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The role of keratinocyte-derived chemokine in hemorrhage-induced acute lung injury in mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, lung injury and cytokine expression were evaluated in LPS- or hemorrhage-induced ALI models of BALB/c mice. The myeloperoxidase activities at 4 hr after hemorrhage and LPS-injection were 47.4+/-13.0 and 56.5+/-16.4 U/g, respectively. NF-kappaB activity peaked at 4 hr after hemorrhage, which was suppressed to the control level by anti-high mobility group B1 (HMGB1) antibody. Lung expressions of TNF-alpha, MIP-2, and IL-1beta were increased by LPS injection. However, there was only a minimal increase in IL-1beta and no expressions of TNF-alpha or MIP-2 in hemorrhage-induced ALI. In contrast, lung KC increased ...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Lee BH, Lee TJ, Jung JW, Oh DJ, Choi JC, Shin JW, Park IW, Choi BW, Kim JY Tags: J Korean Med Sci Source Type: journals

Myocardial protective effect of tezosentan, an endothelin receptor antagonist, for ischemia-reperfusion injury in experimental heart failure models.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, tezosentan, an endothelin receptor antagonist, showed myocardial protection effects only on the ischemic cardiomyopathy rat model, but not in the non-ischemic heart failure rat models. PMID: 19794971 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Ryu SM, Kim HJ, Cho KR, Jo WM Tags: J Korean Med Sci Source Type: journals

Comparison of factors associated with atypical symptoms in younger and older patients with acute coronary syndromes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was conducted to examine and compare the factors associated with atypical symptoms other than chest pain in younger (<70 yr) and older (> or =70 yr) patients with first-time ACS. Data were obtained from the electronic medical records of the patients (n=931) who were newly diagnosed as ACS and hospitalized from 2005 to 2006. The 7.8% (n=49) of the younger patients and 13.4% (n=41) of the older patients were found to have atypical symptoms. Older patients were more likely to complain of indigestion or abdominal discomfort (P=0.019), nausea and/or vomiting (P=0.040), and dyspnea (P<0.001), and less likely ...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Hwang SY, Park EH, Shin ES, Jeong MH Tags: J Korean Med Sci Source Type: journals

The effects of short-duration exercise on arterial stiffness in patients with stable coronary artery disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Arterial stiffness is an important contributor to the development of cardiovascular disease. We investigated the effect of short duration exercise using the treadmill test on arterial stiffness in the presence of coronary artery disease. We enrolled patients with and without coronary artery diseases (CAD and control group, 50 patients each) referred for treadmill testing. Brachial-ankle pulse wave velocity (baPWV) were measured before and after treadmill testing. Values of baPWV were significantly reduced at 10 min after exercise in both groups, more in the CAD group than in the control group (baseline baPWV and post-e...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Sung J, Yang JH, Cho SJ, Hong SH, Huh EH, Park SW Tags: J Korean Med Sci Source Type: journals

Clinical effects of hypertension on the mortality of patients with acute myocardial infarction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The incidence of ischemic heart disease has been increased rapidly in Korea. However, the clinical effects of antecedent hypertension on acute myocardial infarction have not been identified. We assessed the relationship between antecedent hypertension and clinical outcomes in 7,784 patients with acute myocardial infarction in the Korea Acute Myocardial Infarction Registry during one-year follow-up. Diabetes mellitus, hyperlipidemia, cerebrovascular disease, heart failure, and peripheral artery disease were more prevalent in hypertensives (n=3,775) than nonhypertensives (n=4,009). During hospitalization, hypertensive p...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Kang DG, Jeong MH, Ahn Y, Chae SC, Hur SH, Hong TJ, Kim YJ, Seong IW, Chae JK, Rhew JY, Chae IH, Cho MC, Bae JH, Rha SW, Kim CJ, Jang YS, Yoon J, Seung KB, Park SJ, Tags: J Korean Med Sci Source Type: journals

Unilateral antegrade selective cerebral perfusion in aortic surgery: clinical outcomes at different levels of hypothermia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study compared outcomes in patients undergoing UASCP at either <24 or > or =24. Between 2000 and 2007, 104 consecutive patients underwent aortic surgery using UASCP. Patients were divided into two groups according to systemic temperature: group A comprised 64 patients undergoing deep hypothermia (<24); and group B comprised 40 patients undergoing moderate hypothermia (> or =24). Both groups were similar in terms of the extent of aortic replacement and mean UASCP time. The total cardiopulmonary bypass time and aortic cross clamp time were longer in group A. Both groups were similar in terms of 30-day mortal...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Lee JH, Chung CH, Kang JK, Choo SJ, Song H, Lee JW Tags: J Korean Med Sci Source Type: journals

