International ImmunopharmacologyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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626 records returned

Suppressive Effect of Diazepam on IFN-gamma Production by Human T Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Many studies showed that benzodiazepines could modulate immune responses through interaction with peripheral benzodiazepine receptors (PBRs) in immune cells but most of the studies were focused on monocytes and macrophages. In the present study, we revealed that diazepama mixed-type benzodiazepine, inhibited IFN-gamma production by human peripheral blood mononuclear cells (PBMCs) induced by anti-CD3 in dose-dependent manner. Flow cytometry analysis demonstrated that diazepam could inhibit the frequency of IFN-gamma-producing CD4(+) and CD8(+) T cells. The inhibitory effect of diazepam on IFN-gamma production is similar...
Source: International Immunopharmacology - November 12, 2009 Category: Allergy & Immunology Authors: Wei M, Li L, Meng R, Fan Y, Liu Y, Tao L, Liu X, Wu C Tags: Int Immunopharmacol Source Type: journals

Zl-n-91, a selective phosphodiesterase 4 inhibitor, suppresses inflammatory response in a COPD-like rat model.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic obstructive pulmonary disease (COPD) is defined as a disease state characterized by poorly reversible airflow limitation induced by cigarette smoking and/or other noxious particle and gases. Phosphodiesterase (PDE) 4 inhibitors are known to elevated cAMP concentrations in inflammatory cells, leading to inhibition of inflammatory response, relaxation of smooth muscle in the airway, and modulation of sensory nerves in the lung as well. To investigate whether Zl-n-91, a new selective PDE4 inhibitor, could decrease inflammation and improve lung function in a COPD-like rat model, male Sprague-Dawley rats are used to...
Source: International Immunopharmacology - November 12, 2009 Category: Allergy & Immunology Authors: Chen YJ Tags: Int Immunopharmacol Source Type: journals

The novel non-mitogenic anti-CD3 antibody, mini-yCD3, delivers a partial TCR signal.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previous studies indicated that a partial T-cell receptor signal delivered by non-mitogenic anti-CD3 antibodies is critical for dampening the activated T-cell response. The mini-yCD3 is a novel non-mitogenic anti-CD3 antibody based on a murine anti-human CD3 antibody yCD3. However, the mechanism by which mini-yCD3 suppresses immune responses mediated by activated T-cells remains unknown. To elucidate its mechanism, we examined the effects of the mini-yCD3 on early signaling events in T-cells. Similar to the mitogenic anti-CD3 mAb, mini-yCD3 triggered changes in the T-cell receptor (TCR). However, unlike the mitogenic a...
Source: International Immunopharmacology - November 11, 2009 Category: Allergy & Immunology Authors: Lv M, Qiao C, Lin Z, Yu M, Hou C, Sun Y, Li Y, Feng J, Shen B Tags: Int Immunopharmacol Source Type: journals

The fusion protein of HSP65 with tandem repeats beta-hCG acting as a potent tumor vaccine in suppressing Hepatocarcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It has been demonstrated that the beta-subunit of Human chorionic gonadotropin (beta-hCG) is ectopically expressed on a variety of human cancers of different histological types and has been used as an antigenic target in anti-cancer vaccines. We engineered a fusion protein by fusing 10 tandemly repeated copies of the 10-residue sequence of beta-hCG (109-118)in CTP37combined with beta-hCG C-terminal 37 peptides to mycobacterial heat-shock protein 65 and immunized mice via subcutaneous injection. Humoral immune and cellular immune responses were effectively elicited. High titer of anti-beta-hCG antibody was detected in i...
Source: International Immunopharmacology - November 10, 2009 Category: Allergy & Immunology Authors: Hu X, Zhang Y, Lin M, Lu Y, Zhang Y, Zhang H, Chen Y, Hou J, Xing Y, Jin L, Cao R, Liu J Tags: Int Immunopharmacol Source Type: journals

Humanized monoclonal antibody against the chemokine CXCL-8 (IL-8) effectively prevents acute lung injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As one of the most important endogenous chemotatic factors for neutrophils, the chemokine CXCL8 (IL-8) is involved in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), characterized by massive neutrophil infiltration in the lung. Since neutralization of CXCL8 with polyclonal antibody has been shown to reduce the severity of ALI/ARDS in animal models, we explored the potential of humanized anti-CXCL8 antibody as a preventive or therapeutic agent for ALI. We used a 'two-hit' protocol to induce ALI in rabbits that showed extensive edema in the alveolar lumina, marked infiltration ...
Source: International Immunopharmacology - November 9, 2009 Category: Allergy & Immunology Authors: Bao Z, Ye Q, Gong W, Xiang Y, Wan H Tags: Int Immunopharmacol Source Type: journals

Oral administration of an Enoki mushroom protein FVE activates innate and adaptive immunity and induces anti-tumor activity against murine hepatocellular carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
FVE is a documented immunomodulatory protein purified from Enoki mushroom (Flammulina velutipes) and known as an activator for human T lymphocytes. This present study was aimed to investigate the anti-tumor effect and the related mechanisms of oral administration of FVE using a murine hepatoma model. Oral administration of FVE (10 mg/kg) significantly increased the life span and inhibited the tumor size of BNL 1MEA.7R.1 (BNL) hepatoma-bearing mice. Tumor-bearing mice receiving oral FVE treatment had the highest tumoricidal capacity of peritoneal macrophages and tumor-specific splenocytes against BNL hepatoma cells. In ...
Source: International Immunopharmacology - November 9, 2009 Category: Allergy & Immunology Authors: Chang HH, Hsieh KY, Yeh CH, Tu YP, Sheu F Tags: Int Immunopharmacol Source Type: journals

