The Effect of AMA0428, a Novel and Potent ROCK Inhibitor, in a Model of Neovascular Age-Related Macular Degeneration [Retina]
Conclusions.
The results suggest that targeting ROCK with AMA0428 not only reduces neoangiogenesis, but also blocks inflammation and fibrosis (contrary to VEGF suppression). These results point to a potential therapeutic benefit of ROCK inhibition in neovascular AMD. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 27, 2015 Category: Opthalmology Authors: Hollanders, K., Van Bergen, T., Kindt, N., Castermans, K., Leysen, D., Vandewalle, E., Moons, L., Stalmans, I. Tags: Retina Source Type: research
Retinal Ganglion Cells Thinning in Eyes With Nonproliferative Idiopathic Macular Telangiectasia Type 2A [Retina]
Conclusions.
Our study demonstrated that in eyes with nonproliferative MacTel type 2A there was significant and consistent RGCs degeneration, leading to diffuse thinning of RGCs' dendrites, cell bodies, and axons. These findings are suggestive of neurodegeneration in MacTel type 2A. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 25, 2015 Category: Opthalmology Authors: Chhablani, J., Rao, H. B., Begum, V. U., Jonnadulla, G. B., Goud, A., Barteselli, G. Tags: Retina Source Type: research
Near Heterophoria in Early Childhood [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]
Conclusions.
Despite developmental maturation of interpupillary distance, refractive error, and AC/A, in a typical sample of young children the predominant dissociated position is one of exophoria. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 25, 2015 Category: Opthalmology Authors: Babinsky, E., Sreenivasan, V., Candy, T. R. Tags: Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: research
Temperature Oscillations Drive Cycles in the Activity of MMP-2,9 Secreted by a Human Trabecular Meshwork Cell Line [Physiology and Pharmacology]
Conclusions.
Physiologically relevant temperature oscillations drive fluctuations of secreted MMP-2 and MMP-9 activity in hTM5 cells independent of peripheral clock genes and temperature-sensitive TRP channels. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 25, 2015 Category: Opthalmology Authors: Li, S. K.-l., Banerjee, J., Jang, C., Sehgal, A., Stone, R. A., Civan, M. M. Tags: Physiology and Pharmacology Source Type: research
Small Fiber Peripheral Neuropathy in Wilson Disease: An In Vivo Documentation by Corneal Confocal Microscopy [Multidisciplinary Ophthalmic Imaging]
Conclusions.
The CCM showed significant corneal changes in SBNP, with concomitant corneal epithelium changes in WD, demonstrating the presence of small fiber peripheral neuropathy in these patients. The CCM may contribute to diagnosis and monitoring of the peripheral nervous system involvement in WD. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 25, 2015 Category: Opthalmology Authors: Sturniolo, G. C., Lazzarini, D., Bartolo, O., Berton, M., Leonardi, A., Fregona, I. A., Parrozzani, R., Midena, E. Tags: Multidisciplinary Ophthalmic Imaging Source Type: research
Author Response: Postnatal Overexpression of the Human ARMS2 Gene Does Not Induce Abnormalities in Retina and Choroid in Transgenic Mouse Models [Letters]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 25, 2015 Category: Opthalmology Authors: Iwata, T. Tags: Letters Source Type: research
Postnatal Overexpression of the Human ARMS2 Gene Does Not Induce Abnormalities in Retina and Choroid in Transgenic Mouse Models [Letters]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 25, 2015 Category: Opthalmology Authors: Liu, J., Hoh, J. Tags: Letters Source Type: research
Identification of p58IPK as a Novel Neuroprotective Factor for Retinal Neurons [Retinal Cell Biology]
Conclusions.
Our study has demonstrated a protective role of p58IPK in retinal neurons, which may act in part through a mechanism involving modulation of ER homeostasis and apoptosis, particularly under conditions of cellular stresses. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 25, 2015 Category: Opthalmology Authors: Boriushkin, E., Wang, J. J., Li, J., Jing, G., Seigel, G. M., Zhang, S. X. Tags: Retinal Cell Biology Source Type: research
Voriconazole, an Antifungal Triazol That Causes Visual Side Effects, Is an Inhibitor of TRPM1 and TRPM3 Channels [Visual Neuroscience]
Conclusions.
