CXCL4:NLRP3-mediated pyroptosis product that regulates cardiac fibrosis
In this study, we induced Viral myocarditis (VMC) via infection of CVB3 to explore the relationship between pyroptosis and fibrosis. Our results showed that intraperitoneal injection of an NLRP3 inhibitor MCC950 or use of NLRP3-/- mice inhibited cardiac pyroptosis mediated by NLRP3 inflammasome in VMC. CXCL4 is a chemokine that has been reported to have pro-inflammatory and pro-fibrotic functions. In VMC, we further found that pyroptosis of Mouse myocardial fibroblasts (MCF) promoted the secretion of CXCL4 by activating Wnt/β-Catenin signaling. Subsequently, the transcriptome sequencing data showed that CXCL4 could promot...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Jing Wei Ming Yu Peng Sai Nan Wang Hong Xiang Lu Source Type: research
Immune targeting of filarial glutaredoxin through a multi-epitope peptide-based vaccine: A reverse vaccinology approach
Int Immunopharmacol. 2024 Apr 23;133:112120. doi: 10.1016/j.intimp.2024.112120. Online ahead of print.ABSTRACTDespite the efforts of global programme to eliminate lymphatic filariasis (GPELF), the threat of lymphatic filariasis (LF) still looms over humanity in terms of long-term disabilities, and morbidities across the globe. In light of this situation, investigators have chosen to focus on the development of immunotherapeutics targeting the physiologically important filarial-specific proteins. Glutaredoxin (16.43 kDa) plays a pivotal role in filarial redox biology, serving as a vital contributor. In the context of the in...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Nabarun Chandra Das Sampa Gorai Parth Sarthi Sen Gupta Saroj Kumar Panda Malay Kumar Rana Suprabhat Mukherjee Source Type: research
A phytosphingosine derivative mYG-II-6 inhibits histamine-mediated TRPV1 activation and MRGPRX2-dependent mast cell degranulation
CONCLUSIONS: Our findings show that mYG-II-6 can alleviate histamine-induced itch sensation through dual mechanisms. This underscores its potential as a versatile treatment for various pruritic conditions.PMID:38657498 | DOI:10.1016/j.intimp.2024.112113 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Nisha Adhikari Wook-Joo Lee Soojun Park Sanghee Kim Won-Sik Shim Source Type: research
Comprehensive study of the interplay between immunological and metabolic factors in hepatic steatosis
Int Immunopharmacol. 2024 Apr 23;133:112091. doi: 10.1016/j.intimp.2024.112091. Online ahead of print.ABSTRACTThe pathophysiology of hepatic steatosis is thoroughly reviewed in this comprehensive report, with particular attention to the complex interactions between inflammatory pathways, insulin resistance, lipid metabolism, metabolic dysregulation, and immunological responses in the liver including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC). The study highlights the role of immune cell regulation in disease progression and explores the potential of i...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Arnab Banerjee Debasmita Das Sandip Mukherjee Bithin Kumar Maji Source Type: research
Mitochondrial-dependent oxidative phosphorylation is key for postnatal metabolic adaptation of alveolar macrophages in the lung
Int Immunopharmacol. 2024 Apr 23;133:112012. doi: 10.1016/j.intimp.2024.112012. Online ahead of print.ABSTRACTAlveolar macrophages (AMs) seed in lung during embryogenesis and become mature in perinatal period. Establishment of acclimatization to environmental challenges is important, whereas the detailed mechanisms that drive metabolic adaptation of AMs remains to be elucidated. Here, we showed that energy metabolism of AMs was transformed from glycolysis prenatally to oxidative phosphorylation (OXPHOS) postnatally accompanied by up-regulated expression of mitochondrial transcription factor A (TFAM). TFAM deficiency distur...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Jun Zhang Yu Peng Haosen Song Siqi Liu Chuanwei Li Yi Zhang Xiaowei Shi Huifang Guo Yingping Xu Source Type: research
The potential role of SNHG16/ miRNA-146a/ TRAF6 signaling pathway in the protective effect of zoledronate against colorectal cancer and associated osteoporosis in mouse model
Int Immunopharmacol. 2024 Apr 23;133:112125. doi: 10.1016/j.intimp.2024.112125. Online ahead of print.ABSTRACTBone fracture as a consequence of colorectal cancer (CRC) and associated osteoporosis (OP) is considered a risk factor for increasing the mortality rate among CRC patients. SNHG16/ miRNA-146a/ TRAF6 signaling pathway is a substantial contributor to neoplastic evolution, progression, and metastasis. Here, we investigated the effect of zoledronate (ZOL) on the growth of CRC and associated OP in a mouse model. Thirty Balb/c mice were divided into Naïve, azoxymethane (AOM)/dextran sodium sulfate (DSS), and ZOL groups....
