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Starry ThyroidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - September 22, 2009 Category: Pathology Authors: Alsharif, M., Pambuccian, S. Tags: Articles Source Type: journals

Histiocytic Corona Around a Glomeruloid Intrafollicular Polyp of the ThyroidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - September 22, 2009 Category: Pathology Authors: Singh, C., Manivel, J. C., Pambuccian, S. E. Tags: Articles Source Type: journals

A Large Esophageal LeiomyomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - September 22, 2009 Category: Pathology Authors: Angus, A., Slesser, P., Shaw, I. Tags: Articles Source Type: journals

Small-Cell Plasmacytoma With Prominent Myxoid Stroma Mimicking a Soft-Tissue NeoplasmEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - September 22, 2009 Category: Pathology Authors: Lara-Torres, C. O, Gomez-Plata, E., Ortiz-Hidalgo, C. Tags: Articles Source Type: journals

Ovarian Malignancies With Cytologically Negative Pleural and Peritoneal Effusions: Demons' or Meigs' Pseudo-syndromes?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors reviewed the original reports of the association of malignant ovarian tumors with cytologically negative pleural and peritoneal effusions, commonly known as Meigs’ pseudo-syndrome and challenged the recent attribution of this disease to Demons. They underlined the historical and clinical interest of the reports of Demons and Meigs and concluded that the term pseudo-Meigs’ syndrome, and not pseudo-Demons’ syndrome, must be used for malignant ovarian lesions with effusions with negative cytology because Demons did not describe a similar syndrome caused by malignant tumors. (Source: International...
Source: International Journal of Surgical Pathology - September 22, 2009 Category: Pathology Authors: Peparini, N., Chirletti, P. Tags: Articles Source Type: journals

Vascular Endothelial Growth Factor Expression and Neovascularization in Non--Small Cell Lung CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, VEGF or MVD should not be regarded as a solitary prognostic factor but should be supported by other prognostic factors. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - September 22, 2009 Category: Pathology Authors: Ozbudak, I. H., Ozbilim, G., Kucukosmanoglu, I., Dertsiz, L., Demircan, A. Tags: Articles Source Type: journals

Sclerosing Angiomatoid Nodular Transformation (SANT) of the Spleen: A Report of 3 CasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors describe 3 cases of sclerosing angiomatoid nodular transformation (SANT) of the spleen diagnosed at Memorial Sloan-Kettering Cancer Center within a 1-year period (July 2008 to June 2009). All patients were female, older than 50, with lesions ranging in size from 2 to 4 cm. All were alive and well after splenectomy. All the cases showed characteristic histological and immunophenotypical findings as previously described in the literature, including scattered IgG4positive plasma cells in the fibrosclerotic stroma. Of the 3 patients, 2 had a history of carcinoma, and metastasis was of concern, but a PET scan in one...
Source: International Journal of Surgical Pathology - September 22, 2009 Category: Pathology Authors: Koreishi, A. F., Saenz, A. J., Fleming, S. E., Teruya-Feldstein, J. Tags: Articles Source Type: journals

Merits of the PMiT (Papillary Microtumor) Terminology in the Definition of a Subset of Incidental Papillary Microcarcinomas of the ThyroidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An exponential increase in the detection of papillary thyroid microcarcinomas (PTMCs) has been observed in recent times, possibly because of recent improvements in the management of thyroid lesions and extensive histological examination. However, no definitive treatment guideline has been developed for PTMC, resulting in patients undergoing overtreatment. In 2003, the term papillary microtumor of the thyroid (PMiT) was proposed for small (≤1 cm) intrathyroidal tumors with excellent prognostic prospects along with strict definition criteria. Since then, the term PMiT has been adopted by clinicians and surgeons. In this a...
Source: International Journal of Surgical Pathology - September 22, 2009 Category: Pathology Authors: Asioli, S., Odasso, C., Macri, L., Palestini, N., Bussolati, G. Tags: Articles Source Type: journals

