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Activation of two distinct MAPK pathways governs constitutive expression of matrix metalloproteinase-1 in human pancreatic cancer cell lines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study contributes to provide new insights into strategies for inhibiting tumor cell invasion in pancreatic cancer. PMID: 19885545 [PubMed - in process] (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Endo H, Watanabe T, Sugioka Y, Niioka M, Inagaki Y, Okazaki I Tags: Int J Oncol Source Type: journals

Bcr-Abl fusion sequences do not induce immune responses in mice when administered in mouse polyomavirus based virus-like particles.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mouse polyomavirus-like particles (MPyV-VLPs) carrying inside a fragment of the Bcr-Abl hybrid protein containing the epitope of chronic myeloid leukemia fusion region were prepared. A sequence encoding 171 amino acids covering Bcr-Abl breakpoint was fused to the C-terminal part of VP3 minor protein connecting it to the VP1 capsomeres. Chimeric particles, the Bcr-Abl VLPs, were tested for their ability to induce Bcr-Abl specific immune response in mice after their intranasal (i.n.) or intraperitoneal (i.p.) administration without any other adjuvants. Bcr-Abl VLPs induced strong anti-VP1 immune response in both i.n. and...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Hrusková V, Morávková A, Babiarová K, Ludvíková V, Fric J, Vonka V, Forstová J Tags: Int J Oncol Source Type: journals

Targeted disruption of S100P suppresses tumor cell growth by down-regulation of cyclin D1 and CDK2 in human hepatocellular carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this study showed over-expression of S100P in HCC. The aberrant regulation of S100P in HCC might activate cyclin D1 and CDK expression and contribute to the mitogenic potential of tumor cells during HCC carcinogenesis. These findings provide information that suggests new therapeutic strategies for the treatment of liver cancer. PMID: 19885547 [PubMed - in process] (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Kim JK, Jung KH, Noh JH, Eun JW, Bae HJ, Xie HJ, Ahn YM, Ryu JC, Park WS, Lee JY, Nam SW Tags: Int J Oncol Source Type: journals

Use of genetically engineered bone marrow-derived mesenchymal stem cells for glioma gene therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In our previous study, we successfully treated an established C6 brain tumor using neural stem cells transduced with the herpes simplex virus-thymidine kinase gene (HSVtk) and ganciclovir in the rat. In the present study, we investigated the use of mesenchymal stem cells (MSCs), obtained from adult rats and transduced with HSVtk (MSCtk cells), instead of neural stem cells because MSCs are much easier to obtain from the adult subjects. Those cells were used for in vitro co-culture study and in vivo co-implantation study with C6 rat glioma cells to examine bystander tumoricidal effect, which revealed a sufficient bystand...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Amano S, Li S, Gu C, Gao Y, Koizumi S, Yamamoto S, Terakawa S, Namba H Tags: Int J Oncol Source Type: journals

Localization of cortactin is associated with colorectal cancer development.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cortactin is a ubiquitously expressed actin filament (F-actin)-binding protein that stabilizes F-actin networks and promotes actin polymerization by activating the actin-related protein 2/3 (Arp2/3) complex. Overexpression of cortactin in cancer cells stimulate cell migration, invasion, and experimental metastasis; however, the underlying mechanism in cortactin involvement in tumor progression is not fully understood. Recently, a direct interaction between zonula occludens-1 (ZO-1) and cortactin in epithelial cells was reported. The present study aimed to further clarify the significance of the interaction between cort...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Hirakawa H, Shibata K, Nakayama T Tags: Int J Oncol Source Type: journals

alpha-tocopheryl phosphate suppresses tumor invasion concurrently with dynamic morphological changes and delocalization of cortactin from invadopodia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
alpha-tocopheryl phosphate (TocP) has been elucidated for diverse effectiveness through unequivocal mechanisms independent of its conversion to alpha-tocopherol (Toc). The present study showed that TocP, in a dose-dependent manner, repressed invasion of human fibrosarcoma HT-1080 cells through the basement membrane, more markedly than Toc and several other Toc derivatives, although no cytotoxic effect was shown in either HT-1080 cells or human skin dermal fibroblastic cells DUMS-16. TocP diminished intracellular reactive oxygen species such as peroxides, lipid hydroperoxides and superoxide anion radicals in HT-1080 cel...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Saitoh Y, Yumoto A, Miwa N Tags: Int J Oncol Source Type: journals

