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424 records returned

Oncostatin M and leukemia inhibitory factor increase hepcidin expression in hepatoma cell lines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we demonstrated that OSM and LIF can induce hepcidin expression mainly through the JAK/STAT pathways. Further studies are warranted to evaluate the clinical significance of OSM and LIF in the development of anemia in various inflammatory diseases. PMID: 19915946 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - November 14, 2009 Category: Hematology Authors: Kanda J, Uchiyama T, Tomosugi N, Higuchi M, Uchiyama T, Kawabata H Tags: Int J Hematol Source Type: journals

Flow cytometric analysis of skin blister fluid induced by mosquito bites in a patient with chronic active Epstein-Barr virus infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In chronic active Epstein-Barr virus (EBV) infection (CAEBV), ectopic EBV infection has been described in T or natural killer (NK) cells. NK cell-type infection (NK-CAEBV) is characterized by large granular lymphocytosis, high IgE levels and unusual reactions to mosquito bites, including severe local skin reactions, fever and liver dysfunction. However, the mechanisms underlying these reactions remain undetermined. Herein, we describe a patient with NK-CAEBV whose blister fluid after mosquito bites was analyzed. The patient exhibited significant increases in the percentage of CD56(+) NK cells in the fluid compared with...
Source: International Journal of Hematology - November 14, 2009 Category: Hematology Authors: Wada T, Yokoyama T, Nakagawa H, Asai E, Toga A, Sakakibara Y, Shibata F, Tone Y, Shimizu M, Toma T, Yachie A Tags: Int J Hematol Source Type: journals

Gemtuzumab ozogamicin-induced long-term remission in a woman with acute myelomonocytic leukemia and bone marrow relapse following allogeneic transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 56-year-old woman with acute myelomonocytic leukemia underwent myeloablative allogeneic hematopoietic stem cell transplantation (allo-SCT) from a matched unrelated donor in her first complete remission (CR). Veno-occlusive disease (VOD) prophylaxis consisted of low-dose heparin and ursodeoxycholic acid. Graft-versus-host disease (GVHD) prophylaxis comprised tacrolimus and short-term methotrexate. On day 14, VOD developed, but gradually resolved with supportive therapy. On day 58, she showed grade II acute GVHD, but this resolved spontaneously. On day 140, she developed hematological relapse with 40.2% marrow infiltra...
Source: International Journal of Hematology - November 11, 2009 Category: Hematology Authors: Sumi M, Ichikawa N, Nasu K, Shimizu I, Ueki T, Ueno M, Kobayashi H Tags: Int J Hematol Source Type: journals

Evolution of recombinant factor VIII safety: KOGENATE((R)) and Kogenate ((R)) FS/Bayer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of factor VIII (FVIII) concentrates in the treatment of hemophilia A has raised important safety issues, historically of pathogen transmission and increasingly of inhibitor development to FVIII treatment. While manufacturing processes of current recombinant FVIII products have been shaped entirely around preventing pathogen transmission, the same modifications that afford a greater margin of safety could affect immunogenicity of the product, consequences of which could only be seen through long-term clinical experience. This review summarizes pathogen safety and inhibitor reports from clinical trials, post-mark...
Source: International Journal of Hematology - November 3, 2009 Category: Hematology Authors: Lusher JM, Scharrer I Tags: Int J Hematol Source Type: journals

Diagnosis of progressive disseminated histoplasmosis on bone marrow biopsy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19876705 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - October 31, 2009 Category: Hematology Authors: Shah BK, Serban K, Tandon M Tags: Int J Hematol Source Type: journals

Living-donor single lobe lung transplantation for bronchiolitis obliterans from mother to child following previous allogeneic hematopoietic stem cell transplantation from the same donor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19866336 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - October 29, 2009 Category: Hematology Authors: Oshima K, Kikuchi A, Mochizuki S, Yamane M, Date H, Hanada R Tags: Int J Hematol Source Type: journals

Treosulfan-based conditioning regimen in a second matched unrelated peripheral blood stem cell transplantation for a pediatric patient with CGD and invasive aspergillosis, who experienced initial graft failure after RIC.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a 3-year-old boy with CGD, who developed IA despite antifungal prophylaxis. His treatment consisted of a 10-month-long multi-drug antifungal therapy, together with surgery, but these did not cause any substantial clinical improvement. BMT in high-risk patients with CGD remains a challenge due to both, higher risk of graft rejection and inflammatory flare in the course of immune recovery. Our patient rejected the first matched unrelated donor (MUD) allograft after RIC regimen recommended by the EBMT Inborn Errors Working Party for high-risk patients. After treosulfan-based conditioning and second MUD p...
Source: International Journal of Hematology - October 29, 2009 Category: Hematology Authors: Klaudel-Dreszler MA, Kalwak K, Kurenko-Deptuch M, Wolska-Kusnierz B, Heropolitanska-Pliszka E, Pietrucha B, Mikoluc B, Gorczyńska E, Ussowicz M, Chybicka A, Bernatowska E Tags: Int J Hematol Source Type: journals

