Variable clinical expression of a novel FLNC truncating variant in a large family
This study reports two familial cases of SCD and the results of cascade screening of their large family. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 12, 2024 Category: Cardiology Authors: Orr Tomer, Smadar Horowitz-Cederboim, Dini Rivkin, Vardiella Meiner, Michael H. Gollob, Donna R. Zwas, Ronen Durst, Ayelet Shauer Source Type: research

Cost-effectiveness of transthyretin cardiac amyloidosis screening and treatment: A Dilemma for the clinician
Professor Claudio Rapezzi, a pioneer in the field of cardiac amyloidosis (CA), used to cite a William Osler's quote: “there are three phases to treatment: diagnosis, diagnosis, and diagnosis”. Until recently, when no disease-modifying treatments for transthyretin CA (ATTR-CA) were available, the clinical utility of conclusively diagnosing ATTR-CA might be questioned, as it required the invasive demonstration o f amyloid deposits within tissues, without a direct impact on patient management. Thanks to the advances in diagnosis and treatment of ATTR-CA, most patients are now diagnosed through a non-invasive approach, and...
Source: International Journal of Cardiology - February 12, 2024 Category: Cardiology Authors: Vincenzo Castiglione, Alberto Aimo, Giuseppe Vergaro Tags: Editorial Source Type: research

Impact of diabetes mellitus on clinical outcomes after first episode in-stent restenosis PCI: Results from a large registry
Diabetes mellitus (DM) is associated with a high rate of major adverse cardiac events (MACE) after de novo coronary artery percutaneous coronary intervention (PCI). Whether patients with DM undergoing PCI for in-stent restenosis (ISR) experience a similar heightened risk of MACE is not known. Hence, we sought to compare the clinical outcomes of patients with and without DM undergoing PCI for ISR. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 12, 2024 Category: Cardiology Authors: Richard Tanner, Serdar Farhan, Gennaro Giustino, Samantha Sartori, Yihan Feng, Amit Hooda, Manish Vinayak, George Dangas, Roxana Mehran, Annapoorna S. Kini, Samin K. Sharma Source Type: research

Monitoring and treatment of hypercholesterolemia after an atherosclerotic cardiovascular disease event in Denmark from 2015 to 2020
Background and Aims.Lowering the blood concentration of low-density lipoprotein cholesterol (LDL-C), is a cornerstone in preventing atherosclerotic cardiovascular disease (ASCVD). Current European guidelines recommends LDL-C   (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 12, 2024 Category: Cardiology Authors: Jakob Kronkvist Hoe, Marius M ølsted Flege, Espen Jimenez-Solem, Susanne Hansen, Rasmus Huan Olsen, Janne Petersen, Camilla Bjørn Jensen Source Type: research

Estimating the risk of sudden death in hypertrophic cardiomyopathy might be solved by artificial intelligence
Hypertrophic cardiomyopathy (HCM) is a disease defined by inadequate left ventricular hypertrophy [1]. This disease has several major clinical consequences, the most important of which is an increased risk of sudden cardiac death (SCD). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 12, 2024 Category: Cardiology Authors: Josef Veselka Tags: Editorial Source Type: research

Understanding heart failure and cardiomyopathy in Africa: Insights from cardiovascular magnetic resonance
Comprehensive and accurate data on the epidemiology of a condition is vital to understanding how to detect, treat, and ultimately prevent disease. While the epidemiology of heart failure and heart muscle disease in Europe and North America is well understood, there is a dearth of data from Africa and South America [1]. This is likely to hamper the effective deployment of scarce healthcare resources, and to handicap public health measures designed to halt the growth in the prevalence of non-communicable diseases. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 12, 2024 Category: Cardiology Authors: Tevfik F. Ismail Tags: Editorial Source Type: research

Obstetric echodynamics: Approaching a new field of multidisciplinary action
Maternal cardiovascular adaptation during pregnancy is essential for fetal development. Structural and functional changes, including increased blood volume, heart rate, and myocardial hypertrophy, are crucial for optimal tissue perfusion. Recent evidence supports viewing maternal and fetal cardiovascular systems as a unified functional unit, emphasizing the significance of hemodynamic evaluation in pregnancy. Some obstetrical syndromes result from maladaptive maternal cardiovascular responses. Non-invasive hemodynamic tests, like transthoracic echocardiography, aid in distinguishing phenotypes, guiding tailored management ...
Source: International Journal of Cardiology - February 11, 2024 Category: Cardiology Authors: Gianluca Bertschy, Mario Iannaccone, Walter Grosso Marra, Fabrizio Bogliatto Tags: Commentary Source Type: research