Surgical outcomes and post-operative changes in patients with significant aortic stenosis and severe left ventricle dysfunction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Little is known regarding long-term survival and changes in systolic function following surgery after the occurrence of a severe left ventricular (LV) dysfunction in patients with severe aortic stenosis. Inclusion criteria were an aortic valve area less than 1 cm(2) and an LV ejection fraction (EF) less than 35%. Between January 1990 and July 2007, 41 (male: 30) patients were identified. The pre-operative mean EF and mean aortic valve area were 26.7+/-6.1% and 0.54+/-0.2 cm(2), respectively. Concomitant coronary artery bypass surgery was performed in 8 patients (19.6%). Immediate post-operative echocardiogram showed to...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Jung SH, Lee JW, Je HG, Choo SJ, Chung CH, Song H Tags: J Korean Med Sci Source Type: journals

Short- and long-term results of triple valve surgery: a single center experience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined surgical results based on our hospital's experience. A total of 160 consecutive patients underwent triple valve surgery from 1990 to 2006. The most common aortic and mitral valve disease was rheumatic disease (82%). The most common tricuspid valve disease was functional regurgitation (80%). Seventy-four percent of the patients were in New York Heart Association (NYHA) class III and IV. Univariate and multivariable analyses were performed to identify predictors of early and late survival. Operative mortality was 6.9% (n=11). Univariate factors associated with mortality included old age, preoperative renal failur...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Shinn SH, Oh SS, Na CY, Lee CH, Lim HG, Kim JH, Yie KS, Baek MJ, Song DS Tags: J Korean Med Sci Source Type: journals

Predicting recurrence using the clinical factors of patients with non-small cell lung cancer after curative resection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a recurrence prediction model using multiple clinical parameters in patients surgically treated for non-small cell lung cancer. Among 1,578 lung cancer patients who underwent complete resection, we compared the early-recurrence group with the 3-yr non-recurrence group for evaluating those factors that influence early recurrence within one year after surgery. Adenocarcinoma and squamous cell carcinoma were analyzed independently. We used multiple logistic regression analysis to identify the independent clinical predictors of recurrence and Cox's proportional hazard regression method to develop a clinical predicti...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Lee HJ, Jo J, Son DS, Lee J, Choi YS, Kim K, Shim YM, Kim J Tags: J Korean Med Sci Source Type: journals

The relationship between brachial ankle pulse wave velocity and complement 1 inhibitor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, C1 inhibitor is associated with arterial stiffness through its association with increased inflammation. PMID: 19794979 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Chae YM, Park JK Tags: J Korean Med Sci Source Type: journals

Regulation of type IV collagen alpha chains of glomerular epithelial cells in diabetic conditions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An early feature of diabetic nephropathy is the alteration of the glomerular basement membrane (GBM), which may result in microalbuminuria, subsequent macroproteinuria, and eventual chronic renal failure. Although type IV collagen is the main component of thickened GBM in diabetic nephropathy, cellular metabolism of each alpha chains of type IV collagen has not been well studied. To investigate the regulation of alpha(IV) chains in diabetic conditions, we examined whether glucose and advanced glycosylation endproduct (AGE) regulate the metabolism of each alpha(IV) chains in the diabetic tissue and glomerular epithelial...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Ha TS, Hong EJ, Ahn EM, Ahn HY Tags: J Korean Med Sci Source Type: journals

Risk factors for serious bacterial infection in febrile young infants in a community referral hospital.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Differentiation of serious bacterial infection (SBI) from self-limiting viral illness in febrile infants younger than three months is a significant challenge for clinicians. We aimed to assess the risk factors for SBI in febrile infants. Data were obtained from 221 infants younger than three months who visited a single community referral hospital for fever and underwent a complete sepsis workup between August 2003 and July 2006. The causes of fever were febrile illness without a documented cause (FISDC, 65%), urinary tract infection (UTI, 12%), aseptic meningitis (12%), bacteremia (4%), bacterial meningitis (2%). Cereb...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Shin SH, Choi CW, Lee JA, Kim EK, Choi EH, Kim HS, Kim BI, Choi JH Tags: J Korean Med Sci Source Type: journals

Effects of chemical sympathectomy on contralateral testicular histology and fertility in unilateral vasectomy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Unilateral obstruction or injury to the vas deferens can result in significant injury to the contralateral testicle. Although various pathways have been proposed, the mechanism of contralateral testicular deterioration remains controversial. The present animal study was performed to evaluate the effects of unilateral vasectomy on ipsilateral and contralateral testicular histology and fertility in rats that were chemically sympathectomized neonatally. The study comprised 40 male albino rats: 20 received a placebo and the other 20 underwent chemical sympathectomy neonatally. When 60 days old, each group of 20 rats was di...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Kutlu O, Kocabiyik A, Koksal IT, Guntekin E Tags: J Korean Med Sci Source Type: journals

