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MeetingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
December 5-8, 2009 51st ASH Annual Meeting (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Source Type: journals

ASTRO NewsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
On October 1, 2009, the Senate Finance Committee considered an amendment to its health reform bill offered by Sen. Blanche Lincoln (D-Ark.) to overturn at least a portion of the significant proposed Medicare cuts to radiation oncology. Lincoln was brilliant in her description of radiation oncology and the inappropriate nature of these cuts. She said radiation oncology services are “vital” for cancer patients and that radiation oncology technology is “miraculous in many ways.” To read the full story, visit ASTROnews online at http://cs.astro.org/blogs/astronews/pages/web-exclusive-finance-committee-discusses-propose...
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Source Type: journals

In Reply to Dr. Dane et al.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: As Dr. Dane's comment on our article was very logical and reasonable, we undertook the whole process of analysis again according to Dr. Dane's opinion. As there were a lot of questions, we answer here one by one. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Jong Hoon Kim, Young S. Kim Tags: Letters to the Editor Source Type: journals

Adequacy of Lymph Node Dissection Should be Taken into Consideration While Determining the Prognostic Significance of the Lymph Node Ratio: In Regard to Kim et al. (Int J Radiat Oncol Biol Phys 2009;74:796–802)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: We read with interest the article by Kim et al. , which examined the value of the lymph node ratio (LNR) as a prognostic factor in patients with Stage III rectal cancer treated with total mesorectal excision followed by chemoradiotherapy. In agreement with this article, there are several others reporting the importance of LNR as a prognostic factor in colorectal cancer . However, we do have some concerns about the generalization of the conclusion of the Kim et al. study to all Stage III rectal cancer patients. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Faysal Dane, Mehmet Akif Öztürk, Serdar Turhal Tags: Letters to the Editor Source Type: journals

Dose-Rate Effects When Estimating Risks for Second Malignancies: In Reply to Dr. Paganetti et al.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: We thank Dr. Paganetti et al. for their interest in our work. The BEIR committee and others have recommended applying a DDREF only if the dose and dose rate are less than approximately 100 mGy and 0.01 mGy/min , respectively. In our study, tissue doses ranged from 55 to 80,000 mGy, and instantaneous dose rates ranged from 0.5 to 1,000 mGy/min. Therefore, DDREF may apply to only a small fraction of the doses observed in our study (a). In such a scenario, the rationale for applying a conventional DDREF to only a small subset of doses within a broader interval is not obvious at this time. Furthermore, even if ...
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Jonas D. Fontenot, Andrew K. Lee, Wayne D. Newhauser Tags: Letters to the Editor Source Type: journals

Dose-Rate Effects When Estimating Risks for Second Malignancies: In Regard to Fontenot et al (Int J Radiat Oncol Biol Phys 2009;74:616–622)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: In the work by Fontenot et al. , the risk for developing a second malignancy after prostate radiation therapy was estimated for proton therapy and intensity-modulated X-ray therapy (IMRT). The authors conclude that proton therapy can reduce the risk for a second cancer when compared with IMRT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Harald Paganetti, Basit S. Athar, Bryan Bednarz Tags: Letters to the Editor Source Type: journals

In Response to Dr. Muijs et al.: Adequacy of Margins in Chemoradiotherapy for Esophageal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: We thank Dr. Muijs et al. for their letter and the points they raise. As stated in the paper, the gross tumor volume (GTV) was defined using information from diagnostic oesophago-gastro duodenoscopy (OGD) and computed tomographic scan, together with accurate mapping of the tumor from endoscopic ultrasound (with or without biopsy of suspicious lymph nodes). This was then extended by 2 cm in the cranio-caudal axis (following the course of the esophagus) and 1 cm in the lateral and antero-posterior directions to create the clinical target volume (CTV). The CTV was then enlarged to create the planning target vo...
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Michael R. Button, Lucy Wills, Thomas D.L. Crosby Tags: Letters to the Editor Source Type: journals

In Response to: Study to Determine Adequate Margins in Radiotherapy Planning for Esophageal Carcinoma by Detailing Patterns of Recurrence After Definitive ChemoradiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: With interest we have read the paper by Button et al. on patterns of recurrence of esophageal cancer after primary chemoradiotherapy. Their purpose was to ascertain the adequacy of radiotherapy margins by studying the relapse patterns. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Christina T. Muijs, Jannet C. Beukema, Veronique E. Mul, Johannes A. Langendijk Tags: Letters to the Editor Source Type: journals

