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The Porcine Retinal Vasculature Accessed Using an Endovascular Approach: A New Experimental Model for Retinal Ischemia [Visual Psychophysics and Physiological Optics]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study establishes a unique technique for transfemoral endovascular catheterization of the retinal circulation. The technique may be useful to produce clear-cut experimental retinal ischemia. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Moren, H., Undren, P., Gesslein, B., Olivecrona, G. K., Andreasson, S., Malmsjo, M. Tags: Visual Psychophysics and Physiological Optics Source Type: journals

Oxidative Stress-Mediated Induction of MMP-1 and MMP-3 in Human RPE Cells [Retinal Cell Biology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study provides evidence that MMP-1 and MMP-3 in the RPE are highly inducible by oxidative stress leading to increased degradation of type I collagen, a main component of Bruch's membrane. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Alge-Priglinger, C. S., Kreutzer, T., Obholzer, K., Wolf, A., Mempel, M., Kernt, M., Kampik, A., Priglinger, S. G. Tags: Retinal Cell Biology Source Type: journals

Dual Role of Intravitreous Infliximab in Experimental Choroidal Neovascularization: Effect on the Expression of Sulfated Glycosaminoglycans [Retinal Cell Biology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In low doses infliximab reduces angiogenesis and glycosaminoglycan expression, whereas in high doses opposite effects were observed. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Regatieri, C. V., Dreyfuss, J. L., Melo, G. B., Lavinsky, D., Farah, M. E., Nader, H. B. Tags: Retinal Cell Biology Source Type: journals

The Role of PGE2 Receptor EP4 in Pathologic Ocular Angiogenesis [Retinal Cell Biology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Based on its in vitro and in vivo efficacy profile, the PGE2 receptor EP4 shows significant promise as an angiostatic therapy for neovascular diseases of the eye. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Yanni, S. E., Barnett, J. M., Clark, M. L., Penn, J. S. Tags: Retinal Cell Biology Source Type: journals

Thrombospondin-1-Mediated Regulation of Microglia Activation after Retinal Injury [Retinal Cell Biology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Microglia are capable of producing detrimental proinflammatory factors as well as regenerative neurotrophic factors. Factors that regulate these distinct functional phenotypes of microglia still remain unclear. In this paper, the authors introduce thrombospondin-1 as a potential regulator of microglia activation. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Ng, T. F., Turpie, B., Masli, S. Tags: Retinal Cell Biology Source Type: journals

Retrograde Intraflagellar Transport by Cytoplasmic Dynein-2 Is Required for Outer Segment Extension in Vertebrate Photoreceptors but Not Arrestin Translocation [Retinal Cell Biology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The role of active retrograde intraflagellar transport remains unexplored in vertebrate photoreceptors. Morpholino knockdown of cytoplasmic dynein-2 in zebrafish resulted in defects in photoreceptor connecting cilia and outer segments as well as reduced ERG light responses. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Krock, B. L., Mills-Henry, I., Perkins, B. D. Tags: Retinal Cell Biology Source Type: journals

Secondary Retinal Ganglion Cell Death and the Neuroprotective Effects of the Calcium Channel Blocker Lomerizine [Retinal Cell Biology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors define the nature and location of secondary retinal ganglion cell death after partial transection of the optic nerve. They also demonstrate that with time the CNS-specific calcium channel blocker lomerizine had differential neuroprotective effects on necrotic and apoptotic death. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Fitzgerald, M., Payne, S. C., Bartlett, C. A., Evill, L., Harvey, A. R., Dunlop, S. A. Tags: Retinal Cell Biology Source Type: journals

Phenotype-Associated Changes in Retinal Pigment Epithelial Cell Expression of Insulin-Like Growth Factor Binding Proteins [Retinal Cell Biology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Changes in RPE phenotype are accompanied by dramatic changes in insulin-like growth factor binding protein (IGFBP) expression profile. IGFBP-5 appears to be the predominant binding protein expressed by myofibroblastic RPE cells. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Mukherjee, S., King, J. L., Guidry, C. Tags: Retinal Cell Biology Source Type: journals