Differences in circulating dendritic cell subtypes in pregnant women, cord blood and healthy adult women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Different subtypes of dendritic cells (DC) influence the differentiation of naíve T lymphocytes into T helper type 1 (Th1) and Th2 effector cells. We evaluated the percentages of DC subtypes in peripheral blood from pregnant women (maternal blood) and their cord blood compared to the peripheral blood of healthy non pregnant women (control). Circulating DC were identified by flow cytometry as lineage (CD3, CD14, CD16, CD19, CD20, and CD56)-negative and HLA-DR-positive cells. Subtypes of DC were further characterized as myeloid DC (CD11c(+)/CD123(+/-)), lymphoid DC (CD11c(-)/CD123(+++)) and less differentiated DC (C...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Shin S, Jang JY, Roh EY, Yoon JH, Kim JS, Han KS, Kim S, Yun Y, Choi YS, Choi JD, Kim SH, Kim SJ, Song EY Tags: J Korean Med Sci Source Type: journals

The effect of CpG-oligodeoxynucleotides with different backbone structures and 3' hexameric deoxyriboguanosine run conjugation on the treatment of asthma in mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CpG-Oligodeoxynucleotide (ODN) has two backbones. Phosphorothioate backbone (PS) shows a strong immunostimulating effect while phosphodiester (PE) shows little in vivo. 3' hexameric deoxyriboguanosine-run (3' dG(6)-run) conjugation to PE CpG-ODN has been reported to enhance immunostimulation and to protect against asthma when injected at the time of sensitization in mice. We evaluated the treatment effects of PE and PS CpG-ODN with or without 3' dG(6)-run on asthma in presensitized mice. BALB/c mice sensitized with ovalbumin and alum were challenged with 1% ovalbumin on three days. CpG-ODNs (100 microg) or PBS were inj...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Chang YS, Kim YK, Kwon HS, Park HW, Min KU, Kim YY, Cho SH Tags: J Korean Med Sci Source Type: journals

Marked individual variation in isoflavone metabolism after a soy challenge can modulate the skeletal effect of isoflavones in premenopausal women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this randomized, double-blind, placebo-controlled study was to investigate the skeletal effect of isoflavones according to their metabolic variability in premenopausal women. Volunteers were randomly assigned to receive either soy-extract isoflavones (n=32) or lactose (n=21) once a day for three menstrual cycles. After intervention, the urinary excretions of isoflavones and their metabolites were significantly higher in the soy group than in the placebo group and showed a large inter-individual variation. Women in the soy group were divided into subgroups according to their ability to excrete more potent m...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Kwak HS, Park SY, Kim MG, Yim CH, Yoon HK, Han KO Tags: J Korean Med Sci Source Type: journals

Efficacy and safety of cabergoline as first line treatment for invasive giant prolactinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although cabergoline is effective in the treatment of micro- and macro-prolactinoma, little is known about its efficacy in the treatment of invasive giant prolactinoma. We investigated the efficacy and safety of cabergoline in 10 male patients with invasive giant prolactinoma. Before treatment, mean serum prolactin level was 11,426 ng/mL (range, 1,450-33,200 ng/mL) and mean maximum tumor diameter was 51 mm (range, 40-77 mm). Three months after initiation of cabergoline treatment, serum prolactin concentrations decreased more than 97% in 9 patients; at last follow-up (mean treatment duration, 19 months), the mean decrea...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Cho EH, Lee SA, Chung JY, Koh EH, Cho YH, Kim JH, Kim CJ, Kim MS Tags: J Korean Med Sci Source Type: journals

Antihistamine pretreatment to reduce incidence of withdrawal movement after rocuronium injection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study was to determine the effectiveness of antihistamine therapy for withdrawal movements caused by rocuronium injection. One hundred seventy one ASA I-II adults undergoing elective surgery were randomly assigned to one of two groups. Patients in the control group (Group C) were premedicated with 2 mL normal saline, and those in the antihistamine group (Group A) were pre-medicated with 2 mL (45.5 mg) pheniramine maleate. After the administration of thiopental sodium 5 mg/kg, rocuronium 0.6 mg/kg was injected. Withdrawal movements were assessed using a four-grade scale. The administration of antihis...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Lee HJ, Han SJ, Kim H, Lee IO, Kong MH, Kim NS, Lim SH, Lee MK Tags: J Korean Med Sci Source Type: journals

