International Journal of Clinical & Laboratory ResearchThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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VI simposio internationale di conegliano di enzimologia clinica (Venezia)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Information SectionDOI 10.1007/BF03055079 Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 4 Journal Issue Volume 4, Numbers 1-4 / March, 1974
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Corso teoricopratico di immunologia clinicaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Information SectionDOI 10.1007/BF03055098 Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 4 Journal Issue Volume 4, Numbers 1-4 / March, 1974
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

AnnotationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Information SectionDOI 10.1007/BF03055076Authors G. G.G. B.G. M. C.L. S.F. D.F. M.G. C. Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 4 Journal Issue Volume 4, Numbers 1-4 / March, 1974
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

AbstractEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Information SectionDOI 10.1007/BF03055077 Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 4 Journal Issue Volume 4, Numbers 1-4 / March, 1974
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

I meeting internazionale di terapia delle leucemic acute (Roma)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Reports from meetingDOI 10.1007/BF03055064Authors M. C. P. Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 4 Journal Issue Volume 4, Numbers 1-4 / March, 1974
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

AbstractEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/BF03055063 Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 4 Journal Issue Volume 4, Numbers 1-4 / March, 1974
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

AnnotationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/BF03055062Authors G. M. C.L. S.F. D.F. M.G. G.G. C. Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 4 Journal Issue Volume 4, Numbers 1-4 / March, 1974
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

V Simposio di Conegliano di Enzimologia Clinica(Venezia)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Reports from MeetingDOI 10.1007/BF03055047Authors L. L. Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 4 Journal Issue Volume 4, Numbers 1-4 / March, 1974
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

AbstractEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/BF03055046 Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 4 Journal Issue Volume 4, Numbers 1-4 / March, 1974
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Reviews of bookEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Information SectionDOI 10.1007/BF03055078Authors C. D. B.F. D.F. D. Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 4 Journal Issue Volume 4, Numbers 1-4 / March, 1974
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

AnnotationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/BF03055045Authors L. S.G. M. C.F. D.F. M.G. C. Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 4 Journal Issue Volume 4, Numbers 1-4 / March, 1974
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Valutazione della funzione separata dei reni con tecniche radioisotopicheEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary The authors advocate that the renogram with hippuran-131I and indirect clearances of hypaque-131I and of hippuran-131I be used separately or in combination in the assessment of the separate function of each kidney. The application of the calculation technique proposed by Meschan et al. for glomerular filtration rate and of that proposed by Taplin for effective renal plasma flow enables the function of each kidney to be quantified. The authors’ experience is based on the study of 85 patients and is positive. They report certain cases in which the use of these techniques was particularly useful from a...
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Radioimmunoassay of human gonadotrophinsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Radioimmunoassay techniques have been used to estimate the gonadotrophins since 1966 and have greatly simplified the study of reproductive function in health and disease. Specific gonadotrophins can now be measured in small volumes of biologic fluids, allowing repetitive measurements and accurate delineation of physiologic states. These techniques involve a number of steps, of which the following are discussed: 1) separation of damaged labelled hormone from undamaged hormone. This essential step can be achieved by chromatography on DEAE cellulose for FSH, by filtration on Sephadex G 100 or G 200 for ...
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Importanza e limiti delle tecniche immunologiche nella diagnostica delle coagulopatieEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Information SectionDOI 10.1007/BF03055074Authors H. G. Schwick, Behringwerke AG D-3550 Marburg/Lahn Bundesrepublik DeutschlandH. Trobisch, Behringwerke AG D-3550 Marburg/Lahn Bundesrepublik DeutschlandN. Heimburger, Behringwerke AG D-3550 Marburg/Lahn Bundesrepublik Deutschland Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 4 Journal Issue Volume 4, Numbers 1-4 / March, 1974
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Criteri classificatoriali e diagnostici cito-morfologici delle malattie proliferative del sistema emolinfopoietico. le leucemieEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Riassunto Nel corso della presente nota vengono descritte le caratteristiche cito-morfologiche delle leucemie acute non linfoidi e delle leucemie plasmacellulare e mastocitaria. La leucemia eosinofila, basofila e megacariocitica vengono considerate invece come possibili varianti della leucemia granulocitica cronica. Content Type Journal ArticleCategory Practical AnnotationDOI 10.1007/BF03055061Authors Carlo D. Baroni, dell’Università di Roma Istituto di Anatomia e Istologia Patologica II Viale Regina Elena 324 00161 Roma ItaliaM. Laura Peronace, dell’Università di Roma Istituto di Anatomia e Istolog...
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Il test del nitroblu tetrazolioEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Riassunto Il test del nitroblu tetrazolio è stato introdotto da qualche anno in laboratorio per la diagnosi di infezione batterica. Esso è basato sulla riduzione a formazano dei sali di nitroblu tetrazolio posti a contatto con i globuli bianchi in attività fagocitaria. La percentuale di polinucleati neutrofili che al test risultano positivi puó variare dal 5–10 % nel soggetto sano, e superare il50 % in corso di infezione batterica acuta. Il suo impiego, ad onta della semplicità di esecuzione, è tuttavia reso difficile soprattutto dalla possibilità di risposte falsamente positive o falsamente negativ...
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Criteri classificatoriali e diagnostici cito-morfologici delle malattie proliferative del sistema emolinfopoietico. le leucemieEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Riassunto Nel corso della presente nota vengono descritte le caratteristiche citologiche ed enzimatiche che permettono di porre diagnosi di leucemia granulocitica cronica e di metaplasia mieloide idiopatica. Content Type Journal ArticleCategory Practical AnnotationDOI 10.1007/BF03055060Authors Carlo D. Baroni, dell’Università di Roma Istituto di Anatomia e Istologia Patologica II Viale Regina Elena 324 00161 Roma ItaliaM. Laura Peronace, dell’Università di Roma Istituto di Anatomia e Istologia Patologica II Viale Regina Elena 324 00161 Roma Italia Journal International Journal of Clinical & La...
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Fattore XIII: Biochimica e fisiopatologiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Pratical AnnotationDOI 10.1007/BF03055059Authors H. Trobisch, Heinrich-Heine-Strasse 44 355 Marburg/Lahn Bundesrepublik DeutschlandH. Bohn, Heinrich-Heine-Strasse 44 355 Marburg/Lahn Bundesrepublik DeutschlandR. Egbring, Heinrich-Heine-Strasse 44 355 Marburg/Lahn Bundesrepublik Deutschland Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 4 Journal Issue Volume 4, Numbers 1-4 / March, 1974
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Dosaggio della protrombina nei pazienti in trattamento con cumarinici. studio comparativo di tre metodi ad uno-stadioEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Prothrombin (factor II) was assayed in 43 patients under coumarin therapy using three one-stage methods. The three methods used were: classical one-stage method; Taipan snake venom method; Hjort’s et al. method. The substrates used were; a substrate composed of equal parts of adsorbed bovine plasma and pig serum; adsorbed bovine plasma and cephalin; factor II and VII deficient bovine plasma. Prothrombin was also assayed according to a modification of the onestage method. This modification consists in the addition of a small aliquot of human serum to the substrate containing adsorbed bovine plasma a...
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Rivelazione citochimica della perossidasi leucocitaria introduzioneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Riassunto Le varie metodiche per la rivelazione citochimica delle perossidasi presentano alcuni inconvenienti, quali la scarsa stabilità del reattivo alla benzidina e soprattutto la formazione, a livello dei granuli stessi, di lunghi cristalli di blu di benzidina; esse inoltre trascurano il controllo del pH e della temperatura che, per una reazione enzimatica, sono fattori molto importanti. Gli AA., nella metodica qui descritta, propongono un reattivo alla benzidina discretamente stabile ed eseguono la reazione enzimatica a 37 °C ed in ambiente tamponato per evitare la formazione di precipitati cristallini...