Abnormal Retinal Vascular Oxygen Tension Response to Light Flicker in Diabetic Rats [Retina]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors found that diabetic rats lack the flicker-induced increase in arterial Po2 and oxygen saturation and also the arterial-venous difference in Po2 and oxygen saturation observed in normal rats. The best explanation appears to be that diabetes impairs the increase in oxygen consumption normally provoked by light flicker. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Blair, N. P., Wanek, J. M., Mori, M., Shahidi, M. Tags: Retina Source Type: journals

Limited Roles of Rdh8, Rdh12, and Abca4 in all-trans-Retinal Clearance in Mouse Retina [Retina]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study also provides new evidence that all-trans-retinal's condensation products, including A2E and RALdi, are surrogate markers for delayed clearance of all-trans-retinal. The results of this study support the hypothesis that all-trans-retinal is a key contributor to retinal degeneration induced by light. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Maeda, A., Golczak, M., Maeda, T., Palczewski, K. Tags: Retina Source Type: journals

Topographic Arrangement of S-cone Photoreceptors in the Retina of the Diurnal Nile Grass Rat (Arvicanthis niloticus) [Retina]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The results regarding the organization of the cone photoreceptors in the retina of the diurnal rodent A. niloticus show for the first time that this retina represents a highly pertinent model that will improve understanding of the pathologic course of and related therapy for retinal diseases involving cones. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Gaillard, F., Kuny, S., Sauve, Y. Tags: Retina Source Type: journals

Infection of Human Retinal Pigment Epithelial Cells with Influenza A Viruses [Retina]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, influenza A virus replication was studied for the first time in a relevant cell type derived from the retina (primary human retinal pigment epithelial cells), and the results indicate that H5N1 viruses have a greater potential to replicate in these cells than seasonal H3N2 or H1N1 influenza A viruses. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Michaelis, M., Geiler, J., Klassert, D., Doerr, H. W., Cinatl, J. Tags: Retina Source Type: journals

CD73, a Novel Cell Surface Antigen That Characterizes Retinal Photoreceptor Precursor Cells [Retina]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CD73 was found to mark cone/rod common precursors and mature rod cells in mice, and mature rod cells in marmoset. It provides a useful tool to purify photoreceptor cells for transplantation aimed at the regeneration of photoreceptors. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Koso, H., Minami, C., Tabata, Y., Inoue, M., Sasaki, E., Satoh, S., Watanabe, S. Tags: Retina Source Type: journals

Interobserver Agreement for the Detection of Optical Coherence Tomography Features of Neovascular Age-Related Macular Degeneration [Retina]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study reports the interobserver agreement for OCT features of neovascular AMD in a clinical setting. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Patel, P. J., Browning, A. C., Chen, F. K., Cruz, L. D., Tufail, A. Tags: Retina Source Type: journals

Strain-Dependent Increases in Retinal Inflammatory Proteins and Photoreceptor FGF-2 Expression in Streptozotocin-Induced Diabetic Rats [Retina]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The present study compares the expression of more than 50 inflammatory molecules and growth factors in the retina of diabetic rats of three different strains. The results indicate a highly strain-dependent response, with inflammatory changes in Sprague-Dawley, but not in Long-Evans or Brown Norway, rats. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Kirwin, S. J., Kanaly, S. T., Linke, N. A., Edelman, J. L. Tags: Retina Source Type: journals

Inhibition of Pathologic Retinal Neovascularization by a Small Peptide Derived from Human Apolipoprotein(a) [Retina]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the present research, the authors evaluated the inhibitory effect of KV11, a novel small peptide against pathologic retinal neovascularization and its penetration properties and possible toxicity to the retina. It is hoped that the findings of this study will support the potential use of peptides as agents for treatment of neovascular eye disorders. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Zhao, H., Jin, H., Li, Q., Gu, Q., Zheng, Z., Wu, H., Ye, S., Sun, X., Xu, X., Ho, P. C. P. Tags: Retina Source Type: journals