The effects of intravenous ephedrine during spinal anesthesia for cesarean delivery: a randomized controlled trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We designed a randomized, double-blinded study to determine the efficacy and safety of 0.5 mg/kg intravenous ephedrine for the prevention of hypotension during spinal anesthesia for cesarean delivery. Patients were randomly allocated into two groups: ephedrine group (n=21) and control group (n=21). Intravenous preload of 15 mL/kg lactated Ringer's solution was given. Shortly after the spinal injection, ephedrine 0.5 mg/kg or saline was injected intravenous for 60 sec. The mean of highest and lowest heart rate in the ephedrine group was higher than those of control group (P<0.05). There were significant lower inciden...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Kol IO, Kaygusuz K, Gursoy S, Cetin A, Kahramanoglu Z, Ozkan F, Mimaroglu C Tags: J Korean Med Sci Source Type: journals

Long-pulsed Nd:YAG laser treatment of warts: report on a series of 369 cases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, long-pulsed Nd:YAG laser is safe and effective for the removal or reduction of warts and is less dependent on patient compliance than are other treatment options. PMID: 19794989 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Han TY, Lee JH, Lee CK, Ahn JY, Seo SJ, Hong CK Tags: J Korean Med Sci Source Type: journals

Positional reproducibility and effects of a rectal balloon in prostate cancer radiotherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite the increasing use of the rectal balloon in prostate cancer radiotherapy, many issues still remain to be verified objectively including its positional reproducibility and relevance to treatment morbidity. We have developed a custom rectal balloon that has a scale indicating the depth of insertion and dilates symmetrically ensuring positional reproducibility. Fifty patients with prostate cancer treated by definitive 3D-conformal radiotherapy (3D-CRT) or intensity-modulated radiotherapy (IMRT) with rectal balloon were analyzed. Each of first five patients undergone computed tomography (CT) three times with a rect...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Cho JH, Lee CG, Kang DR, Kim J, Lee S, Suh CO, Seong J, Suh YG, Lee I, Kim GE Tags: J Korean Med Sci Source Type: journals

Unrelated hematopoietic stem cell transplantation for children with acute leukemia: experience at a single institution.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, HCT with unrelated donors is effective treatment modality for children with acute leukemia. In children with acute leukemia candidate for HCT but lack suitable sibling donor, unrelated HCT may be a possible treatment option at the adequate time of their disease. PMID: 19794991 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Lee JH, Yoon HS, Song JS, Choi ES, Moon HN, Seo JJ, Im HJ Tags: J Korean Med Sci Source Type: journals

Weekly paclitaxel and trastuzumab as a first-line therapy in patients with HER2-overexpressing metastatic breast cancer: magnitude of HER2/neu amplification as a predictive factor for efficacy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We evaluated the efficacy and safety of weekly paclitaxel plus trastuzumab as first-line chemotherapy in women with HER2-overexpressing metastatic breast cancer (MBC), and we investigated the prognostic factors including magnitude of HER2/neu amplification in this population. We analyzed 54 patients with HER2-overexpressing MBC that were treated with weekly paclitaxel plus trastuzumab as first-line chemotherapy from February 2004 to December 2006. At a median follow-up of 28 months, median time to progression (TTP) was 16.6 months (95% CI, 9.4 to 23.7 months) and median overall survival was 25.6 months (95% CI, 21.8 to...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Han HS, Kim JS, Park JH, Jeon YK, Lee KW, Oh DY, Kim JH, Park SY, Im SA, Kim TY, Park IA, Bang YJ Tags: J Korean Med Sci Source Type: journals

DNA methylation and expression patterns of key tissue-specific genes in adult stem cells and stomach tissues.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CpG-island margins and non-island-CpG sites round the transcription start sites of CpG-island-positive and -negative genes are methylated to various degrees in a tissue-specific manner. These methylation-variable CpG sites were analyzed to delineate a relationship between the methylation and transcription of the tissue-specific genes. The level of tissue-specific transcription was estimated by counting the number of the total transcripts in the SAGE (serial analysis of gene expression) database. The methylation status of 12 CpG-island margins and 21 non-island CpG sites near the key tissue-specific genes was examined i...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Hong SJ, Kang MI, Oh JH, Jung YC, Kim YH, Kim SJ, Choi SH, Seo EJ, Choi SW, Rhyu MG Tags: J Korean Med Sci Source Type: journals

Is intravenous patient controlled analgesia enough for pain control in patients who underwent thoracoscopy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This prospective randomized study was conducted to evaluate the efficacy of two common analgesic techniques, thoracic epidural patient-controlled analgesia (Epidural PCA), and intravenous patient-controlled analgesia (IV PCA), in patients undergoing lobectomy by the video-assisted thoracic surgical (VATS) approach. Fifty-two patients scheduled for VATS lobectomy were randomly allocated into two groups: an Epidural PCA group receiving an epidural infusion of ropivacaine 0.2%+fentanyl 5 microg/mL combination at a rate of 4 mL/hr, and an IV PCA group receiving an intravenous infusion of ketorolac 0.2 mg/kg+fentanyl 15 mic...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Kim JA, Kim TH, Yang M, Gwak MS, Kim GS, Kim MJ, Cho HS, Sim WS Tags: J Korean Med Sci Source Type: journals

