimentalDOI 10.1007/s00134-009-1720-0Authors Xiaolin He, University Health Network Latner Thoracic Surgery Research Laboratory, Toronto General Research Institute Toronto ON CanadaBing Han, University Health Network Latner Thoracic Surgery Research Laboratory, Toronto General Research Institute Toronto ON CanadaX...
Source: Intensive Care Medicine - November 18, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

An intervention to decrease complications related to endotracheal intubation in the intensive care unit: a prospective, multiple-center studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  The implementation of an intubation management protocol can reduce immediate severe life-threatening complications associated with intubation of ICU patients. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1717-8Authors Samir Jaber, Université Montpellier 1 Intensive Care Unit, Anesthesia and Critical Care Department B: DAR B, CHU de Montpellier, Saint Eloi Teaching Hospital 80 avenue Augustin Fliche 34295 Montpellier Cedex 5 FranceBoris Jung, Université Montpellier 1 Intensive Care Unit, Anesthesia and Critical Care Department B: DAR B, CHU de Montpellier, Saint Eloi...
Source: Intensive Care Medicine - November 18, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Effects of reducing beta-lactam antibiotic pressure on intestinal colonization of antibiotic-resistant gram-negative bacteriaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  A 35–39% reduction of β-lactam exposure was not associated with reduced acquisition of CRE, whereas a 243% increase of fluoroquinolone use increased acquisition of FCRE. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1714-yAuthors Saskia Nijssen, St. Elisabethziekenhuis Department of Medical Microbiology Hilvarenbeekse Weg 60 5022 GC Tilburg The NetherlandsAd Fluit, University Medical Center Utrecht Department of Medical Microbiology, Julius Center for Health Sciences and Primary Care Heidelberglaan 100 3584 CX Utrecht The NetherlandsDavid van de Vijver, Erasmus Medic...
Source: Intensive Care Medicine - November 18, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

A successful new method for removal of a large foreign body from the airways of an ARDS patientemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-009-1716-9Authors Veronique Leray, CHU Croix Rousse Medical Intensive Care Unit 103 grande rue de la Croix Rousse 69004 Lyon FrancePascale Nesme, Hôpital de la Croix Rousse, CHU de Lyon Service de Pneumologie Lyon FranceGuillaume Landry, Hôpital de la Croix Rousse, CHU de Lyon Service de Chirurgie ORL Lyon FranceBertrand Pons, Hôpital de la Croix Rousse, CHU de Lyon Service de Réanimation Médicale Lyon FranceJean-christian Pignat, Hôpital de la Croix Rousse, CHU de Lyon Service de Chirurgie ORL Lyon FranceClaude Guerin, Hôpital de la Croix Rou...
Source: Intensive Care Medicine - November 18, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Prevention of acute kidney injury and protection of renal function in the intensive care unitemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions and recommendations  Several measures are recommended, though none carries grade 1A. We recommend prompt resuscitation of the circulation with special attention to providing adequate hydration whilst avoiding high-molecular-weight hydroxy-ethyl starch (HES) preparations, maintaining adequate blood pressure using vasopressors in vasodilatory shock. We suggest using vasopressors in vasodilatory hypotension, specific vasodilators under strict hemodynamic control, sodium bicarbonate for emergency procedures administering contrast media, and periprocedural hemofiltration in severe chronic renal in...