The History of OncologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A Google search on the phrase “history of oncology” brings up approximately 1,700,000 hits, including helpful entries testifying to the excellence of several-thousand individual oncologists and a similar number of promotional advertisements for local, regional, and national self-designated “centers of excellence” in the very latest types of cancer care. With the current hospital marketing emphasis on “cutting-edge” new technologies, it would be easy to imagine that the field of oncology arose in recent decades from peer-reviewed medical evidence drawn from modern biomolecular sciences and digital technologies. ...
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Roger M. Macklis Tags: Book Reviews Source Type: journals

Handbook of Cancer Diagnosis and Treatment EvaluationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This pocket-sized manual intends to define the “specificities” which comprise the “clinical method” developed over the last 7 decades in clinical oncology, the teaching of which, its authors contend, has received little attention during that period. They contrast those shortcoming with the “formidable progress made during that same period by the medical therapy of tumors, i.e., by medical oncology.” (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: John E. Munzenrider Tags: Book Reviews Source Type: journals

Respiratory Motion Changes of Lung Tumors Over the Course of Radiation Therapy Based on Respiration-Correlated Four-Dimensional Computed Tomography ScansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Interfraction consistency in tumor excursion suggests tumor excursion at simulation may direct therapy. Significant variations in phase lag between GTV and other anatomic structures throughout treatment have important implications for techniques that rely on surrogate structures to predict tumor motion (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Kristin J. Redmond, Danny Y. Song, Jana L. Fox, Jessica Zhou, C. Nicole Rosenzweig, Eric Ford Tags: Physics Contributions Source Type: journals

cDNA Microarray Analysis of Serially Sampled Cervical Cancer Specimens From Patients Treated With ThermochemoradiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Microarrays showed minor changes in gene expression after thermochemoradiotherapy in locally advanced cervical cancer. We detected 53 differentially expressed genes, mainly involved in fibrosis, tumorigenesis, and immune response. A limitation with the use of serial biopsy specimens was low quality of ribonucleic acid from tumors that respond to highly effective therapy. Another “key limitation” is timing of the post-treatment biopsy, because 24 h may be too late to adequately assess the impact of hyperthermia on gene expression. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Erling Dahl Borkamo, Baard-Christian Schem, Øystein Fluge, Ove Bruland, Olav Dahl, Olav Mella Tags: Biology Contributions Source Type: journals

Radiation-Induced Interleukin-6 Expression Through MAPK/p38/NF-κB Signaling Pathway and the Resultant Antiapoptotic Effect on Endothelial Cells Through Mcl-1 Expression With sIL6-RαEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Radiation transcriptionally induces IL-6 expression in endothelial cells through mitogen-activated protein kinase/p38-mediated NF-κB/IκB (inhibitor of NF-κB) complex activation. In the presence of sIL6-Rα, radiation-induced IL-6 expression acts through Mcl-1 expression to rescue endothelial cells from radiation-induced death. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Chia-Hung Chou, Shee-Uan Chen, Jason Chia-Hsien Cheng Tags: Biology Contributions Source Type: journals

Effects of Adenovirus-Mediated Delivery of the Human Hepatocyte Growth Factor Gene in Experimental Radiation-Induced Heart DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Based on the study findings, hepatocyte growth factor gene transfer can attenuate radiation-induced cardiac injury and can preserve cardiac function. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Shunying Hu, Yundai Chen, Libing Li, Jinlong Chen, Bin Wu, Xiao Zhou, Guang Zhi, Qingfang Li, Rongliang Wang, Haifeng Duan, Zikuan Guo, Yuefeng Yang, Fengjun Xiao, Hua Wang, Lisheng Wang Tags: Biology Contributions Source Type: journals