Dysregulation of the cell survival/anti-apoptotic NF-kappaB pathway by the novel humanized BM-ca anti-CD20 mAb: implication in chemosensitization.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to develop novel and fully humanized anti-CD20 monoclonal antibodies with enhanced effector functions and molecular signaling that may potentiate their therapeutic efficacy. Novel humanized anti-CD20 monoclonal antibodies were derived from a chimerized form of murine anti-CD20 1K11791, shown to exert a more potent ADCC, CDC and apoptotic activities compared to rituximab. A representative humanized monoclonal antibody, BM-ca was used to examine its biological effect and molecular signaling using Ramos B-NHL cell line as a model. The studies were also performed in parallel with rituximab treat...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Vega MI, Martínez-Paniagua M, Huerta-Yepez S, González-Bonilla C, Uematsu N, Bonavida B Tags: Int J Oncol Source Type: journals

Cigarette smoke-induced DNA damage and repair detected by the comet assay in HPV-transformed cervical cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human papillomavirus (HPV) is the causative factor in the development and progression of cervical cancers in >97% of the cases, although insufficient. Epidemiological studies suggest an elevated risk of cervical cancer for cigarette smokers; therefore, we examined cigarette smoke-induced DNA damage and repair in HPV16-transformed human ectocervical cells (ECT1/E6 E7). Cells were treated with cigarette smoke condensate (CSC) for 72 h to assess the formation of single- and double-strand DNA breaks, measured by alkaline and neutral single cell gel electrophoresis assays, respectively. The mean tail length of cells with...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Moktar A, Ravoori S, Vadhanam MV, Gairola CG, Gupta RC Tags: Int J Oncol Source Type: journals

Inhibition of endothelial cell chemotaxis toward FGF-2 by gefitinib associates with downregulation of Fes activity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gefitinib inhibits epidermal growth factor-independent angiogenesis, but the molecular mechanism underlying this inhibition has yet to be defined. Here we show that gefitinib dose-dependently inhibited chemotaxis of endothelial cells toward fibroblast growth factor-2 (FGF-2), but not toward vascular endothelial growth factor-A (VEGF-A). Gefitinib inhibited lamellipodium formation by endothelial cells induced by FGF-2, but not by VEGF-A. Gefitinib at 10 microM did not inhibit autophosphorylation of FGF receptor 1 or VEGF receptor 2. A non-receptor protein tyrosine kinase, Fes, has two coiled-coil domains (CCDs) in its N...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Kanda S, Naba A, Miyata Y Tags: Int J Oncol Source Type: journals

Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Identifying the genetic variants that alter MUC1 protein expression may further our understanding of the risk for development of gastric cancer (GC). We used PCR-SSPs to identify the genotype of MUC1 A/G polymorphism at its 568 site of exon 2 and immunohistochemistry to detect MUC1 protein expression in GC patients and non-cancer subjects and analyzed the association between this polymorphism and MUC1 protein expression. We found that the frequency of AA genotype was significantly high in the GC patients and the risk for GC in AA genotype carriers increased 1.81-fold. Moreover, we found a significant underexpression of...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Xu Q, Yuan Y, Sun LP, Gong YH, Xu Y, Yu XW, Dong NN, Lin GD, Smith PN, Li RW Tags: Int J Oncol Source Type: journals

Gene expression profiling of archival tongue squamous cell carcinomas provides sub-classification based on DNA repair genes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A subgroup of patients with squamous cell carcinoma of the head and neck (SCCHN) comprise young persons under the age of 40, who have not been heavily exposed to the classical risk factors, smoking and alcohol. The number of SCCHN in young adults, particularly tongue tumours, is increasing in several parts of the world. Here we employed a novel gene expression array methodology specifically developed for analysis of degraded RNA and investigated the expression of 502 cancer-related genes in archival paraffin-embedded SCCHN of the tongue from young (< or =40) and elderly patients (> or =50). Genes detected as de-r...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Rentoft M, Laurell G, Coates PJ, Sjöström B, Nylander K Tags: Int J Oncol Source Type: journals

Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DJ-1 is an oncogene and also a causative gene for a familial form of Parkinson's disease. DJ-1 has multiple functions, including anti-oxidative stress reaction and cysteine 106 (C106) of DJ-1 is an essential amino acid for DJ-1 to exert its function. While increased expression and secretion of DJ-1 into serum in patients with various cancers and regulation of p53 and PTEN by DJ-1 have been reported, the molecular mechanism underlying oncogenicity of DJ-1 is poorly understood. Here, we analyzed the function of DJ-1 in the PI3'K signaling pathway under an oxidative stress condition, focusing on the interaction of DJ-1 wi...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Kim YC, Kitaura H, Taira T, Iguchi-Ariga SM, Ariga H Tags: Int J Oncol Source Type: journals