Isatin down-regulates expression of atrial natriuretic peptide receptor A and inhibits airway inflammation in a mouse model of allergic asthma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we encapsulated isatin in chitosan nanoparticles and tested them in a mouse model of allergic asthma by intranasal delivery to the lung. Isatin nanocapsules reduced lung pathology by blocking ANP signaling, but surprisingly also by reducing expression of NPRA. Ovalbumin-allergic mice were treated intranasally with isatin-containing chitosan nanocapsules either before or after allergen challenge, and lung function, cytokine levels, histopathology and cellular infiltration were determined. ANP activity was quantitated by measuring changes in intracellular cyclic GMP and changes in NPRA levels were determined. F...
Source: International Immunopharmacology - November 6, 2009 Category: Allergy & Immunology Authors: Kandasamy R, Park SJ, Hellermann GR, Lockey RF, Mohapatra SS Tags: Int Immunopharmacol Source Type: journals

Dihydroartemisinin can inhibit Calmodulin, Calmodulin -dependent phosphodiesterase activity and stimulate cellular immune responses.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the effects of Dihydroartemisinin (DHA) that is a semisynthesized agent from the ART on CaM structure was investigated. The result showed that DHA increased fluorescence emission of CaM in higher amounts compared with the ART. Also, the effect of DHA on CaM - dependent PDE-1 activity was studied. Kinetic analysis of the DHA- CaM interaction showed that this agent competitively inhibited the activation of PDE-1 without affecting Vmax. Km value of PDE-1 in the presence of ART and DHA were10 and 15microM, respectively; DHA increased Km value in higher amounts compared with the ART. The Ki constant for ART and D...
Source: International Immunopharmacology - November 6, 2009 Category: Allergy & Immunology Authors: Noori S, Hassan Z, Taghikhani M, Rezaei B, Habibi Z Tags: Int Immunopharmacol Source Type: journals

Immunosuppression with an interleukin-2 fusion protein leads to improved LV function in experimental ischemic cardiomyopathy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several cytokines are activated in chronic heart failure (CHF), including interleukin-2 (IL-2). IL-2 is important for the survival of regulatory T cells, as well as for the function of activated T cells. Its role in ischemic cardiomyopathy has not yet been investigated. We therefore studied left ventricular (LV) performance and remodeling in a rat model of myocardial infarction (MI) after treatment with an IL-2IgG2b fusion protein to stimulate IL-2 signaling. Spraque-Dawley rats (SD) were submitted to permanent ligation of the left descending artery (LAD) to induce a MI or to a sham operation. Twenty-four hours, six da...
Source: International Immunopharmacology - November 5, 2009 Category: Allergy & Immunology Authors: Koch M, Savvatis K, Scheeler M, Dhayat S, Bonaventura K, Pohl T, Riad A, Bulfone-Paus S, Schultheiss HP, Tschöpe C Tags: Int Immunopharmacol Source Type: journals

Sulfur mustard induces immune sensitization in hairless Guinea Pigs.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sulfur mustard (SM, bis-(2-chloroethyl) sulfide) is a well known chemical warfare agent that may cause long-term debilitating injury. Because of the ease of production and storage, it has a strong potential for chemical terrorism; however, the mechanism by which SM causes chronic tissue damage is essentially unknown. SM is a potent protein alkylating agent, and we tested the possibility that SM modifies cellular antigens, leading to an immunological response to "altered self" and a potential long-term injury. To that end, in this communication, we show that dermal exposure of euthymic hairless guinea pigs induced infil...
Source: International Immunopharmacology - October 31, 2009 Category: Allergy & Immunology Authors: Mishra NC, Rir-Sima-Ah J, March T, Weber W, Benson J, Jaramillo R, Seagrave JC, Schultz G, Grotendorst G, Sopori M Tags: Int Immunopharmacol Source Type: journals

Stimulus-specific regulation of CD63 and CD203c membrane expression in human basophils by the flavonoid quercetin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Very low doses of quercetin, within the pharmacological range, inhibit IgE-mediated membrane markers up-regulation but prime the response to the chemotactic peptide fMLP; this stimulus specificity may have implications on the possible therapeutic action of the flavonoid in different pathologies. PMID: 19887118 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - October 31, 2009 Category: Allergy & Immunology Authors: Chirumbolo S, Conforti A, Ortolani R, Vella A, Marzotto M, Bellavite P Tags: Int Immunopharmacol Source Type: journals

Attenuation of cyclosporine A-induced testicular and spermatozoal damages associated with oxidative stress by ellagic acid.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, CsA-induced oxidative stress leads to the structural and functional damages in the testicular tissue and sperm quality of rats, and also EA has a protective effect on these damages. PMID: 19883798 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - October 30, 2009 Category: Allergy & Immunology Authors: Türk G, Sönmez M, Ceribaşı AO, Yüce A, Ateşşahin A Tags: Int Immunopharmacol Source Type: journals

Bisabolangelone isolated from Ostericum koreanum inhibits the production of inflammatory mediators by down-regulation of NF-kappaB and ERK MAP kinase activity in LPS-stimulated RAW264.7 cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the anti-inflammatory effect of bisabolangelone was investigated to address potential therapeutic effects in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells. Bisabolangelone significantly inhibited NO, PGE(2), and pro-inflammatory cytokines by suppressing the mRNA and protein expressions of iNOS and COX-2. Bisabolangelone also inhibited the productions of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6) by suppressing the cytokines mRNA and protein expressions. The molecular mechanism of bisabolangelone-mediated attenuation in RAW 264.7 cells has close a relationship to suppress...
Source: International Immunopharmacology - October 28, 2009 Category: Allergy & Immunology Authors: Jung HW, Mahesh R, Park JH, Boo YC, Park KM, Park YK Tags: Int Immunopharmacol Source Type: journals