Null Retinoschisin-Protein Expression from an RS1 c354del1-ins18 Mutation Causing Progressive and Severe XLRS in a Cross-Sectional Family Study [Retina]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The c354del1-ins18 mutation causes an RS1-null biochemical phenotype and gives a progressive clinical phenotype leading to macular atrophy and marked ERG changes. The phenotypic heterogeneity of this mutation with age argues that XLRS is not a stationary disease and raises questions regarding factors involved in progression. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Vijayasarathy, C., Ziccardi, L., Zeng, Y., Smaoui, N., Caruso, R. C., Sieving, P. A. Tags: Retina Source Type: journals

Cellular and Vascular Changes in the Retina of Neonatal Rats after an Acute Exposure to Hypoxia [Retina]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study describes the changes in neurons and Müller cells of the neonatal retina in response to exposure to hypoxia. The vascular permeability and the therapeutic potential of melatonin in reversing the hypoxic damage were also investigated. Literature on the effects of primary hypoxia on the structure of the developing neonatal retina is scanty. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Kaur, C., Sivakumar, V., Foulds, W. S., Luu, C. D., Ling, E.-A. Tags: Retina Source Type: journals

CREB1/ATF1 Activation in Photoreceptor Degeneration and Protection [Retina]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The CREB1/ATF1 pathway is activated in canine and human rods and cones undergoing degeneration. The pathway is also activated by exposure to the neuroprotective agent CNTF. These data suggest that CREB1/ATF1 contributes to an innate protective response and is of potential therapeutic value in the treatment of RP and AMD. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Beltran, W. A., Allore, H. G., Johnson, E., Towle, V., Tao, W., Acland, G. M., Aguirre, G. D., Zeiss, C. J. Tags: Retina Source Type: journals

The Effect of Ambient Illuminance on the Development of Deprivation Myopia in Chicks [Physiology and Pharmacology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study describes the ability of high light levels to retard the development of form-deprivation myopia in chickens and supports the hypothesis of recent epidemiologic studies that time spent outdoors can protect against the development of school-age myopia. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Ashby, R., Ohlendorf, A., Schaeffel, F. Tags: Physiology and Pharmacology Source Type: journals

Synthetic Triterpenoids Attenuate Cytotoxic Retinal Injury: Cross-talk between Nrf2 and PI3K/AKT Signaling through Inhibition of the Lipid Phosphatase PTEN [Physiology and Pharmacology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The triterpenoid derivatives CDDO-Im, CDDO-EA, and CDDO-TFEA are potent activators of Nrf2 signaling and confer cytoprotection from oxidant-induced cell death. One mechanism of triterpenoid-mediated cytoprotection involves inhibition of the lipid phosphatase PTEN. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Pitha-Rowe, I., Liby, K., Royce, D., Sporn, M. Tags: Physiology and Pharmacology Source Type: journals

The Mydriatic Effect of Intracameral Epinine Hydrochloride [Physiology and Pharmacology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epinine was a more potent intracameral mydriatic than phenylephrine in this porcine eye model, and is a promising candidate substance for intraoperative intracameral use in humans. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Lundberg, B., Behndig, A. Tags: Physiology and Pharmacology Source Type: journals

Intravitreal Infliximab Clearance in a Rabbit Model: Different Sampling Methods and Assay Techniques [Physiology and Pharmacology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This work characterizes the clearance of intravitreal infliximab with the use of different immunoassay techniques and sampling methods. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Giansanti, F., Ramazzotti, M., Giuntoli, M., Virgili, G., Vannozzi, L., Degl'Innocenti, D., Menchini, U. Tags: Physiology and Pharmacology Source Type: journals

TGF{beta}/Smad4-Dependent and -Independent Regulation of Human Lens Epithelial Cells [Lens]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Elucidating the role of Smad-dependent and -independent TGFβ signaling will advance the understanding of fibrotic disorders including posterior capsule opacification following cataract surgery. In the current study, the authors show that Smad4 is critical in cell transdifferentiation, but is not essential for TGFβ2-induced matrix contraction. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Dawes, L. J., Sleeman, M. A., Anderson, I. K., Reddan, J. R., Wormstone, I. M. Tags: Lens Source Type: journals