Iron chelation therapy in the management of thalassemia: the Asian perspectives.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Worldwide, thalassemia is the most commonly inherited hemolytic anemia, and it is most prevalent in Asia and the Middle East. Iron overload represents a significant problem in patients with transfusion-dependent beta-thalassemia. Chelation therapy with deferoxamine has traditionally been the standard therapeutic option but its usage is tempered by suboptimal patient compliance due to the discomfort and demands associated with the administration regimen. Therefore, a great deal of attention has been focused on the development of oral chelating agents. Deferiprone, even though available for nearly two decades in Asia wit...
Source: International Journal of Hematology - October 29, 2009 Category: Hematology Authors: Viprakasit V, Lee-Lee C, Chong QT, Lin KH, Khuhapinant A Tags: Int J Hematol Source Type: journals

Acquired hemophilia A may be associated with itraconazole.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19859652 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - October 27, 2009 Category: Hematology Authors: Tamai H, Inokuchi K, Dan K, Tanosaki S Tags: Int J Hematol Source Type: journals

Mikulicz's disease with severe thrombocytopenia following autologous stem cell transplantation in a multiple myeloma patient.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the first case of Mikulicz's disease (MD) occurring 2 years after autologous peripheral blood stem cell transplantation (PBSCT) for multiple myeloma (MM). A 70-year-old man developed bilateral enlargement of parotid and submandibular glands. The patient had previously received 2 courses of autologous PBSCT for IgG-kappa type MM, and had been stable for 2 years. This salivary gland enlargement was initially felt to represent a recurrence of MM, since along with gland swelling, IgG was also elevated. However, repeated biopsy of the left submandibular gland revealed chronic sclerosing sialadenitis rather than plasma...
Source: International Journal of Hematology - October 24, 2009 Category: Hematology Authors: Sakurai C, Ohashi K, Sakaguchi K, Hishima T, Kamata N, Akiyama H, Sakamaki H Tags: Int J Hematol Source Type: journals

Detection of sputum Aspergillus galactomannan for diagnosis of invasive pulmonary aspergillosis in haematological patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We investigated the diagnostic utility of Aspergillus galactomannan (GM) in sputum for diagnosis of invasive pulmonary aspergillosis (IPA) in haematologic patients and compared the results with those of bronchial lavage fluid (BLF) and serum. Patients were classified into 4 groups using modified European Organization for Research and Treatment of Cancer criteria: group A, proven IPA; group B, probable IPA; group C, possible IPA; group D, others. Groups A and B were considered the IPA group (n = 6); group D was considered non-IPA group (n = 37); group C (n = 13) was equivocal for IPA. As a true negative control, sputa f...
Source: International Journal of Hematology - October 19, 2009 Category: Hematology Authors: Kimura SI, Odawara J, Aoki T, Yamakura M, Takeuchi M, Matsue K Tags: Int J Hematol Source Type: journals

Favorable coagulation profile with fondaparinux after hip surgery in elderly patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Twenty-three patients with fondaparinux prophylaxis over 75 years of age who underwent hip fracture surgery were enrolled in the study. Fondaparinux sodium (2.5 mg) was administered subcutaneously 6 h postoperatively and then every 24 h for 28 days. Coagulation and inflammatory parameters were measured preoperatively, then 10 h, 2, 7, and 28 days postoperatively. Increased D: -dimers, positive acute phase proteins, and IL-6, and decreased negative acute phase proteins were observed preoperatively (P < 0.05). Maximum values were reached 10 h postoperatively for IL-6 and D: -dimer, and on postoperative days 2 and 7 fo...
Source: International Journal of Hematology - October 16, 2009 Category: Hematology Authors: Kudrnová Z, Kvasnička J, Kudrna K, Mazoch J, Malíková I, Zenáhlíková Z, Sudrová M, Brzežková R Tags: Int J Hematol Source Type: journals

Compound heterozygous mutations in the PROS1 gene responsible for quantitative and qualitative protein S deficiency.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19826897 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - October 13, 2009 Category: Hematology Authors: Yamanouchi J, Hato T, Tamura T, Fujiwara H, Yakushijin Y, Yasukawa M Tags: Int J Hematol Source Type: journals

Hairy cell leukemia responsive to anti-thymocyte globulin used as immunosuppressive therapy for aplastic anemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hairy cell leukemia (HCL) is occasionally misdiagnosed as aplastic anemia when only a few leukemic cells are present in the circulation. Here, we describe a patient with HCL who initially presented with pancytopenia and received a diagnosis of aplastic anemia. The patient was treated with immunosuppressive therapy including cyclosporine A and anti-thymocyte globulin (ATG). No blood cell transfusion was required for approximately 3 years after ATG therapy. She was referred to our hospital because of an abdominal mass and requiring periodic blood transfusions. A bone marrow biopsy at this time revealed proliferation of l...
Source: International Journal of Hematology - October 13, 2009 Category: Hematology Authors: Fujiwara S, Miyake H, Nosaka K, Yoshida M, Ishihara S, Horikawa K, Yonemura Y, Iyama K, Mitsuya H, Asou N Tags: Int J Hematol Source Type: journals

