International Journal of Cancer
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. 
Subscribe to this data using MyMedWorm.
Subscribe to this data using GoogleReader.
Subscribe to this data using Bloglines.
Subscribe to this data using MyYahoo.
Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
This page shows you the latest items in this publication.
2014 records returned
A blood-based biomarker panel for stratifying current risk for colorectal cancer
Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Colorectal cancer (CRC) is often curable and preventable using current screening modalities. Unfortunately, screening compliance remains low, partly due to patient dissatisfaction with faecal/endoscopic testing. Recent guidelines advise CRC screening should begin with risk stratification. A blood-based test providing clinically actionable CRC risk information would likely improve screening compliance and enhance clinical decision making. We analyzed 196 gene expression profiles to select candidate CRC biomarkers. qRT-PCR was performed on 642 samples to develop a 7-gene biomarker panel using 112 CRC/120 controls (training s...
Source: International Journal of Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Kenneth Wayne Marshall, Steve Mohr, Faysal El Khettabi, Nadejda Nossova, Samuel Chao, Weisheng Bao, Jun Ma, Xiao-Jun Li, Choong-Chin Liew Source Type: journals
Downregulations of B-cell lymphoma 2 and myeloid cell leukemia sequence 1 by microRNA 153 induce apoptosis in a glioblastoma cell line DBTRG-05MGEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
MicroRNA-153 (miR-153) is a brain-specific miRNA that is expressed at a significantly lower level in glioblastoma (GBM) relative to non-neoplastic brain tissue. Although the expression pattern of miR-153 has been extensively established, its target genes and cellular mechanism remain undefined. To investigate into the potential function of miR-153 in glioblastmas, we transfected a GBM cell line DBTRG-05MG with synthetic miR-153 oligos and observed decreased cell proliferation and increased apoptosis. Bioinformatics analysis revealed that anti-apoptosis family member B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia seque...
Source: International Journal of Cancer - November 10, 2009 Category: Cancer & Oncology Authors: Jianzhen Xu, Xuemei Liao, Chiwai Wong Source Type: journals
Changing cancer incidence in Kampala, Uganda, 1991-2006Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Incidence rates of different cancers have been calculated for the population of Kyadondo County (Kampala, Uganda) for a 16-year period (1991-2006). This period coincides with continuing social and lifestyle changes and the peak and subsequent wane of the epidemic of HIV-AIDS. There has been an overall increase in the risk of cancer during the period in both sexes, with the incidence rates of cancers of the breast and prostate showing particularly marked increases (4.5% annually). Prostate cancer is now the most common cancer in men. The incidence of cancer of the esophagus, formerly the most common cancer in men and second...
Source: International Journal of Cancer - November 6, 2009 Category: Cancer & Oncology Authors: Donald Maxwell Parkin, Sarah Nambooze, Fred Wabwire-Mangen, Henry R. Wabinga Source Type: journals
Risk of cancer among children of cancer patients - A nationwide study in FinlandEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
This study shows that offspring of cancer patients are not at an increased risk of cancer except when the patient has a cancer-predisposing syndrome. These findings are directly relevant to counseling cancer survivors with regard to family planning. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 5, 2009 Category: Cancer & Oncology Authors: Laura-Maria S. Madanat-Harjuoja, Nea Malila, Päivi Lähteenmäki, Eero Pukkala, John J. Mulvihill, John D. Boice Jr., Risto Sankila Source Type: journals
Obligation for cell line authentication: Appeal for concerted actionEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
No abstract. (Source: International Journal of Cancer)
Source: International Journal of Cancer - October 31, 2009 Category: Cancer & Oncology Authors: Harald zur Hausen Source Type: journals
Beneficial and detrimental effects of human endogenous retrovirusesEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In this mini review, we aim to evaluate the structure and function of Human Endogenous Retroviruses (HERVs) with respect to the benefit they may have for humans or the damage they may cause. Emphasis is laid on their putative roles, if any, in pregnancy, in gene regulation and in cancer. As a basis for this discussion it will first be necessary to briefly describe the structure and function of retroelements, including HERVs, before addressing their positive or negative effects at the cellular and organismal level. Finally, we will give an outlook in which we will attempt to define priorities for future research. (Source: I...
Source: International Journal of Cancer - October 29, 2009 Category: Cancer & Oncology Authors: Reinhard Kurth, Norbert Bannert Source Type: journals
Incident cancer burden attributable to excess body mass index in 30 European countriesEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Excess adiposity is associated with increased risks of developing adult malignancies. To inform public health policy and guide further research, the incident cancer burden attributable to excess body mass index (BMI [ge] 25 kg/m2) across 30 European countries were estimated. Population attributable risks (PARs) were calculated using European- and gender-specific risk estimates from a published meta-analysis and gender-specific mean BMI estimates from a World Health Organization Global Infobase. Country-specific numbers of new cancers were derived from Globocan2002. A ten-year lag-period between risk exposure and cancer inc...