Editorial Board
(Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 10, 2024 Category: Cardiology Source Type: research

Reply to: More data on the association of Takotsubo syndrome and stroke are warranted
We thank Drs. Stollberger and Finsterer for their insightful comments in a letter to the editor regarding our referenced study [1]. We hereby address eight points raised by Drs. Stollberger and Finsterer: (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 10, 2024 Category: Cardiology Authors: Nicolai Jessen, Jawad Haider Butt, Christian Torp-Pedersen, Kristian Kragholm Tags: Letter to the Editor Source Type: research

It is time to think about further optimization of the echocardiographic assessment of left ventricular responses to mitral regurgitation
Left ventricular ejection fraction (LVEF) is still used as a key determinant of LV function and timing in mitral regurgitation (MR) intervention in patients with chronic primary MR, although its load dependency and its misleading overestimation of LV pump function in the presence of MR are generally accepted [1]. Even the evidence that the easily measurable forward LVEF (i.e. LV forward stroke volume/end-diastolic volume) can be independently associated with life-threatening aggravation of MR in patients with nearly identical total LVEF and LV global longitudinal strain values [2,3], has not changed that opinion. (Source: ...
Source: International Journal of Cardiology - February 8, 2024 Category: Cardiology Authors: Michael Dandel Tags: Letter to the Editor Source Type: research

Catheter ablation for supraventricular tachycardia and health resource utilization and expenditures: A propensity-matched cohort study
This study aimed to describe expenditures and HRU in patients with PSVT who underwent catheter ablation compared to a matched cohort of patients on medical therapy alone. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 6, 2024 Category: Cardiology Authors: Derek S. Chew, Naomi C. Sacks, Maia R. Emden, Philip L. Cyr, Rick Sherwood, Sean D. Pokorney Source Type: research

Increasing burden of Rheumatic Heart Disease in Children: Challenges persist despite a century of experience
Rheumatic heart disease (RHD), although considered preventable, continues to be a major public health problem worldwide, the heaviest burden borne by low and middle income countries. Its onset in childhood and adolescence results in significant morbidity and premature death, if not treated in time. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 5, 2024 Category: Cardiology Tags: Editorial Source Type: research

Inflammation and myeloperoxidase – The next treatment targets in heart failure?
In heart failure with reduced ejection fraction (HFrEF, EF ≤40%), the neurohormonal hypothesis and treatments targeting maladaptive neurohormonal activation represent an unparallelled success. HF with mildly reduced EF (HFmrEF, EF 41–49%) is milder but otherwise largely resembles HFrEF. Post-hoc and sub-group analyses suggest that neurohormonal antagoni sm and modulation may be effective in HFmrEF as well [1]. HF with preserved EF (HFpEF, EF ≥50%) appears clinically largely distinct from HFrEF and HFmrEF, and neurohormonal treatment has not been effective in HFpEF. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 5, 2024 Category: Cardiology Authors: Camilla Hage, Lars H. Lund Tags: Editorial Source Type: research

Redefining left bundle branch block from high-density electroanatomical mapping
The existing ECG criteria for diagnosing left bundle branch block (LBBB) are insufficient to distinguish between true and false blocks accurately. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 4, 2024 Category: Cardiology Authors: Jun-Hua Zou, Bao-Tong Hua, Xiao-Xia Shao, Chao Wang, Hao Li, Ya-Nan Lu, Xin Tian, Zhi-Xuan Li, Li-Jin Pu, Jing Wang Source Type: research

Hearing disorders, genetic predisposition, and risk of new-onset atrial fibrillation: A prospective cohort study in the UK biobank
Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with significant morbidity and mortality. Hearing impairment has been linked to several cardiovascular diseases. However, the association between hearing disorders, genetic predisposition, and new-onset AF remains largely unknown. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 4, 2024 Category: Cardiology Authors: Yabing Hou, Hongxi Yang, Yanning Xu, Kan Wang, Yinghong Fu, Zuolin Lu Source Type: research