Refractory chronic immune thrombocytopenic purpura in a child with acute lymphoblastic leukemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Immune thrombocytopenic purpura (ITP) has been associated with several hematologic malignancies such as Hodgkin and non-Hodgkin lymphomas and chronic lymphocytic leukemia, but it is rare in children with acute lymphoblastic leukemia (ALL). Here, we report a 7-year-old girl with chronic ITP during early intensive phase of chemotherapy for ALL. She underwent splenectomy because thrombocytopenia had persisted even after treatment with intravenous immunoglobulin (IVIG), steroids, vincristine, rituximab, and anti-D antibody. After splenectomy, her platelet count had recovered, and maintenance therapy could be resumed with a...
Source: International Journal of Hematology - October 9, 2009 Category: Hematology Authors: Horino S, Rikiishi T, Niizuma H, Abe H, Watanabe Y, Onuma M, Hoshi Y, Sasahara Y, Yoshinari M, Kazama T, Hayashi Y, Kumaki S, Tsuchiya S Tags: Int J Hematol Source Type: journals

Complete remission of splenic marginal zone lymphoma after an acute flare-up of hepatitis B in a hepatitis B virus carrier.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 44-year-old female presented with asymptomatic leukocytosis and moderate splenomegaly. The diagnosis of splenic marginal zone lymphoma (SMZL) was made by a splenectomy. A virological examination revealed the patient to be a hepatitis B virus (HBV) carrier. The lymphocyte count in her peripheral blood decreased after splenectomy, but remained high for 2 years and bone marrow infiltration was obvious. Two years after the splenectomy, she was admitted for an acute flare-up of hepatitis B. The liver dysfunction improved without any medication and thereafter returned to the normal range within a few weeks. At the same tim...
Source: International Journal of Hematology - October 5, 2009 Category: Hematology Authors: Fujimoto K, Endo T, Nishio M, Obara M, Yamaguchi K, Takeda Y, Goto H, Kasahara I, Sato N, Koike T Tags: Int J Hematol Source Type: journals

Increase in gamma-globin mRNA content in human erythroid cells treated with angelicin analogs.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the present study was to identify molecular analogs of angelicin (ANG) able to increase erythroid differentiation of K562 cells and expression of gamma-globin genes in human erythroid precursor cells, with low effects on apoptosis. ANG-like molecules are well-known photosensitizers largely used for their antiproliferative activity in the treatment of different skin diseases (i.e., psoriasis, vitiligo, eczema, and mycosis fungoides). To verify the activity of these derivatives, we employed three experimental cell systems: (1) the human leukemic K562 cell line, (2) K562 cell clones stably transfected with a pC...
Source: International Journal of Hematology - September 24, 2009 Category: Hematology Authors: Lampronti I, Bianchi N, Zuccato C, Dall'acqua F, Vedaldi D, Viola G, Potenza R, Chiavilli F, Breveglieri G, Borgatti M, Finotti A, Feriotto G, Salvatori F, Gambari R Tags: Int J Hematol Source Type: journals

Langerhans cell histiocytosis with multifocal bone lesions: comparative clinical features between single and multi-systems.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Langerhans cell histiocytosis (LCH) can be a single system or multi-system disease. Both disease types can be associated with multi-focal bone lesions, but their bone involvement patterns have not been compared systematically. Of the new pediatric LCH cases enrolled into the JLSG-02 study during 2002-2007, 67 cases of single system multifocal bone (SMFB) LCH and 97 cases of multi-system bone (MSB) LCH were analyzed to determine if the bone involvement patterns differ in these two types, and whether these differences correlate with outcome. Statistical analysis was performed with Mann-Whitney U test, Fisher's exact tes...
Source: International Journal of Hematology - September 24, 2009 Category: Hematology Authors: Imashuku S, Kinugawa N, Matsuzaki A, Kitoh T, Ohki K, Shioda Y, Tsunematsu Y, Imamura T, Morimoto A, Tags: Int J Hematol Source Type: journals

The ex vivo production of ammonia predicts L: -asparaginase biological activity in children with acute lymphoblastic leukemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with acute lymphoblastic leukemia (ALL), who develop antiasparaginase antibodies without clinical allergic reactions ("silent inactivation") during L: -asparaginase (L: -Asp) treatment, have poor outcomes. Ammonia is produced by hydrolysis of asparagine by L: -Asp. We postulated that plasma ammonia level might reflect the biological activity of L: -Asp. Five children with ALL treated according to the Tokyo Children's Cancer Study Group (TCCSG) protocol were enrolled. Plasma ammonia levels were analyzed immediately and 1 h after incubation at room temperature and "ex vivo ammonia production" was defined as incr...
Source: International Journal of Hematology - September 18, 2009 Category: Hematology Authors: Watanabe S, Miyake K, Ogawa C, Matsumoto H, Yoshida K, Hirabayashi S, Hasegawa D, Inoue T, Kizu J, Machida R, Ohara A, Hosoya R, Manabe A Tags: Int J Hematol Source Type: journals

Immunosuppressive treatment in patient with pure red cell aplasia associated with chronic myelomonocytic leukemia: harm or benefit?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acquired pure red cell aplasia (PRCA) can be primary or secondary to other diseases. PRCA association with chronic myelomonocytic leukemia (CMML) is very rarely reported. Although treatment is directed to underlying cause in secondary PRCA treatment, optimal treatment in patients with CMML and PRCA is unknown, because only four case reports are available. In addition, the effect of hypomethylating agents can be detrimental due to myelosuppression, at least in the early phase of treatment. Bone marrow examination of a 66-year-old woman with severe anemia revealed PRCA and was suspicious for CMML. There was no HLA-matche...
Source: International Journal of Hematology - September 17, 2009 Category: Hematology Authors: Tanna S, Ustun C Tags: Int J Hematol Source Type: journals