Source: International Journal of Cancer - October 27, 2009 Category: Cancer & Oncology Authors: Andrew G. Renehan, Isabelle Soerjomataram, Margaret Tyson, Matthias Egger, Marcel Zwahlen, Jan Willem Coebergh, Iain Buchan Source Type: journals
Database of misidentified cell linesEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
No abstract. (Source: International Journal of Cancer)
Source: International Journal of Cancer - October 23, 2009 Category: Cancer & Oncology Authors: R. Ian Freshney Source Type: journals
Trends in colorectal cancer incidence in Norway 1962-2006: An interpretation of the temporal patterns by anatomic subsiteEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
There have been rapid increases in the incidence of colorectal cancer in Norway since the 1960s, and rates rank among the highest worldwide. The primary objectives are to describe trends in left- and right-sided colon cancer and rectal cancer by calendar period and birth cohort and to generate hypotheses as to the etiological factors in operation. Although the age-adjusted incidence rates of both colon and rectal cancer increased in Norway in both sexes up to the 1980s, subsite- and age-specific analyses reveal a deceleration in the rate of increase thereafter, apparent in the rates of both left-sided colon and rectal canc...
Source: International Journal of Cancer - September 23, 2009 Category: Cancer & Oncology Authors: Inger Kristin Larsen, Freddie Bray Source Type: journals
Risk factors for breast cancer among Filipino women in ManilaEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Age-adjusted incidence rates of breast cancer vary greatly worldwide with highest rates found in the typically 'westernised' countries of North America and Europe. Much lower rates are observed in Asian and African populations but an exception to this has been reported for the Manila Cancer Registry in the Philippines. The reason for this high rate is unknown but may be associated with the change in lifestyle that has occurred in urban Manila since the 1960s. In 1995, a randomised controlled trial was set up in Manila to evaluate the feasibility of a screening intervention by clinical breast examination as an alternative t...
Source: International Journal of Cancer - September 18, 2009 Category: Cancer & Oncology Authors: Lorna J Gibson, Clarisse Héry, Nicolas Mitton, Abigail Gines-Bautista, D Maxwell Parkin, Corazon Ngelangel, Paola Pisani Source Type: journals
Primary gene-engineered neural stem/progenitor cells demonstrate tumor-selective migration and antitumor effects in gliomaEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The prognosis of patients with glioblastoma multiforme (GBM) is generally poor after surgical tumor resection. With the aim of developing new adjuvant therapeutic strategies, we have investigated primary neural stem/progenitor cells (NSPC) in co-cultures with glioma cells, and in a model of gene therapy on aggressively growing malignant glioma. NSPC exhibited tropism towards medium conditioned by glioma cells, and in adherent low-cell density co-culture, were attracted to, and fused with, tumor cells. Similarly, within 24-48 hr of co-culture in suspension, NSPC-tumor hybrids were observed, representing 2-3% of the total ce...
Source: International Journal of Cancer - September 16, 2009 Category: Cancer & Oncology Authors: Javier Mercapide, Germana Rappa, Fabio Anzanello, Judy King, Oystein Fodstad, Aurelio Lorico Source Type: journals
Diet and serum micronutrients in relation to cervical neoplasia and cancer among low-income Brazilian womenEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Cervical cancer is a leading cancer among women in developing countries. Infection with oncogenic human papillomavirus (HPV) types has been recognized as a necessary cause of this disease. Serum carotenoids and tocopherols have also been associated with risk for cervical neoplasia, but results from previous studies were not consistent. We evaluated the association of serum total carotene and tocopherols, and dietary intakes with the risk of newly diagnosed, histologically confirmed cervical intraepithelial neoplasia (CIN) grades 1, 2, 3 and invasive cancer in a hospital-based case-control study in São Paulo, Brazil. The i...
Source: International Journal of Cancer - September 8, 2009 Category: Cancer & Oncology Authors: Luciana Yuki Tomita, Adhemar Longatto Filho, Maria Cecília Costa, Maria Antonieta Avilla Andreoli, Luisa Lina Villa, Eduardo Luiz Franco, Marly Augusto Cardoso, for the Brazilian Investigation into Nutrition and Cervical Cancer Prevention (BRINCA) Study Source Type: journals
The phosphorylation of ephrin-B2 ligand promotes glioma cell migration and invasionEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
To reveal molecular drivers of glioma invasion, two distinct glioblastoma (GBM) cell phenotypes (invading cells and tumor core cells) were collected from 19 GBM specimens using laser capture microdissection. Isolated RNA underwent whole human genome expression profiling to identify differentially expressed genes. Pathway enrichment analysis highlighted the bidirectional receptor/ligand tyrosine kinase system, EphB/ephrin-B, as the most tightly linked system to the invading cell phenotype. Clinical relevance of ephrin-B genes was confirmed in a clinically annotated expression data set of 195 brain biopsy specimens. Levels o...
Source: International Journal of Cancer - September 2, 2009 Category: Cancer & Oncology Authors: Mitsutoshi Nakada, Eric M. Anderson, Tim Demuth, Satoko Nakada, Linsey B. Reavie, Kelsey L. Drake, Dominique B. Hoelzinger, Michael E. Berens Source Type: journals
Identification of HLA-A2- and A24-restricted T-cell epitopes derived from SOX6 expressed in glioma stem cells for immunotherapyEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In this study, we attempted to identify SOX6-derived peptides as specific targets for effective and safe T-cell-mediated immunotherapy targeting SOX6-positive glioma and GSCs. In vitro stimulation with human leukocyte antigen (HLA)-A*2402 (A24)-restricted peptides, RFENLGPQL (SOX6504) and PYYEEQARL (SOX6628) or the HLA-A*0201 (A2)-restricted peptide, ALFGDQDTV (SOX6447) was capable of inducing SOX6 peptide-specific CTLs in peripheral blood mononuclear cells derived from healthy donors and glioma patients. These CTLs were able to lyse a majority of glioma cell lines and a GSC line derived from human glioblastoma in an HLA C...