CDX2 Expression in Yolk Sac Component of Testicular Germ Cell TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the authors evaluated CDX2 expression in germ cell tumors (GCTs) by immunohistochemistry. Forty cases of testicular GCTs and 8 cases of metastatic GCTs were retrieved for study. In the 40 cases of testicular GCTs, 13 were pure seminomas and 27 mixed GCTs. Yolk sac tumor (YST) was identified by morphology and glypican 3 staining in 20 testicular mixed GCTs. Of these 20 cases, 8 cases showed 1+ positivity for CDX2. Other primitive components of GCTs were negative. For the 6 cases of metastatic mixed GCT with YST, 4 cases were positive, 2+ in 2 cases and 1+ in 2 cases. The positivity of CDX2 in GCTs warrants in...
Source: International Journal of Surgical Pathology - September 22, 2009 Category: Pathology Authors: Bing, Z., Pasha, T., Tomaszewski, J. E., Zhang, P. Tags: Articles Source Type: journals

Thyroid Transcription Factor-1 and "Basal Marker"--Expressing Small Cell Carcinoma of the BreastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This reported case is unique because of the characteristic morphological features and immunohistochemical profile. The invasive tumor demonstrated neuroendocrine differentiation morphologically and immunohistochemically, expressed by TTF-1, EGFR, and basal-type cytokeratins. An unequivocal in situ component was identified intimately admixed with the invasive carcinoma. To the authors’ knowledge, this is the first report of breast small cell carcinoma showing the expression of "basal markers." (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - September 22, 2009 Category: Pathology Authors: Ersahin, C., Bandyopadhyay, S., Bhargava, R. Tags: Articles Source Type: journals

Reduced p16 and Increased Cyclin D1 and pRb Expression Are Correlated With Progression in Cutaneous Melanocytic TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The immunohistochemical expression of cell cycle proteins p16, cyclin D1, and pRb was assessed in 112 benign and malignant melanocytic tumors and correlated with tumor progression, prognosis, and outcome. Comparing benign and malignant tumors, there were significant differences in the median score for all 3 proteins, with decreased p16 (P = .000001), increased cyclin D1 (P = .01), and increased pRb in melanomas (P = .01). There was a progressive loss of expression of p16 with progression from benign naevi to primary melanomas and to metastases. p16 was significantly decreased in primary tumors from melanoma patients who de...
Source: International Journal of Surgical Pathology - September 22, 2009 Category: Pathology Authors: Karim, R. Z., Li, W., Sanki, A., Colman, M. H., Yang, Y. H., Thompson, J. F., Scolyer, R. A. Tags: Articles Source Type: journals

Are Invasive Micropapillary Carcinomas of Breast Really Composed of Papillae?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - July 20, 2009 Category: Pathology Authors: Patriarca, C., Giunta, P. Tags: Article Source Type: journals

Langerhans Cell Sarcoma Involving Gallbladder and Peritoneal Lymph Nodes: A Case ReportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report also includes a review of the literature concerning this rare disease. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - July 20, 2009 Category: Pathology Authors: Gang Zhao, , Meng Luo, , Wu, Z.-Y., Qiang Liu, , Bin Zhang, , Gao, R.-L., Zhang, Z.-Q. Tags: Article Source Type: journals

Puppy in a Cyst: "I'm Trapped! Help Please!"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - July 20, 2009 Category: Pathology Authors: Coffin, R. R., Sidhu, J. S. Tags: Article Source Type: journals

"Dedifferentiated" Adrenal Cortical NeoplasmEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - July 20, 2009 Category: Pathology Authors: Trezzi, R., Poli, F., Fellegara, G. Tags: Article Source Type: journals

Colonic Adenoma With Squamous MetaplasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Squamous metaplasia arising within colon adenomas is a rare occurrence, with a 0.4% incidence noted predominantly in elderly males. A case of squamous metaplasia arising in a tubulovillous adenoma of the cecum, associated with adenocarcinoma, is described. Squamous metaplasia was immunoreactive for beta-catenin, but negative for cytokeratin 20, CDX2, p63, estrogen receptor, progesterone receptor, p16, and human papilloma virus. Squamous differentiation may serve as a precursor lesion for squamous neoplasia of the colorectum. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - July 20, 2009 Category: Pathology Authors: Pantanowitz, L. Tags: Article Source Type: journals