Tumor Necrosis Factor-{alpha} in Ocular Mucous Membrane Pemphigoid and Its Effect on Conjunctival Fibroblasts [Immunology and Microbiology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This paper shows that TNF is expressed in the conjunctiva in mucous membrane pemphigoid and may play a profibrotic role in this disease. These findings are important, in that they provide a scientific rationale for using systemic TNF antagonists in recalcitrant disease and also indicate a potential role for TNF antagonists in antifibrosistherapy. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Saw, V. P. J., Dart, R. J. C., Galatowicz, G., Daniels, J. T., Dart, J. K. G., Calder, V. L. Tags: Immunology and Microbiology Source Type: journals

Increased Vitronectin Production by Complement-Stimulated Human Retinal Pigment Epithelial Cells [Immunology and Microbiology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This experimental work shows that RPE cells produce vitronectin in an enhanced amount after stimulation with human complement serum. This may explain how complement activation can contribute to AMD. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Wasmuth, S., Lueck, K., Baehler, H., Lommatzsch, A., Pauleikhoff, D. Tags: Immunology and Microbiology Source Type: journals

Effects of an Antagonist of the Gastrin-Releasing Peptide Receptor in an Animal Model of Uveitis [Immunology and Microbiology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors demonstrated that gastrin-releasing peptide plays a pivotal role in acute ocular inflammation, thus making it a target for therapeutic applications. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Pereira, D. V., Steckert, A. V., Mina, F., Petronilho, F., Roesler, R., Schwartsmann, G., Ritter, C., Dal-Pizzol, F. Tags: Immunology and Microbiology Source Type: journals

The In Vitro and In Vivo Evaluation of ddC as a Topical Antiviral for Ocular Adenovirus Infections [Immunology and Microbiology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
2',3'-Dideoxycytidine (ddC) represents a new candidate antiviral for the treatment of adenoviral ocular infections. The goals of the present study were to evaluate the in vitro and in vivo efficacy of ddC against adenovirus. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Romanowski, E. G., Yates, K. A., Gordon, Y. J. Tags: Immunology and Microbiology Source Type: journals

Anterior Chamber Angle Opening during Corneoscleral Indentation: The Mechanism of Whole Eye Globe Deformation and the Importance of the Limbus [Glaucoma]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The mechanism by which the anterior chamber angle changes during corneoscleral indentation is studied in a computational model. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Amini, R., Barocas, V. H. Tags: Glaucoma Source Type: journals

Confocal Scanning Laser Ophthalmoscopy in High Myopic Eyes in a Population-Based Setting [Glaucoma]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The discs in high myopia are more oval with smaller cups and higher rim and retinal nerve fiber layer parameters measured by HRT II compared with those in age-matched emmetropic eyes in a populationbased study. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Tsutsumi, T., Tomidokoro, A., Saito, H., Hashizume, A., Iwase, A., Araie, M. Tags: Glaucoma Source Type: journals

Major Genetic Effects in Glaucoma: Commingling Analysis of Optic Disc Parameters in an Older Australian Population [Glaucoma]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Findings from this study are consistent with the presence of a major gene in the determination of vertical cup-to-disc ratio. The results suggest methods of optimizing strategies for gene-finding studies in glaucoma. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: van Koolwijk, L. M. E., Healey, P. R., Hitchings, R. A., Mitchell, P., Sham, P. C., McGuffin, P., Viswanathan, A. C. Tags: Glaucoma Source Type: journals

Twenty-four Hour Ocular Perfusion Pressure Fluctuation and Risk of Normal-Tension Glaucoma Progression [Glaucoma]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ocular perfusion pressure fluctuation was associated with visual field progression in our series of medically treated eyes with normal-tension glaucoma. This finding may suggest a chronic ischemic role in glaucoma progression. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Sung, K. R., Lee, S., Park, S. B., Choi, J., Kim, S. T., Yun, S.-C., Kang, S. Y., Cho, J. W., Kook, M. S. Tags: Glaucoma Source Type: journals

Effect of Bimatoprost, Latanoprost, and Unoprostone on Matrix Metalloproteinases and Their Inhibitors in Human Ciliary Body Smooth Muscle Cells [Glaucoma]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
With the prostaglandin analogues bimatoprost, latanoprost, and unoprostone, the MMP/TIMP balance in ciliary body smooth muscle cells correlates to their observed clinical effectiveness in lowering intraocular pressure. The results in this study indicate that a differential effect on TIMPs may relate to the different clinical effectiveness of unoprostone. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Ooi, Y. H., Oh, D.-J., Rhee, D. J. Tags: Glaucoma Source Type: journals

