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Family Medicine, the specialty of the future: the Portuguese situation within the European contextEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
General Practice/Family Medicine is a specialty focused on the provision of comprehensive, continuing, and community oriented, person-centred care. The lack of prestige and the difficulty in attracting trainees to the specialty have been longstanding problems in most countries around the world. In Europe, General Practice/Family Medicine is also hampered for not being recognized as a specialty throughout Europe. As for Portugal, General Practice/Family Medicine is undergoing a massive organizational reform, as well as unprecedented levels of popularity among trainees.General Practice/Family holds tremendous latent potentia...
Source: International Archives of Medicine - November 11, 2009 Category: Global & Universal Authors: Tiago Villanueva Source Type: journals

Family Medicine, the specialty of the future: the Portuguese situation within the European context.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
General Practice/Family Medicine is a specialty focused on the provision of comprehensive, continuing, and community oriented, person-centred care. The lack of prestige and the difficulty in attracting trainees to the specialty have been longstanding problems in most countries around the world. In Europe, General Practice/Family Medicine is also hampered for not being recognized as a specialty throughout Europe. As for Portugal, General Practice/Family Medicine is undergoing a massive organizational reform, as well as unprecedented levels of popularity among trainees.General Practice/Family holds tremendous latent potentia...
Source: International Archives of Medicine - November 11, 2009 Category: Global & Universal Authors: Tiago Villanueva Source Type: journals

Hypercalcemia in a patient with cholangiocarcinoma: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Clinicians should be aware of this rare manifestation of CC as prompt and aggressive correction of hypercalcemia alleviates symptoms and improves patient's quality of life, despite the poor overall prognosis. (Source: International Archives of Medicine)
Source: International Archives of Medicine - October 30, 2009 Category: Global & Universal Authors: Ioannis XynosStavros SougioultzisAthanasios ZilosKonstantinos EvagellouGregorios Hatzis Source Type: journals

Ultrasonographic screening of urinary schistosomiasis infected patients in Agulu community, Anambra state, southeast NigeriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Health education campaign including showing the community members evidence of damages to the organs (from the ultrasound pictures) will go a long way in the control and prevention of the disease in this community. (Source: International Archives of Medicine)
Source: International Archives of Medicine - October 28, 2009 Category: Global & Universal Authors: Chinyelu EkwunifeFabian OkaforObioma Nwaorgu Source Type: journals

Common mitochondrial polymorphisms as risk factor for endometrial cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endometrial carcinoma is the most commonly diagnosed gynaecological cancer in developed countries. Although the molecular genetics of this disease had been in the focus of many research laboratories for the last 20 years, but relevant prognostic and diagnostic markers are still missing. At the same time mitochondrial DNA mutations have been reported in many types of cancer during last two decades. It is therefore more than possible, that mitochondrial genotype is one of the cancer susceptibility factors. To investigate the presence of mtDNA somatic mutations and distribution of inherited polymorphisms in endometrial adenoc...
Source: International Archives of Medicine - October 28, 2009 Category: Global & Universal Authors: Anna CzarneckaAleksandra KlembaAndrzej SemczukKatarzyna PlakBarbara MarzecTomasz KrawczykBarbara KoflerPawel GolikEwa Bartnik Source Type: journals

Myocardium tissue changes caused by electrical transthoracic discharges in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data suggest that transthoracic electrical discharges induce mitochondrial injuries in atrial cardiac cells of rats. (Source: International Archives of Medicine)
Source: International Archives of Medicine - October 22, 2009 Category: Global & Universal Authors: Marcelo FerreiraCelso FerreiraLuiz Carlos de AbreuVitor ValentiNeif MuradAdriano MeneghiniCelso FilhoJapy Angelini de Oliveira Filho Source Type: journals

Blood pressure lowering treatment for preventing stroke recurrence: a systematic review and meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Despite recent large trials showing no significant effect, in patients that have experienced a TIA or stroke, blood pressure lowering agents reduced the occurrence of subsequent stroke and cardiovascular events. The rate of myocardial infarction and all-cause mortality was unchanged. (Source: International Archives of Medicine)
Source: International Archives of Medicine - October 19, 2009 Category: Global & Universal Authors: Shaheen LakhanMichael Sapko Source Type: journals