Source: International Journal of Cancer - September 2, 2009 Category: Cancer & Oncology Authors: Ryo Ueda, Kozo Ohkusu-Tsukada, Noemi Fusaki, Akio Soeda, Takeshi Kawase, Yutaka Kawakami, Masahiro Toda Source Type: journals
High expression levels of IKK[alpha] and IKK[beta] are necessary for the malignant properties of liver cancerEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
IKK-NF-[kappa]B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy. Therefore, in this study, we analyzed the expression of mRNAs encoding components and targets of NF-[kappa]B signaling including IKK[alpha], IKK[beta], RANK, RANKL, OPG, CyclinD3, mammary serine protease inhibitor (Maspin), CyclinD1, c-FLIP, Bcl-xl, Stat3, Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer. After statistical analysis, 7 indices including IKK[alpha], IKK[beta], RANK, Maspin, c-FLIP, Cip2 and cyclinD1 were found to show significant differences between tumor tissue...
Source: International Journal of Cancer - September 2, 2009 Category: Cancer & Oncology Authors: Runqiu Jiang, Yongxiang Xia, Jun Li, Lei Deng, Liang Zhao, Jian Shi, Xuehao Wang, Beicheng Sun Source Type: journals
Tumor-reactive CD8+ T-cell responses after vaccination with NY-ESO-1 peptide, CpG 7909 and Montanide® ISA-51: Association with survivalEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Peptide-based vaccines have led to the induction of antigen-specific CD8+ T-cell responses in patients with NY-ESO-1 positive cancers. However, vaccine-induced T-cell responses did not generally correlate with improved survival. Therefore, we tested whether a synthetic CpG 7909 ODN (deoxycytidyl-deoxyguanosin oligodeoxy-nucleotides) mixed with NY-ESO-1 peptide p157-165 and incomplete Freund's adjuvants (Montanide® ISA-51) led to enhanced NY-ESO-1 antigen-specific CD8+ immune responses in patients with NY-ESO-1 or LAGE-1 expressing tumors. Of 14 HLA-A2+ patients enrolled in the study, 5 patients withdrew prematurely becaus...
Source: International Journal of Cancer - September 2, 2009 Category: Cancer & Oncology Authors: Julia Karbach, Sacha Gnjatic, Armin Bender, Antje Neumann, Eckhart Weidmann, Jianda Yuan, Cathy A. Ferrara, Eric Hoffmann, Lloyd J. Old, Nasser K. Altorki, Elke Jäger Source Type: journals
Triptolide functions as a potent angiogenesis inhibitorEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In this study, we show that triptolide is an angiogenesis inhibitor based on various angiogenesis assays. The IC50 in in vitro assays was 45 nM, which was much lower than the plasma concentrations of triptolide in the rat or human administered with T. wilfordii extracts for treating inflammation. When dosed in vivo, triptolide potently inhibited angiogenesis at 100 nM in Matrigel plug assay. Triptolide at 0.75 mg/kg/day significantly blocked tumor angiogenesis and tumor progression in murine tumorigenesis assay. The underlying mechanism of triptolide correlated with downregulation of proangiogenic Tie2 and VEGFR-2 expressi...
Source: International Journal of Cancer - September 1, 2009 Category: Cancer & Oncology Authors: Ming-Fang He, Yi-Hsien Huang, Li-Wha Wu, Wei Ge, Pang-Chui Shaw, Paul Pui-Hay But Source Type: journals
How to evaluate emerging technologies in cervical cancer screening?Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Excellent recommendations exist for studying therapeutic and diagnostic questions. We observe that good guidelines on assessment of evidence for screening questions are currently lacking. Guidelines for diagnostic research (STARD), involving systematic application of the reference test (gold standard) to all subjects of large study populations, are not pertinent in situations of screening for disease that is currently not yet present. A five-step framework is proposed for assessing the potential use of a biomarker as a screening tool for cervical cancer: i) correlation studies establishing a trend between the rate of bioma...
Source: International Journal of Cancer - August 26, 2009 Category: Cancer & Oncology Authors: Marc Arbyn, Guglielmo Ronco, Jack Cuzick, Nicolas Wentzensen, Philip E. Castle Source Type: journals
A new multiparameter assay to assess HPV 16/18, viral load and physical status together with gain of telomerase genes in HPV-related cancersEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The objective of this study was to develop a rapid and sensitive multiplex ligation-dependent probe amplification (MLPA) assay for the simultaneous analysis of viral load, integration and copy number gain of TERC and TERT in HPV16/18-associated lesions. The performance of the assay was tested for HPV vs. human gene copy number ratios ranging from 0.1 to 100 and for percentages of integration ranging from 0 to 100%. The model systems used include plasmid mixtures and the HPV-positive cell lines SiHa, HeLa and CaSki described to contain a range of 2-600 viral copies per cell. In samples with low-viral load, viral integration...
Source: International Journal of Cancer - August 26, 2009 Category: Cancer & Oncology Authors: Wendy Theelen, Martin Reijans, Guus Simons, Frans C.S. Ramaekers, Ernst-Jan M. Speel, Anton H.N. Hopman Source Type: journals
The novel tumor-suppressor Mel-18 in prostate cancer: Its functional polymorphism, expression and clinical significanceEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
This study was designed to investigate the clinical and prognostic significance of Mel-18 in patients with prostate cancer. A total of 539 native Japanese subjects consisting of 393 prostate cancer patients and 146 controls were enrolled in this study. Mel-18 genotyping was analyzed using a PCR-RFLP method and an automated sequencer using the GENESCAN software. Immunohistochemistry revealed that Mel-18 expression was diminished in high grade and high stage prostate cancers. Moreover, patients with positive Mel-18 expression had significantly longer PSA recurrence-free survival than patients negative for Mel-18 expression (...