Collision Renal TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - July 20, 2009 Category: Pathology Authors: Vasuri, F., Fellegara, G. Tags: Article Source Type: journals

Pleomorphic Adenoma With Mucinous and Squamous Differentiation: A Mimicker of Mucoepidermoid CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pleomorphic adenoma with foci of squamous and mucinous differentiation can potentially be misdiagnosed as low-grade mucoepidermoid carcinoma. The circumscribed borders of the tumor, gradual merging of mucoepidermoid foci into areas typical of pleomorphic adenoma, and presence of keratinization are features against the latter diagnosis. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - July 20, 2009 Category: Pathology Authors: Guo, S.P., Cheuk, W., Chan, J. K. C. Tags: Article Source Type: journals

Immunohistochemical Expression of the Human Sodium/Iodide Symporter Distinguishes Malignant From Benign Gastric LesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. It seems that lack of hNIS can be useful in distinguishing foveolar hyperplasia from dysplastic glands. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - July 20, 2009 Category: Pathology Authors: Farnedi, A., Eusebi, L. H., Poli, F., Foschini, M. P. Tags: Article Source Type: journals

Diagnostic Accuracy and Prognostic Value of Core Biopsy in the Management of Breast Cancer: A Series of 542 PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Core biopsies allow diagnosis of invasive breast cancer with high accuracy. Levels of agreement have to be improved for the detection of DCIS and Her2/neu status. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - July 20, 2009 Category: Pathology Authors: Richter-Ehrenstein, C., Muller, S., Noske, A., Schneider, A. Tags: Article Source Type: journals

Review Article: Aneurysmal Bone Cysts of the JawsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aneurysmal bone cyst (ABC) is a osteolytic bone lesion that rarely involves the jaws. To date, a total of 92 cases of JABCs have been described in detail in English literature. They prevalently occur in the first 2 decades (72.8%) with slight female predilection. It affects the mandible more often (68.5%) with a predominant location in the mandibular ramus (31.3%) and its posterior regions (20.4%). A painless (54.7%) or painful (43.2%) bone swelling is the most frequent clinical sign. Radiologically 93.8% of the lesions present as a radiolucency; in 69.4% multilocular in appearance. 15.2% of JABCs were secondary in nature,...
Source: International Journal of Surgical Pathology - July 20, 2009 Category: Pathology Authors: Sun, Z.J., Sun, H.L., Yang, R.L., Zwahlen, R.A., Zhao, Y.F. Tags: Article Source Type: journals

Complementary Value of the Ki-67 Proliferation Index to the Oncotype DX Recurrence ScoreEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the relationship between the RS and the cell cycle—related antigen Ki-67 was assessed in 32 breast carcinomas and evaluated for a potential association. Comparison of the RS with tumor type, grade, and the Ki-67 proliferation index (PI) revealed an overall concordance. However, some tumors with a low RS revealed a surprisingly high Ki-67 PI. These cases may correspond to the 7% of low-risk RS carcinomas that recur. Therefore, the authors propose a combined evaluation of the RS and Ki-67 PI to identify tumors with high recurrence potential from the low-risk and intermediate-risk RS groups. (Source: Inte...
Source: International Journal of Surgical Pathology - July 20, 2009 Category: Pathology Authors: Gwin, K., Pinto, M., Tavassoli, F. A Tags: Article Source Type: journals

Microarray-based Gene Expression Profiling as a Clinical Tool for Breast Cancer Management: Are We There Yet?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breast cancer is a heterogeneous disease, encompassing several histological types and clinical behaviors. Current histopathological classification systems are based on descriptive entities with prognostic significance. Few prognostic and predictive markers beyond those offered by histopathological analysis are available. High-throughput molecular technologies are reshaping our understanding of breast cancer, of which microarray-based gene expression has received most attention. This method has been used to derive a molecular taxonomy for breast cancer, which has provided interesting insights into the biology of the disease...
Source: International Journal of Surgical Pathology - July 20, 2009 Category: Pathology Authors: Correa Geyer, F., Reis-Filho, J. S. Tags: Article Source Type: journals