Expression of annexin II in experimental abdominal aortic aneurysms.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Annexin II is a receptor of tissue-type plasminogen activator (t-PA). We have previously identified annexin II by immunolocalization in human atherosclerotic abdominal aortic aneurysms (AAAs). To investigate possible interactions between annexin II and AAA development, we examined annexin II mRNA and protein expression in a rat model of experimental AAA. AAAs were induced in rats by transient aortic infusion of elastase. The rats were divided into three groups: a saline-treated control group, a group with 15-min elastase infusion, and a group with 30-min elastase infusion. The 15-min elastase-infused group had smaller ...
Source: International Journal of Hematology - September 15, 2009 Category: Hematology Authors: Hayashi T, Morishita E, Ohtake H, Oda Y, Asakura H, Nakao S Tags: Int J Hematol Source Type: journals

HHV8-positive, HIV-negative multicentric Castleman's disease: early and sustained complete remission with rituximab therapy without reactivation of Kaposi sarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here the clinical and biologic courses of two HIV-negative, HHV8-positive patients with MCD who were treated with rituximab. In both cases, a significant clinical improvement was observed after the first two infusions, which was shortly followed by a drop in HHV8 viremia to undetectable levels. Both patients underwent complete clinical remission, which persisted without relapse at 30 and 9 months of follow-up, respectively. No reactivation of the Kaposi sarcoma found in a lymph node of one of the patients was observed. Our report, along with additional data present in the literature, suggests that rituximab may b...
Source: International Journal of Hematology - September 11, 2009 Category: Hematology Authors: Nicoli P, Familiari U, Bosa M, Allice T, Mete F, Morotti A, Cilloni D, Saglio G, Guerrasio A Tags: Int J Hematol Source Type: journals

Two rare MPL gene mutations in patients with essential thrombocythemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19728022 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - September 1, 2009 Category: Hematology Authors: Ohashi H, Arita K, Fukami S, Oguri K, Nagai H, Yokozawa T, Hotta T, Hanada S Tags: Int J Hematol Source Type: journals

Suppressed neutrophil function in children with acute lymphoblastic leukemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we analyzed neutrophil function in children with acute lymphoblastic leukemia (ALL). Whole blood samples were obtained from 16 children with ALL at diagnosis, after induction chemotherapy, and after consolidation chemotherapy. Oxidative burst and phagocytic activity of neutrophils were analyzed by flow cytometry. Oxidative burst of neutrophils was impaired in ALL patients. The percentage of neutrophils with normal oxidative burst after PMA stimulation was 59.0 +/- 13.2 or 70.0 +/- 21.0% at diagnosis or after induction chemotherapy, respectively, which was significantly lower compared with 93.8 +/- 6.1% in he...
Source: International Journal of Hematology - September 1, 2009 Category: Hematology Authors: Tanaka F, Goto H, Yokosuka T, Yanagimachi M, Kajiwara R, Naruto T, Nishimaki S, Yokota S Tags: Int J Hematol Source Type: journals

Clinicopathological study on peripheral T-cell non-Hodgkin lymphoma with bone marrow involvement: a retrospective analysis from China.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We reviewed 173 patients with an initial diagnosis of peripheral T-cell non-Hodgkin lymphoma (PTCL) and compared the patients with bone marrow involvement (BMI) to those without to have a better understanding of the clinical characteristics, treatments, survival and prognosis of PTCLs with BMI. We found that 40% (70/173) of the patients had BMI, and its frequency was 64% in angioimmunoblastic T-cell lymphoma (TCL), 46% in PTCL unspecified, 29% in anaplastic large T-cell lymphoma, 23% in extranodal NK/T-cell lymphoma and 13% in enteropathy-type TCL. In the BMI group, 36% of patients had lymphoma-associated hemophagocyti...
Source: International Journal of Hematology - September 1, 2009 Category: Hematology Authors: Tong H, Ren Y, Qian W, Xiao F, Mai W, Meng H, Jin J Tags: Int J Hematol Source Type: journals

Feasibility and eligibility of retreatment with rabbit anti-T lymphocyte globulin for aplastic anemia previously treated with horse anti-thymocyte globulin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19728019 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - August 28, 2009 Category: Hematology Authors: Miura K, Hatta Y, Kobayashi S, Iriyama Y, Takei K, Takeuchi J Tags: Int J Hematol Source Type: journals

Fluctuations in thrombopoietin, immature platelet fraction, and glycocalicin levels in a patient with cyclic thrombocytopenia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19728020 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - August 28, 2009 Category: Hematology Authors: Yujiri T, Tanaka Y, Tanaka M, Tanizawa Y Tags: Int J Hematol Source Type: journals