In vitro stimulation of Balb/c and C57 BL/6 splenocytes by a recombinantly produced banana lectin isoform results in both a proliferation of T cells and an increased secretion of interferon-gamma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study's aim is to explore the immunostimulatory potential of rBanLec in the murine model. Analyses of the responses of Balb/c- and C57 BL/6-originated splenocytes to in vitro rBanLec stimulation were performed to examine the dependency of rBanLec's immunostimulatory potential upon the splenocytes' genetic background. It is shown that the responses of Balb/c- and C57 BL/6-originated splenocytes to rBanLec stimulation differ both qualitatively and in intensity. The hallmarks of the induced responses are T lymphocyte proliferation and intensive interferon-gamma secretion. Both phenomena are more marked in Balb/c-originat...
Source: International Immunopharmacology - October 27, 2009 Category: Allergy & Immunology Authors: Stojanović MM, Zivković IP, Petrušić VZ, Kosec DJ, Dimitrijević RD, Jankov RM, Dimitrijević LA, Gavrović-Jankulović MD Tags: Int Immunopharmacol Source Type: journals

Anti-asthmatic activity of phenolic compounds from the roots of Gastrodia elata Bl.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We previously reported that 4-hydroxy-3-methoxybenzaldehyde has the most potent anti-inflammatory and analgesic activity of eight phenolic compounds obtained from the dried roots of Gastrodiaelata (GE) Blume (Orchidaceae); its activity may be related to inhibition of cyclooxygenase activities and oxidation. In the present study, the effects of nine phenolic compounds from GE on immediate-phase (IAR) and late-phase (LAR) asthmatic responses after aerosolized-ovalbumin (OA) challenge were evaluated by determining the specific airway resistance (sRaw) using a double-chambered plethysmograph in conscious guinea pigs with I...
Source: International Immunopharmacology - October 27, 2009 Category: Allergy & Immunology Authors: Jang YW, Lee JY, Kim CJ Tags: Int Immunopharmacol Source Type: journals

A nontoxic derivative of lipopolysaccharide increases immune responses to Gardasil((R)) HPV vaccine in mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human papillomavirus (HPV) is the causative agent of cervical cancer, the second most common cause of cancer death in women worldwide. The licensed HPV vaccine Gardasil((R)) from Merck & Co. is a quadrivalent vaccine containing virus-like particles (VLPs) of the L1 proteins from HPV types 6, 11, 16, and 18 adsorbed on aluminum salts (alum). CIA07 is an immunostimulatory agent comprised of bacterial DNA fragments (CIA02) and a nontoxic derivative of lipopolysaccharide (CIA05) that has been shown to have antitumor activity and adjuvant activity for viral and bacterial vaccine antigens. We investigated whether these C...
Source: International Immunopharmacology - October 27, 2009 Category: Allergy & Immunology Authors: Han JE, Kim HK, Park SA, Lee SJ, Kim HJ, Son GH, Kim YT, Cho YJ, Kim HJ, Lee NG Tags: Int Immunopharmacol Source Type: journals

Suppression of Toll-like receptor 2 or 4 agonist-induced cyclooxygenase-2 expression by 4-Oxo-4-(2-oxo-oxazolidin-3-yl)-but-2-enoic acid ethyl ester.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Toll-like receptors (TLRs) recognize molecular structures derived from microbes including bacteria, viruses, yeast, and fungi, and regulate the activation of innate immunity. All TLR signaling pathways culminate in the activation of nuclear factor-kappaB (NF-kappaB) transcription factor leading to the induction of inflammatory gene products including cytokines and cyclooxygenase-2 (COX-2). In the present report, we demonstrate biochemical evidence that the fumaryl oxazolidinone derivative 4-Oxo-4-(2-oxo-oxazolidin-3-yl)-but-2-enoic acid ethyl ester (OSL07), which was previously synthesized in our laboratory, inhibits t...
Source: International Immunopharmacology - October 26, 2009 Category: Allergy & Immunology Authors: Yun SM, Kang SH, Lee AN, Park SJ, Kim DY, Youn HS Tags: Int Immunopharmacol Source Type: journals

Morphine-mediated suppression of phagocytosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19853670 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - October 21, 2009 Category: Allergy & Immunology Authors: Bosshart H Tags: Int Immunopharmacol Source Type: journals

Phenotype and functions of spleen dendritic cells in rick-knockout mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
RICK (receptor-interacting caspase-like apoptosis-regulatory kinase), a protein kinase, promotes nuclear factor kappa B and caspase activation. Herein, in order to further learn the immune role of RICK, its gene in mice was knocked out. Then the phenotype, cytokine, endocytosis and stimulatory capacity of spleen dendritic cells (SDCs) from RICK(-) (knockout) and RICK(+) (wild type) mice were analyzed. Our results showed that the levels of I-Ad, CD11b, CD80 on SDCs from RICK(-) mice were higher while the levels of CD8alpha, CD40, CD45R were lower compared with those from RICK(+) mice; The intracellular levels of IL-4, I...
Source: International Immunopharmacology - October 20, 2009 Category: Allergy & Immunology Authors: Yao G, Yang L, Hou Y Tags: Int Immunopharmacol Source Type: journals