Re: Acinic Cell Carcinoma of Salivary Gland with Massive Deposits of Globular AmyloidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 14, 2009 Category: Pathology Authors: Daneshbod, Y., Negahban, S., Khademi, B. Tags: Article Source Type: journals

Nutmeg LiverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 14, 2009 Category: Pathology Authors: Lasitschka, F., Warth, A. Tags: Article Source Type: journals

Single Thyroid Follicle Involved by Papillary Carcinoma: Partially Classic and Partially OncocyticEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 14, 2009 Category: Pathology Authors: Poli, F., Trezzi, R., Rosai, J. Tags: Article Source Type: journals

Sickle Cell DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 14, 2009 Category: Pathology Authors: Gheorghe, G., Rollins-Raval, M., Reyes-Mugica, M. Tags: Article Source Type: journals

"Giant" Solid Cell Rest of the Thyroid: A Hyperplastic Change?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 14, 2009 Category: Pathology Authors: Fellegara, G., Dorji, T., Bajineta, M. R., Rosai, J. Tags: Article Source Type: journals

Subepithelial Pelvic Hematoma (Antopol--Goldman Lesion) Simulating Renal Neoplasm: Report of a Case and Review of the LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the clinico-pathological features of a single case and a review of the literature. A 76-year-old man presented with flank pain and hematuria. Computed tomography showed a hypodense lesion of 6 cm at the left kidney with filling defect at pyelogram. The patient underwent nephroureterectomy for suspected neoplasm. Macroscopically, a mass of 6 cm was present impinging on the pelvi-caliceal system. Microscopically, the lesion was composed by hemorragic material with feature of an hematoma. A diffuse eosinophilic amorphous material suspicious for amyloid was observed among intra- and extraparenchymal vessels. The Cong...
Source: International Journal of Surgical Pathology - May 14, 2009 Category: Pathology Authors: Eccher, A., Brunelli, M., Gobbo, S., Ghimenton, C., Grosso, G., Iannucci, A., Dalla Palma, P., Menestrina, F., Martignoni, G. Tags: Article Source Type: journals

Dye-Containing Histiocytes in Frozen Section of Sentinel Lymph Node: A Potential Mimicker of CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 14, 2009 Category: Pathology Authors: Wu, L.-L., Cheuk, W., Poon, M., Chan, J. K. C. Tags: Article Source Type: journals

The Correlation of the World Health Organization Histologic Classification of Thymic Epithelial Tumors and Its Prognosis: A Clinicopathologic Study of 108 Patients From ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study retrospectively reviewed the clinicopathological features of thymic epithelial tumors in 108 patients, and evaluated World Health Organization (WHO) histologic classification of thymic tumors. Other prognostic factors, including age, gender, clinical stage, and completeness of tumor resection were also analyzed. Seven type A tumors, 19 type AB, 23 type B1, 19 type B2, 27 type B3, and 13 thymic carcinomas were studied. The 5-year and 10-year survival rates were 100% after resection of tumor types A and AB; 93% and 81% for B1; 83% and 70% for B2; and 43% and 33% for B3. The overall 5-year and 10-year survival rate...
Source: International Journal of Surgical Pathology - May 14, 2009 Category: Pathology Authors: Honglin Yin, , Jun Du, , Zhenfeng Lu, , Xia Jiao, , Jiandong Wang, , Xiaojun Zhou, Tags: Article Source Type: journals

Extrapleural Solitary Fibrous Tumor: A Clinicopathologic Study of 19 CasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study reports a series of 19 extrapleural solitary fibrous tumors. The patients included 6 men and 13 women with age ranging from 27 to 86 years. Three patients showed local recurrence. In 2 tumors, a diagnosis of malignancy was made. All of the tumors were strongly positive for CD34, and 3 of them expressed high levels of progesterone receptor. Solitary fibrous tumors are fairly rare, occurring in many parts of the body, and their behavior is unpredictable. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 14, 2009 Category: Pathology Authors: Insabato, L., Siano, M., Somma, A., Gentile, R., Santangelo, M., Pettinato, G. Tags: Article Source Type: journals