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Leucemia acuta a promielociti cosiddetti basofiliEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Acute leukaemia with so-called basophilic promyelocytes is a form of myelogenous leukaemia with peculiar cytoenzymatic patterns. The abundant metachromatic substance and the particular esterase activities (double naphthol-AS and chloroesterase incubation) of these promyelocytes differ from other promyelocytic leukaemias. It is interesting to note that chloroesterase-positive Auer bodies are present in both leukaemic cells with mixed esterase activity and in leukaemic cells with naphthol-AS esterase activity. We believe that this consideration is pointed out here for the first time. Some rare elements...
Source: International Journal of Clinical & Laboratory Research - July 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Idiopathic thrombocytopenic purpura and pregnancy. Maternal platelet count and antiplatelet antibodies do not predict the risk of neonatal thrombocytopeniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary The aim of this study was to try to better characterize, on the basis of maternal platelet count and antiplatelet antibodies, women with ITP or a history thereof at risk of being delivered of a child affected by neonatal thrombocytopenia. Results show that either clinical classification or maternal platelet count were not effective in predicting the occurrence of neonatal thrombocytopenia. Effects of prednisone on platelet-bound and unbound antibodies were studied prospectively in 12 non-pregnant women with ITP; no increase of these parameters was observed after treatment. Thus, the risk of corticost...
Source: International Journal of Clinical & Laboratory Research - January 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Relationships between smooth muscle and cytoskeleton antibodies in human serum samplesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary In order to characterize the relationship between smooth muscle antibodies (SMA) and antibodies directed to the cytoskeleton components 9Microfilaments, intermediate filaments and microtubules), 338 serum samples from patients with various diseases and from healthy control subjects were tested for SMA and anti-cytoskeleton antibodies using a conventional immunofluorescence method employing traditional substrates and vinblastine-treated fibroblasts. The correspondence between SMA and these antibodies turned out to be incomplete and more evident for anti-microfilaments and anti-microtubules than for an...
Source: International Journal of Clinical & Laboratory Research - January 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Cytolytic activity of T lymphocytes isolated from ovarian carcinoma ascitic fluid. Analysis at the population and clonal levelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary T lymphocytes were isolated from ascitic fluid of three patients with ovarian carcinoma at III–IV stage. Surface markers analysis of such purified T cells revealed that T8+ cells were well represented among ascitic T lymphocytes (from 35 to 56%). Low percentages of activated T cells, as indicated by HLA-DR and TAC (interleukin-2 receptor) positivity, were also present. However, fresh ascitic T lymphocytes failed to lyse autologous tumor target cells in a 4-h51Cr release assay. Furthermore, by applying a limiting dilution microculture system that allows optimal conditions for cloning of human T lymp...
Source: International Journal of Clinical & Laboratory Research - January 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Prevalence of antithrombin III deficiency in blood donors selected for personal or familial history of venous thrombosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Antithrombin III (ATIII) was measured using a functional assay in 692 (6.7%) out of 10,332 blood donors selected for their personal or familial history of venous thrombosis. Three subjects with low levels of the protein were observed. Thus, the prevalence of ATIII deficiency was of 0.43%, corresponding to a prevalence of 0.03% in the general population. On the basis of family studies and of clinical and laboratory investigations, inherited ATIII deficiency was excluded and reduced levels of the inhibitor were attributed to an impaired liver function, despite normal blood coagulation tests. Therefore,...
Source: International Journal of Clinical & Laboratory Research - January 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Procollagen-type III peptide serum concentrations in alcoholic and non-alcoholic liver diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary The type III procollagen aminopeptide (sPIIIP) serum levels were measured in 197 patients with liver disease and were correlated with morphological and serological alterations and with alcohol drinking habits. The sPIIIP levels resulted significantly increased in 51% of 43 patients with untreated chronic active hepatitis (CAH), in 61% of 36 patients with CAH plus cirrhosis, in 69% of 26 patients with inactive cirrhosis, in 4 out of 8 patients with alcoholic steatosis and fibrillogenesis, but remained unchanged in 38 cases of alcoholic steatosis plus siderosis and in 13 cases of chronic persistent hep...
Source: International Journal of Clinical & Laboratory Research - January 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Sleep-dependent hyperprolactinemia and Corpus luteum pathogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary The results obtained in wake and sleep conditions by PRL determinations performed in 6 normoprolactinemic infertile women with determined by RIA in blood samples collected at 20-min intervals from 1800 to 0800. LPD has been previously demonstrated by endometrial biopsy, basal temperature and circulating progesterone determinations. PRL levels were also determined in 5 normal women used as control subjects under the same experimental conditions. The results obtained, expressed as means±SD of LPDvs. control group, were 15.9±4.6vs. 11.6±3.3 ng/ml (p>0.1) in wake conditions and 31.9±5.9vs. 21.4±5....
Source: International Journal of Clinical & Laboratory Research - January 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Recombinant DNA techniques in the study of hepatitis B virus infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Recombinant DNA techniques have recently contributed a great deal of informations on hepatitis B virus (HBV) infection. Serum HBV-DNA appeared as the most sensitive marker of viral replication activity both in hepatitis Be antigen (HBeAg)-positive and in anti-HBe-positive patients. In the latter group, a significant correlation between serum viral DNA positivity and liver disease activity was present. In our experience, more than 50% of anti-HBe-positive cases with chronic liver disease showed circulating HBV-DNA, while none of healthy HBsAg chronic carriers was found positive for serum HBV-DNA. In t...
Source: International Journal of Clinical & Laboratory Research - January 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