MicroRNAs that respond to histone deacetylase inhibitor SAHA and p53 in HCT116 human colon carcinoma cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we identified several miRNAs whose expression was affected by both SAHA and p53. Many of the miRNAs showed dramatic changes and were predicted to target many mRNAs. Further studies will be needed to verify these predictions. PMID: 19885557 [PubMed - in process] (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Shin S, Lee EM, Cha HJ, Bae S, Jung JH, Lee SM, Yoon Y, Lee H, Kim S, Kim H, Lee SJ, Park IC, Jin YW, An S Tags: Int J Oncol Source Type: journals

A novel resveratrol analogue HS-1793 treatment overcomes the resistance conferred by Bcl-2 and is associated with the formation of mature PML nuclear bodies in renal clear cell carcinoma Caki-1 cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bcl-2 protects cancer cells from the apoptotic effects of various chemotherapeutic agents. Inhibition or downregulation of Bcl-2 represents a new therapeutic approach to bypass chemoresistance in cancer cells. Previously we designed and synthesized the resveratrol analogue HS-1793 displaying stronger antitumor efficacy than resveratrol and further demonstrated the HS-1793 resistance conferred by Bcl-2 in human leukemic U937 cells. We undertook this study to determine if HS-1793 treatment can bypass the anti-apoptotic effects of Bcl-2 in human renal cancer cells, with a specific focus on the involvement of promyelocytic...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Jeong SH, Lee JS, Jeong NY, Kim TH, Yoo KS, Song S, Suh H, Kwon TK, Park BS, Yoo YH Tags: Int J Oncol Source Type: journals

AAV2-mediated interleukin-12 in the treatment of malignant brain tumors through activation of NK cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrated an encouraging result of immunomodulative therapy in malignant brain tumors by rAAV2 carrying IL-12 through activating NK cells. PMID: 19885559 [PubMed - in process] (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Chiu TL, Lin SZ, Hsieh WH, Peng CW Tags: Int J Oncol Source Type: journals

Fatty acid synthase activity regulates HER2 extracellular domain shedding into the circulation of HER2-positive metastatic breast cancer patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinicopathological assessment of the functional relationship between the HER2 oncogene and tumor-associated fatty acid synthase (FASN) is largely precluded because immunohistochemical and/or mRNA studies should be performed in biopsies from breast cancer patients. We here sought to determine whether serum FASN (sFASN) could associate with circulating HER2 extracellular domain (HER2 ECD) in the blood of metastatic breast cancer (MBC) patients. Concentrations of serum FASN and HER2 ECD were measured with ELISA in sera retrospectively obtained from 201 patients with metastatic breast cancer (MBC) and 31 healthy subjects....
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Vazquez-Martin A, Fernandez-Real JM, Oliveras-Ferraros C, Navarrete JM, Martin-Castillo B, Del Barco S, Brunet J, Menendez JA Tags: Int J Oncol Source Type: journals

Localization of telomerase hTERT protein in frozen sections of basal cell carcinomas (BCC) and tumor margin tissues.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was supplemented with antibodies against Ki-67, nucleolin, common leucocyte antigen CD45 and mutated p53. The immunoreactive scores were determined and included the comparison with telomerase activity. The investigation of hTERT expression was performed in the tissues of 41 patients with BCC and control tissues of 14 patients without tumor. Eleven commercial antibodies were used for a nuclear staining of hTERT expression. With the anti-hTERT antibodies we looked for both satisfactory distribution and intensity of immunohistochemical labeling in the carcinomas and in the squamous epithelia of the tumor centers, o...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Fabricius EM, Kruse-Boitschenko U, Khoury R, Wildner GP, Raguse JD, Klein M, Hoffmeister B Tags: Int J Oncol Source Type: journals

Microarray gene expression profiling in meningiomas: differential expression according to grade or histopathological subtype.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Meningiomas, one of the largest subgroup of intracranial tumours are generally benign, but can progress to malignancy. They are classified into the three World Health Organization grades: benign, atypical and anaplastic meningiomas. Various histopathological features have been associated with aggressiveness or recurrence. Several genes have been suggested as prognostic factors, but molecular signatures have not permitted the classification of the tumours into the three grades. We have performed a microarray transcriptomic study on 17 meningiomas of different malignancy using CodeLink Uniset Human Whole Genome Bioarrays...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Fèvre-Montange M, Champier J, Durand A, Wierinckx A, Honnorat J, Guyotat J, Jouvet A Tags: Int J Oncol Source Type: journals

Osteopontin splice variants differentially modulate the migratory activity of hepatocellular carcinoma cell lines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Osteopontin (OPN, SPP1) is a secretory extracellular matrix protein that has been implicated in cancer-associated mechanisms such as metastasis, invasion and angiogenesis. Three OPN isoforms (OPN-a, -b and -c) derived from alternative splicing are known to exist, but their functional specificity remains unclear. Here, we found that the expression profile of OPN isoforms in hepatocellular carcinoma (HCC) cell lines and patient tissues were correlated with specific cellular phenotypes and tumorigenicity of HCC. Thus, SK-Hep1 cells with a robust migratory capacity dominantly expressed both OPN-a and -b, but non-migratory ...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Chae S, Jun HO, Lee EG, Yang SJ, Lee DC, Jung JK, Park KC, Yeom YI, Kim KW Tags: Int J Oncol Source Type: journals