Induced keratinocyte hyper-proliferation in alpha2beta1 integrin transgenic mice results in systemic immune cell activation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we have followed the integrin transgenic mice for five weeks, where substantial keratinocyte hyper-proliferation, inflammatory infiltration and high cytokine levels within the skin can still be observed. In addition, draining lymph nodes were dramatically increased in size and contained highly activated T cells, as well as APCs secreting large amounts of pro-inflammatory cytokines. Furthermore, the systemic immune response was affected with increased spleen size, elevated cytokine levels in the serum and altered lymphocyte trafficking patterns, very much resembling what is seen in psoriasis patients. Finally...
Source: International Immunopharmacology - October 15, 2009 Category: Allergy & Immunology Authors: Teige I, Bäcklund A, Svensson L, Kvist PH, Petersen TK, Kemp K Tags: Int Immunopharmacol Source Type: journals

Is neuroimmunomodulation a future therapeutic approach for sepsis?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sepsis is considered as a disease of profoundly and uncontrollably activated innate immune response against bacterial infection or their products. Thus, regulation of innate immune response plays a critical role in controlling exaggerated systemic inflammation responsible for sepsis development. However, treatment of patients suffering from sepsis or its more severe form (i.e. severe sepsis or septic shock) with available antibiotics or immunomodulatory agents did not prove effective in controlling multi organ damage and mortality. Therefore it is important to explore cascades of mechanisms associated with pathogenesis...
Source: International Immunopharmacology - October 15, 2009 Category: Allergy & Immunology Authors: Kumar V, Sharma A Tags: Int Immunopharmacol Source Type: journals

CD14 but not MD2 transmit signals from DAMP.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Both pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) activate antigen-presenting cells, often through the same pattern recognition receptors (PRR), such as Toll-like receptors (TLR). The TLR4-CD14-MD2 and TLR2-CD14 complexes have been shown to play a role in the recognition of lipopolysaccharide (LPS) and peptidoglycan (PG), respectively. Since many DAMPs have also been known to activate TLR2 or TLR4 pathways, we dissected the role of each molecule in the receptor complexes (TLR2-CD14-MD2) responding to DAMP (necrotic cells) or PAMP (LPS and PG). CD14 played a significant...
Source: International Immunopharmacology - October 15, 2009 Category: Allergy & Immunology Authors: Chun KH, Seong SY Tags: Int Immunopharmacol Source Type: journals

Effect of the inosine 5'-monophosphate dehydrogenase inhibitor BMS-566419 on rat cardiac allograft rejection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the in vitro and in vivo pharmacological effects of BMS-566419, a novel chemically synthesized IMPDH inhibitor, were compared to those of mycophenolic acid (MPA) and MMF based on results from several immunological experiments. The in vitro inhibitory activity of BMS-566419 on IMPDH type I/II, immune cell proliferation and antibody production from Lipopolysaccharide (LPS)-stimulated B cells was similar, albeit slightly less potent than that of MPA. In a rat heterotopic cardiac transplant model, monotherapy using orally administered BMS-566419 60mg/kg or MMF 40mg/kg prolonged the median survival time (MST) of ...
Source: International Immunopharmacology - October 15, 2009 Category: Allergy & Immunology Authors: Nakanishi T, Morokata T, Kubo K, Umeno H, Eikyu Y, Kozuki Y, Seki N Tags: Int Immunopharmacol Source Type: journals

Antibody concentrations to Abeta1-42 monomer and soluble oligomers in untreated and antibody-antigen-dissociated intravenous immunoglobulin preparations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cognitive improvement in Alzheimer's disease (AD) patients treated with intravenous immunoglobulin (IvIg) has been attributed to its antibodies to amyloid beta (Abeta). We compared the concentrations of specific antibodies to soluble Abeta1-42 conformations, namely Abeta1-42 monomer and Abeta1-42 soluble oligomers, between three IvIg preparations, Gamunex, Gammagard, and Flebogamma. To determine specific antibody concentrations to these Abeta1-42 conformations, nonspecific binding of the IvIg preparations to the Abeta reverse sequence, Abeta42-1, was subtracted. These antibodies were measured in untreated IvIg preparat...
Source: International Immunopharmacology - October 15, 2009 Category: Allergy & Immunology Authors: Klaver AC, Finke JM, Digambaranath J, Balasubramaniam M, Loeffler DA Tags: Int Immunopharmacol Source Type: journals

Therapeutic activity of sunitinib for Her2/neu induced mammary cancer in FVB mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mouse mammary tumor virus-Neu (MMTV/neu) transgenic mice on an FVB-background (FVB-neuN) have increased numbers of myeloid derived suppressor cells (MDSCs) and regulatory T-cells (T-regs) in the spleen during mammary tumor induction and progression. Using this transgenic tumor model, we assessed the therapeutic activity of Sunitinib, a multi-targeted, tyrosine kinase (TK) inhibitor and its effects on immune-regulatory cells. Our preliminary results show that Sunitinib at 40mg/kg/day, p.o. (per os), delayed the time to tumor induction and reduced the incidence and growth of tumors in FVB-neuN mice. In association with i...
Source: International Immunopharmacology - October 11, 2009 Category: Allergy & Immunology Authors: Abe F, Younos I, Westphal S, Samson H, Scholar E, Dafferner A, Hoke TA, Talmadge JE Tags: Int Immunopharmacol Source Type: journals