Source: International Journal of Cancer - August 24, 2009 Category: Cancer & Oncology Authors: Wei Wang, Takeshi Yuasa, Norihiko Tsuchiya, Zhiyong Ma, Shinya Maita, Shintaro Narita, Teruaki Kumazawa, Takamitsu Inoue, Hiroshi Tsuruta, Yohei Horikawa, Mitsuru Saito, Weilie Hu, Osamu Ogawa, Tomonori Habuchi Source Type: journals
A cluster randomized, controlled trial of breast and cervix cancer screening in Mumbai, India: Methodology and interim results after three rounds of screeningEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Cervix and Breast cancers are the most common cancers among women worldwide and extract a large toll in developing countries. In May 1998, supported by a grant from the NCI (US), the Tata Memorial Hospital, Mumbai, India, started a cluster-randomized, controlled, screening-trial for cervix and breast cancer using trained primary health workers to provide health-education, visual-inspection of cervix (with 4% acetic acid-VIA) and clinical breast examination (CBE) in the screening arm, and only health education in the control arm. Four rounds of screening at 2-year intervals will be followed by 8 years of monitoring for inci...
Source: International Journal of Cancer - August 20, 2009 Category: Cancer & Oncology Authors: Indraneel Mittra, Gauravi A. Mishra, Shalini Singh, Sangeeta Aranke, Perin Notani, Rajendra Badwe, Anthony B. Miller, Elkan E. Daniel, Subhadra Gupta, Pallavi Uplap, Meenakshi H. Thakur, Subhash Ramani, Rajendra Kerkar, Balasubramanian Ganesh, Surendra S. Source Type: journals
Glyfoline induces mitotic catastrophe and apoptosis in cancer cellsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Glyfoline exhibits cytotoxic activity in vitro and antitumor activity in mice bearing murine or human solid tumors, but the underlying mechanisms are unknown. In our study, we found that glyfoline inhibited cell growth and induced accumulation of mitotic cells in human cancer cell lines. Glyfoline induced the appearance of spindle abnormalities, chromosome mis-segregation, multipolar cell division and multiple nuclei, all of which are indicative of mitotic catastrophe. However, glyfoline did not bind to DNA and did not inhibit or stabilize tubulin polymerization, but slightly increased the resistance of mitotic spindles to...
Source: International Journal of Cancer - August 20, 2009 Category: Cancer & Oncology Authors: Yi-Chen Wu, Wen-Yen Yen, Hsiao-Yung Ho, Tsann-Long Su, Ling-Huei Yih Source Type: journals
Is the improved prognosis of p16 positive oropharyngeal squamous cell carcinoma dependent of the treatment modality?Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The objective of the present study was to analyze the impact of p16 expression status on the prognosis of OPSCC treated by either radiotherapy (RT) or primary surgery. Results are based upon a tissue microarray (TMA) of 365 head neck squamous cell carcinomas (HNSCC) including 85 OPSCC with clinico-pathological and follow-up data. p16 positivity correlated significantly with oropharyngeal tumor localization (p < 0.001). Patients with p16 positive OPSCC exhibited a significantly better overall survival than those with p16 negative tumors (p = 0.007). In a multivariate analysis, survival benefit of patients with p16 positive ...
Source: International Journal of Cancer - August 20, 2009 Category: Cancer & Oncology Authors: Claude A. Fischer, Inti Zlobec, Edith Green, Simone Probst, Claudio Storck, Alessandro Lugli, Luigi Tornillo, Markus Wolfensberger, Luigi M. Terracciano Source Type: journals
CCK2 receptor expression transforms non-tumorigenic human NCM356 colonic epithelial cells into tumor forming cellsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Expression of gastrin and cholecystokinin 2 (CCK2) receptor splice variants (CCK2R and CCK2i4svR) are upregulated in human colonic adenomas where they are thought to contribute to tumor growth and progression. To determine the effects of ectopic CCK2 receptor variant expression on colonic epithelial cell growth in vitro and in vivo, we employed the non-tumorigenic colonic epithelial cell line, NCM356. Receptor expression was induced using a retroviral expression vector containing cDNAs for either CCK2i4svR or CCK2R. RT-PCR and intracellular Ca2+ ([Ca2+]i) imaging of RIE/CCK2R cells treated with conditioned media (CM) from ...
