RPL9 acts as an oncogene by shuttling miRNAs through exosomes in human hepatocellular carcinoma cells
Int J Oncol. 2024 Jun;64(6):58. doi: 10.3892/ijo.2024.5646. Epub 2024 Apr 19.ABSTRACTThe exosomal pathway is an essential mechanism that regulates the abnormal content of microRNAs (miRNAs) in hepatocellular carcinoma (HCC). The directional transport of miRNAs requires the assistance of RNA‑binding proteins (RBPs). The present study found that RBPs participate in the regulation of miRNA content through the exosomal pathway in HCC cells. First, differential protein expression profiles in the serum exosomes of patients with HCC and benign liver disease were detected using mass spectrometry. The results revealed that riboso...
Source: International Journal of Oncology - April 19, 2024 Category: Cancer & Oncology Authors: Ang Li Jiyan Xie Lihong Lv Zhihua Zheng Weibang Yang Wenfeng Zhuo Sijia Yang Diankui Cai Jinxin Duan Peiqing Liu Jun Min Jinxing Wei Source Type: research
Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review)
Int J Oncol. 2024 May;64(5):56. doi: 10.3892/ijo.2024.5644. Epub 2024 Apr 12.ABSTRACTMicroRNAs (miRNAs) are noncoding small nucleic acids that contain ~22 nucleotides and are considered to promote the degradation or inhibit the translation of mRNA by targeting its 3'‑untranslated region. However, growing evidence has revealed that nuclear miRNAs, combined with gene promoters or enhancers, are able to directly mediate gene transcription. These miRNAs exert a critical influence on cancer progression by affecting cell growth, migration and invasion. In this review, the direct regulation of gene expression by nuclear miRNAs ...
Source: International Journal of Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Ziqiang Wang Yu Zhang Kun Li Source Type: research
Beyond self ‑eating: Emerging autophagy‑independent functions for the autophagy molecules in cancer (Review)
Int J Oncol. 2024 Jun;64(6):57. doi: 10.3892/ijo.2024.5645. Epub 2024 Apr 12.ABSTRACTAutophagy is a conserved catabolic process that controls organelle quality, removes misfolded or abnormally aggregated proteins and is part of the defense mechanisms against intracellular pathogens. Autophagy contributes to the suppression of tumor initiation by promoting genome stability, cellular integrity, redox balance and proteostasis. On the other hand, once a tumor is established, autophagy can support cancer cell survival and promote epithelial‑to‑mesenchymal transition. A growing number of molecules involved in autophagy have ...
Source: International Journal of Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Giulia Tedesco Manuela Santarosa Roberta Maestro Source Type: research
Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review)
Int J Oncol. 2024 May;64(5):56. doi: 10.3892/ijo.2024.5644. Epub 2024 Apr 12.ABSTRACTMicroRNAs (miRNAs) are noncoding small nucleic acids that contain ~22 nucleotides and are considered to promote the degradation or inhibit the translation of mRNA by targeting its 3'‑untranslated region. However, growing evidence has revealed that nuclear miRNAs, combined with gene promoters or enhancers, are able to directly mediate gene transcription. These miRNAs exert a critical influence on cancer progression by affecting cell growth, migration and invasion. In this review, the direct regulation of gene expression by nuclear miRNAs ...
Source: International Journal of Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Ziqiang Wang Yu Zhang Kun Li Source Type: research
Beyond self ‑eating: Emerging autophagy‑independent functions for the autophagy molecules in cancer (Review)
Int J Oncol. 2024 Jun;64(6):57. doi: 10.3892/ijo.2024.5645. Epub 2024 Apr 12.ABSTRACTAutophagy is a conserved catabolic process that controls organelle quality, removes misfolded or abnormally aggregated proteins and is part of the defense mechanisms against intracellular pathogens. Autophagy contributes to the suppression of tumor initiation by promoting genome stability, cellular integrity, redox balance and proteostasis. On the other hand, once a tumor is established, autophagy can support cancer cell survival and promote epithelial‑to‑mesenchymal transition. A growing number of molecules involved in autophagy have ...