Tissue Eosinophilia and its Association with Tumoral Invasion of Oral CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigated if tumor-associated tissue eosinophilia (TATE) could be associated with the process of tissue invasion in oral squamous cell carcinomas (OSCCs) and its influence on patient's prognosis. Forty-three patients treated for OSCCs with or without lymph nodes involvement, at A. C. Camargo Cancer Hospital, Brazil, were selected for TATE analysis. Two degrees of tissue eosinophilia were established in OSCC: absent/mild and intense. The TATE was evaluated in relation to the clinicopathological features and prognostic value using 2 test and the Kaplan—Meier method. Most of the patients with OSCC in advan...
Source: International Journal of Surgical Pathology - May 14, 2009 Category: Pathology Authors: Tostes Oliveira, D., Tjioe, K. C., Assao, A., Sita Faustino, S. E., Lopes Carvalho, A., Landman, G., Kowalski, L. P. Tags: Article Source Type: journals

A Novel Method of Obtaining Prostate Tissue for Gene Expression ProfilingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gene expression profiling by DNA microarray analysis is a technique with great promise in cancer biology. The multifocality and heterogeneity of many prostate cancers makes the collection of adequate biological samples for such profiling particularly challenging. Current methods, such as laser capture microdissection, are not widely available and can have significant limitations. In this article, a novel method of prostatic sampling, which does not affect the histopathological assessment of the surgical specimen and provides adequate RNA yield for microarray analysis is described. This method is simple, inexpensive, easily...
Source: International Journal of Surgical Pathology - May 14, 2009 Category: Pathology Authors: Sooriakumaran, P., Henderson, A., Denham, P., Langley, S. EM. Tags: Article Source Type: journals

Diverticulosis and Diverticulitis of the AppendixEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Diverticulosis of the appendix is a relatively rare pathological finding. The majority are acquired pseudodiverticula. True congenital diverticula are very rare. Appendiceal diverticulosis is usually an incidental finding and clinically asymptomatic. When symptomatic, it is usually complicated by acute or chronic diverticulitis with or without acute appendicitis. It presents with atypical abdominal signs and symptoms, mostly in adult males. Appendiceal diverticulitis is a distinct entity with several clinical and pathological differences from acute appendicitis. It has a more rapid progression to perforation and a higher r...
Source: International Journal of Surgical Pathology - May 14, 2009 Category: Pathology Authors: AbdullGaffar, B. Tags: Article Source Type: journals

The Histology of Pulmonary Sarcoidosis: A Review with Particular Emphasis on Unusual and Underrecognized FeaturesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The pathologist is frequently involved in the diagnostic approach to the patient with suspected sarcoidosis. Although the histologic diagnosis is generally not difficult, atypical and underrecognized features may occasionally occur and may result in diagnostic problems. The authors review the histology of pulmonary sarcoidosis, focusing particularly on these unusual problematic findings. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 14, 2009 Category: Pathology Authors: Cavazza, A., Harari, S., Caminati, A., Barbareschi, M., Carbonelli, C., Spaggiari, L., Paci, M., Rossi, G. Tags: Article Source Type: journals

Review Article: A Reevaluation of the Clinical Significance of Histological Subtyping of Non--Small-Cell Lung Carcinoma: Diagnostic Algorithms in the Era of Personalized TreatmentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The classification of lung cancer has always been primarily based on the morphologic assessment of routinely stained histological sections, but this approach may be difficult or even unfeasible in cytological preparations or small biopsies. Moreover, the simplistic dichotomization between small-cell carcinoma and non-small cell carcinoma (NSCLC) should be overcome, as new drugs have been discovered that are effective in specific subtypes of lung cancer. A more accurate characterization of NSCLC, however, may be hard in carcinomas lacking clear-cut signs of differentiation. The incorporation into the diagnostic algorithm of...
Source: International Journal of Surgical Pathology - May 14, 2009 Category: Pathology Authors: Rossi, G., Pelosi, G., Graziano, P., Barbareschi, M., Papotti, M. Tags: Article Source Type: journals