Sensitivity of Ocular Anterior Chamber Tissues to Oxidative Damage and Its Relevance to the Pathogenesis of Glaucoma [Glaucoma]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study evaluates the susceptibility to oxidative stress of anterior chamber components providing evidence that trabecular meshwork is the most sensitive tissue. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Izzotti, A., Sacca, S. C., Longobardi, M., Cartiglia, C. Tags: Glaucoma Source Type: journals

Glaucoma Filtration Surgery and Retinal Oxygen Saturation [Glaucoma]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Small changes were observed in retinal vessel oxygen saturation after glaucoma filtration surgery. These changes may indicate increased oxygen delivery if increased blood flow is assumed. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Hardarson, S. H., Gottfredsdottir, M. S., Halldorsson, G. H., Karlsson, R. A., Benediktsson, J. A., Eysteinsson, T., Beach, J. M., Harris, A., Stefansson, E. Tags: Glaucoma Source Type: journals

The Relationship between Retinal Ganglion Cell Axon Constituents and Retinal Nerve Fiber Layer Birefringence in the Primate [Glaucoma]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study presents results that support the hypothesis that retinal ganglion cell axon neurotubules are the primary source of birefringence in the retinal nerve fiber layer of the primate. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Pocock, G. M., Aranibar, R. G., Kemp, N. J., Specht, C. S., Markey, M. K., Rylander, H. G. Tags: Glaucoma Source Type: journals

Scleral Biomechanics in the Aging Monkey Eye [Glaucoma]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Using newly developed experimental and computational methods, the authors report significant age-related changes in the nonlinear, anisotropic, inhomogeneous biomechanical properties of monkey posterior sclera and discuss their relevance to glaucoma. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Girard, M. J. A., Suh, J.-K. F., Bottlang, M., Burgoyne, C. F., Downs, J. C. Tags: Glaucoma Source Type: journals

Inhibition of Vascular Endothelial Growth Factor Reduces Scar Formation after Glaucoma Filtration Surgery [Glaucoma]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This paper sheds new light on the role of VEGF in scar formation after trabeculectomy. It also demonstrates possible treatment effects targeting VEGF in glaucoma filtration surgery in a rabbit model. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Li, Z., Van Bergen, T., Van de Veire, S., Van de Vel, I., Moreau, H., Dewerchin, M., Maudgal, P. C., Zeyen, T., Spileers, W., Moons, L., Stalmans, I. Tags: Glaucoma Source Type: journals

Synergistic Divergence: A Distinct Ocular Motility Dysinnervation Pattern [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Synergistic divergence is a distinct congenital strabismus pattern in which the affected eye abducts when it should adduct. It is probably due to denervation of the medial rectus associated with dysinnervation of the ispilateral lateral rectus, and it is not always due to currently recognized genetic causes of congenital strabismus. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Oystreck, D. T., Khan, A. O., Vila-Coro, A. A., Oworu, O., Al-Tassan, N., Chan, W.-M., Engle, E. C., Bosley, T. M. Tags: Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: journals

Impaired Temporal, Not Just Spatial, Resolution in Amblyopia [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The results show that amblyopia strongly deteriorates temporal precision of visual perception for specific tasks, not just spatial vision. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Spang, K., Fahle, M. Tags: Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: journals

The Prevalence of Nystagmus: The Leicestershire Nystagmus Survey [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The prevalence of nystagmus within the general population is unknown. This paper provides an epidemiological study into the prevalence and clinical spectrum of nystagmus within a specific population. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Sarvananthan, N., Surendran, M., Roberts, E. O., Jain, S., Thomas, S., Shah, N., Proudlock, F. A., Thompson, J. R., McLean, R. J., Degg, C., Woodruff, G., Gottlob, I. Tags: Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: journals