Source: International Journal of Cancer - August 20, 2009 Category: Cancer & Oncology Authors: Celia Chao, Xueliang Han, Kirk Ives, Jeseong Park, Andrey A. Kolokoltsov, Robert A. Davey, Mary P. Moyer, Mark R. Hellmich Source Type: journals
Vascular targeting by EndoTAGTM-1 enhances therapeutic efficacy of conventional chemotherapy in lung and pancreatic cancerEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In conclusion, vascular targeting tumor therapy by EndoTAGTM-1 combined with standard small molecular chemotherapy results in markedly enhanced antitumoral efficacy. Therefore, this combination represents a promising novel strategy for clinical cancer therapy. (Source: International Journal of Cancer)
Source: International Journal of Cancer - August 20, 2009 Category: Cancer & Oncology Authors: Martin E. Eichhorn, Ivan Ischenko, Siiri Luedemann, Sebastian Strieth, Armine Papyan, Alexander Werner, Hermann Bohnenkamp, Eric Guenzi, Gerhard Preissler, Uwe Michaelis, Karl-Walter Jauch, Christiane J. Bruns, Marc Dellian Source Type: journals
Tristetraprolin regulates expression of VEGF and tumorigenesis in human colon cancerEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Tristetraprolin (TTP) is an AU-rich element-binding protein that regulates mRNA stability. Here, we report that TTP suppress the growth of human colon cancer cells both in vivo and in vitro by regulating of the expression of vascular endothelial growth factor (VEGF). TTP protein expression in human colonic tissues was markedly decreased in colonic adenocarcinoma compared with in normal mucosa and adenoma. VEGF expression was higher in colonic adenocarcinoma than in normal mucosa and adenoma. Specific inhibition of TTP expression by RNA-interference increased the expression of VEGF in cultured human colon cancer cells, and ...
Source: International Journal of Cancer - August 20, 2009 Category: Cancer & Oncology Authors: Hyun Hee Lee, Young Joon Son, Won Hyeok Lee, Young Woo Park, Seoung Wan Chae, Wha Ja Cho, Young Min Kim, Hye-Jeong Choi, Dae Hwa Choi, Seok Won Jung, Young Joo Min, Soon Eun Park, Byung Ju Lee, Hee Jeong Cha, Jeong Woo Park Source Type: journals
Colorectal cancer chemoprevention by 2 [beta]-cyclodextrin inclusion compounds of auraptene and 4[prime]-geranyloxyferulic acidEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The inhibitory effects of novel prodrugs, inclusion complexes of 3-(4[prime]-geranyloxy-3[prime]-methoxyphenyl)-2-trans propenoic acid (GOFA) and auraptene (AUR) with [beta]-cyclodextrin (CD), on colon carcinogenesis were investigated using an azoxymethane (AOM)/dextran sodium sulfate (DSS) model. Male CD-1 (ICR) mice initiated with a single intraperitoneal injection of AOM (10 mg/kg body weight) were promoted by the addition of 1.5% (w/v) DSS to their drinking water for 7 days. They were then given a basal diet containing 2 dose levels (100 and 500 ppm) of GOFA/[beta]-CD or AUR/[beta]-CD for 15 weeks. At Week 18, the deve...
Source: International Journal of Cancer - August 17, 2009 Category: Cancer & Oncology Authors: Takuji Tanaka, Mariangela B.M. de Azevedo, Nelson Durán, Joel B. Alderete, Francesco Epifano, Salvatore Genovese, Mayu Tanaka, Takahiro Tanaka, Massimo Curini Source Type: journals
Rapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and induction of apoptosisEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Mammalian target of rapamycin (mTOR) inhibitors modulate signaling pathways involved in cell cycle progression, and recent phase II trials demonstrate activity in patients with endometrial cancer. Our objective was to examine the effects of combination therapy with rapamycin and paclitaxel in endometrial cancer cell lines. Paclitaxel inhibited proliferation in a dose-dependent manner in both cell lines with IC50 values of 0.1-0.5 nM and 1-5 nM for Ishikawa and ECC-1 cells, respectively. To assess synergy of paclitaxel and rapamycin, the combination index (CI) was calculated by the method of Chou and Talalay. Simultaneous e...
Source: International Journal of Cancer - August 17, 2009 Category: Cancer & Oncology Authors: Aaron Shafer, Chunxiao Zhou, Paola A. Gehrig, John F. Boggess, Victoria L. Bae-Jump Source Type: journals
PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortalityEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Breast cancer is a common malignancy with current biological therapies tailored to steroid hormone (ER, PR) and HER2 receptor status. Understanding the biological basis of resistance to current targeted therapies and the identification of new potential therapeutic targets is an ongoing challenge. The PI3K pathway is altered in a high proportion of breast cancers and may contribute to therapeutic resistance. We undertook an integrative study of mutational, copy number and expression analyses of key regulators of the PI3K pathway in a cohort of 292 invasive breast cancer patients with known treatment outcomes. The alteration...
Source: International Journal of Cancer - August 14, 2009 Category: Cancer & Oncology Authors: Elena López-Knowles, Sandra A. O'Toole, Catriona M. McNeil, Ewan K.A. Millar, Min R. Qiu, Paul Crea, Roger J. Daly, Elizabeth A. Musgrove, Robert L. Sutherland Source Type: journals
Toll-like receptors on B-CLL cells: Expression and functional consequences of their stimulationEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
We report that TLR stimulation induces expression of CD38, a negative prognostic marker, on B-CLL cells. Expression of CD38 is induced by direct stimulation of B-CLL cells through TLR-7 and TLR-9 or CD38 can be induced on B-CLL cells indirectly by a soluble factor induced in non-B-CLL cells after stimulation with TLR-2, TLR-3 or TLR-5 agonists; the nature of this factor remains unknown. Our results argue for cautious evaluation of immunointervention strategies based on the administration of TLR agonists in the treatment of B-CLL as their effects on B-CLL cells may be tumor promoting as well as tumor suppressing. (Source: I...