Role of Polysomy 17 in Transitional Cell Carcinoma of the Bladder: Immunohistochemical Study of HER2/neu Expression and FISH Analysis of c-erbB-2 Gene and Chromosome 17Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigates the potential clinical significance of c-erbB-2 gene and chromosome 17 alterations by fluorescence in situ hybridization (FISH) analysis and HER2/neu overexpression by immunohistochemical staining in transitional cell carcinoma (TCC) of urinary bladder correlating the results with tumor stage and grade categories and with clinical behavior. Sixty-three cases of TCC retrieved from the files of 2 institutions were analyzed for chromosome 17 aberrations and c-erbB-2 amplification by FISH analysis and evaluated immunohistochemically for HER2/neu overexpression. Five tumors were G1, 29 intermediate grade...
Source: International Journal of Surgical Pathology - May 14, 2009 Category: Pathology Authors: Simonetti, S., Russo, R., Ciancia, G., Altieri, V., De Rosa, G., Insabato, L. Tags: Article Source Type: journals

RET/PTC Rearrangement Occurring in Primary Peritoneal CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
RET/PTC rearrangements are initiating events in the development of a significant proportion of papillary thyroid carcinomas. Activated RET/PTC mutations are thought to be restricted to thyroid disease, but this study proposes that these events may also occur in nonthyroid tumors. A total of 57 nonthyroid papillary tumors were examined for RET/PTC rearrangements using interphase fluorescence in situ hybridization, Taqman reverse transcriptase polymerase chain reaction, and immunohistochemistry. Taqman single nucleotide polymorphism detection was used to analyze for expression of mutated BRAF T1799A. In all, 20% (3/15) of pr...
Source: International Journal of Surgical Pathology - May 14, 2009 Category: Pathology Authors: Flavin, R., Jackl, G., Finn, S., Smyth, P., Ring, M., O'Regan, E., Cahill, S., Unger, K., Denning, K., Jinghuan Li, , Aherne, S., Tallini, G., Gaffney, E., O'Leary, J.J., Zitzelsberger, H., Sheils, O. Tags: Article Source Type: journals

Correlation Between Thymidylate Synthase Protein Expression and Gene Polymorphism with Clinicopathological Parameters in Colorectal CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
5-Fluorouracil (5-FU) represents the basis of chemotherapy for colorectal carcinoma, inhibiting thymidylate synthase (TS), an essential enzyme for DNA replication. Previous studies have associated high TS protein expression by tumor cells with poor outcome of patients with colorectal carcinoma, but others have refuted these findings. In view of the potential role of TS as predictive parameter and the lack of consensus in the literature, the present study compared 2 methods: protein expression and gene polymorphism, correlating them with clinicopathological findings. Immunohistochemical detection of TS in tumor cells and de...
Source: International Journal of Surgical Pathology - May 14, 2009 Category: Pathology Authors: Moreira, L. R., Almeida Schenka, A., Latuff Filho, P., Nascimento, H., Passos Lima, C. S., Silva Trevisan, M. A., Vassallo, J. Tags: Article Source Type: journals

Micropapillary-Type Invasion in Low-Grade Mammary CarcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 18, 2009 Category: Pathology Authors: Zamecnik, M. Tags: Article Source Type: journals

Multilocular Cystic Nephroma and Multicystic Clear Cell Carcinoma: Two Faces of the Roman God Janus?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 18, 2009 Category: Pathology Authors: Stamatiou, K. N., Sofras, F. Tags: Article Source Type: journals

Heavily Pigmented Renal Cell Carcinoma: A Case Report, With Review of the Literature and Differential DiagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clear cell carcinoma is the most common histotype among renal cell tumors. The prominent vascular network of sinusoidal vessels lined by delicate endothelial cells may often lead to hemorrhagic areas with secondary deposition of chunky birefringent hemosiderin granules. The finding of pigmentation other than iron, and in particular melanin deposits, in renal tumors is a rare occurrence that should lead to differential diagnosis with other primary and metastatic tumors of the kidney. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 18, 2009 Category: Pathology Authors: Rossi, G., Cadioli, A., Costantini, M., Grazia Del Buono, M., Oleari, G. Tags: Article Source Type: journals

