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31 records returned

Molecular pathogenetic mechanisms and new therapeutic perspectives in anthracycline-induced cardiomyopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reports possible subcellular molecular alterations of anthracycline-induced cardiomyopathy (reactive oxygen species formation, apoptosis, inflammatory signalling, altered expression of cardiomyocytes specific genes, etc) and indicates some new therapeutic perspectives resulting from a better understanding of the molecular pathogenetic mechanisms. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - November 20, 2009 Category: Pediatrics Authors: Giuseppe Distefano Source Type: journals

Body fluids and salt metabolism - Part IEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is a high frequency of diarrhea and vomiting in childhood. As a consequence the focus of the present review is to recognize the different body fluid compartments, to clinically assess the degree of dehydration, to know how the equilibrium between extracellular fluid and intracellular fluid is maintained, to calculate the effective blood osmolality and discuss both parenteral fluid requirments and repair. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - November 19, 2009 Category: Pediatrics Authors: Mario BianchettiGiacomo SimonettiAlberto Bettinelli Source Type: journals

A stump appendicitis in a child: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Stump appendicitis is rare and should be considered in any patient with right lower quadrant pain even if there is a history of appendectomy. Complete removal of the appendix is the only mean to prevent the occurrence of this complication. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - November 17, 2009 Category: Pediatrics Authors: Manef GasmiFatma FitouriSondes SahliRadhia JemaiMourad Hamzaoui Source Type: journals

Staphylococcus aureus and autoimmune uveitis reactivation in childhood: a possible correlation?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The role of infectious agents in autoimmune diseases has been the subject of several studies and is still under investigation. Here a paediatric case series of autoimmune uveitis is reported. An exacerbation of the ocular inflammation occurred in concomitance with nasal colonisation by Staphylococcus aureus (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - November 12, 2009 Category: Pediatrics Authors: Paolo MoraErilda KamberiFrancesca ManzottiLaura ZavotaJelka Orsoni Source Type: journals

Can procalcitonin measurement help the diagnosis of osteomyelitis and septic arthritis? A prospective trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: PCT is not a good screening test for identifying skeletal infection in children. Larger studies are needed to evaluate still more the place of PCT measurements in the diagnosis of osteomyelitis and septic arthritis. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - November 4, 2009 Category: Pediatrics Authors: Sabine FaeschBogdan CojocaruCarole HennequinStephanie PannierChristophe GlorionBernard LacourGerard Cheron Source Type: journals

The use of Edinburgh Postnatal Depression Scale to identify postnatal depression symptoms at well child visitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PD is common in the average population. Using a simple and standardized instrument, pediatricians are able to detect parents with higher risk of suffering from PD. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - October 28, 2009 Category: Pediatrics Authors: Vincenzo CurroEmilia De RosaSilvia MaulucciMaria Lucia MaulucciMaria Teresa SilvestriAnnaluce ZambranoVincenza Regine Source Type: journals

Metabolomics: moving towards personalized medicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In many fields of medicine there is a growing interest in characterizing diseases at molecular level with a view to developing an individually tailored therapeutic approach. Metabolomics is a novel area that promises to contribute significantly to the characterization of various disease phenotypes and to the identification of personal metabolic features that can predict response to therapies. Based on analytical platforms such as mass spectrometry or NMR-based spectroscopy, the metabolomic approach enables a comprehensive overview of the metabolites, leading to the characterization of the metabolic fingerprint of a given s...
Source: Italian Journal of Pediatrics - October 22, 2009 Category: Pediatrics Authors: Eugenio BaraldiSilvia CarraroGiuseppe GiordanoFabiano RenieroGiorgio PerilongoFranco Zacchello Source Type: journals

Isolated liver transplantation for treatment of liver failure secondary to intestinal failureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Intestinal Failure is a permanent loss of digestive and absorptive functions as a consequence of short bowel syndrome and/or other primary intestinal conditions. Patients with intestinal failure (IF) require long term parenteral nutrition to survive. The only alternative to parenteral nutrition is intestinal transplantation which still entails high mortality. Children with intestinal failure on parenteral nutrition may develop liver failure (LF),as a consequence of central line infections and other conditions. In children with both irreversible IF and LF a combined transplantation is generally considered. Despite low survi...
Source: Italian Journal of Pediatrics - September 14, 2009 Category: Pediatrics Authors: Maria Immacolata SpagnuoloEliana RubertoAlfredo Guarino Source Type: journals

Dravet syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
"Dravet syndrome" (DS) previously named severe myoclonic epilepsy of infancy (SMEI), or epilepsy with polymorphic seizures, is a rare disorder characterized by an early, severe, generalized, epileptic encephalopathy.DS is characterized by febrile and afebrile seizures beginning in the 1st year of life followed by different types of seizures ( either focal or generalized), which are typically resistant to antiepileptic drugs. A developmental delay from the 2nd to 3rd year of life becomes evident, together with motor disturbances and personality disorders.Beside the classic syndrome, there are milder cases which have been ca...
Source: Italian Journal of Pediatrics - September 7, 2009 Category: Pediatrics Authors: Gemma Incorpora Source Type: journals