Source: Intensive Care Medicine - November 18, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Clinical guidelines for the protection of kidney function and prevention of acute kidney injury in the intensive care unit: common sense rather than magic bullets?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s00134-009-1683-1Authors Andrew Davenport, University College London Medical School UCL Center for Nephrology, Royal Free Campus Rowland Hill Street London NW3 2PF UK Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - November 18, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Open the doors of the ICU to patients with malignancies and neurological complicationsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s00134-009-1713-zAuthors Michael Piagnerelli, Erasme University Hospital, Université Libre de Bruxelles Department of Intensive Care 808, route de Lennik 1070 Brussels BelgiumBenjamin Legros, Erasme University Hospital, Université Libre de Bruxelles Department of Neurology 808, route de Lennik 1070 Brussels Belgium Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - November 11, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Central neurological complications in critically ill patients with malignanciesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  In cancer patients, central neurological events are mainly related to malignant brain infiltration and drug-related toxicity. Despite advanced severity, a standardized intensive management strategy yields a 55% hospital survival rate. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1709-8Authors Stéphane Legriel, Hôpital Saint-Louis Medical Intensive Care Unit, AP-HP 75010 Paris FranceHélène Marijon, Hôpital Saint-Louis Medical Intensive Care Unit, AP-HP 75010 Paris FranceMichael Darmon, Hôpital Saint-Louis Medical Intensive Care Unit, AP-HP 75010 Paris FranceVirgin...
Source: Intensive Care Medicine - November 11, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Obstetric intensive care unit admission: a 2-year nationwide population-based cohort studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Population-based incidence of obstetric ICU admission in the Netherlands was 2.4 per 1,000 deliveries. Obstetric ICU admission accounts for only one-third of all cases of severe maternal morbidity in the Netherlands. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1707-xAuthors Joost J. Zwart, Leiden University Medical Centre Department of Obstetrics, K6-P-35 P.O. Box 9600 2300 RC Leiden The NetherlandsJust R. O. Dupuis, Leiden University Medical Centre Department of Obstetrics, K6-P-35 P.O. Box 9600 2300 RC Leiden The NetherlandsAnnemiek Richters, Leiden University Medi...
Source: Intensive Care Medicine - November 9, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Does PELOD measure organ dysfunction…and is organ function a valid surrogate for death?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s00134-009-1712-0Authors Shane M. Tibby, Guy’s and St Thomas’ NHS Foundation Trust Paediatric Intensive Care Unit, Evelina Children’s Hospital Westminster Bridge Road London SE1 7EH UK Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - November 9, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Semi-recumbent position and body mass percentiles: effects on intra-abdominal pressure measurements in critically ill childrenemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  Patient position should be considered when interpreting IAP. BMI did not influence IAP measurements in children. Content Type Journal ArticleCategory Pediatric OriginalDOI 10.1007/s00134-009-1708-9Authors Janeth Chiaka Ejike, Loma Linda University Department of Pediatrics, School of Medicine 11175 Campus Street, Suite A1117 Loma Linda CA 92354 USAJose Kadry, Loma Linda University School of Nursing, Children’s Hospital Loma Linda USAKhaled Bahjri, Loma Linda University Department of Epidemiology and Biostatistics, School of Public Health Loma Linda CA USAMudit Mathur, Loma Linda University D...
Source: Intensive Care Medicine - November 6, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

A retrospective analysis on the impact of caloric intake on glycemic control in critically ill patientsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-009-1679-xAuthors Yuen Ting Lau, Detroit Receiving Hospital Department of Pharmacy Services 4201 St. Antoine Blvd Detroit MI 48201 USALance J. Oyen, Hospital Pharmacy Services, Mayo Clinic-Rochester 200 First St. S.W. Rochester MN 55905 USAMichael Malinchoc, Mayo Clinic-Rochester Department of Biostatistics 200 First St. S.W. Rochester MN 55905 USAChristopher J. Arendt, Hospital Pharmacy Services, Mayo Clinic-Rochester 200 First St. S.W. Rochester MN 55905 USAMelissa M. Barth, Mayo Clinic-Rochester Department of Nursing 1216 Second Street SW Rocheste...
Source: Intensive Care Medicine - November 5, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

The impact of crystalloid and colloid infusion on the kidney in rodent sepsisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  None of the examined volume solution was inert to the kidney. In a CLP rodent sepsis model, animals infused with balanced crystalloid SteroIso exhibited the least effects on kidney function. Both hydroxyethyl starch 6% 130/0.4 and gelatin 4% derogated the kidney, whereas gelatin was more harmful when compared with hydroxyethyl starch. Content Type Journal ArticleCategory ExperimentalDOI 10.1007/s00134-009-1704-0Authors Martin Alexander Schick, University of Würzburg Klinik und Poliklinik für Anästhesiologie, Zentrum für Operative Medizin Oberdürrbacherstrasse 6 97080 Würzburg GermanyT...