Source: International Journal of Cancer - August 14, 2009 Category: Cancer & Oncology Authors: Daniela Ro[zcaron]ková, Linda Novotná, Robert Pytlík, Ivana Hochová, Tomá[scaron] Kozák, Ji[rcaron]ina Bart[uring][ncaron]ková, Radek [Scaron]pí[scaron]ek Source Type: journals
Antioxidant intake from fruits, vegetables and other sources and risk of non-Hodgkin's lymphoma: The Iowa Women's Health StudyEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In conclusion, these results support a role for vegetables, and perhaps fruits and associated antioxidants from food sources, as protective factors against the development of NHL and follicular lymphoma in particular. (Source: International Journal of Cancer)
Source: International Journal of Cancer - August 14, 2009 Category: Cancer & Oncology Authors: Carrie A. Thompson, Thomas M. Habermann, Alice H. Wang, Robert A. Vierkant, Aaron R. Folsom, Julie A. Ross, James R. Cerhan Source Type: journals
Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in miceEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In this study, we generated transgenic mice that systemically express Western CagA (CagA-ABCCC), the levels of which are comparable to those in mice expressing East Asian CagA. The mice developed gastric epithelial hypertrophy and gastrointestinal tumors and also showed lymphoid abnormality but not myeloid abnormalities such as granulocytosis and myeloid leukemia found in mice carrying East Asian CagA. The incidence of tumors in mice expressing Western CagA was significantly lower than that in mice expressing East Asian CagA. Our results indicate that Western CagA is qualitatively less oncogenic than East Asian CagA. Diffe...
Source: International Journal of Cancer - August 13, 2009 Category: Cancer & Oncology Authors: Motohiro Miura, Naomi Ohnishi, Shinya Tanaka, Kohei Yanagiya, Masanori Hatakeyama Source Type: journals
GLUT-1 expression and response to chemoradiotherapy in rectal cancerEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Preoperative chemoradiotherapy is used in locally advanced rectal cancer to reduce local recurrence and improve operability, however a proportion of tumors do not undergo significant regression. Identification of predictive markers of response to chemoradiotherapy would improve patient selection and may allow response modification by targeting of specific pathways. The aim of this study was to determine whether expression of glucose transporter-1 (GLUT-1) and p53 in pretreatment rectal cancer biopsies was predictive of tumor response to chemoradiotherapy. Immunohistochemical staining for GLUT-1 and p53 was performed on 69 ...
Source: International Journal of Cancer - August 12, 2009 Category: Cancer & Oncology Authors: Sarah Brophy, Katherine M. Sheehan, Deborah A. McNamara, Joseph Deasy, David J. Bouchier-Hayes, Elaine W. Kay Source Type: journals
CD133 is indicative for a resistance phenotype but does not represent a prognostic marker for survival of non-small cell lung cancer patientsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In this study, we evaluated whether CD133 expression in non-small cell lung cancer (NSCLC) has a prognostic value in patients' survival. We also analyzed whether CD133 positivity of NSCLC correlates with the expression of resistance-related proteins, angiogenic factors, oncogenes, proliferative activity or apoptosis. CD133 expression was retrospectively examined in a total of 88 cases of previously untreated NSCLC by immunohistochemistry. We found no correlation between CD133 positivity or the amount of CD133+ cells with NSCLC patients' survival, expression of oncogenes c-myc, c-N-ras, c-jun, c-fos, c-erbB1, c-erbB2 or p53...
Source: International Journal of Cancer - August 12, 2009 Category: Cancer & Oncology Authors: Alexei V. Salnikov, Jury Gladkich, Gerhard Moldenhauer, Manfred Volm, Jürgen Mattern, Ingrid Herr Source Type: journals
Sensitization of ovarian carcinoma cells to the atypical retinoid ST1926 by the histone deacetylase inhibitor, RC307: Enhanced DNA damage responseEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The synthetic atypical retinoids containing an adamantyl group exhibit antiproliferative or proapoptotic activities. Apoptosis induction is a dose-dependent effect independent of retinoid receptors. We have reported that induction of apoptosis by the atypical retinoid, ST1926, is associated with early manifestations of genotoxic stress. Indeed, in this study performed in ovarian carcinoma cells, we show that exposure to ST1926 resulted in an increase of early markers of DNA damage, including ATM and H2AX phosphorylation. In addition, we found that a novel histone deacetylase (HDAC) inhibitor (RC307) was able to enhance sen...
Source: International Journal of Cancer - August 11, 2009 Category: Cancer & Oncology Authors: Valentina Zuco, Valentina Benedetti, Michelandrea De Cesare, Franco Zunino Source Type: journals
BIIB021, a synthetic HSP90 inhibitor, has broad application against tumors with acquired multidrug resistanceEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
17-AAG, the first-generation clinical Hsp90 inhibitor, exhibits promising antitumor activity in clinical studies, but is limited by poor solubility and hepatotoxicity. To pursue compounds with better biopharmaceutical properties, we have developed a series of fully synthetic orally bioavailable inhibitors of Hsp90. Here, we report that 17-AAG and other ansamycin derivatives are inactive in P-gp and/or MRP-1 expressing cell lines and sensitivity could be restored by coadministration of P-gp or MRP inhibitors. In contrast, the synthetic Hsp90 inhibitor, BIIB021 was active in these models. Accordingly, BIIB021 was considerabl...