Plasmablastic Lymphoma Affecting the Lung and Bone Marrow With CD10 Expression and t(8;14)(q24;q32) TranslocationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we document a rare instance in which this neoplasm besides affecting the bone marrow also involved the lung. In addition, the lymphoma in our case disclosed CD10 positivity on immunohistochemistry and t(8;14)(q24;q34) translocation on cytogenetic analysis, mimicking a Burkitt/atypical Burkitt lymphoma. The problems in diagnosis are discussed. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 18, 2009 Category: Pathology Authors: Khoon Leong Chuah, , Siok Bian Ng, , Poon, L., Wai Ming Yap, Tags: Article Source Type: journals

A Case of Liver Metastasis From an Oncocytoma With a Focal Area of Chromophobe Renal Cell Carcinoma: A Wolf in Sheep's ClothingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In 2004, the World Health Organization classified the renal oncocytomas as benign neoplasms of the kidney. There are reports of subtypes of renal tumors, with similar histological morphology to oncocytoma, but with malignant potential, one of these tumors is the eosinophilic variant of chromophobe renal cell carcinoma. It is important to characterize the histological features and the subtype of tumor, as this predicts biological behavior and cancer-specific survival rate. A rare case of a liver metastasis from a focal area of eosinophilic variant of chromophobe renal cell carcinoma mixed in oncocytoma in a 69-year-old woma...
Source: International Journal of Surgical Pathology - March 18, 2009 Category: Pathology Authors: Aslam, M. I., Spencer, L., Garcea, G., Pollard, C., Metcalfe, M. S., Harrison, R. F., Dennison, A. R. Tags: Article Source Type: journals

Pigmented Oral Squamous Cell Carcinoma: A Case Report and Brief Review of the LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Melanin impregnation in squamous cell carcinoma (SCC) is an uncommon histological finding. Rare nonmelanocytic entities were previously described as having melanocyte colonization. A 57-year-old Brazilian woman was referred with a pigmented lesion in the lower lip and alveolar ridge with a prior clinical diagnosis of melanoma. The incisional biopsy of the tumor revealed an SCC with strong colonization of melanocytes in the stroma. The authors report a case of an unusual SCC variant and a brief review of the literature. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 18, 2009 Category: Pathology Authors: Lisboa Castro, J., Cazal, C., Gomes Henriques, A. C., Carneiro Leao, J., de Vasconcelos Carvalho, M., de Carvalho Dourado, H. T., Carvalho, A. A. T. Tags: Article Source Type: journals

Myxoid Epithelioid Sarcoma: Clinicopathologic Analysis of 2 CasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the nearly 4 decades since its original delineation as a distinct clinicopathologic entity, several morphologic variations of epithelioid sarcoma have been described. Proximal, angiomatoid, and fibroma-like variants have been reported, as have cases displaying significant hyalinization, calcification, and/or ossification. Furthermore, it has long been recognized that epithelioid sarcoma may display focal myxoid change. Herein, the authors describe 2 examples of epithelioid sarcoma that displayed diffuse myxoid change. Both cases were otherwise typical, both morphologically and immunophenotypically, of epithelioid sarcom...
Source: International Journal of Surgical Pathology - March 18, 2009 Category: Pathology Authors: Fadare, O. Tags: Article Source Type: journals

Art Exemplified in PathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 18, 2009 Category: Pathology Authors: Coyne, J. D., Whooley, B. Tags: Article Source Type: journals

Even the Bone Smiles!Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 18, 2009 Category: Pathology Authors: Arena, V., Vita, G., Siciliano, P., Capelli, A. Tags: Article Source Type: journals

Multifocal Sclerosing ThyroiditisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 18, 2009 Category: Pathology Authors: Poli, F., Trezzi, R., Fellegara, G., Rosai, J. Tags: Article Source Type: journals