Source: Intensive Care Medicine - November 4, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Organ dysfunction is associated with hyperglycemia in critically ill childrenemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Organ dysfunction (≥3 versus <3) was significantly associated with hyperglycemia for ≥24 h and hypoglycemia. Hyperglycemia trended toward significance with mortality in critically ill children. There was no association between hypoglycemia and mortality. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1703-1Authors Ursula G. Kyle, Baylor College of Medicine Pediatric Critical Care Medicine, Texas Children’s Hospital 6621 Fannin, WT6-006 Houston Texas 77030 USAJorge A. Coss Bu, Baylor College of Medicine Pediatric Critical Care Medicine, Texas Children’s H...
Source: Intensive Care Medicine - October 31, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Ultrasound-guided arterial catheterization: a narrative reviewemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Arterial catheterization is the second most common invasive procedure performed in the intensive care unit. Despite the ubiquity of the procedure, complications including failure to place the catheter occur. While many clinicians are familiar with the use of ultrasound (US) guidance to decrease complication rates of central venous catheter insertion, fewer are familiar with the use of ultrasound to guide arterial catheterization. This manuscript reviews the evidence for the utility of ultrasound for this indication. Technical aspects of the procedure and limitations of the existing evidence are revi...
Source: Intensive Care Medicine - October 31, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Mortality in very long-stay pediatric intensive care unit patients and incidence of withdrawal of treatmentemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Children with prolonged stay in the PICU have a significantly high risk of mortality. Death is typically preceded by limitation of care. Content Type Journal ArticleCategory Pediatric OriginalDOI 10.1007/s00134-009-1693-zAuthors Sara Naghib, Erasmus Medical Centre, Sophia Children’s Hospital Department of Intensive Care P.O. Box 2060 3000 CB Rotterdam The NetherlandsCynthia van der Starre, Erasmus Medical Centre, Sophia Children’s Hospital Department of Intensive Care P.O. Box 2060 3000 CB Rotterdam The NetherlandsSaskia J. Gischler, Erasmus Medical Centre, Sophia Children’s Hospital ...
Source: Intensive Care Medicine - October 23, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injuryemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Higher PAI-1 levels are associated with increased mortality and fewer ventilator-free days among pediatric patients with ALI. These findings suggest that impaired fibrinolysis may play a role in the pathogenesis of ALI in pediatric patients and suggest that PAI-1 may serve as a useful biomarker of prognosis in patients with ALI. Content Type Journal ArticleCategory ExperimentalDOI 10.1007/s00134-009-1690-2Authors Anil Sapru, University of California, San Francisco Division of Critical Care Medicine, Department of Pediatrics Box 0106 San Francisco CA 94143 USAMartha A. Q. Curley, University...
Source: Intensive Care Medicine - October 23, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Reply to Dubinemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-009-1682-2Authors Marcio Manozzo Boniatti, Hospital de Clínicas de Porto Alegre-Critical Care Ramiro Barcellos Porto Alegre 90670090 BrazilPaulo Ricardo Cerveira Cardoso, Hospital de Clínicas de Porto Alegre-Critical Care Ramiro Barcellos Porto Alegre 90670090 BrazilRodrigo Kappel Castilho, Hospital de Clínicas de Porto Alegre-Critical Care Ramiro Barcellos Porto Alegre 90670090 BrazilSilvia Regina Rios Vieira, Hospital de Clínicas de Porto Alegre-Critical Care Ramiro Barcellos Porto Alegre 90670090 Brazil Journal Intensive Care MedicineOn...