Cord blood transplantation with a reduced-intensity conditioning regimen for patients with relapsed aggressive multiple myeloma after cytoreduction with bortezomib.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two multiple myeloma patients relapsed after autologous stem cell transplantation (ASCT). Conventional chemotherapy, including thalidomide, showed very little effect, but both patients responded well to a standard dose of bortezomib. One patient was treated with two additional cycles of bortezomib, but his clinical course suddenly deteriorated. Unrelated cord blood transplantation (CBT) with reduced-intensity conditioning regimen (RIC) was performed in refractory disease. After CBT, the clinical course was aggravated by tumor lysis syndrome and other conditions, thus resulting in patient death on day 34. Thereafter, we...
Source: International Journal of Hematology - August 28, 2009 Category: Hematology Authors: Kasahara I, Nishio M, Yamamoto S, Endo T, Fujimoto K, Yamaguchi K, Takeda Y, Goto H, Sato N, Koike T Tags: Int J Hematol Source Type: journals

Cytogenetic abnormalities in essential thrombocythemia at presentation and transformation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe cytogenetic abnormalities in 172 patients with ET at a single institution. At presentation nine (5.2%) patients had cytogenetic abnormality and three (1.7%) additional patients acquired them during follow-up. Survival of patients with cytogenetic changes at presentation did not differ when compared to the patients with normal karyotype. The more common were abnormalities of chromosome 9 (n = 4), 20 (n = 2), 5 (n = 2), and complex abnormalities (n = 2). Forty-one patients (23.8%) had additional cytogenetic tests performed for monitoring purposes during follow-up. Five patients (2.9%) with normal karyotype transf...
Source: International Journal of Hematology - August 28, 2009 Category: Hematology Authors: Sever M, Kantarjian H, Pierce S, Jain N, Estrov Z, Cortes J, Verstovsek S Tags: Int J Hematol Source Type: journals

Effect of artesunate on inhibiting proliferation and inducing apoptosis of SP2/0 myeloma cells through affecting NFkappaB p65.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The initial treatment of multiple myeloma (MM) experienced a paradigm shift, in the past decade, with the introduction of novel agents such as thalidomide, lenalidomide and bortezomib, leading to improved outcomes. High dose therapy and autologous stem cell transplantation remain an important therapeutic option for patients with MM eligible for the procedure. However, most of these treatment regimens are too expensive for Chinese patients. Therefore, we investigated the effects of artesunate, which is commonly used in the treatment of severe malaria, on inhibition of proliferation and induction of apoptosis of a mouse ...
Source: International Journal of Hematology - August 28, 2009 Category: Hematology Authors: Li S, Xue F, Cheng Z, Yang X, Wang S, Geng F, Pan L Tags: Int J Hematol Source Type: journals

Plasma cell leukemia producing monoclonal immunoglobulin E.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 78-year-old male with lumbar pain and dim consciousness presented the clinical pictures of plasma cell leukemia (PCL) producing a large amount of monoclonal immunoglobulin E (IgE)/kappa protein. Laboratory investigation demonstrated an elevated serum calcium level and renal dysfunction. Systemic bone X-ray survey disclosed only a solitary osteolytic lesion. Circulating plasma cells demonstrated CD19(-)/CD56(-) and MPC-1(-)/CD49e(-)/CD45(+/-), the latter indicating the immature phenotype of the tumor cells. Bone marrow was occupied with immature, atypical plasma cells, of which cytoplasms were positive for IgE by dire...
Source: International Journal of Hematology - August 28, 2009 Category: Hematology Authors: Takemura Y, Ikeda M, Kobayashi K, Nakazawa Y, Mori Y, Mitsuishi T, Ishigame H, Kameko F, Fujita K, Ichinohasama R Tags: Int J Hematol Source Type: journals

Prospective analysis of clinical and cytogenetic features of 435 cases of MDS diagnosed using the WHO (2001) classification: a prognostic scoring system for predicting survival in RCMD.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We characterized the prevalence, clinical and cytogenetic characteristics and survival of 435 patients diagnosed with de novo MDS in a single laboratory according to WHO criteria, and compared the utility of different scoring systems to predict survival for individual subtypes of MDS. The mean follow-up period was 25.1 (5.5-53.2) months. Our results confirm major differences in the age-distribution and prevalence of individual subtypes of MDS between Asian and Western patients with a median age of 58 years and a predominance of RCMD (69.9%). Survival rates were similar to those reported in the West: the 3-year survival...
Source: International Journal of Hematology - August 28, 2009 Category: Hematology Authors: Wang XQ, Ryder J, Gross SA, Lin G, Irons RD Tags: Int J Hematol Source Type: journals

CD34+ cell subpopulations detected by 8-color flow cytometry in bone marrow and in peripheral blood stem cell collections: application for MRD detection in leukemia patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fast development in polychromatic flow cytometry (PFC) makes it possible to study CD34+ cells with two scatter and eight fluorescence parameters. Minimal residual disease (MRD) is determined as persistence of leukemic cells at submicroscopic levels in bone marrow (BM) of patients in complete remission. MRD can be present in collections of hematopoietic stem cell from blood (HSC-B). Using PFC, we have defined patterns of antigen expression in CD34+ cell subpopulations in BM and applied them as templates in MRD analysis. Twelve BM samples from hospital control (HC) patients with no signs of hematological malignancy were ...
Source: International Journal of Hematology - August 28, 2009 Category: Hematology Authors: Björklund E, Gruber A, Mazur J, Mårtensson A, Hansson M, Porwit A Tags: Int J Hematol Source Type: journals