An improved method for measuring red blood cell filterabilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary A new simple method for measuring red blood cell (RBC) filterability by weighing the amount of RBC filtered through micropore membranes is described. Red cell filterability by weighing (RCFW) is determined on washed RBC resuspended in phosphate-buffered saline (PBS) at low (5%) hematocrit. The filtration step is performed using gravity alone and the amount of the filtered suspension is referred to the filtration of PBS alone through the same membrane. The new method shows a reproducibility better than that of the widely used Dormandy technique, with a lower coefficient of variation (5.3vs. 7.2%) and ...
Source: International Journal of Clinical & Laboratory Research - January 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Characterization of growth parameters of a human hepatoma cell line cultured under serum-free conditionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary The PLC/PRF/5 human hepatoma cell line has at least four complete series of hepatitis B virus (HBV)-DNA sequences integrated into the host DNA and produces hepatitis B surface antigen (HBsAg) and several serum proteins in the culture medium. In order to study serum proteins and HBsAg released by these cells under controlled conditions, the serum-free growth of several human hepatoma-derived cell lines was recently investigated. In this paper the growth of PLC/PRF/5 human hepatoma cell line in a serum- and hormone-free medium was investigated. The results represent a tool which might be used in pharma...
Source: International Journal of Clinical & Laboratory Research - January 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Side effects of prostacyclin in patients with angina pectoris and coronary artery diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Although the exposure of human subjects to prostacyclin (PGI2) infusion has been broad, no systematic approaches have been made in order to investigate the dose-related side effects in patients with angina pectoris and coronary artery disease (CAD). We studied 25 patients with typical chest pain and overt CAD. All patients underwent a cycloergometer stress testing (25 W increments at 2-min intervals). PGI2 was infused in scalar doses up to 10 ng/kg/min. During the infusion 25 patients (100%) had facial flushing, 7 (28%) moderate headache and one (4%) had nausea. In addition, 4 patients experienced the...
Source: International Journal of Clinical & Laboratory Research - January 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Microfilament organization in human plateletsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Morphological and biochemical studies suggest that actin in human platelets polymerizes from monomers or oligomers into long filaments more tightly structured in activated than in resting platelets. The polymerization and reorganization of actin filaments are regulated by cellular proteins. Profilin prevents actin polymerization by forming tight complexes with monomeric actin; gelsolin acts both severing filaments and inhibiting their elongation by capping at the barded end; other actin-binding proteins nucleate polymerization and cross-link actin filaments into networks or bundles. The changes in th...
Source: International Journal of Clinical & Laboratory Research - January 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Paraproteinemia and neoplasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary According to the various case series, both myelomatous and non-myelomatous paraproteinemias are associated with a second malignant neoplasia in afrequency that ranges between 10 and 22%. This association, with a frequency higher than that statistically expected, is 2 to 4 times higher when compared to the association between two tumors of other origin. The association paraproteinemia-neoplasia was found in 10% of cases of our series of 311 paraproteinemias. In this seriesepithelial neoplasias as associated with paraproteinemias more frequently than lymphoreticular neoplasias. As far as the Ig class is...
Source: International Journal of Clinical & Laboratory Research - January 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Hermann E. Schultze 19.06.1904 08.04.1985Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/BF03029825Authors H. G. Schwick Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 15 Journal Issue Volume 15, Number 2 / April, 1985
Source: International Journal of Clinical & Laboratory Research - January 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Classification of albumin and proalbumin genetic variantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Original ContributionsDOI 10.1007/BF03029839Authors Comitato Italiano di Standardizzazione in Ematologia e Medicina di Laboratorio Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 15 Journal Issue Volume 15, Number 2 / April, 1985
Source: International Journal of Clinical & Laboratory Research - January 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Inappropriate thyroid-stimulating hormone release in the elderly?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary In three hyperthyroid women aged more than 60 years serum TSH levels, inhibited as usual before treatment, rose and remained elevated for more than one year while on treatment with methymazole and l-thyroxine, in spite of serum T3 and T4 levels within the normal range. In two hypothyroid women aged more than 60 years, serum TSH levels, raised under basal conditions, failed to be suppressed by a one-year treatment with 1-thyroxine. Repeated attempts to increase serum T3 and T4 concentrations by giving additional doses of 1-thyroxine or by tapering methymazole dosage, led to clinical signs of hyperthyr...
Source: International Journal of Clinical & Laboratory Research - January 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