Source: Intensive Care Medicine - October 23, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Improving acid–base evaluation: the proper use of the old toolsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-009-1680-4Authors Arnaldo Dubin, Universidad Nacional de La Plata Cátedra de Farmacología Aplicada, Facultad de Ciencias Médicas Calle 42 no. 577 La Plata Buenos Aires 1900 ArgentinaFabio D. Masevicius, Sanatorio Otamendi y Miroli Servicio de Terapia Intensiva Buenos Aires Argentina Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 23, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Dilutional acidosis or uncovered cellular metabolism?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s00134-009-1700-4Authors Andrew Davenport, University College London Medical School Center for Nephrology Royal Free Campus, Rowland Hill Street London NW3 2PF UK Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 22, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

The influence of the airway driving pressure on pulsed pressure variation as a predictor of fluid responsivenessemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  In patients mechanically ventilated with low VT, PPV values <13% do not rule out fluid responsiveness, especially when (Pplat − PEEP) is ≤20 cmH2O. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1686-yAuthors Laurent Muller, Groupe Hospitalo-Universitaire Caremeau, CHU Nîmes Division Anesthésie Réanimation Douleur Urgences Place du Professeur Robert Debré 30029 Nîmes Cedex 9 FranceGuillaume Louart, Groupe Hospitalo-Universitaire Caremeau, CHU Nîmes Division Anesthésie Réanimation Douleur Urgences Place du Professeur Robert Debré 30029 Nîmes...
Source: Intensive Care Medicine - October 21, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

The bispectral index and suppression ratio are very early predictors of neurological outcome during therapeutic hypothermia after cardiac arrestemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  In our single-center cohort utilizing moderate sedation, the bispectral index and suppression ratio recorded after the first dose of intermittent neuromuscular blockade were accurate and very early predictors of neurological outcome during therapeutic hypothermia after cardiac arrest. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1691-1Authors David B. Seder, Maine Medical Center Neuroscience Institute 22 Bramhall St Portland ME 04102 USAGilles L. Fraser, Maine Medical Center Neuroscience Institute 22 Bramhall St Portland ME 04102 USATracy Robbins, Maine Medical Cente...
Source: Intensive Care Medicine - October 21, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Moderate hypothermia with intracranial pressure monitoring as a therapeutic paradigm for the management of acute liver failure: a systematic reviewemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Limited data exist concerning the safety and efficacy of moderate hypothermia and ICP monitoring for the treatment of ICH in acute liver failure. The available evidence shows that induction of moderate hypothermia in this clinical setting is feasible and possibly efficacious. Well-designed prospective clinical trials are warranted in this challenging context, given the potential of providing a bridge to liver transplantation or even clinical recovery. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00134-009-1702-2Authors Dayton Dmello, Saint Louis University School of Medicine Di...
Source: Intensive Care Medicine - October 21, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

F-18-fluorodeoxyglucose positron emission tomography combined with CT in critically ill patients with suspected infectionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  FDG-PET/CT scanning is of additional value in the evaluation of suspected infection in critically ill patients in whom conventional diagnostics did not lead to a diagnosis. Apart from the high accuracy, in this study it appeared that, in addition to conventional diagnostic techniques that were routinely performed, a normal FDG-PET/CT ruled out important infections requiring prolonged antibiotic therapy or drainage. Since sensitivity is lower in highly metabolic active tissues (e.g., endocarditis, meningitis), the FDG-PET/CT scan is not suited to detect infections in these tissues. Content ...
Source: Intensive Care Medicine - October 21, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Incidence and prognosis of dysnatremias present on ICU admissionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Our results suggest that both hypo- and hypernatremia present on admission to the ICU are independent risk factors for poor prognosis. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1692-0Authors Georg-Christian Funk, Otto Wagner Spital Department of Respiratory and Critical Care Medicine Vienna AustriaGregor Lindner, Medical University of Vienna Department of Anesthesiology and General Intensive Care Medicine Währingergürtel 18-20 1090 Vienna AustriaWilfred Druml, Medical University of Vienna Department of Nephrology and Dialysis Vienna AustriaBarbara Metnitz, Medica...