Deficient histone acetylation and excessive deacetylase activity as epigenomic marks of prostate cancer cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aberrant epigenomic alterations include incorrect histone modifications involving altered expression of chromatin-modifying proteins. They contribute to gene silencing and carcinogenesis. The nature of the epigenomic alterations occurring with prostate cancer remains to be fully identified. The acetylation status of histone H3 in human prostate cancer cells was assessed with multiple acetylation sites at N-termini. In contrast to the non-malignant prostatic cell lines RC165N/h and RC170N/h which possess stem cell properties, cancer cell lines LNCaP, DU-145, and PC-3 were either not acetylated or reduced in density (50-...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Cang S, Feng J, Konno S, Han L, Liu K, Sharma SC, Choudhury M, Chiao JW Tags: Int J Oncol Source Type: journals

Vasculogenic mimicry of human ovarian cancer cells: role of CD147.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we found significant correlations between expression of CD147 in ovarian cancer cell lines and tumor invasiveness, the activity of the proteases and the ability to form vascular channels. The treatment of SKOV3 cells with small interfering RNA against CD147 suppressed the ability of these cells to generate non-endothelial cell-lined channels. In contrast, transfection of CD147 cDNA into the CABA I cell line resulted in an increased tumor invasiveness and enabled the formation of vascular channels. Altogether, our data suggest that CD147 may play a critical role in VM of CABA I and SKOV3, human ovarian cancer...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Millimaggi D, Mari M, D' Ascenzo S, Giusti I, Pavan A, Dolo V Tags: Int J Oncol Source Type: journals

Cell density-dependent regulation of p73 in breast cancer cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Molecular regulation of p73, a p53 family member, remains unclear. Here we report that p73 expression is significantly regulated by cell densities. In particular, we found that p73alpha and p73beta are differentially regulated. While p73beta protein levels were inversely correlated with cell densities, p73alpha protein levels behaved oppositely. We further showed that density-dependent changes of p73alpha follow the same patterns as E2F-1 and TAp73 mRNA levels, suggesting transcriptional regulation. Our data also suggest that high levels of p73beta at lower densities may be due to increased protein stability. However, ...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Tophkhane C, Yang S, Zhao ZJ, Yang X Tags: Int J Oncol Source Type: journals

Thioredoxin2 enhances the damaged DNA binding activity of mtTFA through direct interaction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we found that expression levels of both mtTFA and the mitochondrial antioxidant protein thioredoxin2 (TRX2) are upregulated in cisplatin-resistant cell lines. In addition, TRX2 directly interacts with mtTFA and enhances its damaged DNA binding activity. The interaction between mtTFA and TRX2 requires the HMG box 1 motif of mtTFA. Furthermore, when amino acid substitutions were introduced at either C49G or C246stop, TRX2 interacted with mtTFA. However, the interaction of TRX2 with mtTFA was enhanced when both mutations (C49G and C246stop) were introduced. Binding to cisplatin-damaged DNA was similar among mut...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Kidani A, Izumi H, Yoshida Y, Kashiwagi E, Ohmori H, Tanaka T, Kuwano M, Kohno K Tags: Int J Oncol Source Type: journals

Modulation of the transforming growth factor-beta1-induced Smad phosphorylation by the extracellular matrix receptor beta1-integrin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study focuses on the alterations of the regulatory Smads (R-Smads) by TGF-beta1 in beta1-integrin-transfected HepG2 cells. The phosphorylation at the C-terminal site of R-Smads by TGF-beta1 was impaired in the beta1-integrin-transfected cells. However, the R-Smads were constitutively phosphorylated at the linker region in a MAP kinase-dependent manner. Furthermore, the expression of a mutant Smad3, that lacks the phosphorylation sites in the linker region, restored the TGF-beta1-induced Smad transcriptional activity. These results suggest that beta1-integrin impairs the TGF-beta1-mediated signals through the altered p...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Hamajima H, Ozaki I, Zhang H, Iwane S, Kawaguchi Y, Eguchi Y, Matsuhashi S, Mizuta T, Matsuzaki K, Fujimoto K Tags: Int J Oncol Source Type: journals