Effect of biofeedback-assisted autogenic training on headache activity and mood states in Korean female migraine patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to examine the effect of biofeedback treatment on headache activity, anxiety, and depression in Korean female patients with migraine headache. Patients were randomized into the treatment group (n=17) and monitoring group (n=15). Mood states including anxiety and depression, and psychophysiological variables such as mean skin temperature of the patients were compared with those of the normal controls (n=21). We found greater treatment response rate (defined as > or =50% reduction in headache index) in patients with biofeedback-assisted autogenic training than in monitoring group. The scores on the anxiet...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Kang EH, Park JE, Chung CS, Yu BH Tags: J Korean Med Sci Source Type: journals

Increased transforming growth factor-beta1 in alcohol dependence.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ethanol and its metabolite acetaldehyde increase transforming growth factor beta1 (TGF-beta1) expression in animal studies. TGF-beta1 is related with the hepatic stellate cell (the key element of hepatic fibrogenesis) and the radial glia (the key element of neuronal migration). Blood samples were collected from 41 patients with alcohol dependence, TGF-beta1 levels measured by ELISA were compared with 41 normal subjects. Plasma TGF-beta1 levels in the patients with alcohol dependence (1,653.11+/-532.45 pg/mL) were significantly higher than those of healthy subjects (669.87+/-366.53 pg/mL) (P=0.000). Patients with or wit...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Kim YK, Lee BC, Ham BJ, Yang BH, Roh S, Choi J, Kang TC, Chai YG, Choi IG Tags: J Korean Med Sci Source Type: journals

Phase II study of combination chemotherapy with etoposide and ifosfamide in patients with heavily pretreated recurrent or persistent epithelial ovarian cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this trial was to investigate the efficacy and toxicity of combination chemotherapy with etoposide and ifosfamide (ETI) in the management of heavily pretreated recurrent or persistent epithelial ovarian cancer (EOC). Patients with recurrent or persistent EOC who had measurable disease and at least two prior chemotherapy participating in this phase II trial were to receive etoposide at a dose of 100 mg/m(2)/day intravenously (IV) on days 1 to 3 in combination with ifosfamide 1 g/m(2)/day IV on days 1 to 5, every 21 days. Thirty-seven patients were treated; about 78% had previously received more than two separ...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Kang H, Kim TJ, Choi CH, Lee JW, Lee JH, Bae DS, Kim BG Tags: J Korean Med Sci Source Type: journals

The efficacy and safety of inflatable obstetric belts for management of the second stage of labor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the uterine fundal pressure exerted by the Labor Assister reduces the duration of the second stage of labor without attendant complications. PMID: 19794998 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Kang JH, Lee GH, Park YB, Jun HS, Lee KJ, Hahn WB, Park SW, Park HJ, Cha DH Tags: J Korean Med Sci Source Type: journals

Primary biliary lymphoma mimicking cholangiocarcinoma: a characteristic feature of discrepant CT and direct cholangiography findings.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a patient with extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue (MALT), who presented with obstructive jaundice and describe the distinctive radiologic features that may suggest the correct preoperative diagnosis of primary lymphoma of the bile duct. Primary MALT lymphoma of the extrahepatic bile duct should be considered in the differential diagnosis when there is a mismatch in imaging findings on computed tomography or magnetic resonance imaging and cholangiography. PMID: 19794999 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Yoon MA, Lee JM, Kim SH, Lee JY, Han JK, Choi BI, Kim SW, Jang JJ Tags: J Korean Med Sci Source Type: journals

Renocolic fistula secondary to a perinephric abscess: a late complication of a forgotten double J stent.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Late complications of ureteral stents are frequent, and longer indwelling times are associated with an increased frequency of complications. Although there are reports of various complications of long-term indwelling ureteral stents, a renocolic fistula secondary to a perinephric abscess resulting from an indwelling ureteral stent has not been reported. Here, we present a fatal case of a renocolic fistula secondary to a perinephric abscess caused by an encrusted forgotten double J stent in a functionally solitary kidney. PMID: 19795000 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Lee SW, Kim JH Tags: J Korean Med Sci Source Type: journals