Source: Intensive Care Medicine - October 21, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Blunting the response to endotoxin in healthy subjects: effects of various doses of intravenous fish oilemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Having previously shown that the response to LPS was reproducible, this study shows that three FO doses blunted it to various degrees. The 0.2 g/kg perfusion immediately before LPS was the most efficient in blunting the responses, suggesting LPS capture in addition to the systemic and membrane effects. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1689-8Authors Yann K. Pittet, CHUV Service of Adult Intensive Care Medicine and Burns Centre 1011 Lausanne SwitzerlandMette M. Berger, CHUV Service of Adult Intensive Care Medicine and Burns Centre 1011 Lausanne Switzer...
Source: Intensive Care Medicine - October 21, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Acute gastrointestinal bleeding due to oesophageal varices: an unusual case of a thoracic spleenemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-009-1696-9Authors Gerrit C. Hagenah, Georg-August University of Goettingen Medical School Department of Nephrology and Rheumatology Robert-Koch Str. 40 37075 Göttingen GermanyJens-Gerd Scharf, Georg-August University of Goettingen Medical School Department of Gastroenterology and Endocrinology Göttingen GermanyAlexander Emmert, Georg-August University of Goettingen Medical School Department of Thoracic and Cardiovascular Surgery Göttingen GermanyB. Michael Ghadimi, Georg-August University of Goettingen Medical School Department of General Surgery ...
Source: Intensive Care Medicine - October 21, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Value of procalcitonin for diagnosis of early onset pneumonia in hypothermia-treated cardiac arrest patientsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  The diagnostic value of PCT is poor after cardiac arrest and should not be performed to assess early onset pneumonia. The post-resuscitation disease itself could play a major role in this lack of specificity and predictive value. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1681-3Authors Nicolas Mongardon, Cochin Hospital, AP-HP Medical Intensive Care Unit 27 rue du Faubourg Saint-Jacques 75679 Paris Cedex 14 FranceVirginie Lemiale, Cochin Hospital, AP-HP Medical Intensive Care Unit 27 rue du Faubourg Saint-Jacques 75679 Paris Cedex 14 FranceSébastien Perbet, Cochin ...
Source: Intensive Care Medicine - October 21, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Early physiological and biological features in three animal models of induced acute lung injuryemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  The early responses to direct or remote lung insult in our three models of ALI captured different physiological and biological features that could lead to respiratory and/or multiorgan failure. Content Type Journal ArticleCategory ExperimentalDOI 10.1007/s00134-009-1695-xAuthors Josefina López-Aguilar, Corporació Parc Taulí, Institut Universitari, Esfera UAB Critical Care Center, Hospital de Sabadell Parc Taulí s/n 08208 Sabadell SpainMaría Elisa Quilez, Corporació Parc Taulí, Institut Universitari, Esfera UAB Critical Care Center, Hospital de Sabadell Parc Taulí s/n 08208 Sabadell ...
Source: Intensive Care Medicine - October 21, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Reply to Auzinger et al.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-009-1676-0Authors Alessandro Protti, Università degli Studi di Milano, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche Via F. Sforza 35 20122 Milan ItalyLuciano Gattinoni, Università degli Studi di Milano, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche Via F. Sforza 35 20122 Milan Italy Journal Intensive Care MedicineOnline ISSN 1432-1238Pr...