Increased expression of inhibitor of apoptosis proteins, survivin and XIAP, in non-small cell lung carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the overexpression of survivin in the majority of NSCLCs together with the abundant or upregulated expression of HBXIP and XIAP suggest that tumours are endowed with resistance against a variety of apoptosis-inducing conditions. PMID: 19885569 [PubMed - in process] (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Krepela E, Dankova P, Moravcikova E, Krepelova A, Prochazka J, Cermak J, Schützner J, Zatloukal P, Benkova K Tags: Int J Oncol Source Type: journals

The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the anti-cancer effect of safingol as a single agent or in combination with irinotecan using HT-29 and LS-174T colon cancer cells as our in vitro models. As a single agent, safingol was more potent than irinotecan and 5-FU, with IC50 values of 2.5+/-1.1 microM and 3.4+/-1.0 microM achieved in HT-29 and LS-174T cells, respectively. However, protein kinase C (PKC) was not inhibited with concentrations of safingol which could induce substantial cell kill. The combination of safingol/irinotecan at 1:1 molar ratio was found to be additive in HT-29 cells (CI=0.94) and synergistic in LS-174T cells (...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Ling LU, Lin H, Tan KB, Chiu GN Tags: Int J Oncol Source Type: journals

Vascular endothelial growth inhibitor, expression in human prostate cancer tissue and the impact on adhesion and migration of prostate cancer cells in vitro.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the expression of VEGI is decreased in prostate cancer and is almost absent in tumours with high Gleason scores. Together with its inhibitory effect on cellular motility and adhesion, this suggests that VEGI functions as a negative regulator for aggressiveness during the development and progression of prostate cancer. PMID: 19885571 [PubMed - in process] (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Zhang N, Sanders AJ, Ye L, Kynaston HG, Jiang WG Tags: Int J Oncol Source Type: journals

Novel 8-hydroxylquinoline analogs induce copper-dependent proteasome inhibition and cell death in human breast cancer cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report that when substitutions are made on the hydroxyl group of 8-OHQ, their copper mixtures have profound effects on the proteasome-inhibitory and apoptosis-inducing abilities in breast cancer MDA-MB-231 cells. In addition, the proteasome-inhibitory and apoptosis-inducing activities of 8-OHQ analog-copper mixtures are determined by both the polarity and position of the substituents. Finally, a synthetic complex of 8-OHQ analog-copper was able to inhibit the proteasome activity, induce cell death and suppress the growth selectively in breast cancer MDA-MB-231 cells, but not in normal immortalized human breast MCF-10A c...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Milacic V, Jiao P, Zhang B, Yan B, Dou QP Tags: Int J Oncol Source Type: journals

The adenoviral E1A oncoprotein activates the Smad7 promoter: requirement of a functional E-box.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, these results unravel a novel mechanism of how the AdV E1A oncoprotein induces a cellular inhibitor of TGF-beta signalling. PMID: 19885573 [PubMed - in process] (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Dole VS, Smola H, Dooley S, Said HM, Oldak M, Pfister HJ, Smola S Tags: Int J Oncol Source Type: journals

Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this study suggests that the anthocyanins isolated from Vitis coignetiae Pulliat induce apoptosis might at least in part through activating p38-MAPK and suppressing Akt in human colon cancer HCT-116 cells. PMID: 19885574 [PubMed - in process] (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Shin DY, Lee WS, Lu JN, Kang MH, Ryu CH, Kim GY, Kang HS, Shin SC, Choi YH Tags: Int J Oncol Source Type: journals

Immunophenotyping of diffuse large B-cell lymphoma (DLBCL) defines multiple sub-groups of germinal centre-like tumours displaying different survival characteristics.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Diffuse large B-cell lymphoma (DLBCL) forms a heterogeneous collection of aggressive non-Hodgkin's Lymphoma in which three principle classes of neoplasia have been defined according to gene expression and immunophenotyping studies. The present investigation sought to examine the immunophenotype of proposed subgroups and relate these to patient survival. A series of 155 DLBCL treated uniformly with anthracycline therapy in clinical trials, were stratified upon the basis of common biomarker expression with combination immunophenotype being related to patient overall survival. Stratification of tumours with respect to com...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Anderson JJ, Fordham S, Overman L, Dignum H, Wood K, Proctor SJ, Crosier S, Angus B, Culpin RE, Mainou-Fowler T Tags: Int J Oncol Source Type: journals

Screening for genetic abnormalities involved in ovarian carcinogenesis using retroviral expression libraries.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study was to screen for genes involved in ovarian carcinogenesis in an attempt to develop an effective molecular-targeted therapy for ovarian cancer. We constructed retroviral expression libraries for the human ovarian cancer cell lines SHIN-3 and TYK-CPr, and performed a focus formation assay with 3T3 cells. As a result, proteasome subunit beta-type 2 (PSMB2), ubiquitin-specific protease 14 (USP14), and keratin 8 (KRT8) were identified from SHIN-3, and polymerase II RNA subunit (POLR2E), chaperonin containing T-complex polypeptide 1 subunit 4 (CCT4), glia maturation factor beta (GMFB), and neurobla...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Wada T, Yamashita Y, Saga Y, Takahashi K, Koinuma K, Choi YL, Kaneda R, Fujiwara S, Soda M, Watanabe H, Kurashina K, Hatanaka H, Enomoto M, Takada S, Mano H, Suzuki M Tags: Int J Oncol Source Type: journals

Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we analyzed mutations in 11 cancer-related genes with mononucleotide repeats susceptible to MSI in a coding region [hMSH3 (A8), hMSH6 (C8), TGF-beta RII (A10), MBD4 (A10), BAX (G8), PTEN (A6 in exon 7), HDAC2 (A9), EPHB2 (A9), Caspase-5 (A10), TCF-4 (A9) and Axin2 (G7)] in 22 patients with MSI-H sporadic endometrial cancer. Mutations in hMSH6 (C8) and TGF-beta RII (A10) were found most frequently, at rates of 36.3% (8/22) each. Mutations of BAX (G8) and TCF-4 (A9), which are common in MSI-positive colorectal cancer, occurred at rates of 22.7 and 0%, respectively, which suggests that the MSI target gene may d...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Kawaguchi M, Banno K, Yanokura M, Kobayashi Y, Kishimi A, Ogawa S, Kisu I, Nomura H, Hirasawa A, Susumu N, Aoki D Tags: Int J Oncol Source Type: journals

Does the expression of HPV16/18 E6/E7 in head and neck squamous cell carcinomas relate to their clinicopathological characteristics?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the expression of HPV16/18 E6/E7 in 71 cases of HNSCCs and investigated abnormalities of the p53 gene in 62 of these 71 cases. Expression of HPV16 E6/E7 was observed in 11 of the 71 cases (15.5%), while expression of HPV18 E6/E7 was not observed in any of the cases. Most of the HPV16 E6/E7-positive cases were histopathologically characterized by their verrucous or papillary structure and koilocytosis of the adjacent mucosa. There was no clear relationship between expression of HPV16 E6/E7 and tumor stage, prognosis or the positive rate of p53 abnormality. These results suggest that approximately 15% of HNSCCs a...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Yamakawa-Kakuta Y, Kawamata H, Doi Y, Fujimori T, Imai Y Tags: Int J Oncol Source Type: journals

Regulation of protein tyrosine kinases in tumour cells by the transcription factor Ets-1.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, HeLa cells stably overexpressing and underexpressing Ets-1 were used for real-time PCR analysis of all known human PTKs. The results suggest that Ets-1 is an essential transcription factor that cannot be substituted by other members of the ETS family. Transcription of most PTKs was found to be increased by Ets-1. In contrast Ets-1 seems to act as a transcriptional repressor of other PTKs. The data presented here underscore the importance of Ets-1 in tumour development and progression. PMID: 19787252 [PubMed - in process] (Source: International Journal of Oncology)
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Hahne JC, Kummer S, Heukamp LC, Fuchs T, Gun M, Langer B, Von Ruecker A, Wernert N Tags: Int J Oncol Source Type: journals

Epigenetic regulation of the embryonic oncogene ERas in gastric cancer cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ERas is a recently identified oncogene that supports the tumorigenic growth of embryonic stem cells, it is constitutively active in the absence of mutation. ERas oncogene is expressed only in viviparity phase cells, but not in somatic cells because of epigenetic transcriptional silencing in the somatic phase. The aim of this study was to clarify the ERas expression and its epigenetic regulation in gastric cancer of somatic phase. Fifteen gastric cancer cell lines were used. ERas mRNA expression and its epigenetic regulation were examined by reverse transcription-polymerase chain reaction and bisulfite sequencing analys...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Yashiro M, Yasuda K, Nishii T, Kaizaki R, Sawada T, Ohira M, Hirakawa K Tags: Int J Oncol Source Type: journals

Cytoskeletal changes during epithelial-to-fibroblastoid conversion as a crucial mechanism of des-gamma-carboxy prothrombin production in hepatocellular carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, cytoskeletal changes during EFC or EMT plays a critical mechanistic role in DCP production via impairments in vitamin K uptake. PMID: 19787254 [PubMed - in process] (Source: International Journal of Oncology)
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Murata K, Suzuki H, Okano H, Oyamada T, Yasuda Y, Sakamoto A Tags: Int J Oncol Source Type: journals

