Sotagliflozin: an insight into the first dual SGLT inhibitor now approved for heart failure
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 25, 2024 Category: General Medicine Source Type: research

Text generative artificial intelligence tools for clinical applications: scope and concerns
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 25, 2024 Category: General Medicine Source Type: research

Association between chitinase-3-like protein 1 and metabolic-associated fatty liver disease in patients with type 2 diabetes mellitus
ConclusionsSerum CHI3L1 demonstrates an association with significant liver fibrosis. High serum levels of CHI3L1 may indicate the existence of significant liver fibrosis in T2DM-MAFLD patients. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 23, 2024 Category: General Medicine Source Type: research

Validity of galactin-3 in acromegaly: comparison with traditional markers
ConclusionIn a summary, this study recommended clinicians measure serum Gal-3 as biomarkers for patients with acromegaly. In addition, the result above shed light on role of Gal-3 on acromegaly pathogenesis and might provide a therapeutic target of acromegaly patients. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 23, 2024 Category: General Medicine Source Type: research

Sexual health behaviours and partner notification practices related to sexually transmitted infections in young adults in Ireland
ConclusionsAs STIs are becoming increasingly prevalent in young adults, it is important to gain a deeper understanding of the interventions used to break the transmission chain and how different beliefs and attitudes may affect them. Self-efficacy was a key component in PN intentions, suggesting that the belief in someone ’s ability or skillset to perform a sexual health behaviour is positively related to their intention to perform the behaviour. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 22, 2024 Category: General Medicine Source Type: research

Study of prevalence, risk factors for acute kidney injury, and mortality in liver cirrhosis patients
ConclusionAKI is common in cirrhosis of liver patients. Elevated levels of direct bilirubin and MELD score emerged as significant factors associated with AKI development. Furthermore, AKI and MELD scores were identified as independent risk factors for mortality at both 30 and 90  days. Survival rates were influenced by both the type and stage of AKI; AKI stage 3 and ATN patients had significantly higher mortality rate. Early AKI detection and management are crucial for reducing mortality risk in liver cirrhosis patients. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 22, 2024 Category: General Medicine Source Type: research

The role of thiol-disulfide homeostasis and ischemia-modified albumin  in osteosarcopenia
ConclusionIn our study, the role of oxidative stress in OS was demonstrated by using TDH as an oxidative stress parameter. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 21, 2024 Category: General Medicine Source Type: research

A comparison of available guidelines for the detection of cauda equina syndrome and assessing the need for further clinical guidance in Ireland
AbstractThe cauda equina syndrome (CES) is a rare but critical disorder, which can result in devastating motor weakness and sensory deficit, alongside often irreversible bladder, bowel and sexual dysfunction. In addition to the clinical burden of disease, this syndrome results in a disproportionately high medicolegal strain due to missed or delayed diagnoses. Despite being an emergency diagnosis, often necessitating urgent surgical decompression to treat, we believe there is a lack of clarity for clinicians in the current literature, with no published Irish guideline concerning screening or detection. The current study aim...
Source: Irish Journal of Medical Science - March 20, 2024 Category: General Medicine Source Type: research

Effect of oral naloxone on opioid-induced constipation in methadone maintenance treatment patients, a double-blind, placebo-control, clinical trial
ConclusionOral naloxone at doses of 0.5 and 2  mg/day was significantly more effective than placebo on OIC in MMT. However, the dose of 4 mg induced intolerable OWS. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 19, 2024 Category: General Medicine Source Type: research

Eating disorders and COVID-19 - different or just more?
ConclusionsThis study supports the growing consensus of a pandemic specific increase in eating disorder referrals to both medical and psychiatry services. However, there was little to indicate a change in clinical profile or severity. Ongoing monitoring of referrals is necessary to ensure adequate service availability and expertise. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 16, 2024 Category: General Medicine Source Type: research

Roles of ghrelin, hepcidin and HIF-2 α in iron metabolism in iron deficiency anemia
ConclusionThe study suggests that the low hepcidin levels in IDA patients enhance iron absorption. The lack of significant HIF-2 α level differences may be due to the absence of chronic hypoxia in current hemoglobin levels of IDA patients. Moreover, the low ghrelin levels in patients and the correlations between ghrelin, hepcidin, and HIF-2α in both groups indicate their involvement in iron metabolism. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 16, 2024 Category: General Medicine Source Type: research

A survey of non-consultant hospital doctors ’ perspectives, knowledge, and practices toward delirium in a large Irish hospital
ConclusionsThis study highlights the disparity between what is known and practiced by hospital doctors regarding delirium care. This implies increased training for delirium management with frequent use of assessment tools and ongoing education aimed at enhancing patient outcomes in cases of delirium. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 15, 2024 Category: General Medicine Source Type: research

Sleep duration and quality are associated with health-related quality of life in adults aged 60  years and older
ConclusionThe current study confirmed that short sleep duration and poor sleep quality were independently associated with lower HRQoL in the older persons. Therefore, interventional courses should be planned to enrich sleep-related healthcare and general HRQoL in the older persons. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 15, 2024 Category: General Medicine Source Type: research

Diagnostic yield from cardiac gene testing for inherited cardiac conditions and re-evaluation of pre-ACMG variants of uncertain significance
ConclusionOur study highlights the importance of collation and review of pre-ACMG genetic variants to increase diagnostic utility of genetic testing for inherited heart disease. Almost half of patients with pre-ACMG VUS reviewed had their variant re-classified to likely pathogenic/likely benign which resulted in a positive clinical impact for patients and their families. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 15, 2024 Category: General Medicine Source Type: research

Comparison of Manchester, qSOFA, emergency severity index, and national early warning scores for prognostic estimation and effective triage system in geriatric patients
ConclusionSignificant differences in patients ’ methods of presentation to the ED were observed based on the MTS, qSOFA, NEWS, and ESI scores. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 14, 2024 Category: General Medicine Source Type: research