A case of gastritis associated with gastric capillariasis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report is about the case of gastritis associated with capillariasis. The patient was a 52-yr-old Korean woman who occasionally ate raw fish and chicken. She complained of mild abdominal pain and nausea, but not diarrhea. An endoscopic examination revealed an exudative flat erosive change on the gastric mucosa of the antrum. She was microscopically diagnosed as chronic gastritis with numerous eosinophil infiltrations. The sectioned worms and eggs in mucosa were morphologically regarded as belonging to the genus Capillaria. This is the first case of gastric capillariasis reported in the Republic of Korea. PMID: 1979...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Kim J, Joo HS, Jung S, Kim HS, Lee MY, Jeong JJ, Kim HS Tags: J Korean Med Sci Source Type: journals

Pseudo-no-reflow phenomenon in carotid artery stenting using FilterWire EX: successful recovery by aspiration thrombectomy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of pseudo-no-reflow phenomenon after postdilatation of the stent in a patient with asymptomatic carotid artery stenosis. After several passes using an Export Aspiration catheter, normal flow in the internal carotid artery was restored. Aspiration thrombectomy can successfully recover pseudo-no-reflow phenomenon. PMID: 19795002 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Han SH, Kang WC, Ahn TH, Shin EK Tags: J Korean Med Sci Source Type: journals

Kaposi sarcoma herpes virus-associated hemophagocytic syndrome complicated by multicentric castleman disease and kaposi sarcoma in a HIV-negative immunocompetent patient: an autopsy case.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report herein an unusual case of KSHV-associated HPS in an immunocompetent patient. A previously healthy 62-yr-old male was referred for evaluation of leukocytopenia and multiple lymphadenopathies. After a lymph node biopsy, he was diagnosed with MCD of the plasma cell type. KSHV DNA was detected in the lymph node tissue by polymerase chain reaction. Following a short-term response of the leukocytopenia to prednisolone, mental change, left side weakness, fever, thrombocytopenia, hemolytic anemia, and renal failure developed. Despite intravenous immunoglobulin therapy and plasmapheresis, he expired. The lymph nodes were ...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Kim B, Jeon YK, Kim CW Tags: J Korean Med Sci Source Type: journals

Antibiotic-induced severe neutropenia with multidrug-dependent antineutrophil antibodies developed in a child with Streptococcus pneumoniae infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a child with pneumococcal pneumonia, who experienced severe neutropenia during various antibiotic treatments. We detected 4 kinds (cefotaxim, augmentin, vancomycin, and tobramycin) of antibiotic-dependent antineutrophil antibodies by using the mixed passive hemagglutination assay (MPHA) technique with this child. PMID: 19795004 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Lee YH, Lee HB, Kim JY, Lim YJ, Shin SA, Han TH Tags: J Korean Med Sci Source Type: journals

Familial glucocorticoid deficiency with a point mutation in the ACTH receptor: a case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a 2 month-old boy of nonconsanguineous parents, presented with hyperpigmentation. Physical examination showed diffuse dark skin of body including, oral mucosa, gum, hands, nails and scrotum. Laboratory evaluation revealed low serum cortisol (0.3 microg/dL), with very high plasma ACTH level (18,000 pg/mL), and serum cortisol level did not increase after ACTH stimulation test. Serum sodium, potassium, plasma renin activity, aldosterone and 17-hydroxyprogesterone were normal. Sequence analysis of the ACTH receptor (MC2R) gene showed a homozygous mutation of D103N. Diagnosis of FGD was made and treatment started with...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Kim CJ, Woo YJ, Kim GH, Yoo HW Tags: J Korean Med Sci Source Type: journals

Exodeviated ophthalmoplegia in a patient with progressive supranuclear palsy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a patient with progressive supranuclear palsy (PSP) with his serial photographs before the onset of ocular symptoms and after the onset with two year intervals. These photographs show his progressive eyeball deviations toward complete exotropia. There were no effective voluntary eyeball movements, Bell's phenomenon, doll's eye movements, and vestibulo-ocular reflexes. These signs indicate the involvement of the oculomotor nuclear complex by the disease. We suggest that PSP may cause not only 'supranuclear' but also 'nuclear' complete ophthalmoplegia with exodeviation of the eyes. PMID: 19795006 [PubMed - in p...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Kim C, Lee HW, Park MY Tags: J Korean Med Sci Source Type: journals

Adenocarcinoma in ileal pouch after proctocolectomy for familial adenomatous polyposis: report of a case.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of adenocarcinoma in ileal pouch after proctocolectomy with ileal pouch-anal anastomosis. A 56-yr-old woman was diagnosed as having familial adenomatous polyposis. Total colectomy with ileorectal anastomosis was performed. Six years later, she underwent completion-proctectomy with ileal J pouch-anal anastomosis including anorectal mucosectomy for rectal cancer. After 7 yr, she presented with anal spotting. Endoscopic biopsies revealed adenocarcinoma at the ileal pouch. Resection of the ileal pouch and permanent ileostomy were performed. The risk of cancer in an ileal pouch and its prevention with regular s...
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Lee SH, Ahn BK, Chang HK, Baek SU Tags: J Korean Med Sci Source Type: journals