PRIMA-1 inhibits growth of breast cancer cells by re-activating mutant p53 protein.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mutation of the p53 tumor suppressor gene is a common event in many types of tumors, including breast cancers. Mutant p53 (mtp53) protein is thought to promote tumor cell survival and resistance to chemotherapeutic drugs. Therefore, restoring p53 function by converting existing mtp53 to the wild-type p53 (wtp53) conformation is being pursued as one strategy to promote apoptosis of tumor cells. PRIMA-1 (p53 re-activation and induction of massive apoptosis) is a non-toxic small molecule that converts mtp53 to the active conformation and induces apoptosis in tumor cells. Here we examined whether PRIMA-1 activates mtp53 an...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Liang Y, Besch-Williford C, Hyder SM Tags: Int J Oncol Source Type: journals

Cepharanthine inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing expression of vascular endothelial growth factor and interleukin-8.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cepharanthine is a biscoclaurine alkaloid extracted from Stephania cepharantha Hayata, which is widely used for the treatment of many acute and chronic diseases, and can exert antitumor effects on several human cancer cell lines. However, little is known about the detailed mechanisms of the antitumor activity of Cepharanthine. In the present study, we determined whether Cepharanthine could suppress angiogenesis and growth of human oral squamous cell carcinoma (OSCC) cells in vitro and in vivo. Cepharanthine significantly inhibited expression of two major pro-angiogenic molecules, vascular endothelial growth factor (VEG...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Harada K, Ferdous T, Itashiki Y, Takii M, Mano T, Mori Y, Ueyama Y Tags: Int J Oncol Source Type: journals

Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Progression of colon cancer is associated with the up-regulation of cyclooxygenase-2 (COX-2) and hydroxymethyl glutaryl CoA reductase (HMG-R). Clinical and preclinical evidence shows that a combination of COX-2 and HMG-R inhibitors provide additive/synergistic chemopreventive effects against colorectal cancer. However, the mechanism by which statins and NSAIDs inhibit cancer growth is not yet fully understood. We aimed to identify critical molecules and signal pathways modulated by a combination of lovastatin and celecoxib in the human HCT-116 colon cancer cell line. HCT-116 cells were exposed to 50 microM celecoxib, 2...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Guruswamy S, Rao CV Tags: Int J Oncol Source Type: journals

Impaired medulloblastoma cell survival following activation of the FOXO1 transcription factor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Medulloblastoma is the most frequent type of childhood brain tumour. The insulin-like growth factor I receptor (IGF-IR) plays a significant neuroprotective role in medulloblastoma survival through regulation of the downstream effectors of the phosphoinositide-3-kinase-protein kinase-B (PI3K-PKB/c-Akt) pathway. One such target is Forkhead box O1 (FOXO1; FKHR), which is part of the FOXO family of Forkhead transcription factors. Phosphorylation by Akt results in cytoplasmic sequestration of FOXO1 thus inhibiting the expression of genes controlling cell death, cell proliferation, differentiation, cellular metabolism and ox...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Srivastava VK, Yasruel Z, Nalbantoglu J Tags: Int J Oncol Source Type: journals

Expression of mRNA for human type-I LHRH receptor transcript forms in human benign prostatic hyperplasia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we detected mRNA for LHRH-R-I in human BPH specimens. Our results suggest that LHRH-R-I gene may have more than two splice variants or uncharacterised transcript forms of LHRH-R-I. Our findings support the merit of further investigation of the expression of LHRH-R-I and its transcript forms in human BPH. PMID: 19787259 [PubMed - in process] (Source: International Journal of Oncology)
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Rózsa B, Juhász A, Treszl A, Tóth G, Flaskó T, Dezsö B, Block NL, Schally AV, Halmos G Tags: Int J Oncol Source Type: journals

Organophosphorous pesticides and estrogen induce transformation of breast cells affecting p53 and c-Ha-ras genes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cancer progression has been associated with an increase in genomic instability indicated by inactivation of tumor suppressor genes and activation of oncogenes. Epidemiological and experimental evidence has implicated estrogens in the etiology of breast cancer. To study environmental organophosphorous pesticides is of interest since evidence indicate that pesticides may enhance cell division, increasing the risk of breast cancer. The aim was to evaluate the effects of these pesticides, such as parathion and malathion in the presence of estrogen on malignant transformation as well as on genomic instability, that is in th...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Calaf GM, Echiburu-Chau C, Roy D Tags: Int J Oncol Source Type: journals

Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) in human ovarian cancer and indentification of the therapeutic potential of APE1/Ref-1 inhibitor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we examined APE1/Ref-1 expression by immunohistochemistry in sections of ovarian cancers from 78 patients who were administered standard adjuvant chemotherapy based on platinum post-operatively. Altered levels and subcellular APE1/Ref-1 expression was found in patients not responding to platinum-based chemotherapy comparing with those who responded to platinum-based chemotherapy. Meanwhile, we detected the APE1/Ref-1 expression in A2780 and CP70 cell lines which have different sensitivity to cisplatin. We found similar altered APE1/Ref-1 expression in them. We hypothesized that the APE1/Ref-1 expression is r...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Zhang Y, Wang J, Xiang D, Wang D, Xin X Tags: Int J Oncol Source Type: journals