Follow-up of Mild Papilledema in Idiopathic Intracranial Hypertension with Optical Coherence Tomography [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Peripapillary RNFL thickness abnormalities assessed by OCT in patients with mild papilledema were quantitatively correlated with visual field sensitivity losses. OCT could be useful for monitoring retinal nerve fiber layer loss in mild papilledema. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Rebolleda, G., Munoz-Negrete, F. J. Tags: Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: journals

Local Deformation of Extraocular Muscles during Eye Movement [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Motion-encoded MRI, a noninvasive imaging technique, was used to show the contraction and elongation of horizontal extraocular muscles while the eye was moving. For a more detailed understanding of extraocular muscle physiology, deformation profiles of healthy subjects and two patients with Duane's syndrome type I are provided. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Piccirelli, M., Luechinger, R., Sturm, V., Boesiger, P., Landau, K., Bergamin, O. Tags: Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: journals

Blocking Mast Cell-Mediated Type I Hypersensitivity in Experimental Allergic Conjunctivitis by Monocyte Chemoattractant Protein-1/CCR2 [Cornea]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stimulation of the co-stimulatory axis of CCR2 by MCP-1 is required for mast cell–mediated experimental allergic conjunctivitis. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Tominaga, T., Miyazaki, D., Sasaki, S.-i., Mihara, S., Komatsu, N., Yakura, K., Inoue, Y. Tags: Cornea Source Type: journals

Pigment Epithelium-Derived Factor (PEDF) Attenuated Capsaicin-Induced Neurotrophic Keratouveitis [Cornea]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This experimental study showed neuroprotective and antiangiogenic effect of PEDF in capsaicin-induced keratouveitis. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Feher, J., Kovacs, I., Pacella, E., Keresz, S., Spagnardi, N., Balacco Gabrieli, C. Tags: Cornea Source Type: journals

Comparison of the Histology, Gene Expression Profile, and Phenotype of Cultured Human Limbal Epithelial Cells from Different Limbal Regions [Cornea]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is the first to compare the histology, gene expression profile, and phenotype of cultured limbal epithelial cells from different limbal regions. Explants of superior origin demonstrated the highest outgrowth success rate and generated epithelia with greater thickness and number of cell layers, which may prove beneficial for transplantation purposes. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Utheim, T. P., Raeder, S., Olstad, O. K., Utheim, O. A., de La Paz, M., Cheng, R., Huynh, T. T., Messelt, E., Roald, B., Lyberg, T. Tags: Cornea Source Type: journals

3D Collagen Orientation Study of the Human Cornea Using X-ray Diffraction and Femtosecond Laser Technology [Cornea]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
X-ray scattering was used to determine the predominant orientation and distribution of collagen at different tissue depths throughout the entire human cornea. This information will help improve understanding of the biomechanical properties of the cornea. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Abahussin, M., Hayes, S., Knox Cartwright, N. E., Kamma-Lorger, C. S., Khan, Y., Marshall, J., Meek, K. M. Tags: Cornea Source Type: journals

Corneal Subbasal Nerves Changes in Patients with Diabetic Retinopathy: An In Vivo Confocal Study [Cornea]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This is the first study to show, by means of laser confocal microscopy, morphologic changes in the subbasal nerves plexus in diabetic patients after panretinal photocoagulation. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Cilla, S. D., Ranno, S., Carini, E., Fogagnolo, P., Ceresara, G., Orzalesi, N., Rossetti, L. M. Tags: Cornea Source Type: journals

A Quantitative Ultrasonic Spectroscopy Method for Noninvasive Determination of Corneal Biomechanical Properties [Cornea]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel ultrasound method for noninvasive measurement of the biomechanical properties of the cornea was validated in this study. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: He, X., Liu, J. Tags: Cornea Source Type: journals

Driving with Hemianopia, I: Detection Performance in a Driving Simulator [Clinical and Epidemiologic Research]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Within the controlled environment of a driving simulator, blind-side detection rates of drivers with hemianopia were found to range from 6% to 100% on a realistic pedestrian-detection task. Most of the participants showed poor compensation for their hemifield loss and had detection rates that seem incompatible with safe driving. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Bowers, A. R., Mandel, A. J., Goldstein, R. B., Peli, E. Tags: Clinical and Epidemiologic Research Source Type: journals