A primary extragonadal teratoma of the proximal humerus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a extremely rare case of malignant teratoma of the left proximal humerus in a 14-yr-old female. Radiologic evaluations, including magnetic resonance imaging, suggested a malignant bone tumor, but a pathological examination revealed an immature bony teratoma. Bone scintigraphy and positron emission tomography computed tomography scan showed increased uptake of proximal humerus but no other abnormal lesion. PMID: 19795008 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Koh JS, Park JH, Kang CH Tags: J Korean Med Sci Source Type: journals

Transitional cell carcinoma in a remnant ureter after retroperitoneoscopic simple nephrectomy for benign renal disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 70-yr-old man presented with painless gross hematuria. He underwent right nephrectomy for benign disease 9 yr ago. Computed tomography and cystoscopy showed a mass in the distal region of the right ureteral stump. He underwent right ureterectomy and bladder cuff resection. Pathological examination showed T1 and WHO grade 2 transitional cell carcinoma. At 6 months postoperatively, the patient is alive without any evidence of recurrence. PMID: 19795009 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Park JY, Park J, Ku JH, Kim HH Tags: J Korean Med Sci Source Type: journals

Comparison of cytokine expression in mesenchymal stem cells from human placenta, cord blood, and bone marrow.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mesenchymal stem cells (MSCs) are capable of self-renewal and differentiation into lineages of mesenchymal tissues that are currently under investigation for a variety of therapeutic applications. The purpose of this study was to compare cytokine gene expression in MSCs from human placenta, cord blood (CB) and bone marrow (BM). The cytokine expression profiles of MSCs from BM, CB and placenta (amnion, decidua) were compared by proteome profiler array analysis. The cytokines that were expressed differently, in each type of MSC, were analyzed by real-time PCR. We evaluated 36 cytokines. Most types of MSCs had a common ex...
Source: J Korean Med Sci - July 31, 2009 Category: Journals (General) Authors: Hwang JH, Shim SS, Seok OS, Lee HY, Woo SK, Kim BH, Song HR, Lee JK, Park YK Tags: J Korean Med Sci Source Type: journals

Influence of lactate dehydrogenase and cyclosporine A level on the incidence of acute graft-versus-host disease after allogeneic stem cell transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we retrospectively analyzed the records of 24 patients who received allogeneic SCT from an HLA-matched sibling donor for acute and chronic myelogenous leukemia. Univariate analysis showed that two factors (the serum CsA level at the third week after SCT and the LDH level at the third week after SCT) were significantly associated with the incidence of aGVHD among several variables (age, sex, stem cell source, cell dose, C-reactive protein, absolute lymphocyte count, conditioning regimens, and time to engraftment). A higher serum level of CsA and lower serum LDH level at the third week after SCT were associate...
Source: J Korean Med Sci - July 31, 2009 Category: Journals (General) Authors: Song MK, Chung JS, Seol YM, Kwon BR, Shin HJ, Choi YJ, Cho GJ Tags: J Korean Med Sci Source Type: journals

Paraoxonase gene polymorphism in south-western Korean population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Paraoxonase (PON) has anti-atherogenic activity. Considering the important role of polymorphism in the genetic susceptibility to cardiovascular disease and the variability of its allele frequencies in different ethnic groups, the distribution of genotypes and allele frequencies of PON1M55L, PON1Q192R, PON2A148G, and PON2S311C polymorphisms was analyzed in a total 988 South-western Koreans and determined their effects on lipid parameters. The genotype distribution of PON1 at position 55 was LL=0.886, LM=0.114; and at position 192 was QQ=0.406, QR=0.594. The frequencies of the PON1 55L allele and the PON1 192R allele wer...
Source: J Korean Med Sci - July 31, 2009 Category: Journals (General) Authors: Shin BS Tags: J Korean Med Sci Source Type: journals

Predictive factors associated with the reversibility of post-transplantation diabetes mellitus following liver transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the prevalence and predictive factors of transient PTDM following liver transplantation. Forty-two of 74 PTDM patients showed the clinical features of transient PTDM. Compared with the persistent PTDM patients, they were characterized by younger age at the time of transplantation (49+/-7 vs. 53+/-8 yr, P<0.05), longer time before the development of PTDM (44+/-59 vs. 13+/-20 days, P<0.05), lower rate of hepatitis c virus seropositivity (0.0 vs. 9.4%, P<0.05), and use of mycophenolate mofetil (59.5 vs. 28.1%, P<0.05). Among these risk factors, age at the time of transplantation is the single independe...
Source: J Korean Med Sci - July 31, 2009 Category: Journals (General) Authors: Ahn HY, Cho YM, Yi NJ, Suh KS, Lee KU, Park KS, Kim SY, Lee HK Tags: J Korean Med Sci Source Type: journals