Varying etiologies lead to different molecular changes in Australian and South African hepatocellular carcinomas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is significant regional variation in the etiologic agents responsible for hepatocellular carcinoma (HCC), which influences the genetic and epigenetic mechanisms of malignant transformation. The aim of the present study was to investigate the prevalence of allelic imbalance (AI) and CpG island methylation in HCCs from Australia and South Africa. Genomic DNA was extracted from malignant and non-malignant liver from 37 Australian and 24 South African HCCs and histologically normal liver from 20 transplant donors. AI was examined at 1p, 4p, 4q, 8p, 9p, 13q, 16q and 17p, using 23 microsatellite markers. Methylation st...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Herath NI, Purdie DM, Kew MC, Smith JL, Young J, Leggett BA, MacDonald GA Tags: Int J Oncol Source Type: journals

Efficacy and mechanism of anti-tumor action of new potential CK2 inhibitors toward glioblastoma cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Malignant gliomas are highly resistant to current therapeutic approaches due to genetic alterations rendering them resistant to cell death. CK2, a ubiquitous and constitutively active serine/threonine kinase, frequently elevated in tumors, contributes to enhanced cell proliferation and resistance to apoptosis. Inhibition of CK2 expression or treatment with inhibitors of CK2 affected survival or induced apoptosis in various cancer cells. Here we compared cytotoxic effects of well-known and new CK2 inhibitors: 4,5,6,7-tetrabromo-1H-benzotriazole (TBB), 4,5,6,7-tetrabromo-1H-benzimidazole (TBI), 2-dimethylamino-4,5,6,7-te...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Kaminska B, Ellert-Miklaszewska A, Oberbek A, Wisniewski P, Kaza B, Makowska M, Bretner M, Kazimierczuk Z Tags: Int J Oncol Source Type: journals

BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Survival rate of metastatic colorectal cancers is less than 5%. A major reason is that those cancers respond poorly to chemotherapy drugs. However, factors contributing to chemoresistance in colorectal cancers are barely known, thus isolation of factors involved is the critical first step for mechanistic understanding and therapy improvement. With expression cloning, we isolated human BRD8 (bromodomain 8) as an influential factor for spindle poison sensitivity. BRD8 is an accessory subunit of human NuA4-HAT (histone acetyl transferase) complex (also known as TRRAP/TIP60 complex), but its role in cancer and drug resista...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Yamada HY, Rao CV Tags: Int J Oncol Source Type: journals

The microtubule-associated protein MAPRE2 is involved in perineural invasion of pancreatic cancer cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, MAPRE2 is highly expressed in pancreatic cancer cells, and seems to be involved in perineural invasion. Therefore, targeting this microtubule-associated protein might be a promising approach in the therapy of pancreatic cancer. PMID: 19787265 [PubMed - in process] (Source: International Journal of Oncology)
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Abiatari I, Gillen S, DeOliveira T, Klose T, Bo K, Giese NA, Friess H, Kleeff J Tags: Int J Oncol Source Type: journals

Phosphoglucose isomerase enhances colorectal cancer metastasis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, overexpression of PGI significantly contributes to the aggressive phenotype of human colon cancer and, thus, may provide a novel therapeutic target. PMID: 19787266 [PubMed - in process] (Source: International Journal of Oncology)
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Tsutsumi S, Fukasawa T, Yamauchi H, Kato T, Kigure W, Morita H, Asao T, Kuwano H Tags: Int J Oncol Source Type: journals

The 10q25.3-26.1 G protein-coupled receptor gene GPR26 is epigenetically silenced in human gliomas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Loss of heterozygosity (LOH) of the entire chromosome 10 is the most frequent genetic alteration in human glioblastoma (GBM). In addition to PTEN/MMAC1 on 10q23.3, clustering of partial deletion break-points on 10q25.3-26.1 points to a second suppressor locus. The proposed target gene DMBT1 was not confirmed. By somatic deletion mapping of this region, we identified the complementary DNA encoding the human homologue of rat orphan G protein-coupled receptor GPR26. GPR26 is highly expressed in fetal and adult brain, but frequently reduced or absent in glioma cells and biopsies, due to de novo methylation of its 5' CpG is...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Boulay JL, Ionescu MC, Sivasankaran B, Labuhn M, Dolder-Schlienger B, Taylor E, Morin P, Hemmings BA, Lino MM, Jones G, Maier D, Merlo A Tags: Int J Oncol Source Type: journals