The visual disturbances associated with voriconazole are likely due to block of TRPM1 channels in retinal ON-bipolar cells. Other neurological effects of voriconazole may be due to block of TRPM3 channels expressed in the brain. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 25, 2015 Category: Opthalmology Authors: Xiong, W.-H., Brown, R. L., Reed, B., Burke, N. S., Duvoisin, R. M., Morgans, C. W. Tags: Visual Neuroscience Source Type: research
Intravitreal Delivery of Human NgR-Fc Decoy Protein Regenerates Axons After Optic Nerve Crush and Protects Ganglion Cells in Glaucoma Models [Glaucoma]
Conclusions.
Human NgR1(310)-Fc has favorable pharmacokinetics in the vitreal space and rescues large diameter RGC counts from increased IOP. Thus, the NgR1 blocking decoy protein may have efficacy as a disease-modifying therapy for glaucoma. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 23, 2015 Category: Opthalmology Authors: Wang, X., Lin, J., Arzeno, A., Choi, J. Y., Boccio, J., Frieden, E., Bhargava, A., Maynard, G., Tsai, J. C., Strittmatter, S. M. Tags: Glaucoma Source Type: research
The Role of B Cells in the Early Onset of the First Demyelinating Event of Acute Optic Neuritis [Visual Neuroscience]
Conclusions.
Our findings demonstrate that CD19+ B cells have a significant role in the pathogenesis of the first demyelinating event of acute ON and suggest their role as a possible target for immunomodulation. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 23, 2015 Category: Opthalmology Authors: Feldman, A., Gurevich, M., Huna-Baron, R., Achiron, A. Tags: Visual Neuroscience Source Type: research
Retinal Adaptation Abnormalities in Primary Open-Angle Glaucoma [Visual Psychophysics and Physiological Optics]
Conclusions.
Neural adaptation is weaker in glaucoma patients for all three classes of RGCs. Since adaptation abnormalities are manifested even at retinal locations not exhibiting a visual field loss, this novel form of assessment may offer a functional insight into glaucoma and an early diagnosis tool. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 23, 2015 Category: Opthalmology Authors: Dul, M., Ennis, R., Radner, S., Lee, B., Zaidi, Q. Tags: Visual Psychophysics and Physiological Optics Source Type: research
Evidence for Nontraditional Lymphatics in the Choroid [Research Highlight]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 23, 2015 Category: Opthalmology Authors: Alexander, J. S., Becker, F. Tags: Research Highlight Source Type: research
Evidence for Lymphatics in the Developing and Adult Human Choroid [Retinal Cell Biology]
Conclusions.
The system of blind-ended initial lymphatic segments seen just external to the fenestrated vessels of the choriocapillaris is ideally placed for recirculating extracellular fluid and strategically placed for immune surveillance. The presence of a system of lymphatic-like channels in the human choroid provides an anatomical basis for antigen presentation in the posterior eye, with a possible route from the eye to the sentinel lymph nodes, similar to that already described for anterior eye lymphatics. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 23, 2015 Category: Opthalmology Authors: Koina, M. E., Baxter, L., Adamson, S. J., Arfuso, F., Hu, P., Madigan, M. C., Chan-Ling, T. Tags: Retinal Cell Biology Source Type: research
DNA Damage, Poly(ADP-Ribose) Polymerase Activation, and Phosphorylated Histone H2AX Expression During Postnatal Retina Development in C57BL/6 Mouse [Retinal Cell Biology]
Conclusions.
Oxidative DNA damage in postnatal retina increases during development. It is low during the first postnatal week when PARP-1 activity is high but increases thereafter. The rise in DSBs when PARP activity is downregulated may be attributable to accumulated oxidative damage and SSBs. At P7 and P14, -H2AX–positive cells are repairing naturally occurring DNA damage, but some are dying (mostly at P7), probably due to an accumulation of irreparable DNA damage. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 23, 2015 Category: Opthalmology Authors: Martin-Oliva, D., Martin-Guerrero, S. M., Matia-Gonzalez, A. M., Ferrer-Martin, R. M., Martin-Estebane, M., Carrasco, M.-C., Sierra, A., Marin-Teva, J. L., Calvente, R., Navascues, J., Cuadros, M. A. Tags: Retinal Cell Biology Source Type: research
