International Journal of Medical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The crucial relationship between miRNA-27 and CSE/H 2 S, and the mechanism of action of GLP-1 in myocardial hypertrophy
In this study, we aimed to investigate whether inhibition of miR-27a could protect against cardiac hypertrophy by modulating H2S signaling. We established a model of cardiac hypertrophy by obtaining hypertrophic tissue from mice subjected to transverse aortic constriction (TAC) and from cells treated with angiotensin-II. Molecular alterations in the myocardium were quantified using quantitative real time PCR (qRT-PCR), Western blotting, and ELISA. Morphological changes were characterized by hematoxylin and eosin (HE) staining and Masson's trichrome staining. Functional myocardial changes were assessed using echocardiograph...
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Shan Gao Ying Li Mei-Ming Liu Xue Xiong Chang-Peng Cui Qing-Ji Huo Ke-Xin Li Xun Sun Rong Zhang Di Wu Bai-Yan Li Source Type: research

The Outcomes of Patients with Omicron Variant Infection who Undergo Elective Surgery: A Propensity-score-matched Case-control Study
Conclusion: Omicron infection does not significantly increase the risk of perioperative major complications. The Omicron infection may not be a sufficient risk factor to postpone elective surgery.PMID:38616997 | PMC:PMC11008485 | DOI:10.7150/ijms.90695 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Xiaojuan Xiong Rui Li Hong Yan Qingxiang Mao Source Type: research

Depression risk in chronic tonsillitis patients underwent tonsillectomy: a global federated health network analysis
Conclusion: This real-world analysis found tonsillectomy was associated with a 30% higher 5-year depression risk versus matched non-tonsillectomy patients with chronic tonsillitis. Further mechanistic research is needed to clarify the pathophysiologic association between depression and tonsillectomy. Depression is not commonly mentioned in the current post-tonsillectomy care realm; however, the outcome of our study emphasized the possibility of these suffering condition after operation. Attention to psychological impacts following tonsillectomy is warranted to support patient well-being, leading to better management of pos...
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Hui-Chin Chang Hsin-Yo Lu Yu-Chen Guo Chen-Yu Lin Shiu-Jau Chen Shuo-Yan Gau Source Type: research

The Expression and Prognostic Significance of ICOS in NSCLC Integrated Pan-Cancer and Multi-Omics Analyses
Conclusion: Our findings support that ICOS suggests lower pathological staging and better prognosis. ICOS is a potential diagnostic and prognostic biomarker for NSCLC.PMID:38616999 | PMC:PMC11008490 | DOI:10.7150/ijms.93262 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Mengting Chen Xiaotian Yan Bo Hong Yufei Xiao Yun Qian Source Type: research

A chronic stress-induced microbiome perturbation, highly enriched in Ruminococcaceae_UCG-014 , promotes colorectal cancer growth and metastasis
Conclusion: CRS exposure altered diversity, composition and metabolites of the gut microbiome, with Ruminococcaceae_UCG-014 perturbation consistently correlated to inflammatory responses, suggesting a particular role of this bacterial genus in CRC growth and metastasis.PMID:38617000 | PMC:PMC11008488 | DOI:10.7150/ijms.90612 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Ling Zhao Xinxin Hou Yuanyuan Feng Yingru Zhang Shiyun Shao Xinnan Wu Junfeng Jim Zhang Zhaozhou Zhang Source Type: research

Homeobox B2 promotes malignant behavior and contributes to the radioresistance of nasopharyngeal carcinoma by regulating forkhead box protein O1
Conclusion: Our findings showed that HOXB2 acts as a tumor promoter in NPC, activating malignant behaviors and radioresistance of tumors via FOXO1 regulation. Moreover, the inactivation of HOXB2 or activation of FOXO1 are potential strategies to inhibit tumor progression and overcome radioresistance in NPC.PMID:38617001 | PMC:PMC11008478 | DOI:10.7150/ijms.93128 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Jinhai Chen Min Mao Zhaoen Ma Jie Liu Minqiong Jiang Guangui Chen Yali Xu Source Type: research

Natural Product Quercetin-3-methyl ether Promotes Colorectal Cancer Cell Apoptosis by Downregulating Intracellular Polyamine Signaling
Int J Med Sci. 2024 Mar 25;21(5):904-913. doi: 10.7150/ijms.93903. eCollection 2024.ABSTRACTDysregulation of cellular metabolism is a key marker of cancer, and it is suggested that metabolism should be considered as a targeted weakness of colorectal cancer. Increased polyamine metabolism is a common metabolic change in tumors. Thus, targeting polyamine metabolism for anticancer therapy, particularly polyamine blockade therapy, has gradually become a hot topic. Quercetin-3-methyl ether is a natural compound existed in various plants with diverse biological activities like antioxidant and antiaging. Here, we reported that Qu...
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Jincheng Zeng Yuancheng Zhang Yuming Fang Jiachun Lian Hailiang Zhang Shaobing Zhang Bihua Lin Ziyu Ye Caihong Li Xianxiu Qiu Yanfang Liang Source Type: research