Source: Intensive Care Medicine - October 20, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Why we need guidelines and recommendations for research on intra-abdominal hypertensionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-009-1677-zAuthors Manu L. N. G. Malbrain, Ziekenhuis Netwerk Antwerpen, ZNA Stuivenberg Department of Intensive Care Lange Beeldekensstraat 267 2060 Antwerpen BelgiumInneke De laet, Ziekenhuis Netwerk Antwerpen, ZNA Stuivenberg Department of Intensive Care Lange Beeldekensstraat 267 2060 Antwerpen Belgium Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 20, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Delayed colopericardial fistula and pyopneumopericardiumemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-009-1701-3Authors François Jouret, Cliniques Universitaires Saint-Luc, Université catholique de Louvain Department of Intensive Care Medicine Avenue Hippocrate, 10 1200 Brussels BelgiumDiego Castanares-Zapatero, Cliniques Universitaires Saint-Luc, Université catholique de Louvain Department of Intensive Care Medicine Avenue Hippocrate, 10 1200 Brussels BelgiumPierre-François Laterre, Cliniques Universitaires Saint-Luc, Université catholique de Louvain Department of Intensive Care Medicine Avenue Hippocrate, 10 1200 Brussels Belgium Journa...
Source: Intensive Care Medicine - October 20, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Comment on “Relationship between gas exchange response to prone position and lung recruitability during acute respiratory failure”email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-009-1674-2Authors Georg Auzinger, King’s College Hospital, Institute of Liver Studies Denmark Hill London SE5 9RS UKWilliam Bernal, King’s College Hospital, Institute of Liver Studies Denmark Hill London SE5 9RS UKJulia Wendon, King’s College Hospital, Institute of Liver Studies Denmark Hill London SE5 9RS UK Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 20, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

The ongoing H1N1 flu pandemic and the intensive care community: challenges, opportunities, and the duties of scientific societies and intensivistsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s00134-009-1706-yAuthors Rui P. Moreno, Centro Hospitalar de Lisboa Central, E.P.E Unidade de Cuidados Intensivos Polivalente, Hospital de St. António dos Capuchos Lisbon PortugalAndrew Rhodes, St George’s Healthcare NHS Trust Department of Intensive Care Medicine London SW17 0QT UKJean-Daniel Chiche, Université Paris Descartes Service de Réanimation Médicale, Hôpital Cochin (AP-HP) Unité Inserm U567 75014 Paris France Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 20, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Reply to Malbrain and de Laetemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-009-1675-1Authors Andreas Umgelter, Technische Universität München II. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar Ismaningerstr. 22 81675 Munich GermanyValentin Becker, Technische Universität München II. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar Ismaningerstr. 22 81675 Munich Germany Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 20, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

The effects of vasopressin on acute kidney injury in septic shockemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Vasopressin may reduce progression to renal failure and mortality in patients at risk of kidney injury who have septic shock. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1687-xAuthors Anthony C. Gordon, Imperial College NHS Trust Intensive Care Unit, Charing Cross Hospital Fulham Palace Road London W6 8RF UKJames A. Russell, University of British Columbia iCAPTURE Centre, St. Paul’s Hospital Vancouver CanadaKeith R. Walley, University of British Columbia iCAPTURE Centre, St. Paul’s Hospital Vancouver CanadaJoel Singer, University of British Columbia Department of ...
Source: Intensive Care Medicine - October 20, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Do we need to know body anthropomorphic data whilst measuring abdominal pressure?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-009-1685-zAuthors Manu L. N. G. Malbrain, ZiekenhuisNetwerk Antwerpen, ZNA Stuivenberg Department of Intensive Care Lange Beeldekensstraat 267 2060 Antwerp BelgiumInneke De laet, ZiekenhuisNetwerk Antwerpen, ZNA Stuivenberg Department of Intensive Care Lange Beeldekensstraat 267 2060 Antwerp Belgium Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 20, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Prognostic factors in non-exertional heatstrokeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  We observed a low survival rate and developed a risk score based on easily obtained variables that may be useful to clinicians managing casualties from future heat waves. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1694-yAuthors Pierre Hausfater, Centre Hospitalo-Universitaire (CHU) Pitié-Salpêtrière, Assistance-Publique Hôpitaux de Paris Emergency Department Paris FranceBruno Megarbane, Centre Hospitalo-Universitaire (CHU) Lariboisière, Assistance-Publique Hôpitaux de Paris Critical Care Department Paris FranceSandrine Dautheville, Centre Hospitalo-Universitai...