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Amany Helmy Mohamed Ahmed Noureldin Hassan Nesma Hussein Abdel Hay Manar Fouad Ahmed Marwa M El Sawy Mohamed M Sonbol Reham Hussein Mohamed Source Type: research
Geniposide ameliorates psoriatic skin inflammation by inhibiting the TLR4/MyD88/NF- κB p65 signaling pathway and MMP9
Int Immunopharmacol. 2024 Apr 22;133:112082. doi: 10.1016/j.intimp.2024.112082. Online ahead of print.ABSTRACTPsoriasis is an incurable immune-mediated disease affecting the skin or the joints. There are continuing studies on drugs for psoriasis prevention and treatment. This research found that Geniposide (GE) significantly thinned IMQ mice's skin lesions, reduced the scales, and lowered the presence of inflammatory cells in the pathology in a dose-dependent manner. GE inhibited IL-23, IL-22, IL-17A, IL-12, IL-6, and TNF-α levels in psoriatic mice serum. AKT1, TNF, TLR4, MMP9, MAPK3, and EGFR were selected as the top 6 t...
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Lijuan Liu Huiling Zhang Xinran Tang Mengge Zhang Yayun Wu Ya Zhao Chuanjian Lu Ruizhi Zhao Source Type: research
Expression of HLA-DR and KLRG1 enhances the cytotoxic potential and cytokine secretion capacity of CD3 < sup > + < /sup > T cells in tuberculosis patients
CONCLUSIONS: Expression of HLA-DR and KLRG1 enhances the cytotoxic potential and cytokine secretion capacity of CD3+ T cells in TB patients, suggesting CD3+ T cells expressing HLA-DR and KLRG1 are important effector cell phenotypes involved in the host anti-TB infection. HLA-DR and KLRG1 expressed by CD3+ T cells may be potential predictive markers of TB disease progression and clinical immune assessment.PMID:38652959 | DOI:10.1016/j.intimp.2024.112115 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Yiqi Yang Hanlu Shi Yu Zhou Yonglie Zhou Source Type: research
Potential mitigating impact of a dipeptidyl peptidase-IV inhibitor, vildagliptin, on oxazolone-induced ulcerative colitis: Targeting the role of PI3K/AKT/mTOR and AMPK/Nrf2 signaling pathways
Int Immunopharmacol. 2024 Apr 22;133:112110. doi: 10.1016/j.intimp.2024.112110. Online ahead of print.ABSTRACTGrowing evidence suggests that phosphoinositide 3-kinase (PI3K) and adenosine monophosphate-activated protein kinase (AMPK) signaling cascades are critical in ulcerative colitis (UC) pathophysiology by influencing gut mucosal inflammation. Recently, the coloprotective properties of dipeptidyl peptidase-IV (DPP-IV) inhibitors have emerged. Thus, this study assessed for the first time the potential mitigating impact of a DPP-IV inhibitor, vildagliptin (Vilda), on oxazolone (OXZ)-induced colitis in rats, targeting the...