Renin-Angiotensin System Suppression Mitigates Experimental Radiation PneumonitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Purpose: To find the mitigators of pneumonitis induced by moderate doses of thoracic radiation (10–15 Gy).Methods and Materials: Unanesthetized WAG/RijCmcr female rats received a single dose of X-irradiation (10, 12, or 15 Gy at 1.615 Gy/min) to the thorax. Captopril (an angiotensin-converting enzyme inhibitor) or losartan (an angiotensin receptor blocker) was administered in the drinking water after irradiation. Pulmonary structure and function were assessed after 8 weeks in randomly selected rats by evaluating the breathing rate, ex vivo vascular reactivity, and histopathologic findings. Survival analysis was undertake...
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Swarajit N. Ghosh, Rong Zhang, Brian L. Fish, Vladimir A. Semenenko, X. Allen Li, John E. Moulder, Elizabeth R. Jacobs, Meetha Medhora Tags: Biology Contributions Source Type: journals

Poly(ADP-Ribose) Polymerase-1 and DNA-Dependent Protein Kinase Have Equivalent Roles in Double Strand Break Repair Following Ionizing RadiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: DNA-PK and PARP-1 are both required in a pathway facilitating the fast phase of DNA DSB repair. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Jody Mitchell, Graeme C.M. Smith, Nicola J. Curtin Tags: Biology Contributions Source Type: journals

Cytotoxic Effects of Temozolomide and Radiation are Additive- and Schedule-DependentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: TMZ is not a radiosensitizing agent but yields additive cytotoxicity in combination with radiation. Our data indicate that TMZ treatment should commence at least 3 days before radiation to achieve maximum benefit. Activation of G2/M checkpoint signaling by TMZ and radiation has a cytoprotective effect that can be overcome by dual inhibition of ATM and ATR. More specific inhibition of checkpoint signaling will be required to increase treatment efficacy without exacerbating toxicity. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Anthony J. Chalmers, Elliot M. Ruff, Christine Martindale, Nadia Lovegrove, Susan C. Short Tags: Biology Contributions Source Type: journals

Roles of Radiation Dose and Chemotherapy in the Etiology of Stomach Cancer as a Second MalignancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Purpose: To evaluate the roles of radiation dose, chemotherapy, and other factors in the etiology of stomach cancer in long-term survivors of testicular cancer or Hodgkin lymphoma.Methods and Materials: We conducted a cohort study in 5,142 survivors of testicular cancer or Hodgkin lymphoma treated in the Netherlands between 1965 and 1995. In a nested case–control study, detailed information on treatment, smoking, gastrointestinal diseases, and family history was collected for 42 patients with stomach cancer and 126 matched controls. For each subject, the mean radiation dose to the stomach was estimated. Relative risks (R...
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Alexandra W. van den Belt-Dusebout, Berthe M.P. Aleman, Gijs Besseling, Marie L. de Bruin, Michael Hauptmann, Mars B. van 't Veer, Ronald de Wit, Jacques G. Ribot, Evert M. Noordijk, J. Martijn Kerst, Jourik A. Gietema, Flora E. van Leeuwen Tags: Stomach Source Type: journals

Dr. Felix Leborgne, 1935–2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Born in Montevideo, Uruguay, Felix Leborgne grew up in a family with a strong tradition of innovative research in the field of radiation medicine. During the 1930s, his father, Dr. Felix Leborgne, and his uncle, Dr. Raul Leborgne, developed new techniques in radiology, including mammography, for the early diagnosis and treatment of cancer with radiation. No doubt, Felix followed this tradition. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Raul C. Urtasun, Jack Fowler Tags: Editorial Source Type: journals

HighlightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we present our early results related to normal tissue effects of this technique. In the data presented, we found a higher then expected rate of moderate-to-severe late tissue effects, mainly related to development of subcutaneous fibrosis/necrosis. The development of fibrosis and the overall cosmetic outcome correlated with several dose-volume parameters. Radiobiologic principles and recent data regarding α/β values for breast tissue may explain the higher rate of late effects observed.” (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Source Type: journals