Source: Intensive Care Medicine - October 20, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Secondary decline of cerebral autoregulation is associated with worse outcome after intracerebral hemorrhageemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Cerebral autoregulation is primarily preserved in acute ICH, but a secondary decline mainly ipsilateral to the ICH can occur. This is associated with poor clinical status, ventricular hemorrhage, lower cerebral perfusion pressure and worse clinical outcome. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1698-7Authors Matthias Reinhard, University of Freiburg Department of Neurology, Neurocenter Breisacherstr. 64 79106 Freiburg GermanyFlorian Neunhoeffer, University of Freiburg Department of Neurology, Neurocenter Breisacherstr. 64 79106 Freiburg GermanyThomas A. Gerds,...
Source: Intensive Care Medicine - October 16, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Non-invasive management of acute respiratory distress syndrome related to Influenza A (H1N1) virus pneumonia in a pregnant womanemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-009-1684-0Authors Michel Djibré, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie Service de Pneumologie et Réanimation, Hôpital Tenon 4 Rue de la Chine 75020 Paris FranceNadia Berkane, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie Service de Gynécologie Obstétrique, Hôpital Tenon 4 Rue de la Chine 75020 Paris FranceAnne Salengro, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie Département d’Anesthésie et Réanimation Chirurgicale, Hôpital Tenon 4 Rue de la Chin...
Source: Intensive Care Medicine - October 10, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Thyroid hormone and cortisol concentrations after congenital heart surgery in infants younger than 3 months of ageemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Infants <3 months of age with low tri-iodothyronine or high cortisol concentration on PICU admission have a more complicated PICU course. Low cortisol concentration is common in the early postoperative period, but is not associated with postoperative complications. Content Type Journal ArticleCategory Pediatric OriginalDOI 10.1007/s00134-009-1648-4Authors Kevin R. Plumpton, Starship Children’s Hospital Park Road, Grafton Private Bag 92024 Auckland New ZealandBrian J. Anderson, Starship Children’s Hospital Park Road, Grafton Private Bag 92024 Auckland New ZealandJohn Beca, Stars...
Source: Intensive Care Medicine - October 7, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Lung recruitment assessed by total respiratory system input reactanceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  These results suggest that FOT and the measurement of C X5 could be a useful tool for the non-invasive measurement of lung volume recruitment/derecruitment. Content Type Journal ArticleCategory ExperimentalDOI 10.1007/s00134-009-1673-3Authors Raffaele L. Dellaca, Politecnico di Milano University Dipartimento di Bioingegneria Piazza Leonardo da Vinci 32 20133 Milan ItalyMarie Andersson Olerud, Uppsala University Department of Surgical Sciences, Anaesthesia and Intensive Care Uppsala SwedenEmanuela Zannin, Politecnico di Milano University Dipartimento di Bioingegneria Piazza Leonardo da Vinci ...
Source: Intensive Care Medicine - September 29, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Severe cutaneous adverse reactions: emergency approach to non-burn epidermolytic syndromesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  SCAR patients will substantially benefit from early interdisciplinary care and thorough consideration of complications during EMS transport and intensive care treatment. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00134-009-1659-1Authors Manuel Florian Struck, Burn Trauma Center, Bergmannstrost Hospital Department of Plastic and Hand Surgery Merseburger Str. 165 06112 Halle/Saale GermanyPeter Hilbert, Intensive Care and Emergency Medicine, Bergmannstrost Hospital Department of Anaesthesiology Halle/Saale GermanyMaja Mockenhaupt, University Medical Center Dokumentationszentrum sch...
Source: Intensive Care Medicine - September 29, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Beneficial effects of the heme oxygenase-1/carbon monoxide system in patients with severe sepsis/septic shockemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Arterial CO and monocyte HO-1 protein expression were increased in critically ill patients, particularly those with severe sepsis or septic shock, suggesting that oxidative stress is closely related to HO-1 expression. The HO-1/CO system may play an important role in sepsis. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1575-4Authors Shoji Takaki, Aichi Medical University Department of Emergency and Critical Care Medicine Nagakute-cho Aichi JapanNaoshi Takeyama, Aichi Medical University Department of Emergency and Critical Care Medicine Nagakute-cho Aichi JapanYuka Ka...