Capsaicin inhibits IFN-gamma-induced MHC class II expression by suppressing transcription of class II transactivator gene in murine peritoneal macrophages.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Major histocompatibility complex (MHC) class II molecules play crucial roles in adaptive immune response and antigen presentation. Owing to enlargement of capsaicin's availability as an anti-inflammatory agent in medical therapeutics, we investigated the new effects of capsaicin that are related to adaptive immune response in terms of MHC class II expression in murine primary cultured macrophages. Capsaicin (0.1-10microM) reduced the expression of MHC class II mRNA levels in peritoneal cultured macrophages upon treatment with interferon (IFN)-gamma (100units/ml). In agreement with this, treatment of the cells with caps...
Source: International Immunopharmacology - October 9, 2009 Category: Allergy & Immunology Authors: Mahmoud ME, Nikami H, Shiina T, Takewaki T, Shimizu Y Tags: Int Immunopharmacol Source Type: journals

CpG ODN pretreatment attenuates concanavalin A-induced hepatitis in mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
T cell-mediated hepatic damage plays a key role in the pathogenesis of liver diseases such as autoimmune hepatitis, viral hepatitis and acute liver failure. CpG-containing oligodeoxynucleotides (CpG ODN), a ligand for toll-like-receptor (TLR) 9, is widely used as an immunological adjuvant. In the present study, we investigated the effect of CpG ODN on T cell-mediated liver injury in a murine model of concanavalin A (Con A)-induced hepatitis. We found that the aminotransferase level was significantly decreased in CpG ODN pretreated mice and the survival of the mice was markedly prolonged. CpG ODN pretreatment inhibited ...
Source: International Immunopharmacology - October 5, 2009 Category: Allergy & Immunology Authors: Zhang H, Gong Q, Li JH, Kong XL, Tian L, Duan LH, Tong J, Song FF, Fang M, Zheng F, Xiong P, Tan Z, Gong FL Tags: Int Immunopharmacol Source Type: journals

Effects of Esculentoside A on Autoimmune Syndrome Induced by Campylobacter Jejuni in Mice and its Modulation on T-lymphocyte Proliferation and Apoptosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Esculentoside A (EsA), a saponin isolated from the root of Phytolacca esculenta, has been reported to exert anti-inflammatory effects in several animal models of acute and chronic inflammation by inhibiting the production and activity of pro-inflammatory cytokines in macrophages and epithelial cells. However, little is known about its modulation on T cells. In the present study, we further investigated its potential in treatment of autoimmune disease and its modulation on T cells, using an experimental autoimmune model established through immunizing mice with campylobacter jejuni strain CJ-S(131) in Freund s complete a...
Source: International Immunopharmacology - October 5, 2009 Category: Allergy & Immunology Authors: Hu Z, Qiu L, Xiao Z, Wang J, Yu Q, Li J, Feng H, Guo C, Zhang J Tags: Int Immunopharmacol Source Type: journals

The effects of dexamethasone on cigarette smoke induced gene expression changes in COPD macrophages.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic obstructive pulmonary disease (COPD) is a smoking related inflammatory airway disease in which macrophages play a key role. Previously we have shown that cigarette smoke extract (CSE) causes suppression of macrophage inflammatory mediators, with the exception of IL-8. We now investigate the effects of dexamethasone on these gene expression changes. Monocyte derived macrophages (MDMs) were cultured with CSE and dexamethasone. Microarray analysis was used to assess inflammatory mediator regulation, with qPCR and ELISA also performed for selected cytokines. The major effect of CSE was down-regulation of inflammato...
Source: International Immunopharmacology - October 5, 2009 Category: Allergy & Immunology Authors: Kent LM, Fox SM, Farrow SN, Singh D Tags: Int Immunopharmacol Source Type: journals

Evaluation of antidiabetic activity of polysaccharide isolated from Phellinus linteus in non-obese diabetic mouse.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Polysaccharide (PLP) isolated from Phellinus linteus inhibits tumor growth and metastasis by enhancing immune functions of macrophages, dendritic cells, NK cells, T cells, and B cells. Here, we report that PLP can inhibit the development of autoimmune diabetes in non-obese diabetic (NOD) mice. Although 80% of the NOD mice had developed diabetes by 24 weeks of age, none of the PLP-treated NOD mice developed diabetes. The mean blood glucose levels were 110 mg/dl in PLP-treated mice and 499 mg/dl in control NOD mice. Histological examination of the pancreatic islets revealed that most of the islets isolated from PLP-treat...
Source: International Immunopharmacology - October 3, 2009 Category: Allergy & Immunology Authors: Kim HM, Kang JS, Kim JY, Park SK, Kim HS, Lee YJ, Yun J, Hong JT, Kim Y, Han SB Tags: Int Immunopharmacol Source Type: journals

Sodium selenite inhibits the expression of VEGF, TGFbeta(1) and IL-6 induced by LPS in human PC3 cells via TLR4-NF(K)B signaling blockage.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lipopolysaccharide (LPS)-induced TLR4-NF(K)B signaling plays an important role in the development of prostatic tumors from chronic bacterial prostatic infection. Although many studies support the role of selenium in protecting against the development of prostate cancer secondary to chronic prostatitis, the mechanism of action remains unclear. The aim of our study was to investigate whether selenium inhibits the LPS-induced TLR4 signaling pathway in human prostate cancer PC3 cells. Using real-time quantitative PCR and ELISA analysis, we found that pretreatment with selenium (0.5-5uM) inhibited the LPS-induced expression...
Source: International Immunopharmacology - October 3, 2009 Category: Allergy & Immunology Authors: Pei Z, Li H, Guo Y, Lin D Tags: Int Immunopharmacol Source Type: journals