Lung disease assessment in primary ciliary dyskinesia: a comparison between chest high-field magnetic resonance imaging and high-resolution computed tomography findingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Chest high-field 3T MRI appears to be as effective as HRCT in assessing the extent and severity of lung abnormalities in PCD. MRI scores might be used for longitudinal assessment and be an outcome surrogate in future studies. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - August 5, 2009 Category: Pediatrics Authors: Silvia MontellaFrancesca SantamariaMarco SalvatoreMarco MaglionePaola IacotucciMaria Margherita De SantiCarmine Mollica Source Type: journals

Neonatal diabetes mellitus due to pancreatic agenesis and pervasive developmental disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent studies suggest a link between type 1 diabetes mellitus and pervasive developmental disorder. Moreover, permanent neonatal diabetes mellitus due to pancreatic agenesis can be associated with neurological deficit involving cerebellar functions, but no association with pervasive developmental disorder has been described so far. Clinical and neuropsychological evaluation of a child with pancreatic agenesis, mental retardation and pervasive developmental disorder is reported. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - July 30, 2009 Category: Pediatrics Authors: Alessandro GiannattasioMaria PintaudiMaria Margherita MancardiFrancesca Maria BattagliaEdvige VeneselliRenata LoriniGiuseppe d'Annunzio Source Type: journals

Exhaled nitric oxide measurements in the first 2 years of life: methodological issues, clinical and epidemiological applicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fractional exhaled nitric oxide (FeNO) is a useful tool to diagnose and monitor eosinophilic bronchial inflammation in asthmatic children and adults. In children younger than 2 years of age FeNO has been successfully measured both with the tidal breathing and with the single breath techniques. However, there are a number of methodological issues that need to be addressed in order to increase the reproducibility of the FeNO measurements within and between infants. Indeed, a standardized method to measure FeNO in the first 2 years of life would be extremely useful in order to meaningfully interpret FeNO values in this age gr...
Source: Italian Journal of Pediatrics - July 19, 2009 Category: Pediatrics Authors: Carmelo GabrieleFernando de BenedictisJohan de Jongste Source Type: journals

Study of non-standard auto-antibodies as prognostic markers in auto immune hepatitis in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Antibodies to chromatin may be superior to those to soluble liver antigen in predicting relapse and may be useful as prognostic marker. Further studies with larger number of patients and combined testing of more than one antibody will improve the performance parameters of these antibodies and define optimal testing conditions for them before they can be incorporated into management algorithms that project prognosis. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - July 19, 2009 Category: Pediatrics Authors: Lerine B. El-Din ElshazlyAzza YoussefNermine MahmoudMona Ibrahim Source Type: journals

Metabolic Bone Disease in preterm newborn: an update on nutritional issuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the pathophysiology of foetal and neonatal bone metabolism, focuses on the nutrient requirements of premature babies and on the ways to early detect and treat osteopenia. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - July 13, 2009 Category: Pediatrics Authors: Valentina BozzettiPaolo Tagliabue Source Type: journals

Adequacy and tolerance to ass's milk in an Italian cohort of children with cow's milk allergyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data confirm the high rate of AM tolerability in children with moderate symptoms of CMPA. Moreover, we found that AM seems to have nutritional adequacy in subjects with a varied diet. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - July 8, 2009 Category: Pediatrics Authors: Riccardina TesseClaudia PaglialungaSerena BraccioLucio Armenio Source Type: journals

Bifid T waves in leads V2 and V3 in children: a normal variantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The incidence of bifid T waves in leads V2 and V3 in normal children is high, and awareness of this phenomenon avoids possible misinterpretations leading to a diagnosis of ECG abnormalities. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - June 25, 2009 Category: Pediatrics Authors: Maria Pia CalabroIgnazio BarberiAntonella La MazzaMaria Chiara TodaroFrancesco De LucaLilia OretoMario RussoMarco CerritoLetteria BrunoGiuseppe Oreto Source Type: journals

Distribution and seasonality of rhinovirus and other respiratory viruses in a cross-section of asthmatic children in Trinidad, West IndiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Emergent wheezing illnesses during childhood can be linked to infection with rhinovirus in Trinidad's tropical environment. Viral-induced exacerbations of asthma are independent of seasons in this tropical climate. Further clinical and virology investigations are recommended on the role of infections with the rhinovirus in Caribbean childhood wheeze. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - June 24, 2009 Category: Pediatrics Authors: Jason MatthewLexley Pinto PereiraTressa PappasCheri SwensonKris GrindleKathy RobergRobert LemanskeWai-Ming LeeJames Gern Source Type: journals