Establishment of an Animal Model of Dog Bite Injuries
This study also indicates the feasibility of using digital technology in establishing animal bite models.PMID:38617003 | PMC:PMC11008484 | DOI:10.7150/ijms.94432 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Dou Huang Wenhao Jia Kaide Li Zhiru Liu Lei Liu Source Type: research

Sudden Infant Death Syndrome (SIDS): State of the Art and Future Directions
Int J Med Sci. 2024 Mar 25;21(5):848-861. doi: 10.7150/ijms.89490. eCollection 2024.ABSTRACTSudden infant death syndrome (SIDS) is a type of death that occurs suddenly and without any apparent explanation, affecting infants between 28 days of life and up to a year. Recognition of this entity includes performing an autopsy to determine if there is another explanation for the event and performing both an external and internal examination of the different tissues to search for possible histopathological findings. Despite the relative success of awareness campaigns and the implementation of prevention measures, SIDS still repr...
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Oscar Fraile-Martinez Cielo Garc ía-Montero Sof ía Castellanos Díez Coral Bravo Mar ía de Guadalupe Quintana-Coronado Laura Lopez-Gonzalez Silvestra Barrena-Bl ázquez Natalio Garc ía-Honduvilla Juan A De Le ón-Luis Sonia Rodriguez-Mart ín Miguel A Source Type: research

Fatty Acid Binding Protein 1 is an Independent Prognostic Biomarker for Gallbladder Cancer with Direct Hepatic Invasion
Conclusions: Elevated expression of FABP1 in DI region serves as a potential prognostic biomarker for advanced GBC with DI.PMID:38617005 | PMC:PMC11008480 | DOI:10.7150/ijms.93413 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Shimei Qiu Zhaonan Liu Jun Hu Ziyi Wang Zhuying Yue Ziheng Jia Wenhua Zhang Ziru Xue Zebing Liu Yingbin Liu Source Type: research

The characterization and comorbidities of heterozygous Bardet-Biedl syndrome carriers
Conclusion: We found that aside from the association with overweight and obesity, heterozygous BBS mutations did not appear to increase the predisposition of individuals to comorbidities and metabolic diseases. To gain a more comprehensive understanding of the genetic susceptibility associated with Bardet-Biedl Syndrome (BBS), further research is warranted.PMID:38617006 | PMC:PMC11008491 | DOI:10.7150/ijms.92766 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Meng-Hua Li I-Chieh Chen Hui-Wen Yang Hsin-Chien Yen Yung-Chieh Huang Chia-Chi Hsu Yi-Ming Chen Yu-Yuan Ke Source Type: research

Prediction of outcomes for rescue cerclage in cervical insufficiency: A multicenter retrospective study
Conclusion: The developed logistic regression models offer a valuable tool for the prognostic assessment of patients undergoing rescue cerclage, enabling informed clinical decision-making.PMID:38617007 | PMC:PMC11008492 | DOI:10.7150/ijms.87941 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Subeen Hong Hyun Sik Chung Sujin Choi Yun Sung Jo Source Type: research

Hidradenitis suppurativa as a potential risk factor of periodontitis: a multi-center, propensity-score-matched cohort study
Conclusion: The observed increased risk suggests the need for heightened awareness and potential interdisciplinary care for individuals with HS to address periodontal health.PMID:38617008 | PMC:PMC11008474 | DOI:10.7150/ijms.93178 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Shuo-Yan Gau Yu-Chen Guo Hsin-Yo Lu Chen-Yu Lin Chien-Ying Lee Ru-Yin Tsai Hui-Chin Chang Meng-Che Wu Chen-Pi Li Source Type: research

Protective Effect of Fermented Sea Tangle Extract on Skin Cell Damage Caused by Particulate Matter
Int J Med Sci. 2024 Mar 31;21(5):937-948. doi: 10.7150/ijms.93034. eCollection 2024.ABSTRACTThe skin is directly exposed to atmospheric pollutants, especially particulate matter 2.5 (PM2.5) in the air, which poses significant harm to skin health. However, limited research has been performed to identify molecules that can confer resistance to such substances. Herein, we analyzed the effect of fermented sea tangle (FST) extract on PM2.5-induced human HaCaT keratinocyte damage. Results showed that FST extract, at concentrations less than 800 μg/mL, exhibited non-significant toxicity to cells and concentration-dependent inhib...
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Mei Jing Piao Kyoung Ah Kang Pincha Devage Sameera Madushan Fernando Herath Mudiyanselage Udari Lakmini Herath Young Sang Koh Hee Kyoung Kang Yung Hyun Choi Jin Won Hyun Source Type: research

Biomarker Potential of LINC00313 in Head and Neck Squamous Cell Carcinoma: Correlation with Epithelial-Mesenchymal Transition and Immune Cell Infiltration
In conclusion, LINC00313 is a potential biomarker of HNSC prognosis and a potential target for immunotherapy.PMID:38617010 | PMC:PMC11008489 | DOI:10.7150/ijms.93044 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Yikun Ju Fang Zhu Bairong Fang Source Type: research