Critical Appraisal of Volumetric Modulated Arc Therapy in Stereotactic Body Radiation Therapy for Metastases to Abdominal Lymph NodesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Purpose: A planning study was performed comparing volumetric modulated arcs, RapidArc (RA), fixed beam IMRT (IM), and conformal radiotherapy (CRT) with multiple static fields or short conformal arcs in a series of patients treated with hypofractionated stereotactic body radiation therapy (SBRT) for solitary or oligo-metastases from different tumors to abdominal lymph nodes.Methods and Materials: Fourteen patients were included in the study. Dose prescription was set to 45 Gy (mean dose to clinical target volume [CTV]) in six fractions of 7.5 Gy. Objectives for CTV and planning target volume (PTV) were as follows: Dosemin >...
Source: International Journal of Radiation Oncology * Biology * Physics - November 2, 2009 Category: Radiology Authors: Mario Bignardi, Luca Cozzi, Antonella Fogliata, Paola Lattuada, Pietro Mancosu, Piera Navarria, Gaetano Urso, Sabrina Vigorito, Marta Scorsetti Tags: Physics Contributions Source Type: journals

ASTRO NewsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The 2010 Multidisciplinary Head and Neck Cancer Symposium, co-sponsored by AHNS, ASCO, ASTRO and SNM, is scheduled to take place February 25-27, 2010, at the Sheraton Wild Horse Pass Resort and Spa in Chandler, Ariz. Registration and housing are now open. The program chair is Randal S. Weber, M.D. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 26, 2009 Category: Radiology Source Type: journals

MeetingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
November 26-29, 2009 31st Annual Conference of Association of Radiation Oncologists of India (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 26, 2009 Category: Radiology Source Type: journals

In Reply to Dr. LawrenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the editor: I appreciate the opportunity to respond to Dr. Lawrence's thoughtful letter. He makes several excellent points. The title of Dr. Lawrence's letter is “All Prostate Cancers Are Not Created Equal.” I wholeheartedly agree. Dr. Lawrence points out that the excellent short-term results achieved with several new, expensive technologies are likely the result of the underlying indolent natural history of low-risk prostate cancer. Score another point for Dr. Lawrence! There is some evidence that we (myself included) may be “overtreating” prostate cancer . To be fair, however, it should be acknowledged that th...
Source: International Journal of Radiation Oncology * Biology * Physics - October 26, 2009 Category: Radiology Authors: W. Robert Lee Tags: Letters to the Editor Source Type: journals

In Reply to Dr. Lee: Are Prostate Cancers Created Equal?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: Dr. Lee's response on optimum prostate cancer treatment , which appeared a few weeks before major trials , reported no benefit to screening. With different stages, age-adjusted and absolute prostate-specific antigen (PSA) levels, velocities, PSA doubling times (PSADT), Gleason scores, perineural invasion, etc., all prostate cancers are not equal. Of the 218,890 prostate cancers diagnosed annually, about 12.5% kill the patient. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 26, 2009 Category: Radiology Authors: Gilbert Lawrence Tags: Letters to the Editor Source Type: journals

In Reply to Dr. Azria et al.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: In their letter Azria et al. point to methodologic limitations of our study that were addressed in the study conclusions . We agree that a major limitation was the time delay between therapy and blood collection in our patients. Although this may cause confounding, it is unlikely to affect the data quality because patient toxicity was collected prospectively with blood collection occurring afterward, making our study similar in design to theirs . (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 26, 2009 Category: Radiology Authors: Ian Dayes, Kara Schnarr, Jim Julian, Jinka Sathya, Doug Boreham Tags: Letters to the Editor Source Type: journals

Radiation-Induced Sequelae Measured by Means of Lymphocyte Apoptosis: Importance of Certain Single Nucleotide Polymorphisms: In Regard to Schnarr et al. (Int J Radiat Oncol Biol Phys 2009)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: We read with great interest the article by Schnarr et al. on the prediction of radiation therapy late toxicity in prostate cancer patients measured by means of lymphocyte apoptosis. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 26, 2009 Category: Radiology Authors: David Azria, Mahmut Ozsahin, Barry Rosenstein Tags: Letters to the Editor Source Type: journals

Esophageal Cancer: Principles and PracticeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This book fills a niche that has remained open for years: a text devoted to the evolving treatment of esophageal cancer. Although other oncology and surgery textbooks have covered the topic in chapter form, no textbook has attempted to comprehensively cover this broad subject in many years. This text addresses several important developments over the last few years, including results from clinical trials, advances in technology, and progress in our understanding of molecular oncology. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 26, 2009 Category: Radiology Authors: David T. Marshall Tags: Book Reviews Source Type: journals