Source: International Journal of Cancer - August 11, 2009 Category: Cancer & Oncology Authors: Hong Zhang, Laura Neely, Karen Lundgren, Yong-Ching Yang, Rachel Lough, Noel Timple, Francis Burrows Source Type: journals
Diagnostic and prognostic implications of microRNA profiling in prostate carcinomaEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
This study aimed to investigate the microRNA (miRNA) profile in prostate carcinoma tissue by microarray analysis and RT-qPCR, to clarify associations of miRNA expression with clinicopathologic data and to evaluate the potential of miRNAs as diagnostic and prognostic markers. Matched tumor and adjacent normal tissues were obtained from 76 radical prostatectomy specimens. Twenty-four tissue pairs were analyzed using human miRNA microarrays for 470 human miRNAs. Differentially expressed miRNAs were validated by TaqMan RT-qPCR using all 76 tissue pairs. The diagnostic potential of miRNAs was calculated by receiver operating ch...
Source: International Journal of Cancer - August 11, 2009 Category: Cancer & Oncology Authors: Annika Schaefer, Monika Jung, Hans-Joachim Mollenkopf, Ina Wagner, Carsten Stephan, Florian Jentzmik, Kurt Miller, Michael Lein, Glen Kristiansen, Klaus Jung Source Type: journals
ErratumEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
No abstract. (Source: International Journal of Cancer)
Source: International Journal of Cancer - August 11, 2009 Category: Cancer & Oncology Source Type: journals
Cancer and viral infections in immunocompromised individualsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Over the last 30 years, the increasing use of organ and stem cell transplantation and the AIDS epidemic have led to the realization that some, but not all, human cancers occur more frequently in immunosuppressed individuals. With the notable exception of non-melanoma skin cancer (NMSC), most tumors that show strongly increased incidence rates in both transplant recipients and AIDS patients have been found to have a viral etiology. Among these are Kaposi sarcoma, diffuse large cell B-cell lymphoma, cervical cancer, liver cancer, Merkel cell carcinoma and a subset of Hodgkin's disease. A viral etiology for NMSC, i.e., [beta]...
Source: International Journal of Cancer - August 11, 2009 Category: Cancer & Oncology Authors: Thomas F. Schulz Source Type: journals
Bisphosphonates suppress insulin-like growth factor 1-induced angiogenesis via the HIF-1[alpha]/VEGF signaling pathways in human breast cancer cellsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In this study, we investigated the potential molecular mechanisms underlying the antiangiogenic effect of non-nitrogen-containing and nitrogen-containing bisphosphonates, clodronate and pamidronate, respectively, in insulin-like growth factor (IGF)-1 responsive human breast cancer cells. We tested whether bisphosphonates had any effects on hypoxia-inducible factor (HIF)-1[alpha]/vascular endothelial growth factor (VEGF) axis that plays a pivotal role in tumor angiogenesis, and our results showed that both pamidronate and clodronate significantly suppressed IGF-1-induced HIF-1[alpha] protein accumulation and VEGF expression...
Source: International Journal of Cancer - August 8, 2009 Category: Cancer & Oncology Authors: Xudong Tang, Qunzhou Zhang, Shihong Shi, Yun Yen, Xiangyong Li, Yuefei Zhang, Keyuan Zhou, Anh D. Le Source Type: journals
Versican overexpression in human breast cancer lesions: Known and new isoforms for stromal tumor targetingEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
This study provides for the first time a comprehensive mRNA and protein analysis of versican isoforms expression in human breast tissues, and offers insights into which therapeutic strategy would be best suited to target versican in human breast cancer lesions. © 2009 UICC (Source: International Journal of Cancer)
Source: International Journal of Cancer - August 5, 2009 Category: Cancer & Oncology Authors: Philippe Kischel, David Waltregny, Bruno Dumont, Andrei Turtoi, Yannick Greffe, Stephanie Kirsch, Edwin De Pauw, Vincent Castronovo Source Type: journals
Cytotoxic effects of antipsychotic drugs implicate cholesterol homeostasis as a novel chemotherapeutic targetEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In this study, 6 antipsychotic agents with a range of structural and pharmacological properties (reserpine, chlorpromazine, haloperidol, pimozide, risperidone and olanzapine), were screened for their effect on the viability of cell lines derived from lymphoblastoma, neuroblastoma, non-small cell lung cancer and breast adenocarcinoma. We aimed to determine if antipsychotic drugs in general possess cancer-specific cytotoxic potential, and whether it can be attributed to a common mode of action. With the exception of risperidone, all drugs tested displayed selective inhibition of the viability of cancer cell lines compared wi...
Source: International Journal of Cancer - August 5, 2009 Category: Cancer & Oncology Authors: Erik D. Wiklund, Vibeke S. Catts, Stanley V. Catts, Teng Fong Ng, Noel J. Whitaker, Andrew J. Brown, Louise H. Lutze-Mann Source Type: journals
Isolation of circulating epithelial and tumor progenitor cells with an invasive phenotype from breast cancer patientsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Recent research advances show that tumor cell intravasation (entry into the circulation) and metastasis occur very early in breast cancer progression. Clinical studies also illustrate the potential importance of detection of circulating tumor cells (CTCs) in outcomes of patients with metastatic breast cancer. Whether these cells exhibit the invasiveness and express tumor stem or progenitor markers, hallmark of the metastatic phenotype, is less well characterized. To detect CTCs with the invasive phenotype and to explore their molecular features, we applied a functional cell separation method, called collagen adhesion matri...