Primary stroke prevention for sickle cell disease in north-east Italy: the role of ethnic issues in establishing a Transcranial Doppler screening programEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our preliminary data set the base to further evaluate the implementation of a primary stroke prevention program in our setting of HbS/HbS African immigrants and HbS/beta thalassemia Italians. Parental education -preferably in the native language- on stroke risk and prevention in SCD increases compliance and should be a necessary part of the program. Ethnic background does not seem to influence TCD velocity and internationally accepted reference values already validated in African-American SCD pediatric patients can be used, but long prospective trials are needed to verify their efficacy in defining stroke risk ...
Source: Italian Journal of Pediatrics - June 21, 2009 Category: Pediatrics Authors: Raffaella ColombattiGiorgio MeneghettiMario EmaniMarta PierobonLaura Sainati Source Type: journals

Perinatal Hypoxic-Ischemic Encephalopathy - epileptic and paretic outcome at one year of ageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The issue concerning neurologic outcome in patients with perinatal Hypoxic-Ischemic Encephalopathy (H.I.E) has inspired many studies which tried to identify adequate prognostic factors. Our work aims to find among neonatal parameters:-factors which help to predict the risk to develop both Cerebral Palsy (CP) and secondary Epilepsy at one year of age in subjects affected by perinatal Hypoxic-Ischemic Encephalopathy,-correlations between the neonatal parameters and the variable severity of above mentioned sequelae. Methods: We have recruited 32 subjects, whose history and neuroimages suggested a perinatal H.I.E a...
Source: Italian Journal of Pediatrics - June 4, 2009 Category: Pediatrics Authors: Federico AllemandFederica RealeMarco SposatoAlessandro Allemand Source Type: journals

Family-oriented and family-centered care in pediatrics.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionThe concepts of family-centered and family-oriented care are discussed with the aim to emphasize their importance in pediatrics. Notions related to family-centered care, such as cultural diversity and cultural competence, are also discussed given the importance they have gained following the recent transformations of socioeconomic, demographic and ethnic characteristics of economically advantaged Countries. Family-centered care has developed as a result of the increased awareness of the importance of meeting the psychosocial and developmental needs of children and of the role of families in promoting the health a...
Source: Italian Journal of Pediatrics - May 12, 2009 Category: Pediatrics Authors: Massimo Pettoello-Mantovani, Angelo Campanozzi, Luigi Maiuri and Ida Giardino Source Type: journals

Spot diagnosis: An ominous rash in a newbornEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a female preterm infant with extensive PF due to group B streptococcus (GBS) septicemia. She developed multi-organ system failure despite neonatal intensive care support and succumbed 9 days later. GBS, sensitive to penicillin, was isolated from the blood cultures of the mother and the infant. Invasive early GBS infection is common in the newborn and is empirically treated with prompt institution of intravenous antibiotics. PF associated with GBS is a rare cutaneous sign that must not be missed. Mortality remains high despite aggressive treatment and ICU support. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - April 30, 2009 Category: Pediatrics Authors: Kam-Lun E Hon, King Woon ALAN So, William Wong and Kam-Lau Cheung Source Type: journals

Subtelomeric FISH analysis in 76 patients with syndromic developmental delay/intellectual disability.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Mental retardation affects approximately 1 to 3% of the general population. The etiology is still poorly understood and it is estimated that one-half of the cases are due to genetic factors. Cryptic subtelomeric aberrations have been found in roughly 5 to 7% of all cases. Methods: We performed a subtelomeric FISH analysis of 76 unrelated children with normal standard karyotype ascertained by developmental delay or mental retardation, associated with congenital malformations, and/or facial dysmorphisms. Results: Ten cryptic chromosomal anomalies have been identified in the whole cohort (13,16%), 8 in the group...
Source: Italian Journal of Pediatrics - April 27, 2009 Category: Pediatrics Authors: Elga F Belligni, Elisa Biamino, Cristina Molinatto, Jole Messa, Mauro Pierluigi, Francesca Faravelli, Orsetta Zuffardi, Giovanni B Ferrero and Margherita Cirillo Silengo Source Type: journals

Maturation of gastric electrical activity, gastric emptying and intestinal permeability in preterm newborns during the first month of lifeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In preterm healthy newborns of 34 weeks gestational age, electrical and motor activity are completely developed at birth whilst the intestinal epithelial barrier clearly improves during the first week of life. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 15, 2009 Category: Pediatrics Authors: Giuseppe Riezzo, Flavia Indrio, Francesco Raimondi, Osvaldo Montagna, Gennaro Salvia, Bisceglia Massimo, Lorenzo Polimeno, Luciano Cavallo and Ruggiero Francavilla Source Type: journals