Primary cutaneous anaplastic large cell lymphoma of the vulva: a typical cutaneous lesion with an 'atypical' presenting site.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a patient who has primary cutaneous anaplastic large cell (C-ALCL) with an unusual presentation as a vulvar ulcer. She received a brief course of chemotherapy followed by local irradiation and has remained disease-free more than a year from the time of diagnosis. To our knowledge, primary C-ALCL involving the vulva has never been reported. Despite its typical cutaneous manifestation of C-ALCL, the uncommon presenting site of this entity warrants recognition because of its prognostic and therapeutic implication. PMID: 19707712 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - August 25, 2009 Category: Hematology Authors: Koh LP, Wong LC, Ng SB, Poon ML, Low JJ Tags: Int J Hematol Source Type: journals

Phenotypic variations between affected siblings with ataxia-telangiectasia: ataxia-telangiectasia in Japan.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A nationwide survey was conducted for identifying ataxia-telangiectasia (AT) patients in Japan. Eighty-nine patients were diagnosed between 1971 and 2006. Detailed clinical and laboratory data of 64 patients including affected siblings were collected. Analyses focused on malignancy, therapy-related toxicity, infection, and hematological/immunological parameters. The phenotypic variability of AT was assessed by comparing 26 affected siblings from 13 families. Malignancy developed in 22% of the cases and was associated with a high rate of severe therapy-related complications: chemotherapy-related cardiac toxicity in 2 ch...
Source: International Journal of Hematology - August 24, 2009 Category: Hematology Authors: Morio T, Takahashi N, Watanabe F, Honda F, Sato M, Takagi M, Imadome KI, Miyawaki T, Delia D, Nakamura K, Gatti RA, Mizutani S Tags: Int J Hematol Source Type: journals

Successful treatment of young-onset adult T cell leukemia/lymphoma and preceding chronic refractory eczema and corneal injury by allogeneic hematopoietic stem cell transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Only some carriers of human T cell lymphotropic virus type I (HTLV-1) develop adult T cell leukemia/lymphoma (ATLL) after a long latency period, and an association has been reported between chronic refractory eczema, known as infective dermatitis, and young-onset ATLL. A 25-year-old female developed ATLL and underwent allogeneic hematopoietic stem cell transplantation (HSCT) in non-remission. She had chronic refractory eczema and corneal injury at the onset of ATLL. Remission of ATLL was achieved, and the HTLV-1 proviral load decreased after HSCT. In addition, her pre-existing eczema and corneal injuries almost disappe...
Source: International Journal of Hematology - August 24, 2009 Category: Hematology Authors: Miyamura F, Kako S, Yamagami H, Sato K, Sato M, Terasako K, Kimura SI, Nakasone H, Aoki S, Okuda S, Yamazaki R, Oshima K, Yoshinaga K, Higuchi T, Nishida J, Demitsu T, Kakehashi A, Kanda Y Tags: Int J Hematol Source Type: journals

Lenalidomide is active in Japanese patients with symptomatic anemia in low- or intermediate-1 risk myelodysplastic syndromes with a deletion 5q abnormality.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lenalidomide is an immunomodulatory agent recently reported to be effective in the treatment of transfusion-dependent anemia due to low- or intermediate-1 risk myelodysplastic syndromes (MDS) associated with a deletion 5q (del 5q) cytogenetic abnormality. We conducted a multicenter, single-arm clinical trial to evaluate the safety and efficacy of lenalidomide in Japanese patients with anemia in low- or intermediate-1 risk MDS associated with the del 5q cytogenetic abnormality. Eleven patients (5 with transfusion-dependent anemia; 6 with transfusion-independent symptomatic anemia) received once daily oral administration...
Source: International Journal of Hematology - August 24, 2009 Category: Hematology Authors: Harada H, Watanabe M, Suzuki K, Yanagita S, Suzuki T, Yoshida Y, Kimura A, Tsudo M, Matsuda A, Tohyama K, Taniwaki M, Takeshita K, Takatoku M, Ozawa K Tags: Int J Hematol Source Type: journals

A study of rasburicase for the management of hyperuricemia in pediatric patients with newly diagnosed hematologic malignancies at high risk for tumor lysis syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study in Japanese patients evaluated the efficacy, safety, and pharmacokinetic profile of rasburicase in pediatric patients with hematologic malignancies. Patients aged <18 years at high risk for TLS, with newly diagnosed hematologic malignancies, were randomized to intravenous rasburicase 0.15 mg/kg/day (n = 15) or 0.20 mg/kg/day (n = 15) for 5 days. Chemotherapy was started 4-24 h after the first rasburicase dose. Response was defined as a reduction in plasma uric acid to </=6.5 mg/dL (patients <13 years) or </=7.5 mg/dL (patients >/=13 years) by 48 h after the first administration, lasting until 24 h...
Source: International Journal of Hematology - August 21, 2009 Category: Hematology Authors: Kikuchi A, Kigasawa H, Tsurusawa M, Kawa K, Kikuta A, Tsuchida M, Nagatoshi Y, Asami K, Horibe K, Makimoto A, Tsukimoto I Tags: Int J Hematol Source Type: journals