The Johns Hopkins Medical InstitutionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory NewsDOI 10.1007/BF03029840 Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 15 Journal Issue Volume 15, Number 2 / April, 1985
Source: International Journal of Clinical & Laboratory Research - January 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

International Symposium on ‘Monoclonals and DNA Probes in Diagnostic and Preventive Medicine (Florence)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory NewsDOI 10.1007/BF03029841 Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 15 Journal Issue Volume 15, Number 2 / April, 1985
Source: International Journal of Clinical & Laboratory Research - January 31, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Dono Neglegens DonariEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/BF03029154Authors Luigi Condorelli Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 15 Journal Issue Volume 15, Number 1 / January, 1985
Source: International Journal of Clinical & Laboratory Research - January 30, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

High-performance liquid chromatographic assay of serotonin in human plasmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary A sensitive and reproducible reversed-phase high-performance liquid chromatography with electrochemical detection for determination of serotonin in human plasma is described. The method has an average coefficient of variation of 3.5%; the recovery of serotonin and 5-hydroxy-N-methyltryptamine (internal standard) accounts for 95±2%. Average serotonin concentrations in platelet-free plasma and in platelet-rich plasma from 21 normal subjects (22-63-year-old) ranged from 0.6 to 4.9 ng/ml (mean 2.8±1.3 SD) and from 38.3 to 106.5 ng/108 platelets (mean 66.8±18.9 SD), respectively. The release of endogen...
Source: International Journal of Clinical & Laboratory Research - January 30, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Cholinesterase evaluation in the prenatal diagnosis of open neural tube defectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary α-fetoprotein (AFP) and cholinesterase levels in amniotic fluid were determined and the efficiency of these laboratory tests in the prenatal diagnosis of neural tube defects was examined. Using the AFP test with cut-off levels correlated to gestational age, we have detected 8 cases of neural tube defects and one case of abdominal wall defect in about 1,200 pregnancies; false-negative values were absent. Acetylcholinesterase (AChE) and butyrylcholinesterase activities were measured and the electrophoretic pattern of AChE was examined in 100 amniotic fluid samples. The diagnosis of neural tube defects...
Source: International Journal of Clinical & Laboratory Research - January 30, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Phenotypic and functional heterogeneity of human T cell clones producing γ-interferonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Human T cell clones were derived from peripheral blood and screened for their ability to release γ-interferon (γ-IF) following PHA stimulation. Nine clones producing more than 20 U/ml of γ-IF were expanded and analyzed for cytolytic activity in a lectin-dependent assay and for the ability to release interleukin-2 (IL-2). In addition, clones were analyzed for T4 and T8 antigen expression. Five out of nine clones had cytolytic T lymphocyte activity, while four released relatively large amounts of IL-2. Five clones were T4+ while the remaining expressed the T8+ phenotype. These results clearly indica...
Source: International Journal of Clinical & Laboratory Research - January 30, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Hemorheologic changes in patients with a history of stroke or cerebral remittent ischemic attacksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Hemorheologic parameters were measured in cerebrovascular patients with a history of stroke or recurrent ischemic attacks in a quiescent phase of the disease. All patients were submitted to aortic arch angiography and then classified according to the presence or absence of detectable arterial lesions. In comparison with a group of control subjects, cerebrovascular patients had significantly elevated levels of blood and plasma viscosity, fibrinogen, factors VIII:C and VIIIR:Ag and lowered values of erythrocyte filtration. Blood viscosity was increased and erythrocyte filtration reduced only in male pa...
Source: International Journal of Clinical & Laboratory Research - January 30, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Detection of anti-extractable nuclear antigens in connective tissue diseases: Comparison between passive hemagglutination, counterimmunoelectrophoresis and double immunodiffusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Antibodies to the three major components of the complex called soluble extractable nuclear antigen (ENA) were detected by passive hemagglutination (HA), counterimmunoelectrophoresis (CIE) and double immunodiffusion (DI) in 256 patients with connective tissue diseases. Anti-ENA antibodies were demonstrated by all the three employed methods in only 44.9% of the cases. These methods were not able to detect all antibodies to these antigens or any single specificity; CIE was however the most sensitive method for anti-RNP and HA for anti-Sm antibodies, while DI was the most suitable technique for serum sam...
