Extracellular vesicles and their therapeutic applications: a review article (part1)
Int J Physiol Pathophysiol Pharmacol. 2024 Feb 25;16(1):1-9. eCollection 2024.ABSTRACTExtracellular vesicles (EVs) have emerged as a captivating field of study in molecular biology with diverse applications in therapeutics. These small membrane-bound structures, released by cells into the extracellular space, play a vital role in intercellular communication and hold immense potential for advancing medical treatments. EVs, including exosomes, microvesicles, and apoptotic bodies, are classified based on size and biogenesis pathways, with exosomes being the most extensively studied. The aim of this study was to examine the mo...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - April 15, 2024 Category: Physiology Authors: Diana Rafieezadeh Aryan Rafieezadeh Source Type: research

Association between patellofemoral osteoarthritis with demographic features and anatomical variants of the knee in non-traumatic patients
CONCLUSION: Anatomical knee variants, including the TT-TG distance, trochlear dysplasia, and Insall-Salvati ratio, are significant risk factors for PFOA progression. The results also indicate that higher BMI and older age are significantly associated with more measures of MRI Osteoarthritis Knee Score (MOAKS) than demographic information. Among anatomical variants, a higher TT-TG distance and an increased grade of trochlear dysplasia show a significant relationship with more measures of MOAKS. Understanding the relationship between these factors has important clinical and research implications and can help inform the devel...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - January 12, 2024 Category: Physiology Authors: Ghazaleh Jamalipour Soufi Ali Hekmatnia Farzaneh Hekmatnia Andrew Parviz Zarei Mahshid Bahrami Sina Rasti Farshad Riahi Source Type: research