Decisional flow with a scoring system to start platelet-lowering treatment in patients with essential thrombocythemia: long-term results.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We prospectively tested, at diagnosis in essential thrombocythemia (ET) patients with no clear indication to platelet (PLT)-lowering treatment, a scoring system based on age, PLT level, cardiovascular diseases, previous thrombotic events, smoking and dysmetabolic diseases. From 04/92 to 03/98, 168 consecutive patients were enrolled. Hydroxyurea (HU) was started at diagnosis in 32 "symptomatic" patients and in 33 patients aged >70 years. The remaining 103 patients ("asymptomatic" and aged <70 years) were classified according to our scoring system. Thirty-two patients with score >/=4 started HU early after diagn...
Source: International Journal of Hematology - August 21, 2009 Category: Hematology Authors: Latagliata R, Rago A, Spadea A, Santoro C, Carmosino I, Breccia M, Napoleone L, Fama A, Biondo F, Volpicelli P, Vozella F, Stefanizzi C, Petti MC, Alimena G, Mazzucconi MG Tags: Int J Hematol Source Type: journals

Second unrelated cord blood transplantation using a reduced-intensity conditioning regimen combined with gemtuzumab ozogamicin in patients with relapsed acute myelogenous leukemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here for the first time three AML cases that relapsed after allogeneic SCT and underwent unrelated cord blood transplantation (UCBT) following reduced-intensity conditioning (RIC) comprising fludarabine, melphalan, and low-dose total body irradiation combined with GO. Primary neutrophil engraftment occurred in all cases, while recovery of platelet count was delayed. Only one case of reversible hepatic sinusoidal obstruction syndrome was documented. Non-relapse mortality at day 100 was not documented. Notably, one patient who responded to GO survived for 6 months after UCBT in remission with excellent performance ...
Source: International Journal of Hematology - August 21, 2009 Category: Hematology Authors: Yamauchi T, Mori Y, Miyamoto T, Kamezaki K, Aoki T, Yamamoto A, Takenaka K, Iwasaki H, Harada N, Nagafuji K, Teshima T, Akashi K Tags: Int J Hematol Source Type: journals

Stable mixed donor-donor chimerism after double cord blood transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, in this study donor-donor mixed chimerism was common after high dose ATG and DCBT. Further studies are warranted concerning the immunological consequences of the phenomenon of donor-donor mixed chimerism after DCBT. PMID: 19697099 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - August 21, 2009 Category: Hematology Authors: Berglund S, Okas M, Gertow J, Uhlin M, Mattsson J Tags: Int J Hematol Source Type: journals

Successful allogeneic bone marrow transplantation for myelodysplastic syndrome complicated by severe pulmonary alveolar proteinosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report herein a rare case of myelodysplastic syndrome (MDS-RAEB) complicated by severe PAP, and successful allogeneic bone marrow transplantation (BMT) for both disorders. An unrelated BMT was planned for a 48-year-old male with advanced MDS-RAEB. Just before the initiation of the conditioning regimen for unrelated BMT in March 2007, he developed dyspnea. A diagnosis of PAP was made based on findings of chest X-ray, CT scanning, and the fluid obtained by bronchoalveolar lavage. To improve his dyspnea and improve BMT safety, whole lung lavage (WLL) was performed twice, with the partial improvement of PAP. Unrelated allog...
Source: International Journal of Hematology - August 19, 2009 Category: Hematology Authors: Tabata S, Shimoji S, Murase K, Takiuchi Y, Inoue D, Kimura T, Nagai Y, Mori M, Togami K, Kurata M, Ito K, Hashimoto H, Matushita A, Nagai K, Takahashi T Tags: Int J Hematol Source Type: journals

Donor cell-derived acute lymphocytic leukemia after allogeneic stem cell transplantation for multiple myeloma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of donor cell-derived acute lymphocytic leukemia (ALL) occurring in a 55-year-old man after allogeneic bone marrow transplantation (allo-BMT) from an HLA-matched unrelated donor for refractory multiple myeloma (MM). Molecular analysis using short tandem repeat sequences proved the ALL to be of donor origin. He underwent combination chemotherapy and second allo-BMT from an alternative donor. After second allo-BMT, extramedullary myeloma relapsed as tumor, but was successfully treated with proteasome inhibitor, bortezomib. However, he died from severe graft-versus-host disease four months after the second tr...
Source: International Journal of Hematology - August 19, 2009 Category: Hematology Authors: Igarashi N, Chou T, Hirose T, Imai Y, Ishiguro T, Nemoto K Tags: Int J Hematol Source Type: journals

Detection of submicroscopic disease in the bone marrow and unaffected testis of a child with T-cell acute lymphoblastic leukemia who experienced "isolated" testicular relapse.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Testicular relapse has an impact on the prognosis of boys with acute lymphoblastic leukemia (ALL). Because isolated testicular relapse often precedes hematological relapse, systemic therapy is required in addition to local therapy. However, a rationale for the use of a combination of systemic chemotherapy and local therapy is unclear. A 12-year-old boy with T-ALL suffered from isolated testicular relapse at 27 months after diagnosis. He was successfully treated with systemic chemotherapy with orchiectomy and prophylactic irradiation to the contralateral testis. We retrospectively estimated the minimal residual disease ...
Source: International Journal of Hematology - August 17, 2009 Category: Hematology Authors: Arima K, Hasegawa D, Ogawa C, Kato I, Imamura T, Takusagawa A, Takahashi H, Kitagawa Y, Hori T, Tsurusawa M, Manabe A, Hosoya R Tags: Int J Hematol Source Type: journals