Interleukin -6 subfamily cytokines and rheumatoid arthritis: Role of antagonists.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Many cytokines have been implicated in the inflammatory pathways that characterise rheumatoid arthritis (RA) and related inflammatory diseases of the joints. These include members of the interleukin-6 (IL-6) family of cytokines, several of which have been detected in excess in the synovial fluid from RA patients. What makes the IL-6 group of cytokines a family is their common use of the glycoprotein 130 (gp130) receptor subunit, to which they bind with different affinities. Several strategies have been developed to block the pro-inflammatory activities of IL-6 subfamily cytokines. These include the application of monoc...
Source: International Immunopharmacology - October 1, 2009 Category: Allergy & Immunology Authors: Jazayeri JA, Carroll GJ, Vernallis AB Tags: Int Immunopharmacol Source Type: journals

Glucans from the Caripia. montagnei mushroom present anti-inflammatory activity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Caripia montagnei is basidiomycetes species which contains polysaccharides with immunomodulatory properties. An extract of this mushroom underwent removal of the fat content by organic solvent and subsequently proteolysis. The aqueous phase obtained after proteolysis was precipitated with methanol yielding a fraction containing carbohydrates (98.7+/-3.3%) and protein (1.3+/-0.25%). Chemical Analysis, infrared spectroscopy and nuclear magnetic resonance (NMR) showed that the carbohydrate fraction contained (63.3+/-4.1) of beta-glucans and proteins (2.2+/-0.3%). These glucans (50mg/kg of body weight) significantly reduce...
Source: International Immunopharmacology - October 1, 2009 Category: Allergy & Immunology Authors: Queiroz LS, Nascimento MS, Cruz AK, Castro AJ, Moura MD, Baseia IG, Araújo RM, Benevides NM, Lima LF, Leite EL Tags: Int Immunopharmacol Source Type: journals

Pre-exposure to Staphylococcal enterotoxin A exacerbates the pulmonary allergic eosinophil recruitment in rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, airways pre-exposure to SEA causes a selective increase in eosinophil number in BAL fluid and bone marrow of OVA-challenged rats by mechanisms involving enhancement of TNF-alpha and eotaxin synthesis. PMID: 19800992 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 30, 2009 Category: Allergy & Immunology Authors: Mariano NS, de Mello GC, Ferreira T, Schenka A, Camargo EA, de Nucci G, Desouza IA, Antunes E Tags: Int Immunopharmacol Source Type: journals

A cysteine-type carboxypeptidase, cathepsin X, generates peptide receptor agonists.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The kallikrein-kinin system and the renin-angiotensin system interact at different levels and are linked by various molecules such as angiotensin-converting enzyme which degrades bradykinin into inactive peptides. Here we report that a cysteine-type carboxypeptidase, cathepsin X, is able to modulate the kallikrein-kinin system through carboxyterminal processing of the small peptide hormones bradykinin and kallidin. Both peptides are thereby converted from bradykinin B(2) receptor ligands to bradykinin B(1) receptor specific ligands. Cathepsin X, which has previously been recognized as an inflammatory marker may therefo...
Source: International Immunopharmacology - September 30, 2009 Category: Allergy & Immunology Authors: Nägler DK, Kraus S, Feierler J, Mentele R, Lottspeich F, Jochum M, Faussner A Tags: Int Immunopharmacol Source Type: journals

Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The TNF superfamily member LIGHT has potent anti-tumor activity through direct cytotoxicity and activation of the immune response, and is a promising candidate for cancer therapy. Natively, LIGHT exists as both a membrane-anchored form and a proteolytically processed, secreted form. However, the strength of the anti-tumor activity of each form of LIGHT has not been well defined. Here, to identify the optimal form of LIGHT for cancer gene therapy, we constructed fiber-mutant adenovirus vectors (AdRGD) encoding native full-length LIGHT (LIGHT/FL), stably membrane-anchored LIGHT (LIGHT/mem), and fully secreted LIGHT (LIGH...
Source: International Immunopharmacology - September 30, 2009 Category: Allergy & Immunology Authors: Morishige T, Yoshioka Y, Tanabe A, Yao X, Mizuguchi H, Tsunoda SI, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S Tags: Int Immunopharmacol Source Type: journals

The anti-inflammatory effect of tussilagone, from Tussilago farfara, is mediated by the induction of heme oxygenase-1 in murine macrophages.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tussilagone (TSL), isolated from the flower of buds of Tussilago farfara (Compositae), is a sesquiterpenoid that is known to exert a variety of pharmacological activities. In the present study, we demonstrated that TSL exerts anti-inflammatory activities in murine macrophages by inducing heme oxygenase-1 (HO-1) expression. Treatment of RAW264.7 cells with TSL induced HO-1 protein expression in a dose- and time-dependent manner without the induction of HO-1 mRNA expression. TSL-mediated HO-1 protein induction was not inhibited by treatment with actinomycin D, a transcriptional inhibitor, but by cycloheximide, a translat...
Source: International Immunopharmacology - September 29, 2009 Category: Allergy & Immunology Authors: Hwangbo C, Lee HS, Park J, Choe J, Lee JH Tags: Int Immunopharmacol Source Type: journals