Brain Metastasis—A Multidisciplinary ApproachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This textbook is a welcome addition to the literature dealing with the common clinical problem of brain metastases. As the editor points out in the Preface, this is an increasingly important topic because of advances in the treatment of brain metastases as well as improvements in systemic therapies that result in longer survival and thus more time to develop brain metastases. I recommend this book for radiation oncologists, neurosurgeons, and medical oncologists who care for patients with brain metastases. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 26, 2009 Category: Radiology Authors: Paul W. Sperduto Tags: Book Reviews Source Type: journals

Strategies for Online Organ Motion Correction for Intensity-Modulated Radiotherapy of Prostate Cancer: Prostate, Rectum, and Bladder Dose EffectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: With online correction of both translations and rotations, a 4-mm margin was sufficient for 15 of 19 patients, whereas the remaining four patients had an underdosed CTV volume (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 26, 2009 Category: Radiology Authors: Erik-Jan Rijkhorst, Annemarie Lakeman, Jasper Nijkamp, Josien de Bois, Marcel van Herk, Joos V. Lebesque, Jan-Jakob Sonke Tags: Physics Contributions Source Type: journals

Membrane-Dependent Bystander Effect Contributes to Amplification of the Response to Alpha-Particle Irradiation in Targeted and Nontargeted CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A complex interaction of direct irradiation and bystander signals leads to a membrane-dependent amplification of cell responses that could influence therapeutic outcomes in tissues exposed to low doses or to environmental exposure. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 26, 2009 Category: Radiology Authors: Maïté Hanot, Jim Hoarau, Marie Carrière, Jaime F. Angulo, Hicham Khodja Tags: Biology Contributions Source Type: journals

Validation of Temporal Optimization Effects for a Single Fraction of Radiation In VitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results verify the assertions of the modeling study in vitro, and imply that the temporal pattern of applied dose should be considered in treatment planning and delivery. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 26, 2009 Category: Radiology Authors: Michael B. Altman, Michelle A. Stinauer, Desler Javier, Brett D. Smith, Lauren C. Herman, Matthew L. Pytynia, Bulent Aydogan, Charles A. Pelizzari, Steven J. Chmura, John C. Roeske Tags: Biology Contributions Source Type: journals

Identification of Genes Associated With Progression and Metastasis of Advanced Cervical Cancers After Radiotherapy by cDNA Microarray AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The present results may provide valuable information for identified predictive markers and novel therapeutic target molecules for progression and metastasis of advanced cervical cancer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 26, 2009 Category: Radiology Authors: Yoko Harima, Koshi Ikeda, Keita Utsunomiya, Toshiko Shiga, Atsushi Komemushi, Hiroyuki Kojima, Motoo Nomura, Minoru Kamata, Satoshi Sawada Tags: Biology Contributions Source Type: journals

Radiation Response of Cancer Stem-Like Cells From Established Human Cell Lines After Sorting for Surface MarkersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: CSLC subpopulations showed no general radioresistant phenotype, despite the quantities of CSLC subpopulations shown to correspond relatively well in other reports. Likewise, CSLC characteristics were found in some but not all of the tested cell lines. The reported problems in testing for CSLC in cell lines may be overcome by additional techniques, beyond sorting for markers. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 26, 2009 Category: Radiology Authors: Osama Al-Assar, Ruth J. Muschel, Tine S. Mantoni, W. Gillies McKenna, Thomas B. Brunner Tags: Biology Contributions Source Type: journals

Bevacizumab as Therapy for Radiation Necrosis in Four Children With Pontine GliomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In children with pontine gliomas, bevacizumab may provide both therapeutic benefit and diagnostic information. More formal evaluation of bevacizumab in these children is needed. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 26, 2009 Category: Radiology Authors: Arthur K. Liu, Margaret E. Macy, Nicholas K. Foreman Tags: Brain Source Type: journals