Health-care associated infections rates, length of stay, and bacterial resistance in an intensive care unit of Morocco: Findings of the International Nosocomial Infection Control Consortium (INICC)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: HAI rates, LOS, mortality, and bacterial resistance were high. Even if data may not reflect accurately the clinical setting of the country, programs including surveillance, infection control, and antibiotic policy are a priority in Morocco. (Source: International Archives of Medicine)
Source: International Archives of Medicine - October 6, 2009 Category: Global & Universal Authors: Naoufel MadaniVictor RosenthalTarik DendaneKhalid AbidiAmine Ali ZeggwaghRedouane Abouqal Source Type: journals

Regulation of the epithelial sodium channel [ENaC] in kidneys of salt-sensitive Dahl rats: Insights on alternative splicingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The epithelial sodium channel [ENaC] is critical for the maintenance of sodium balance, extracellular fluid volume and long term blood pressure control. Monogenic disorders causing ENaC hyperactivity have led to a severe form of hereditary hypertension in humans, known as Liddle's syndrome. Similarly, in animal models, ENaC hyperactivity has been well documented in kidneys of salt-sensitive [S] Dahl rats [a genetic model of salt-sensitive hypertension] versus their normotensive control [Dahl salt-resistant [R] rats]. The purpose of the present review is to highlight the differential regulation of ENaC in kidneys of Dahl S ...
Source: International Archives of Medicine - September 28, 2009 Category: Global & Universal Authors: Marlene Shehata Source Type: journals

The interventionalism of medicine: interventional radiology, cardiology, and neuroradiologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Interventional medical practitioners are specialists who do minimally invasive procedures instead of surgery or other treatment. Most often, these procedures utilize various imaging and catheterization techniques in order to diagnose and treat vascular issues in the body. Interventionalist techniques, including injecting arteries with dye, visualizing these via x-ray, and opening up blockages, developed from early pioneers' bold and sometimes controversial experiments which aimed to find safer and better ways to treat coronary artery and other atherosclerotic vascular disease. Currently, the major interventional specialtie...
Source: International Archives of Medicine - September 8, 2009 Category: Global & Universal Authors: Shaheen LakhanAnna KaplanCyndi LairdYaacov Leiter Source Type: journals

Prolonged QT interval in a man with anorexia nervosaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the case of a male who was diagnosed with anorexia nervosa and developed asthenia, a long QT interval and also a severe both hypokalaemia and hypomagnesaemia. We intend to discuss the pathogenic paths as well as prophylactic and therapeutic measures to this potentially-lethal pathology. (Source: International Archives of Medicine)
Source: International Archives of Medicine - July 30, 2009 Category: Global & Universal Authors: Maria Dolores Macias-RoblesAna Maria Perez-ClementeCarmen Macia-BobesMaria Asuncion Alvarez-RuedaSergio Pozo-Nuevo Source Type: journals

Congenital heart block associated with Sjogren syndrome: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The literature relating to this association is discussed including the suggested mechanism, long-term outcome of mothers of children with congenital heart block and preventive treatment strategies. (Source: International Archives of Medicine)
Source: International Archives of Medicine - July 27, 2009 Category: Global & Universal Authors: Karwan MoutasimPenelope ShirlawMichael EscudierTimothy Poate Source Type: journals

Physical trauma experience among school children in periurban Blantyre, MalawiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Many school children in Blantyre, Malawi have been exposed to trauma either involving themselves or someone they observed. Prevention, including education, supervision and management of trauma must receive the necessary attention they deserve in terms of resources, surveillance and impact mitigation. (Source: International Archives of Medicine)
Source: International Archives of Medicine - July 23, 2009 Category: Global & Universal Authors: Adamson MuulaHumphreys Misiri Source Type: journals

Characterization of lipid parameters in diabetes mellitus - a Nigerian reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Having defined the scope of dyslipidaemia in our patients and also highlighting its gross undertreatment , we hope that our data will help sensitize health care practitioners on screening for and treating dyslipidaemia. Elevated LDL-C and reduced HDL-C should be the primary targets of treatment in our patients with dyslipidaemia. (Source: International Archives of Medicine)
Source: International Archives of Medicine - July 19, 2009 Category: Global & Universal Authors: Anthonia OgberaOlufemi FasanmadeSonny ChinenyeAkinyele Akinlade Source Type: journals

Comparison of reduction of edema after rest and after muscle exercises in treatment of chronic venous insufficiencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In conclusion, exercises are more efficient to reduce the edema of lower limbs than resting in the Trendelenburg position. (Source: International Archives of Medicine)
Source: International Archives of Medicine - July 13, 2009 Category: Global & Universal Authors: Belczak Cleusa Ema QuiliciCavalheri Jr GildoJose Maria Pereira de GodoyBelczak Sergio QuiliciCaffaro Roberto Augusto Source Type: journals

Concurrent reactive arthritis and myelitis - a case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reactive arthritis is a post infectious multisystem illness which usually occurs after episodes of diarrhea or urinary tract infections. It can cause many manifestations other than the musculoskeletal system including skin, urogenital system and eyes. However the central nervous system is only occasionally involved. We discuss the case of a 32 year old male who presented with myelitis in association with reactive arthritis. (Source: International Archives of Medicine)
Source: International Archives of Medicine - June 2, 2009 Category: Global & Universal Authors: Mukul AgarwalSubhash GiriVishal SharmaGaurav Bhardwaj Source Type: journals

Co-morbid disorders and sexual risk behavior in Nigerian adolescents with bipolar disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: When planning interventions for children and adolescents with bipolar disorder, special attention may need to be focused on group of adolescents with co-morbid disorders and propensity towards impulsivity and sexual risk behavior. This may help in improving long term outcome in this group of adolescents. (Source: International Archives of Medicine)
Source: International Archives of Medicine - June 1, 2009 Category: Global & Universal Authors: Muideen BakareAhamefule AgomohPeter EbigboGabriel OnyeamaJulian EatonJojo OnwukweKevin Okonkwo Source Type: journals

Addressing the primary care physician shortage in an evolving medical workforceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionThere are several factors at play which contribute to the decrease in the number of practicing physicians in primary specialties. Lifestyle concerns, such as schedule and income, as well as the lack of prestige associated with this field seem to be among the most prevalent reasons cited for the diminishing interest. Multifaceted concerns such as these, however, are difficult to adequately invalidate; doing so would not only require a great deal research, but also a good deal of time -- a resource which is in short supply given the current physician shortage being faced. Thus, a more immediate solution may lie in ...
Source: International Archives of Medicine - May 5, 2009 Category: Global & Universal Authors: Shaheen E Lakhan and Cyndi Laird Source Type: journals

Salivary VEGF: a non-invasive angiogenic and lymphangiogenic proxy in head and neck cancer prognosticationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We present independent normative data on the levels of endothelial growth factor in the saliva of a healthy control population. We also suggest the use of simple non-invasive tests in helping to predict head and neck tumour biology and outcomes. (Source: International Archives of Medicine)
Source: International Archives of Medicine - April 24, 2009 Category: Global & Universal Authors: Tahwinder Upile, Waseem Jerjes, Panagiotis Kafas, Shash Harini, Sandeep U Singh, Marcel Guyer, Melissa Bentley, Holger Sudhoff and Colin Hopper Source Type: journals

Internal dislocation of scapula following thoracotomy for lung transplantation – a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This case highlights the importance of careful positioning of the patient perioperatively and when they are sedated and ventilated after the surgical procedure. (Source: International Archives of Medicine)
Source: International Archives of Medicine - April 16, 2009 Category: Global & Universal Authors: V Palissery, T Veenith, NB Siddaiah and L Brennan Source Type: journals

Delayed internal dislocation of scapula following thoracotomy for lung transplantation: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This case highlights the importance of careful positioning of the patient perioperatively and when they are sedated and ventilated after the surgical procedure. (Source: International Archives of Medicine)
Source: International Archives of Medicine - April 16, 2009 Category: Global & Universal Authors: V Palissery, T Veenith, N B Siddaiah and L Brennan Source Type: journals

Ethical and technical considerations for the creation of cell lines in the head & neck and tissue harvesting for research and drug development (Part I): Techniques of tissue harvesting and propagationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The advantages of hospital-based cell line creation are numerous. We can be more certain that cell lines are developed from the particular tissues of interest and accurate anatomical and appropriate clinico-pathological control tissues are also harvested. We can also be certain of less cell line cross contamination. (Source: International Archives of Medicine)
Source: International Archives of Medicine - April 3, 2009 Category: Global & Universal Authors: Tahwinder Upile, Waseem Jerjes, Panagiotis Kafas, Sandeep U Singh, Holger Sudhoff, Jaspal Mahil, Ann Sandison and Colin Hopper Source Type: journals

Ethical and technical considerations for the creation of cell lines in the head & neck and tissue harvesting for research and drug development (Part II): Ethical aspects of obtaining tissue specimensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Consent is also more proximate and assurance can be given of appropriate usage. Ethical questions concerning tissue ownership are in many institutions raised during the current consenting procedure. We provide a robust ethical framework, based on the current legislation, which allows clinicians to be directly involved in cell and tissue harvesting. (Source: International Archives of Medicine)
Source: International Archives of Medicine - April 3, 2009 Category: Global & Universal Authors: Tahwinder Upile, Waseem Jerjes, Panagiotis Kafas, Sandeep U Singh, Jaspal Mahil, Ann Sandison, Colin Hopper and Holger Sudhoff Source Type: journals

Preoperative gemcitabine based chemo-radiotherapy in locally advanced non metastatic pancreatic adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Preoperative gemcitabine based chemoradiation might benefit patients with locally advanced non metastatic pancreatic cancer by increasing the resectability without significant acute toxicity. (Source: International Archives of Medicine)
Source: International Archives of Medicine - March 27, 2009 Category: Global & Universal Authors: Doaa W Maximous, Mostafa E Abdel-Wanis, Mohammed I El-Sayed and Alaa A Abd-Elsayed Source Type: journals

Pain management among medical in-patients in Blantyre, MalawiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Pain is a leading symptom which influences patients to seek medical attention. The management of pain among patients attending in-patient care in southern African countries has been little described. Information regarding the prevalence of pain and the quality of its management may be useful in guiding clinical decisions, training of health workers and health care quality improvements. MethodA hospital-based audit was conducted to estimate the prevalence of pain and examine the quality of its management among patients admitted to adult medical wards at Queen Elizabeth Central Hospital (QECH), Blantyre, Malawi i...
Source: International Archives of Medicine - March 26, 2009 Category: Global & Universal Authors: Adamson S Muula and Humphreys E Misiri Source Type: journals

Safety and benefits of large-volume liposuction: a single center experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Large-volume liposuction can be performed safely and it can produce desirable morphological and hematological changes. (Source: International Archives of Medicine)
Source: International Archives of Medicine - February 2, 2009 Category: Global & Universal Authors: Youssef Saleh, Mahmoud El-Oteify, Abd-El-Radi Abd- El-Salam, Ahmed Tohamy and Alaa A Abd-Elsayed Source Type: journals

Health challenges in Africa and the way forwardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Africa is confronted by a heavy burden of communicable and non-communicable diseases. Cost-effective interventions that can prevent the disease burden exist but coverage is too low due to health systems weaknesses. This editorial reviews the challenges related to leadership and governance; health workforce; medical products, vaccines and technologies; information; financing; and services delivery. It also provides an overview of the orientations provided by the WHO Regional Committee for Africa for overcoming those challenges. It cautions that it might not be possible to adequately implement those orientations without a co...
Source: International Archives of Medicine - December 18, 2008 Category: Global & Universal Authors: Joses M Kirigia and Saidou P Barry Source Type: journals

Dermatomyositis and supraventricular tachycardiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Cardiac involvement in dermatomyositis is a very rare, but well known entity. Dermatomyositis patients with palpitations should be monitored on a Holter monitor, and appropriate therapy initiated if found to have a significant arrhythmia. (Source: International Archives of Medicine)
Source: International Archives of Medicine - November 13, 2008 Category: Global & Universal Authors: Abhijeet Dhoble, Chethan Puttarajappa and Alan Neiberg Source Type: journals

Pulmonary Bacterial Pathogens in Cystic Fibrosis Patients and Antibiotic Therapy: a tool for the health workersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this review was to describe the bacterial pathogens colonizing patients with cystic fibrosis. A systematic search was conducted using the international bibliographic databanks SCIELO, HIGHWIRE, PUBMED, SCIRUS and LILACS to provide a useful and practical review for healthcare workers to make them aware of these microorganisms. Today, B. cepacia, P. aeruginosa and S. aureus are the most important infectious agents in cystic fibrosis patients. However, healthcare professionals must pay attention to emerging infectious agents in these patients, because they represent a potentially serious future problem. There...
Source: International Archives of Medicine - November 7, 2008 Category: Global & Universal Authors: Henrique D Coutinho, Vivyanne S Falcao-Silva and Gregorio F Goncalves Source Type: journals

Muscle disorders and dentition-related aspects in temporomandibular disorders: controversies in the most commonly used treatment modalitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review explores the aetiology of temporomandibular disorders and discusses the controversies in variable treatment modalities. Pathologies of the temporomandibular joint (TMJ) and its' associated muscles of mastication are jointly termed temporomandibular disorders (TMDs). TMDs present with a variety of symptoms which include pain in the joint and its surrounding area, jaw clicking, limited jaw opening and headaches. It is mainly reported by middle aged females who tend to recognize the symptoms more readily than males and therefore more commonly seek professional help. Several aetiological factors have been acknowl...
Source: International Archives of Medicine - October 30, 2008 Category: Global & Universal Authors: Waseem Jerjes, Tahwinder Upile, Syedda Abbas, Panagiotis Kafas, Michael Vourvachis, Jubli Rob, Eileen Mc Carthy, Nikolaos Angouridakis and Colin Hopper Source Type: journals

Diagnostic performance and predictive value of rheumatoid factor, anti- cyclic -citrullinated peptide antibodies and HLA-DRB1 locus genes in rheumatoid arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings suggest that anti-CCP2 is superior to RF for the detection of RA and provided predictive information on joint destruction and disease activity. The presence of RA associated antibodies (ACCP or RF) and/or the SE genes are indicative for a poorer radiological outcome and higher grade of activity. (Source: International Archives of Medicine)
Source: International Archives of Medicine - October 22, 2008 Category: Global & Universal Authors: Nihal A Fathi, Azza M Ezz-Eldin, Eman Mosad, Rania M Bakry, Hosny B Hamed, Sahar Ahmed, Marwa Mahmoud, Hebat-Allah G Rashed and Fatma Abdullah Source Type: journals

Expression of interleukin-17RC protein in normal human tissuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: IL-17RC protein is expressed in most human tissues, the function of which warrants further investigation. Translation: This article is translated from English to Spanish, originally published in International Archives of Medicine. The original work is at doi: (Source: International Archives of Medicine)
Source: International Archives of Medicine - October 17, 2008 Category: Global & Universal Authors: Dongxia Ge and Zongbing You Source Type: journals

Locally induced neural stem cells/pluripotent stem cells for in vivo cell replacement therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neural stem cells hold the key to innovative new treatments for age-associated degeneration and traumatic injury to the brain and spinal cord. We hypothesized that the in vivo induced pluripotent stem cells or neural stem cells through "forced gene expression" can be used to repair damaged brain areas or treat degenerative diseases. Hopefully, these in vivo patient-specific stem cells can bring a new avenue for cell replacement therapies. (Source: International Archives of Medicine)
Source: International Archives of Medicine - September 24, 2008 Category: Global & Universal Authors: Ti-Fei Yuan and Oscar Arias-Carrion Source Type: journals

Percutaneous transluminal angioplasty in the treatment of stenosis of arteriovenous fistulae for hemodialysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Percutaneous transluminal angioplasty is an efficacious method for the correction of stenosis of arteriovenous fistulae for hemodialysis, prolonging the patency of the fistula and enabling new interventions (Source: International Archives of Medicine)
Source: International Archives of Medicine - September 23, 2008 Category: Global & Universal Authors: Miquelin Daniel Gustavo, Reis Luis Fernando, Silva Adinaldo Adhemar Menezes and Jose Maria Pereira Godoy Source Type: journals

An unusual complication following radiological percutaneous gastrostomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The malrotation of the intestine can make a relatively straight forward procedure fraught with complications. Clinicians should have high index of suspicion about malrotation when performing a procedures like percutaneous gastrostomy and radiologically guided entrostomy. If there is an index of suspicion they should be screened prior to the procedure. (Source: International Archives of Medicine)
Source: International Archives of Medicine - August 12, 2008 Category: Global & Universal Authors: Tonny Veenith, Manasi Bhagwat and Andrew Bailey Source Type: journals

Plasmatic level of neurosin predicts outcome of mild cognitive impairmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The measurement of plasmatic neurosin level in patients diagnosed with MCI may predict conversion from MCI to Dementia with vascular component. A single measurement is also valuable to estimate the risk of developing AD and Dementia with vascular component. Finally, repeated measurement of plasmatic neurosin might be a useful test to predict outcome in patients with MCI. (Source: International Archives of Medicine)
Source: International Archives of Medicine - July 11, 2008 Category: Global & Universal Authors: Manuel Menendez-Gonzalez, Patricia Castro-Santos, Maria Teresa Calatayud, Pablo Perez-Pinera, Renee Ribacoba, Marta Martinez-Rivera, Carmen Gutierrez, Alfonso Lopez-Muniz and Ana Suarez Source Type: journals

The variant Creutzfeldt-Jakob Disease: Risk, uncertainty or safety in the use of blood and blood derivatives?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It has been long since French physician Jean-Baptiste Denys carried out the first successful blood transfusion to a human being. Using bird feathers as canules, sheep blood was transfused to a young man. The patient died soon after Denys' treatment and Denys was accused of murder. In the XXI century, known as the biotechnology century, we face new challenges in Medicine. New emerging and reemerging diseases, such as Creutzfeldt-Jakob disease (CJD) or "mad cow disease" and its human variant (vCJD), challenge the biosafety aspects of a widely extended and extremely useful technique, that is, the perfusion of blood, of its de...
Source: International Archives of Medicine - June 23, 2008 Category: Global & Universal Authors: Antonio Liras Source Type: journals

The variant Creutzfeldt-Jakob Disease. Risk, uncertainty or safety in the use of the blood and blood derivatives?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Long period of time has elapsed since the French physician Jean-Baptiste Denys carried out the first successful blood transfusion to a human being. Using bird feathers as canules, sheep blood was transfused to a young man which died soon after Denys' treatment and Denys was accused of murder. Now, in the our present century, the biotechnology century, we face new challenges in Medicine. New emerging and reemerging diseases like the Creutzfeldt-Jakob disease (CJD) or "mad cow disease" and its human variant (vCJD), challenge the biosafety aspects of a widely extended and extremely useful technique as is the perfusion of bloo...
Source: International Archives of Medicine - June 23, 2008 Category: Global & Universal Authors: Antonio Liras Source Type: journals

Fat feeding potentiates the diabetogenic effect of dexamethasone in Wistar ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: From the results obtained, it can be speculated that the altered lipid and cortisol metabolism could affect one another, forming a vicious cycle. (Source: International Archives of Medicine)
Source: International Archives of Medicine - May 23, 2008 Category: Global & Universal Authors: Shanmugam Sivabalan, Shanmugam Renuka and Venugopal P Menon Source Type: journals

Partial trisomy 13q22-qter associated to leukoencephalopathy and late onset generalised epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case with a partial trisomic component 13q22 and a monosomic component 5p15 from paternal origin. This patient developed early menopause and major neurological disorders as leukoencephalopathy, late onset generalised epilepsy and stroke. She also had fatty acids disturbances and their potential relation to the neurological disorders and early menopause is discussed. The presented case illustrates the phenotype of 13q22-qter in adult age and reaffirms the importance of studying the karyotype of any patient with seizures or leukoencephalopathy particularly when there are associated other clinical features includ...
Source: International Archives of Medicine - April 29, 2008 Category: Global & Universal Authors: Renee Ribacoba, Manuel Menendez-Gonzalez, Ines Hernando, Javier Salas and Maria Luisa Giros Source Type: journals

Recombinant proteins in therapeutics: haemophilia treatment as an exampleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One of the most spectacular advances in the history of scientific knowledge was the discovery of deoxyribonucleic acid (DNA) by Watson and Crick in 1953. This enabled certain proteins to be prepared in this way for their therapeutic use in clinical practice. Today, in the first decade of the 21st century, hundreds of therapeutic proteins have been produced recombinantly and about 50 of them have been approved for clinical use. Because of the specific procedure used for obtaining these products, which is based on expressing a atherapeutica gene from a fragment of DNA in a cell to produce a functional protein that is free fr...
Source: International Archives of Medicine - April 28, 2008 Category: Global & Universal Authors: Antonio Liras Source Type: journals

Defining the profile of International Archives of MedicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This editorial accompanies the launch of International Archives of Medicine, a novel scientific journal born in response to the new needs that have emerged as a result of globalization. (Source: International Archives of Medicine)
Source: International Archives of Medicine - April 15, 2008 Category: Global & Universal Authors: Manuel Menendez-Gonzalez Source Type: journals

Basic mechanisms of rTMS: Implications in Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The mechanisms underlying the disease-modifying effects of these and related rTMS in animals are the principle subject of the current review. The possible applications for treatment of Parkinson's disease are discussed. (Source: International Archives of Medicine)
Source: International Archives of Medicine - April 15, 2008 Category: Global & Universal Authors: Oscar Arias-Carrión Source Type: journals

A case of lactic acidosis complicating assessment and management of asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Lactic acidosis secondary to inhaled beta-agonist administration may be a common scenario which can be misinterpreted very easily and can confuse the clinical picture. Further studies will be needed to establish the exact aetiology of this lactic acid production. (Source: International Archives of Medicine)
Source: International Archives of Medicine - April 15, 2008 Category: Global & Universal Authors: Tonny V Veenith and Abigail Pearce Source Type: journals