Evaluation of anti-leukemia effect of resveratrol by modulating SATA3 signaling.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we examine its anti-leukemia effect both in vitro and in vivo. Our data indicate that resveratrol contributes to inhibiting growth, inducing apoptosis and cell cycle arrest in the three leukemia cell lines (Jurkat, SUP-B15, and Kasumi-1), and reducing the phosphorylation of STAT3, meanwhile modulating the expression of Bcl-2 and Bax. In vivo, resveratrol could prolong the life span of Kasumi-1-bearing mice, and attenuate the activity of STAT3. Taken altogether, this investigation focuses on signaling pathways involved in STAT3 by resveratrol and to delineate its molecular mechanisms underlying anti-leukemia ...
Source: International Immunopharmacology - September 27, 2009 Category: Allergy & Immunology Authors: Li T, Wang W, Chen H, Li T, Ye L Tags: Int Immunopharmacol Source Type: journals

Immunomodulating effects of Korean mistletoe lectin in vitro and in vivo.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The immunomodulatory effects of Korean mistletoe lectin (KML), one of the major active components in Viscum album L. var. coloratum, were investigated in vitro in immune cell proliferation and natural killer (NK) cell- and macrophage-mediated cytotoxicity, and in vivo in the forced swim test and cold stress. In mitogen-induced lymphocyte proliferation of murine splenocytes, concanavalin A and lipopolysaccharide significantly increased the proliferation of T cell and B cell lymphocytes, respectively. KML exposure increased lymphocyte proliferation in response to mitogen. KML also increased the splenic NK cell and macrop...
Source: International Immunopharmacology - September 25, 2009 Category: Allergy & Immunology Authors: Lee CH, Kim JK, Kim HY, Park SM, Lee SM Tags: Int Immunopharmacol Source Type: journals

Oral administration of xanthan gum enhances antitumor activity through toll-like receptor 4.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These results suggest beneficial effects of oral administration of XG on immune-surveillance against neoplasms. PMID: 19788935 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 25, 2009 Category: Allergy & Immunology Authors: Takeuchi A, Kamiryou Y, Yamada H, Eto M, Shibata K, Haruna K, Naito S, Yoshikai Y Tags: Int Immunopharmacol Source Type: journals

Immunomodulation of Rheum tanguticum polysaccharide (RTP) on the immunosuppressive effects of Dexamethasone (DEX) on the treatment of colitis in rats induced by 2,4,6-trinitrobenzene sulfonic acid.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, DEX-RTP microsphere delivered DEX directly to colon avoiding the absorption at the upper intestinal tract and showed synergistic effects on colitis both from the strong anti-inflammatory effects of DEX and from the immunoregulation of RTP. PMID: 19788936 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 25, 2009 Category: Allergy & Immunology Authors: Liu L, Yuan S, Long Y, Guo Z, Sun Y, Li Y, Niu Y, Li C, Mei Q Tags: Int Immunopharmacol Source Type: journals

Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Excessive production of nitric oxide (NO) and proinflammatory cytokines from activated microglia contributes to human neurodegenerative disorders. Our previous study demonstrated the potent inhibition of lipopolysaccharide (LPS)-induced NO production in rat primary microglial cells by rhynchophylline (RIN) and isorhynchophylline (IRN), a pair of isomeric alkaloids of Uncaria rhynchophylla (Miq.) Jacks. that has been used in China for centuries as a "cognitive enhancer" as well as to treat strokes. We further investigated whether RIN and IRN effectively suppress release of proinflammatory cytokines in LPS-activated micr...
Source: International Immunopharmacology - September 21, 2009 Category: Allergy & Immunology Authors: Yuan D, Ma B, Yang JY, Xie YY, Wang L, Zhang LJ, Kano Y, Wu CF Tags: Int Immunopharmacol Source Type: journals

Doxorubicin enhances CD4(+) T-cells immune responses by inducing expression of CD40 ligand and 4-1BB.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chemotherapy agents have adverse immunotherapeutic effects secondary to inhibition of hematopoietic stem cell proliferation, particularly in committed lymphoblast. Certain anti-cancer drugs have immuno-modulatory properties, although mechanisms are still not fully understood. In the current study, we explored the effects of doxorubicin on peripheral blood CD4(+) and CD8(+) T cells responses pre- and post-stimulation. Doxorubicin treatment alone had no effects on peripheral blood T lymphocytes and regulatory T cells in vivo and in vitro. However, CD4(+) T-cells were resistant to doxorubicin and demonstrated more robust ...
Source: International Immunopharmacology - September 20, 2009 Category: Allergy & Immunology Authors: Park JY, Jang MJ, Chung YH, Kim KY, Kim SS, Lee WB, You S, Choi YS, Hur DY, Kim D Tags: Int Immunopharmacol Source Type: journals

SM934, a water-soluble derivative of arteminisin, exerts immunosuppressive functions in vitro and in vivo.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the present study, we investigated the immunosuppressive effects and underlying mechanisms of beta-aminoarteether maleate (SM934), a derivative of artemisinin, against T cell activation in vitro and in vivo. In vitro, SM934 significantly inhibited the proliferation of splenocytes induced by concanavalin A (Con A), lipopolysaccharide (LPS), mixed lymphocyte reaction (MLR), and anti-CD3 plus anti-CD28 (anti-CD3/28). SM934 significantly inhibited interferon (IFN)-gamma production and CD4(+) T cell division stimulated by anti-CD3/28. SM934 also promoted apoptosis of CD69(+) population in CD4(+) T cells stimulated by ant...
Source: International Immunopharmacology - September 18, 2009 Category: Allergy & Immunology Authors: Hou LF, He SJ, Wang JX, Yang Y, Zhu FH, Zhou Y, He PL, Zhang Y, Yang YF, Li Y, Tang W, Zuo JP Tags: Int Immunopharmacol Source Type: journals