American College of Radiology Appropriateness Criteria on Multiple Brain MetastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As many as 170,000 cancer patients will develop brain metastases each year . Brain metastases represent the most common neurologic manifestation of cancer, occurring in 15% of cancer patients, particularly those with lung and breast cancer diagnoses . Clinical , imaging , and autopsy series have shown that approximately half of brain metastases will be solitary and half will be multiple. Among patients with multiple lesions, the majority of metastases (70%) are found supratentorially . The most common symptoms of brain metastases are headache, altered mental status, and focal weakness, occurring in up to half of patients. ...
Source: International Journal of Radiation Oncology * Biology * Physics - October 26, 2009 Category: Radiology Authors: Gregory M.M. Videtic, Laurie E. Gaspar, Amr M. Aref, Isabelle M. Germano, Brian J. Goldsmith, Joseph P. Imperato, Karen J. Marcus, Michael W. McDermott, Mark W. McDonald, Roy A. Patchell, H. Ian Robins, C. Leland Rogers, John H. Suh, Aaron H. Wolfson, Fra Tags: ACR Report Source Type: journals

Issue HighlightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
C. Cozzarini, F. Montorsi, C. Fiorino, F. Alongi, A. Bolognesi, L. Filippo Da Pozzo, G. Guazzoni, M. Freschi, M. Roscigno, V. Scattoni, P. Rigatti, and N. Di Muzio “The end-point of this study was to assess whether early adjuvant RT (EART) doses ≥70 Gy after radical prostatectomy significantly improved the clinical outcome of high-risk, node-negative, patients. After a median follow-up of 9 years, both 5-year biochemical relapse-free (bRFS) and disease-free survival (DFS) were significantly higher in patients receiving EART dose ≥70.2 Gy. In the hormono-naïve cases, the impact of high-dose EART on bRFS and DFS was ...
Source: International Journal of Radiation Oncology * Biology * Physics - October 26, 2009 Category: Radiology Source Type: journals

Gains From Real-Time Tracking of Prostate Motion During External Beam Radiation TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Real-time motion tracking and threshold-based intrafractional intervention may play a significant roll in treatment margin reduction for a small fraction of patients but not for the general patient population. Four-dimensional treatments with prostate rotation correction can reduce the treatment margin more significantly. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 15, 2009 Category: Radiology Authors: Jin Sheng Li, Lihui Jin, Alan Pollack, Eric M. Horwitz, Mark K. Buyyounouski, Robert A. Price, Chang-Ming Ma Tags: Physics Contributions Source Type: journals

ASTRO NewsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ASTRO is pleased to announce the election results for the ASTRO Board of Directors and Nominating Committee. These individuals will begin their terms at ASTRO's 51st Annual Meeting in Chicago. The new officers are: (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 5, 2009 Category: Radiology Source Type: journals

MeetingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
November 1-3, 2009 American Society of Radiologic Technologists 33rd Radiation Therapy Conference (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 5, 2009 Category: Radiology Source Type: journals

Proton Beam Radiotherapy Versus Three-Dimensional Conformal Stereotactic Body Radiotherapy in Primary Peripheral, Early-Stage Non–Small-Cell Lung Carcinoma: A Comparative Dosimetric AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Single-, two-, or three-field passively or actively scanned proton therapy delivered comparable PTV dose with generally less dose to normal tissues in these hypothetic treatments. Actively scanned beam plans typically had more favorable dose characteristics to the target, lung, and other soft tissues compared with the passively scanned plans. The clinical significance of these findings remains to be determined. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 5, 2009 Category: Radiology Authors: O. Kenneth Macdonald, Jon J. Kruse, Janelle M. Miller, Yolanda I. Garces, Paul D. Brown, Robert C. Miller, Robert L. Foote Tags: Physics Contributions Source Type: journals

Study of Robustness of IMPT and IMRT for Prostate Cancer Against Organ MovementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The sensitivities of IMPT and IMRT to organ movement are of the same order if appropriate planning strategies are applied. The latter is especially crucial for IMPT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 5, 2009 Category: Radiology Authors: Martin Soukup, Matthias Söhn, Di Yan, Jian Liang, Markus Alber Tags: Physics Contributions Source Type: journals

Adaptive Replanning Strategies Accounting for Shrinkage in Head and Neck IMRTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Shrinkage does not result in significant dosimetric difference in targets and critical structures, except for the parotid gland, for which the mean dose increases by ∼10%. The benefit of replanning is improved sparing of the parotid. The combination of replanning and reduced margins can provide up to a 30% difference in parotid dose. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 5, 2009 Category: Radiology Authors: Qiuwen Wu, Yuwei Chi, Peter Y. Chen, Daniel J. Krauss, Di Yan, Alvaro Martinez Tags: Physics Contributions Source Type: journals