Source: International Journal of Clinical & Laboratory Research - January 30, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Serotonin receptors on pulmonary alveolar macrophagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Pulmonary alveolar macrophages harvested from the albino mouse lung were shown to possess surface receptor sites capable of binding physiological concentrations of serotonin (5-hydroxytryptamine). These specific, high affinity binding sites showed temperature-dependent kinetics with a single order high affinity binding site for serotonin. The presence of serotonin receptors on pulmonary alveolar macrophages provides a basis for relating at least one mediator of pulmonary inflammatory processes and transport processes to effects upon the macrophage surface. Content Type Journal ArticleCategory Orig...
Source: International Journal of Clinical & Laboratory Research - January 30, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Betamethasone increases the β-adrenergic receptor density of human polymorphonuclear leukocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Prolonged incubation (18h) of human polymorphonuclear leukocytes (PMNs) with betamethasone (BT)(10−7 M) increased (3H)-DHA binding to human PMN membranes, apparently causing an increase in the number of β-adrenergic receptors. Inhibition of this effect by cycloheximide (2 µg/ml) suggests that it is dependent on protein synthesis. BT had no effect on basal levels of cAMP in PMNs, but synergistically potentiated the increase in cyclic AMP (cAMP) induced by isoproterenol. Propranolol completely abolished the synergistic effect of BT plus isoproterenol, suggesting that the potentiating effect of BT on...
Source: International Journal of Clinical & Laboratory Research - January 30, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Genesis and evolution of proteinuria in diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Approximately 40–45% of insulin-dependent diabetic (IDD) patients will develop, with time, clinical proteinuria, a forerunner of certain renal failure. Before this, however, up to 45% of IDD patients excrete supranormal amounts of protein in the urine, though still undetectable by dipstix test. This microproteinuria appears to be glomerular in origin, consists mainly of albumin and IgG, and is associated with poor glycemic control and marginal elevation of arterial pressure. Glomerular hemodynamic disturbances, and loss of charge selectivity of the glomerular membrane, are probably responsible for ...
Source: International Journal of Clinical & Laboratory Research - January 30, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Idiotypic-antiidiotypic interactions in manEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Anti-idiotypic (anti-Id) antibodies are directed against antigenic determinants expressed by the antigen-binding region of the immunoglobulin molecules. Their interaction with antigen receptors on immune cells modulates the immune response. In man auto-anti-Id antibodies have been demonstrated. These antibodies not only participate in the regulation of the immune response, but can result in disease as in the case of acquired angioedema with B cell malignancy and possibly in autoimmune diseases. Anti-Id antibodies may be useful tools in cancer immunotherapy and in the production of vaccines. Conten...
Source: International Journal of Clinical & Laboratory Research - January 30, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Establishment of international federation of infection controlEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory NewsDOI 10.1007/BF03029167 Journal International Journal of Clinical & Laboratory ResearchOnline ISSN 1434-4467Print ISSN 0940-5437 Journal Volume Volume 15 Journal Issue Volume 15, Number 1 / January, 1985
Source: International Journal of Clinical & Laboratory Research - January 30, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

Prognostic significance of serum lactic acid dehydrogenase in Ewing’s tumor of boneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Pretreatment serum lactic acid dehydrogenase (LDH) levels were examined in 82 patients with Ewing’s tumor of bone (23 metastatic and 59 localized). The percentage of patients with increased serum LDH levels was significantly higher in the metastatic group than in the group of patients with localized disease (87 vs. 45%). After treatment with combined therapy, in this latter group the recurrence rate was significantly higher in patients with elevated serum LDH levels at admission than in those with normal serum LDH levels (50 vs. 9%). Of the 16 patients with localized disease who relapsed, 13 (81%) ...
Source: International Journal of Clinical & Laboratory Research - January 30, 2009 Category: Laboratory Medicine Tags: International Journal of Clinical & Laboratory Research Source Type: journals

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