Protective effect of florfenicol on acute lung injury induced by lipopolysaccharide in mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Florfenicol, an antibiotic used to treat infection, has previously been shown to modulate early cytokine responses and increase mouse survival in endotoxemia. In the present study, we investigated in vivo the effect of florfenicol on acute lung injury (ALI) induced by lipopolysaccharide (LPS). In the mouse model of LPS-induced inflammatory lung injury, we found that pretreatment with a single 100mg/kg dose of florfenicol significantly decreases the W/D ratio of lungs and protein concentration in the bronchoalveolar lavage fluid (BALF) and significantly reduces the number of total cells, neutrophils and macrophages in t...
Source: International Immunopharmacology - September 15, 2009 Category: Allergy & Immunology Authors: Zhang X, Song K, Xiong H, Li H, Chu X, Deng X Tags: Int Immunopharmacol Source Type: journals

Preventive and curative glycoside kaempferol treatments attenuate the TH2-driven allergic airway disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Asthma is a chronic respiratory disease characterized by airway inflammation and airway hyperresponsiveness (AHR). One strategy to treat allergic diseases is the development of new drugs. Flavonoids are compounds derived from plants and are known to have antiallergic, anti-inflammatory, and antioxidant properties. To investigate whether the flavonoid kaempferol glycoside 3-O-[beta-D-glycopiranosil-(1 --> 6)-alpha-L-ramnopiranosil]-7-O-alpha-L-ramnopiranosil-kaempferol (GRRK) would be capable of modulating allergic airway disease (AAD) either as a preventive (GRRK P) or curative (GRRK C) treatment in an experimental ...
Source: International Immunopharmacology - September 11, 2009 Category: Allergy & Immunology Authors: Medeiros KC, Faustino L, Borduchi E, Nascimento RJ, Silva TM, Gomes E, Piuvezam MR, Russo M Tags: Int Immunopharmacol Source Type: journals

Pharmacological characterization of anaphylaxis-like shock responses induced in mice by mannan and lipopolysaccharide.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Intravenous injection of lipopolysaccharide (LPS, a component of the Gram-negative bacterial cell-surface) or mannan (Man, a component of the fungal cell-surface) into mice reportedly induces anaphylaxis-like shock (ALS) via complement-associated platelet degradation and platelet-activating factor (PAF), respectively. However, it is unclear whether PAF is involved in LPS-ALS or whether complements and/or platelets are involved in Man-ALS. Here, using preparations of Man from Saccharomyces cerevisiae and LPS from Klebsiella O3, we characterized and compared LPS-ALS and Man-ALS, with the following results. (1) ALS depend...
Source: International Immunopharmacology - September 11, 2009 Category: Allergy & Immunology Authors: Funayama H, Huang L, Sato T, Ohtaki Y, Asada Y, Yokochi T, Takada H, Sugawara S, Endo Y Tags: Int Immunopharmacol Source Type: journals

Editorial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19751693 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - September 10, 2009 Category: Allergy & Immunology Authors: Ghazanfari T, Hassan ZM Tags: Int Immunopharmacol Source Type: journals

Alterations in serum levels of inflammatory cytokines (TNF, IL-1alpha, IL-1beta and IL-1Ra) 20years after sulfur mustard exposure: Sardasht-Iran cohort study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mustard gas, even in low doses, has the ability to inflict damage in multiple organs especially the skin, eyes, as well as the respiratory tract. This damage may cause many complications which persist during the lifespan of exposed subjects. Pro-inflammatory cytokines including TNF, IL-1alpha, IL-1beta and IL-1Ra cause systemic inflammatory reactions and numerous changes including altered cell signaling and migration, changes in cytokine production and fever. The aim of this study was to determine the serum levels of these cytokines in subjects who were exposed to mustard gas 20years ago in comparison with an unexposed...
Source: International Immunopharmacology - September 9, 2009 Category: Allergy & Immunology Authors: Yaraee R, Ghazanfari T, Ebtekar M, Ardestani SK, Rezaei A, Kariminia A, Faghihzadeh S, Mostafaei A, Vaez-Mahdavi MR, Mahmoudi M, Naghizadeh MM, Soroush MR, Hassan ZM Tags: Int Immunopharmacol Source Type: journals

Serum levels of IL-8 and IL-6 in the long term pulmonary complications induced by sulfur mustard: Sardasht-Iran Cohort Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sulfur mustard (SM) is a blistering chemical agent which has short and long term toxicity against many organs. The respiratory tract is one of the main targets, and is the most disabling long-term complication of SM. Inflammatory mediators especially IL-8 and IL-6 play the primary role in the various chronic pulmonary diseases. Sardasht- Iran Cohort Study (SICS) was designed to evaluate immunological and molecular parameters in SM exposed people 20 years after exposure. In the present study, the association of the serum levels of IL-8, IL-6, C reactive protein (CRP) and rheumatoid factor (RF) with long term pulmonary i...
Source: International Immunopharmacology - September 9, 2009 Category: Allergy & Immunology Authors: Pourfarzam S, Ghazanfari T, Yaraee R, Ghasemi H, Hassan ZM, Faghihzadeh S, Ardestani SK, Kariminia A, Fallahi F, Soroush MR, Merasizadeh J, Mahlojirad M, Naghizadeh MM, Ghanei M Tags: Int Immunopharmacol Source Type: journals