Source: International Journal of Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Giulia Tedesco Manuela Santarosa Roberta Maestro Source Type: research
Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review)
Int J Oncol. 2024 May;64(5):56. doi: 10.3892/ijo.2024.5644. Epub 2024 Apr 12.ABSTRACTMicroRNAs (miRNAs) are noncoding small nucleic acids that contain ~22 nucleotides and are considered to promote the degradation or inhibit the translation of mRNA by targeting its 3'‑untranslated region. However, growing evidence has revealed that nuclear miRNAs, combined with gene promoters or enhancers, are able to directly mediate gene transcription. These miRNAs exert a critical influence on cancer progression by affecting cell growth, migration and invasion. In this review, the direct regulation of gene expression by nuclear miRNAs ...
Source: International Journal of Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Ziqiang Wang Yu Zhang Kun Li Source Type: research
Beyond self ‑eating: Emerging autophagy‑independent functions for the autophagy molecules in cancer (Review)
Int J Oncol. 2024 Jun;64(6):57. doi: 10.3892/ijo.2024.5645. Epub 2024 Apr 12.ABSTRACTAutophagy is a conserved catabolic process that controls organelle quality, removes misfolded or abnormally aggregated proteins and is part of the defense mechanisms against intracellular pathogens. Autophagy contributes to the suppression of tumor initiation by promoting genome stability, cellular integrity, redox balance and proteostasis. On the other hand, once a tumor is established, autophagy can support cancer cell survival and promote epithelial‑to‑mesenchymal transition. A growing number of molecules involved in autophagy have ...
Source: International Journal of Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Giulia Tedesco Manuela Santarosa Roberta Maestro Source Type: research
Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review)
Int J Oncol. 2024 May;64(5):56. doi: 10.3892/ijo.2024.5644. Epub 2024 Apr 12.ABSTRACTMicroRNAs (miRNAs) are noncoding small nucleic acids that contain ~22 nucleotides and are considered to promote the degradation or inhibit the translation of mRNA by targeting its 3'‑untranslated region. However, growing evidence has revealed that nuclear miRNAs, combined with gene promoters or enhancers, are able to directly mediate gene transcription. These miRNAs exert a critical influence on cancer progression by affecting cell growth, migration and invasion. In this review, the direct regulation of gene expression by nuclear miRNAs ...
Source: International Journal of Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Ziqiang Wang Yu Zhang Kun Li Source Type: research
Beyond self ‑eating: Emerging autophagy‑independent functions for the autophagy molecules in cancer (Review)
Int J Oncol. 2024 Jun;64(6):57. doi: 10.3892/ijo.2024.5645. Epub 2024 Apr 12.ABSTRACTAutophagy is a conserved catabolic process that controls organelle quality, removes misfolded or abnormally aggregated proteins and is part of the defense mechanisms against intracellular pathogens. Autophagy contributes to the suppression of tumor initiation by promoting genome stability, cellular integrity, redox balance and proteostasis. On the other hand, once a tumor is established, autophagy can support cancer cell survival and promote epithelial‑to‑mesenchymal transition. A growing number of molecules involved in autophagy have ...
Source: International Journal of Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Giulia Tedesco Manuela Santarosa Roberta Maestro Source Type: research
Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review)
Int J Oncol. 2024 May;64(5):56. doi: 10.3892/ijo.2024.5644. Epub 2024 Apr 12.ABSTRACTMicroRNAs (miRNAs) are noncoding small nucleic acids that contain ~22 nucleotides and are considered to promote the degradation or inhibit the translation of mRNA by targeting its 3'‑untranslated region. However, growing evidence has revealed that nuclear miRNAs, combined with gene promoters or enhancers, are able to directly mediate gene transcription. These miRNAs exert a critical influence on cancer progression by affecting cell growth, migration and invasion. In this review, the direct regulation of gene expression by nuclear miRNAs ...