Source: Intensive Care Medicine - September 29, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Patients’ characterization, hospital course and clinical outcomes in five Italian respiratory intensive care unitsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  The clinical outcomes of our units worsened over 15 years, likely as consequence of admitting more severely ill patients. The potential further negative influence of reduced medical staff availability on weaning success, home discharge and LOS warrants future prospective investigations. Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s00134-009-1658-2Authors Eva Polverino, FSM Respiratory Department Lumezzane ItalyStefano Nava, S. Maugeri Foundation Respiratory Intensive Care Unit, Respiratory Department via Maugeri n.10 27100 Pavia ItalyMiquel Ferrer, Hospital Clinic-IDI...
Source: Intensive Care Medicine - September 28, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

The evolving role of dedicated weaning facilities in critical careemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s00134-009-1672-4Authors Jeremy M. Kahn, University of Pennsylvania School of Medicine Division of Pulmonary, Allergy and Critical Care, Center for Clinical Epidemiology and Biostatistics Blockley Hall 723, 423 Guardian Drive Philadelphia PA 19104 USA Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - September 28, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Bronchoalveolar lavage fluid peptidomics suggests a possible matrix metalloproteinase-3 role in bronchopulmonary dysplasiaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  This study shows that proteomic techniques can be applied to investigate the involvement of proteolytic enzymes on the airways of mechanically ventilated premature infants. Content Type Journal ArticleCategory Pediatric OriginalDOI 10.1007/s00134-009-1646-6Authors Giovanni Vento, Catholic University Division of Neonatology, Department of Pediatrics, School of Medicine Largo F. Vito 1 00168 Rome ItalyChiara Tirone, Catholic University Division of Neonatology, Department of Pediatrics, School of Medicine Largo F. Vito 1 00168 Rome ItalyPaola Lulli, Catholic University Institute of Biochemistr...
Source: Intensive Care Medicine - September 24, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Influence of different blood flows through a pumpless lung assist system on transpulmonary thermodilution-derived variablesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-009-1670-6Authors Martin Mroß, University of Witten/Herdecke, Medical Center Cologne-Merheim Department of Anesthesiology and Operative Intensive Care Medicine Ostmerheimerstr. 200 51109 Cologne GermanySamir George Sakka, University of Witten/Herdecke, Medical Center Cologne-Merheim Department of Anesthesiology and Operative Intensive Care Medicine Ostmerheimerstr. 200 51109 Cologne Germany Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - September 24, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

A novel adaptive control system for noisy pressure-controlled ventilation: a numerical simulation and bench test studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  The new control system for noisy PCV can prove useful for controlled mechanical ventilation in the intensive care unit. Content Type Journal ArticleCategory Physiological and Technical NotesDOI 10.1007/s00134-009-1665-3Authors Alessandro Beda, University Hospital Dresden Department of Anesthesiology and Intensive Care Therapy Dresden GermanyPeter M. Spieth, University Hospital Dresden Department of Anesthesiology and Intensive Care Therapy Dresden GermanyThomas Handzsuj, Dräger Medical Lübeck GermanyPaolo Pelosi, University of Insubria Department of Ambient Health and Safety Varese ItalyNad...
Source: Intensive Care Medicine - September 24, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Glucontrol, no control, or out of control?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-009-1666-2Authors Marcus J. Schultz, University of Amsterdam Department of Intensive Care Medicine, Academic Medical Center Amsterdam The NetherlandsPeter E. Spronk, Gelre Hospital Department of Intensive Care Medicine Location Lukas Apeldoorn The NetherlandsFloris van Braam Houckgeest, Tergooi Hospitals Department of Intensive Care Medicine Hilversum The Netherlands Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - September 24, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals