Evaluating olfactory function and quality of life in patients with traumatic brain injury
Key points Patients with traumatic brain injury (TBI) had worse olfactory quality of life (QoL) and Sino-Nasal Outcome Test-22 scores compared to a normal cohort. A worse olfactory QoL correlated with concussion symptom burden. Olfactory dysfunction among TBI patients should be addressed to improve overall outcomes. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 15, 2024 Category: Allergy & Immunology Authors: Amelia S. Lawrence, Rahul Alapati, Sarah F. Wagoner, Antonio Bon Nieves, Cole Bird, Robert Wright, Shah Jafri, Michael Rippee, Jennifer A. Villwock Tags: RESEARCH NOTE Source Type: research

SinoNasal Microbiota Transfer to treat recalcitrant chronic rhinosinusitis: A case series
Key Points SinoNasal Microbiota Transfer (SNMT) was safe with immediate benefit in all recipients, with sustained improvement in two of three recipients for up to 180 days. The addition of antimicrobial photodynamic therapy worsened chronic rhinosinusitis. These promising SNMT results warrant further study of safety and efficacy. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 15, 2024 Category: Allergy & Immunology Authors: Sandeep K. Gill, Juan C. Hernaiz ‐Leonardo, Thaddeus J. Edens, Athenea Pascual, Chris Tang, Judy Fan, Andrew Thamboo, Warren Mullings, Saad Alsaleh, Bader M. Alim, Amin R. Javer, Amee R. Manges Tags: RESEARCH NOTE Source Type: research

Patients with parosmia respond faster to unpleasant odors than patients with hyposmia: Insights from olfactory event ‐related potentials
ConclusionOverall, the present findings support the idea that parosmia predominantly occurs during olfactory recovery, significantly disturbing patients and warranting the development of effective treatments. Notably, the relatively faster responses of hyposmic patients with severe parosmia suggest that the generation of distorted olfactory responses may involve early stages of the processing of olfactory information. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 9, 2024 Category: Allergy & Immunology Authors: Zetian Li, Luisa Richter, Tanja Krueger, Herbert Eichwald, Antje H ähner, Thomas Hummel Tags: ORIGINAL ARTICLE Source Type: research

Recurrence morbidity of olfactory neuroblastoma
ConclusionsRecurrent cases of ONB have significantly different stages and preoperative imaging factors. Patients with local or neck recurrence, however, have better DSS than those with intracranial or distant recurrence, independent of initial tumor stage or Hyams grade. Identifying specific factors that confer an increased risk of recurrence and DSS is important for patient counseling in addition to surveillance planning. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 4, 2024 Category: Allergy & Immunology Authors: Katie Melder, Jess C. Mace, Garret Choby, Joao Paulo Almeida, Pierre ‐Olivier Champagne, Erik Chan, Jeremy Ciporen, Mark B. Chaskes, Juan Fernandez‐Miranda, Nicholas K. Fung, Paul Gardner, Peter Hwang, Keven Seung Yong Ji, Aristotelis Kal Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 1, 2024 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Evaluating health utility score through direct and indirect methods in patients with chronic rhinosinusitis
ConclusionThe overall HUS of CRS was approximately 0.79 –0.89. High SNOT-22 score and those who failed medications, presence of comorbid AR/asthma, increased age, high endoscopy score, and low education negatively impacted HUS. Our data suggest that EQ-5D-5L is a preferable method for measuring HUS in patients with CRS. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 1, 2024 Category: Allergy & Immunology Authors: Wirach Chitsuthipakorn, Narissara Pracharktam, Juthaporn Phetpong, Patlada Kowatanamongkon, Kittichai Mongkolkul, Kornkiat Snidvongs Tags: ORIGINAL ARTICLE Source Type: research

American Rhinologic Society expert practice statement part 1: Skull base reconstruction following endoscopic skull base surgery
AbstractThe goal of this American Rhinologic Society expert practice statement (EPS) is to summarize the best available evidence for technical factors that optimize outcomes in skull base reconstruction following endoscopic skull base surgery for intradural pathologies. These topics include the use of free mucosal grafts versus vascularized pedicled nasoseptal flaps; the use of autologous versus synthetic grafts; and the roles of lumbar drains, dural sealants, and nasal packing. This EPS was developed following the recommended methodology and approval process as previously outlined. As there are a myriad of techniques and ...
Source: International Forum of Allergy and Rhinology - March 30, 2024 Category: Allergy & Immunology Authors: Jennifer E. Douglas, Nithin D. Adappa, Garret Choby, Corinna G. Levine, Mindy R. Rabinowitz, Raj Sindwani, Eric W. Wang, Bradford A. Woodworth, Edward C. Kuan Tags: ORIGINAL ARTICLE Source Type: research

Treatment of unilateral olfactory neuroblastoma: Appropriate extent of surgical resection and potential for olfactory preservation
AbstractHistorically, comprehensive surgical resection for olfactory neuroblastoma has included the bilateral olfactory epithelium, cribriform plate, overlying dura, olfactory bulbs and tracts. This results in postoperative anosmia that may significantly impact a patient's quality of life without definitive added benefit in survival. The prevalence of occult intracranial disease is low, especially for Hyams grade I and II tumors. A unilateral approach sparing the contralateral cribriform plate and olfactory system can be considered for select cases of early stage, low-grade tumors when the disease does not cross midline to...
Source: International Forum of Allergy and Rhinology - March 26, 2024 Category: Allergy & Immunology Authors: Harish Dharmarajan, Garret Choby, Ralph Abi Hachem, Edward C. Kuan, Corinna G. Levine, Olabisi Sanusi, Theodore Schuman, Dennis Tang, Michael Yim, Mathew Geltzeiler Tags: VIEWPOINT Source Type: research

Detection of plagiarism among rhinology scientific journals
Key Points Automated plagiarism-checking software can be a valuable tool for detecting plagiarism in manuscripts. Twenty-five of 60 articles (42%) had at least one incidence of plagiarism, predominately text recycling. A “similarity score” ranging from 22% to 35% could be a potential cut-off value when screening submitted manuscripts. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 25, 2024 Category: Allergy & Immunology Authors: Ezer H. Benaim, Saima Wase, Saif Zaidi, Aurelia Monk, Cristine Klatt ‐Cromwell, Brian D. Thorp, Charles S. Ebert Jr., Adam J. Kimple, Brent A. Senior Tags: RESEARCH NOTE Source Type: research

Double blind randomized controlled trial measuring the efficacy of nebulized steroid at half dose in comparison to high volume squeeze bottle steroid irrigation in management of patients with chronic rhinosinusitis
Key Points Nebulized budesonide is effective at half dose compared to budesonide irrigation in CRS. Nasal nebulizers provide an alternative for delivery of topical steroids to the sinuses. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 14, 2024 Category: Allergy & Immunology Authors: Anna Megow, George Bouras, Eng H. Ooi, Sarah Vreugde, Alkis Psaltis, Peter ‐John Wormald Tags: RESEARCH NOTE Source Type: research

A novel staging system to consolidate silent sinus syndrome and chronic maxillary atelectasis: A systematic review and case series
Key Points Silent sinus syndrome (SSS) and chronic maxillary atelectasis (CMA) represent an overlapping clinical entity, both likely lying on the spectrum of one disease process. There is widespread inconsistency of diagnosis in the literature of reported cases of SSS and CMA. We propose a novel, comprehensive staging system to simplify diagnosis and inform management. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 13, 2024 Category: Allergy & Immunology Authors: Dev Amin, Shreya Mandloi, Kathryn Nunes, Neha Garg, Chase Kahn, Alexander Duffy, Elina Toskala, Mindy Rabinowitz, Marc Rosen, Gurston Nyquist Tags: RESEARCH NOTE Source Type: research

Dupilumab prevents nasal epithelial function alteration by IL ‐4 in vitro: Evidence for its efficacy
ConclusionDupilumab, in vitro, restored epithelial integrity by counteracting the effect of IL-4 on the epithelial barrier (increased epithelial permeability, decreased ciliary beating efficiency, and decreased wound repair rate). (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 12, 2024 Category: Allergy & Immunology Authors: Maxime Fieux, Florent Carsuzaa, Yvan Bellanger, Sophie Bartier, Virginie Fournier, Jean Claude Lecron, Matthieu Bainaud, Bruno Louis, St éphane Tringali, Xavier Dufour, André Coste, Laure Favot, Emilie Bequignon Tags: ORIGINAL ARTICLE Source Type: research

The Inflation Reduction Act: Implications for Medicare spending and access to biologic therapies for chronic rhinosinusitis with nasal polyposis and asthma
Key Points In 2021, Medicare spending on biologics was $926  million in Part B (FFS) and $1.3 billion in Part D (FFS/MA). Between 2017 and 2021, annual Medicare spending on biologics increased by approximately 200%. Between 2023 and 2025, Medicare Part D OOP costs for biologics will decrease by an estimated 50%–60%. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 11, 2024 Category: Allergy & Immunology Authors: Vinay K. Rathi, Zachary M. Soler, Rodney J. Schlosser, Alan D. Workman, Nikita Chapurin, Nicholas R. Rowan, Stacie B. Dusetzina Tags: RESEARCH NOTE Source Type: research

Combined balloon Eustachian tuboplasty/endoscopic sinus surgery for patients with chronic rhinosinusitis and Eustachian tube dysfunction
ConclusionCombined BET/ESS could decrease otologic symptoms and improve Eustachian tube function. BET may be an appropriate adjunctive procedure for treating chronic rhinosinusitis with obstructive ETD. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 11, 2024 Category: Allergy & Immunology Authors: Cheng ‐Yu Hsieh, Wei‐Chieh Lin, Chung‐Ching Lin, Yi‐Fan Chou Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 11, 2024 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research