The PPARα Agonist Fenofibrate Preserves Hippocampal Neurogenesis and Inhibits Microglial Activation After Whole-Brain IrradiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data highlight a novel role for PPARα ligands in improving neurogenesis after WBI and offer the promise of improving the quality of life for brain cancer patients receiving radiotherapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 5, 2009 Category: Radiology Authors: Sriram Ramanan, Mitra Kooshki, Weiling Zhao, Fang-Chi Hsu, David R. Riddle, Mike E. Robbins Tags: Biology Contributions Source Type: journals

Radiosensitization Effect of STI-571 on Pancreatic Cancer Cells In VitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: STI-571 enhances radiation response in pancreatic cancer cells. This effect is affected by the attenuation levels of p-c-Kit or p-PDGFRβ, and K-ras mutation status. Among them, p-c-Kit plays more important roles in the radiosensitivity in pancreatic cancer compared with p-PDGFRβ or K-ras mutation status. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 5, 2009 Category: Radiology Authors: Hye Won Chung, Jing Wen, Jong-Baeck Lim, SeungMin Bang, Seung Woo Park, Si Young Song Tags: Biology Contributions Source Type: journals

Combination of Vandetanib, Radiotherapy, and Irinotecan in the LoVo Human Colorectal Cancer Xenograft ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The tumor growth delay kinetics observed in this study of the LoVo colorectal model suggest concurrent and sustained post-sequencing of vandetanib with cytotoxic therapy may be beneficial in tumors of this type. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 5, 2009 Category: Radiology Authors: Phyllis Wachsberger, Randy Burd, Anderson Ryan, Constantine Daskalakis, Adam P. Dicker Tags: Biology Contributions Source Type: journals

Issue HighlightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A. V. Taira, G. S. Merrick, R. W. Galbreath, W. M. Butler, K. E. Wallner, B. S. Kurko, R. Anderson, and J. H. Lief In the majority of men, potency preservation after brachytherapy is durable. However, post-treatment erectile function is closely related to pre-treatment function. Men with good pretreatment erectile function (EF) had 7 year potency preservation was 73.6% compared to 23% for men with borderline pre-treatment EF. Radiation dose to proximal penile structures strongly predicted for long term potency. Younger men and men with better pretreatment EF appear to tolerate higher proximal penile doses with less impact...
Source: International Journal of Radiation Oncology * Biology * Physics - October 5, 2009 Category: Radiology Source Type: journals

Stereotactic Body Radiation Therapy Boost in Locally Advanced Pancreatic CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings indicate that a SBRT boost provides a safe means of increasing radiation dose. Based on the results of this study, we recommend that a well controlled Phase II study be conducted on locally advanced pancreatic cancer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 23, 2009 Category: Radiology Authors: YoungSeok Seo, Mi-Sook Kim, SungYul Yoo, ChulKoo Cho, KwangMo Yang, HyungJun Yoo, ChulWon Choi, DongHan Lee, Jin Kim, Min Suk Kim, HyeJin Kang, YoungHan Kim Tags: Pancreas Source Type: journals

NTCP Modeling of Subacute/Late Laryngeal Edema Scored by Fiberoptic ExaminationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A clear volume effect was found for edema, consistent with a parallel architecture of the larynx for this endpoint. On the basis of our findings, an EUD (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 9, 2009 Category: Radiology Authors: Tiziana Rancati, Claudio Fiorino, Giuseppe Sanguineti Tags: Physics Contributions Source Type: journals

Intensity-Modulated Radiotherapy Optimization in a Quasi-Periodically Deforming Patient ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The presented 4D planning concept offers an alternative to gating by providing the optimal dose for free-breathing IMRT treatment. Although the focus of this study was 4D lung planning, the approach can be generally applied for IMRT optimization in randomly deforming patient models. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 9, 2009 Category: Radiology Authors: Matthias Söhn, Martin Weinmann, Markus Alber Tags: Physics Contributions Source Type: journals