Source: International Journal of Cancer - August 5, 2009 Category: Cancer & Oncology Authors: Janice Lu, Tina Fan, Qiang Zhao, Wei Zeng, Eva Zaslavsky, John J. Chen, Michael A. Frohman, Marc G. Golightly, Stefan Madajewicz, Wen-Tien Chen Source Type: journals
BIIB021, a novel HSP90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapyEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Heat shock protein 90 (Hsp90) is a molecular chaperone that promotes the conformational maturation of numerous client proteins, many of which play critical roles in tumor cell growth and survival. The ansamycin-based Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) is currently in Phase III clinical testing. However, 17-AAG is difficult to formulate and associated with dose-limited toxicity issues. A fully synthetic and bioavailable Hsp90 inhibitor, BIIB021, was evaluated for antitumor activity in a variety of head and neck squamous cell carcinoma (HNSCC) cell lines and HNSCC xenograft models, either as a si...
Source: International Journal of Cancer - August 5, 2009 Category: Cancer & Oncology Authors: Xiaoying Yin, Hong Zhang, Karen Lundgren, Lynn Wilson, Francis Burrows, Carol G. Shores Source Type: journals
Infiltrating CD11b+CD11c+ cells have the potential to mediate inducible nitric oxide synthase-dependent cell death in mammary carcinomas of HER-2/neu transgenic miceEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The development of autochtonous mammary tumors in HER-2/neu transgenic mice is facilitated by immune tolerance to the neu-transgene. However, appropriate vaccination strategies can initiate immune system-mediated antitumor response by a process that requires IFN-[gamma]. We investigated the role of inducible nitric oxide synthase (iNOS) induction by IFN-[gamma] to promote tumor cell apoptosis. Tumors from FVBN202 mice expressing the normal neu gene under the control of the MMTV-LTR were treated in slice cultures with IFN-[gamma] for up to 24 hr. Apoptosis was induced, which depended on iNOS enzymatic activity. iNOS express...
Source: International Journal of Cancer - August 3, 2009 Category: Cancer & Oncology Authors: Nirmala Parajuli, Elisabeth Müller-Holzner, Günther Böck, Ernst R. Werner, Andreas Villunger, Wolfgang Doppler Source Type: journals
Transactivation and expression patterns of Jun and Fos/AP-1 super-family proteins in human oral cancerEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Transcription factor activator protein-1 (AP-1) super-family is known to modulate expression of array of genes during development of many cancers and considered as an important target for modern therapeutics. But the role of AP-1 during development of human oral cancers is still poorly understood. Because oral cancer is one of the most common cancers in India and south-east Asia, we studied the activation and expression pattern of AP-1 family of proteins and mRNA in different stages of oral carcinogenesis. Gel-shift assay, western blotting, immunohistochemistry and northern blotting have been used to assess the binding act...
Source: International Journal of Cancer - August 3, 2009 Category: Cancer & Oncology Authors: Alok Mishra, Alok C. Bharti, Daman Saluja, Bhudev C. Das Source Type: journals
Validation of predictive models for germline mutations in DNA mismatch repair genes in colorectal cancerEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Lynch syndrome is defined by the presence of germline mutations in mismatch repair (MMR) genes. Several models have been recently devised that predict mutation carrier status (Myriad Genetics, Wijnen, Barnetson, PREMM and MMRpro models). Families at moderate-high risk for harboring a Lynch-associated mutation, referred to the BC Cancer Agency (BCCA) Hereditary Cancer Program (HCP), underwent mutation analysis, immunohistochemistry and/or microsatellite testing. Seventy-two tested cases were included. Twenty-five patients were mutation positive (34.7%) and 47 were mutation negative (65.3%). Nineteen of 43 patients who were ...
Source: International Journal of Cancer - August 3, 2009 Category: Cancer & Oncology Authors: Jose G. Monzon, Carol Cremin, Linlea Armstrong, Jennifer Nuk, Sean Young, Doug E. Horsman, Kristy Garbutt, Chris D. Bajdik, Sharlene Gill Source Type: journals
Lef-1 isoforms regulate different target genes and reduce cellular adhesionEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The lymphoid enhancer factor 1 (Lef-1) belongs to the nuclear transducers of canonical Wnt-signalling in embryogenesis and cancer. Lef-1 acts, in cooperation with [beta]-catenin, as a context-dependent transcriptional activator or repressor, thereby influencing multiple cellular functions such as proliferation, differentiation and migration. Here we report that an increased Lef-1 expression in human pancreatic cancer correlates with advanced tumour stages. In pancreatic tumours, two different transcripts of Lef-1 have been detected in various stages, as demonstrated by RT-PCR analysis. One transcript was identified as the ...
Source: International Journal of Cancer - August 2, 2009 Category: Cancer & Oncology Authors: Sarah Jesse, Alexander Koenig, Volker Ellenrieder, Andre Menke Source Type: journals
Enhanced antiproliferative and proapoptotic effects on prostate cancer cells by simultaneously inhibiting androgen receptor and cAMP-dependent protein kinase AEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In this study, we show that combined inhibition of the AR and the regulatory subunit I alpha of PKA (RI[alpha]) with small interference RNAs significantly increased the growth-inhibitory and proapoptotic effects of AR knockdown. This treatment strategy was effective in androgen-sensitive and in androgen ablation-resistant prostate cancer cells. In addition, we report that downregulating PKA RI[alpha] was sufficient to inhibit PKA signaling and interestingly also impaired ARexpression and activation. Vice versa, AR knockdown induced a decline in PKA RI[alpha], associated with reduced PKA activity. Thismutual influence on ex...
Source: International Journal of Cancer - August 2, 2009 Category: Cancer & Oncology Authors: Andreas Desiniotis, Georg Schäfer, Helmut Klocker, Iris E. Eder Source Type: journals