Source: International Journal of Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Ziqiang Wang Yu Zhang Kun Li Source Type: research
Beyond self ‑eating: Emerging autophagy‑independent functions for the autophagy molecules in cancer (Review)
Int J Oncol. 2024 Jun;64(6):57. doi: 10.3892/ijo.2024.5645. Epub 2024 Apr 12.ABSTRACTAutophagy is a conserved catabolic process that controls organelle quality, removes misfolded or abnormally aggregated proteins and is part of the defense mechanisms against intracellular pathogens. Autophagy contributes to the suppression of tumor initiation by promoting genome stability, cellular integrity, redox balance and proteostasis. On the other hand, once a tumor is established, autophagy can support cancer cell survival and promote epithelial‑to‑mesenchymal transition. A growing number of molecules involved in autophagy have ...
Source: International Journal of Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Giulia Tedesco Manuela Santarosa Roberta Maestro Source Type: research
Knockdown of PGBD5 inhibits the malignant progression of glioma through upregulation of the PPAR pathway
In conclusion, interference with PGBD5 could inhibit the malignant progression of glioma through the PPAR pathway, suggesting that PGBD5 may be a potential molecular target of glioma.PMID:38577941 | DOI:10.3892/ijo.2024.5643 (Source: International Journal of Oncology)
Source: International Journal of Oncology - April 5, 2024 Category: Cancer & Oncology Authors: Pengren Luo Jinhong Yang Lipeng Jian Jigen Dong Shi Yin Chao Luo Shuai Zhou Source Type: research
Heterogeneity of primary and metastatic CAFs: From differential treatment outcomes to treatment opportunities (Review)
Int J Oncol. 2024 May;64(5):54. doi: 10.3892/ijo.2024.5642. Epub 2024 Apr 5.ABSTRACTCompared with primary tumor sites, metastatic sites appear more resistant to treatments and respond differently to the treatment regimen. It may be due to the heterogeneity in the microenvironment between metastatic sites and primary tumors. Cancer‑associated fibroblasts (CAFs) are widely present in the tumor stroma as key components of the tumor microenvironment. Primary tumor CAFs (pCAFs) and metastatic CAFs (mCAFs) are heterogeneous in terms of source, activation mode, markers and functional phenotypes. They can shape the tumor microen...
Source: International Journal of Oncology - April 5, 2024 Category: Cancer & Oncology Authors: Zixing Kou Cun Liu Wenfeng Zhang Changgang Sun Lijuan Liu Qiming Zhang Source Type: research
Knockdown of PGBD5 inhibits the malignant progression of glioma through upregulation of the PPAR pathway
In conclusion, interference with PGBD5 could inhibit the malignant progression of glioma through the PPAR pathway, suggesting that PGBD5 may be a potential molecular target of glioma.PMID:38577941 | DOI:10.3892/ijo.2024.5643 (Source: International Journal of Oncology)
Source: International Journal of Oncology - April 5, 2024 Category: Cancer & Oncology Authors: Pengren Luo Jinhong Yang Lipeng Jian Jigen Dong Shi Yin Chao Luo Shuai Zhou Source Type: research
Heterogeneity of primary and metastatic CAFs: From differential treatment outcomes to treatment opportunities (Review)
Int J Oncol. 2024 May;64(5):54. doi: 10.3892/ijo.2024.5642. Epub 2024 Apr 5.ABSTRACTCompared with primary tumor sites, metastatic sites appear more resistant to treatments and respond differently to the treatment regimen. It may be due to the heterogeneity in the microenvironment between metastatic sites and primary tumors. Cancer‑associated fibroblasts (CAFs) are widely present in the tumor stroma as key components of the tumor microenvironment. Primary tumor CAFs (pCAFs) and metastatic CAFs (mCAFs) are heterogeneous in terms of source, activation mode, markers and functional phenotypes. They can shape the tumor microen...
Source: International Journal of Oncology - April 5, 2024 Category: Cancer & Oncology Authors: Zixing Kou Cun Liu Wenfeng Zhang Changgang Sun Lijuan Liu Qiming Zhang Source Type: research