Maturation of gastric electrical activity, gastric emptying and intestinal permeability in preterm newborns during the first month of life.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. In preterm healthy newborns of 34 weeks gestational age, electrical and motor activity are completely developed at birth whilst the intestinal epithelial barrier clearly improves during the first week of life. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 15, 2009 Category: Pediatrics Authors: Giuseppe Riezzo, Flavia Indrio, Francesco Raimondi, Osvaldo Montagna, Massimo Bisceglia, Gennaro Salvia, Lorenzo Polimeno, Luciano Cavallo and Ruggiero Francavilla Source Type: journals

Cost-utility analysis of palivizumab in Italy: results from a simulation model in the prophylaxis of respiratory syncytial virus infection (RSV) among high-risk preterm infantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study suggests that, compared with no prophylaxis, palivizumab is cost-effective in the prevention of respiratory syncytial virus infection among high risk preterm infants. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - February 25, 2009 Category: Pediatrics Authors: Gaetano Chirico, Roberto Ravasio and Urbano Sbarigia Source Type: journals

Access to paediatric emergency departments in Italy: a comparison between immigrant and Italian patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In our survey immigrants didn't access to emergency departments more than Italian children. Both of them referred to emergency departments mainly for semi-urgent or non-urgent problems. Foreign and Italian patients suffered from the same pathologies. Infectious diseases traditionally thought to be a potential problem in immigrant populations actually seem to be quite infrequent. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - February 22, 2009 Category: Pediatrics Authors: Erica Clara Grassino, Carla Guidi, Alice Monzani, Pasquale Di Pietro and Gianni Bona Source Type: journals

The Italian national register of infants with congenital hypothyroidism: twenty years of surveillance and study of congenital hypothyroidismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
All the Italian Centres in charge of screening, diagnosis, and follow-up of infants with congenital hypothyroidism participate in the Italian National Register of affected infants, which performs the nationwide surveillance of the disease. It was established in 1987 as a program of the Health Ministry and is coordinated by the Istituto Superiore di Sanita. The early diagnosis performed by the nationwide newborn screening programme, the prompt treatment and the appropriate clinical management of the patients carried out by the Follow-up Centres, and the surveillance of the disease performed by the National Register of infan...
Source: Italian Journal of Pediatrics - February 20, 2009 Category: Pediatrics Authors: Antonella Olivieri and The Study Group for Congenital Hypothyroidism (sgch) Source Type: journals

Association between PFO and neurological decompression illnessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Congenital heart disease is recognised as a major cause of stroke in children. Persistence of patent foramen ovale is present in up to 25% of general population. During conditions of increased endothoracic pressure, the PFO can open allowing potential for right-to-left shunt. This opens the cerebral circulation to the systemic venous circulation and has been implicated in the pathogenesis of stroke. Although rare, cryptogenic stroke in childhood is devastating, and investigation of patent foramen ovale-associated right-to-left shunt is largely warranted in such condition. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - February 7, 2009 Category: Pediatrics Authors: Diletta de Benedictis and Francesco Marcucci Source Type: journals

Pediatric palliative careEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The WHO defines pediatric palliative care as the active total care of the child's body, mind and spirit, which also involves giving support to the family. Its purpose is to improve the quality of life of young patients and their families, and in the vast majority of cases the home is the best place to provide such care, but for cultural, affective, educational and organizational reasons, pediatric patients rarely benefit from such an approach. In daily practice, it is clear that pediatric patients experience all the clinical, psychological, ethical and spiritual problems that severe, irreversible disease and death entail. ...
Source: Italian Journal of Pediatrics - December 1, 2008 Category: Pediatrics Authors: Franca Benini, Marco Spizzichino, Manuela Trapanotto and Anna Ferrante Source Type: journals

A new era for Italian Journal of PediatricsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
On behalf of the Editorial Board, welcome to the new Italian Journal of Pediatrics, the official journal of the ISP/SIP (Italian Society of Pediatrics/Società Italiana di Pediatria), now publishing on BioMed Central's open access publishing platform. The move to BioMed Central will benefit authors by having their manuscripts published faster with rapid global dissemination. Readers will also benefit from free online access to the journal via the website and a range of full text archives. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - November 18, 2008 Category: Pediatrics Authors: Sergio Bernasconi Source Type: journals

A new era for Italian Journal of PediatricsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
On behalf of the Editorial Board, welcome to the new Italian Journal of Pediatrics, the official journal of the ISP/SIP (Italian Society of Pediatrics/ Societa Italiana di Pediatria), now publishing on BioMed Central's open access publishing platform. The move to BioMed Central will benefit authors by having their manuscripts published faster with rapid global dissemination. Readers will also benefit from free online access to the journal via the website and a range of full text archives. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - November 18, 2008 Category: Pediatrics Authors: Sergio Bernasconi Source Type: journals