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Marwa Mahmoud Awad Rehab M El-Gohary Sarah Ibrahim Muhammad Tarek Abdel Ghafar Eman E Farghal Alshimaa Aboalsoud Rehab Ahmed Ahmed El-Shaer Source Type: research
Innovative insights: ITLN1 modulates renal injury in response to radiation
This study highlights the significant role of ITLN1 in regulating kidney injury, providing a novel target for future treatments of radiation-induced kidney injury.PMID:38652961 | DOI:10.1016/j.intimp.2024.111987 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Peng He Ying Guo Shize Wang Siyuan Bu Source Type: research
Protective role of pretreatment with Anisodamine against sepsis-induced diaphragm atrophy via inhibiting JAK2/STAT3 pathway
In conclusion, Anisodamine alleviates sepsis-induced diaphragm atrophy, and the mechanism may be related to inhibiting the JAK2/STAT3 signaling pathway.PMID:38652962 | DOI:10.1016/j.intimp.2024.112133 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Yurou Wang Yun Chu Hongkai Dai Yingfang Zheng Renyu Chen Chenchen Zhou Yanxia Zhong Chengye Zhan Jinlong Luo Source Type: research
PD-L1 blockade in mitigating severe acute pancreatitis induced pancreatic damage through modulation of immune cell apoptosis
Int Immunopharmacol. 2024 Apr 22;133:112081. doi: 10.1016/j.intimp.2024.112081. Online ahead of print.ABSTRACTAcute pancreatitis (AP) is a prevalent gastrointestinal disorder. The immune response plays a crucial role in AP progression. However, the impact of immune regulatory checkpoint PD-L1 on severe acute pancreatitis (SAP) remains uncertain. Hence, this study aimed to examine the influence of PD-L1 on SAP. We assessed PD-L1 expression in neutrophils and monocytes obtained from SAP patients. We induced SAP in C57BL/6J mice, PD-L1 gene-deficient mice, and PD-L1 humanized mice using intraperitoneal injections of cerulein ...
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Du-Jiang Yang Ke-Ling Chen Zhao-Ying Lv Bin Zhou Zong-Guang Zhou Yuan Li Source Type: research
Knockdown of KBTBD7 attenuates septic lung injury by inhibiting ferroptosis and improving mitochondrial dysfunction
In this study, we evaluated the role and related mechanisms of KBTBD7 in septic lung injury. In in vitro studies, we established an in vitro model by inducing human alveolar epithelial cells with lipopolysaccharide (LPS) and found that KBTBD7 was highly expressed in the in vitro model. KBTBD7 knockdown could reduce the inflammatory response by inhibiting the secretion of pro-inflammatory factors and inhibit the production of ROS, ferroptosis and mitochondrial dysfunction. Mechanistic studies show that KBTBD7 interacts with FOXA1, promotes FOXA1 expression, and indirectly inhibits SLC7A11 transcription. In vivo studies have...
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Xiang Li Zhao Lin ShiYu Xu Ning Zhang Jun Zhou Bo Liao Source Type: research
The immunostimulatory roles of gold nanoparticles in immunization and vaccination against Brucella abortus antigens
Int Immunopharmacol. 2024 Apr 22;133:112121. doi: 10.1016/j.intimp.2024.112121. Online ahead of print.ABSTRACTOne effective antigen carrier proposed for use in immunization and vaccination is gold nanoparticles. Prior work has shown that gold nanoparticles themselves have adjuvant properties. Currently, gold nanoparticles are used to design new diagnostic tests and vaccines against viral, bacterial, and parasitic infections. We investigated the use of gold nanoparticles as immunomodulators in immunization and vaccination with an antigen isolated from Brucella abortus. Gold nanoparticles with a diameter of 15 nm were synthe...
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Sergey A Staroverov Roman D Vyrshchikov Vladimir A Bogatyrev Lev A Dykman Source Type: research
The histamine H < sub > 4 < /sub > receptor antagonist 1-[(5-chloro-2,3-dihydro-1-benzofuran-2-yl)methyl]-4-methyl-piperazine(LINS01007) prevents the development of DSS-induced colitis in mice
Int Immunopharmacol. 2024 Apr 22;133:112128. doi: 10.1016/j.intimp.2024.112128. Online ahead of print.ABSTRACTUlcerative colitis (UC) is a chronic inflammatory bowel disease with growing incidence worldwide. Our group reported the compound 5-choro-1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazine (LINS01007) as H4R antagonist (pKi 6.2) and therefore the effects and pharmacological efficacy on a DSS-induced mice model of UC were assessed in this work. Experimental acute colitis was induced in male BALB/c mice (n = 5-10) by administering 3 % DSS in the drinking water for six days. The test compound LINS01007 was administer...
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Beatriz K Lippi Gustavo A B Fernandes Gabriela A Azevedo Nathani G S Negreiros Antonio W Soares Maristella A Landgraf Jo ão Paulo S Fernandes Richardt G Landgraf Source Type: research