Pediatric post-transplant lymphoproliferative disorder after cardiac transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Post-transplant lymphoproliferative disorder (PTLD) is a well recognized and potentially fatal complication after pediatric cardiac transplantation. PTLD encompasses a wide spectrum, ranging from benign hyperplasia to more aggressive lymphoma. Most cases are Epstein-Barr virus (EBV)-related B-cell tumors resulting from impaired immunity due to immunosuppressive therapy. Pediatric recipients, often seronegative for EBV at transplantation, have a greater risk for PTLD than adults. The clinical presentation of PTLD varies from isolated lymphadenopathy to systemic disease; common sites involved are gastrointestinal tract, ...
Source: International Journal of Hematology - August 11, 2009 Category: Hematology Authors: Ohta H, Fukushima N, Ozono K Tags: Int J Hematol Source Type: journals

Can a high platelet count be responsible for diabetes insipidus in acute myelogenous leukemia with monosomy 7 and inversion 3 (q21q26)?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19669858 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - August 11, 2009 Category: Hematology Authors: Sonmez M, Erkut N, Tat TS, Celep F, Cobanoglu U, Ersoz HO Tags: Int J Hematol Source Type: journals

Acute lower limb ischemia in a patient with aortic thrombus and essential thrombocytosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aortic thrombus is rare in patients with essential thrombocytosis (ET), so the optimal treatment remains undefined. A 45-year-old man with history of ET, under chronic treatment with aspirin, presented to the emergency department complaining of acute onset in both the legs and abdominal pain. Physical examination revealed that both dorsalis pedis pulses were not palpable with cold and pale feet. His abdomen was soft and nondistended. The platelet count was 436 x 10(9)/L. The thoraco-abdominal computerized tomographic scanning revealed normal aortic diameter with supraceliac and infrarenal nonoccluding thrombus and infa...
Source: International Journal of Hematology - August 10, 2009 Category: Hematology Authors: Morata Barrado PC, Blanco Cañibano E, García Fresnillo B, Guerra Requena M Tags: Int J Hematol Source Type: journals

Long-term culture of leukemic bone marrow primary cells in biomimetic osteoblast niche.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our "biomimetic osteoblast niche" might provide a more adaptive microenvironment for leukemic stem/progenitor cell growth. The biological characteristics of leukemic stem/progenitor cells were partially maintained. It was suggested that the 3D biomimetic niche might be a new tool for studying the behaviors of leukemic hematopoietic stem cells/hematopoietic progenitor cells in vitro. PMID: 19669860 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - August 10, 2009 Category: Hematology Authors: Hou L, Liu T, Tan J, Meng W, Deng L, Yu H, Zou X, Wang Y Tags: Int J Hematol Source Type: journals

Successful treatment with rituximab of refractory idiopathic thrombocytopenic purpura in a patient with Kabuki syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kabuki syndrome (KS) is often associated with autoimmune abnormalities, such as idiopathic thrombocytopenic purpura (ITP), autoimmune hemolytic anemia, leukoplakia and thyroiditis, as well as congenital anomalies. We herein present a KS patient with refractory ITP who achieved durable and complete remission in response to a total of four once-monthly infusions of rituximab. KS patients are often more susceptible to infection, so splenectomy should be avoided. Therefore, rituximab therapy is an alternative option for KS patients with ITP who fail to respond to first-line therapy. PMID: 19662467 [PubMed - as supplied...
Source: International Journal of Hematology - August 6, 2009 Category: Hematology Authors: Torii Y, Yagasaki H, Tanaka H, Mizuno S, Nishio N, Muramatsu H, Hama A, Takahashi Y, Kojima S Tags: Int J Hematol Source Type: journals

Comparison of mesenchymal stem cells derived from arterial, venous, and Wharton's jelly explants of human umbilical cord.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We isolated mesenchymal stem cells (MSC) from arteries (UCA), veins (UCV), and Wharton's jelly (UCWJ) of human umbilical cords (UC) and determined their relative capacities for sustained proliferation and multilineage differentiation. Individual UC components were dissected, diced into 1-2 mm(3) fragments, and aligned in explant cultures from which migrating cells were isolated using trypsinization. Preparations from 13 UCs produced 13 UCWJ, 11 UCV, and 10 UCA cultures of fibroblast-like, spindle-shaped cells negative for CD31, CD34, CD45, CD271, and HLA-class II, but positive for CD13, CD29, CD44, CD73, CD90, CD105, a...
Source: International Journal of Hematology - August 5, 2009 Category: Hematology Authors: Ishige I, Nagamura-Inoue T, Honda MJ, Harnprasopwat R, Kido M, Sugimoto M, Nakauchi H, Tojo A Tags: Int J Hematol Source Type: journals