Comparison of quantitative cytomegalovirus real-time PCR in whole blood and pp65 antigenemia assay: clinical utility of CMV real-time PCR in hematopoietic stem cell transplant recipients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Successful preemptive therapy for cytomegalovirus (CMV) infection in transplant patients depends on the availability of sensitive, specific, and timely diagnostic tests for CMV infection. Although the pp65 antigenemia assay has been widely used for this purpose, real-time quantification of CMV DNA has recently been recognized as an alternative diagnostic approach. However, the guidelines for antiviral therapy based on real-time quantitative polymerase chain reaction (RQ-PCR) have yet to be established. From November 2004 to March 2005, a total of 555 whole blood samples from 131 hematopoietic stem cell transplant (HSCT...
Source: J Korean Med Sci - July 31, 2009 Category: Journals (General) Authors: Choi SM, Lee DG, Lim J, Park SH, Choi JH, Yoo JH, Lee JW, Kim Y, Han K, Min WS, Shin WS, Kim CC Tags: J Korean Med Sci Source Type: journals

Comparison of the novel human papillomavirus 4 auto-capillary electrophoresis test with the hybrid capture 2 assay and with the PCR HPV typing set test in the detection of high-risk HPV including HPV 16 and 18 genotypes in cervical specimens.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to compare the novel human papillomavirus (HPV) detection method, the HPV 4 Auto-capillary Electrophoresis (ACE) test with the hybrid capture (HC) 2 assay for the detection of high-risk HPVs. In addition, we compared the HPV 4 ACE test with the polymerase chain reaction HPV Typing Set test for the detection of HPV 16 and HPV 18 genotypes. One hundred ninety-nine cervical swab samples obtained from women with previous abnormal Pap smears were subjected to testing with the three HPV tests. The HPV 4 ACE test and the HC 2 assay showed substantial agreement for detection of high-risk HPVs (85.4%, ...
Source: J Korean Med Sci - July 31, 2009 Category: Journals (General) Authors: Hong JH, Song SH, Kim JK, Han JH, Lee JK Tags: J Korean Med Sci Source Type: journals

Comparison of genotypes and enterotoxin genes between Staphylococcus aureus isolates from blood and nasal colonizers in a Korean hospital.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the genetic background of 70 Staphylococcus aureus isolates (36 methicillin-resistant S. aureus [MRSA] and 34 methicillin-susceptible S. aureus [MSSA]) obtained from blood at a Korean tertiary-care hospital, using spa typing, multilocus sequence typing, and SCCmec typing. In addition, the prevalence of enterotoxin (sea, seb, sec, sed, see, seg, seh, sei, and sek), tst, and pvl genes among the samples was assessed via polymerase chain reaction, and the results were compared with those of 95 isolates of S. aureus obtained from nasal swabs. All MRSA isolates from blood, except one, belonged to t...
Source: J Korean Med Sci - July 31, 2009 Category: Journals (General) Authors: Peck KR, Baek JY, Song JH, Ko KS Tags: J Korean Med Sci Source Type: journals

Multidrug-resistant pulmonary tuberculosis among young Korean soldiers in a communal setting.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The goal of this study was to evaluate the prevalence of first-line anti-tuberculosis drug resistance and risk factors associated with multidrug-resistant tuberculosis (MDR TB) among young soldiers in the Korean military, which has a strict tuberculosis control program. All patients with culture-confirmed pulmonary tuberculosis during their service at the Armed Forces Capital Hospital from January 2001 to December 2006 were enrolled in the study. Drug resistant Mycobacterium tuberculosis was isolated from 18 patients (12.2%) and multidrug-resistant M. tuberculosis was isolated from 12 patients (8.1%). Previous treatmen...
Source: J Korean Med Sci - July 31, 2009 Category: Journals (General) Authors: Lee SW, Jeon K, Kim KH, Min KH Tags: J Korean Med Sci Source Type: journals

Atherosclerotic progression attenuates the expression of Nogo-B in autopsied coronary artery: pathology and virtual histology intravascular ultrasound analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The relation of Nogo-B to atherosclerotic plaque progression is not well understood. Thus, the purpose of this study was to assess the expression of Nogo-B in fibroatheromas (FA) of different stages, classified using virtual histology intravascular ultrasound (VH-IVUS) analysis in 19 autopsied cases of non-sudden cardiac death. VH-IVUS imaging analysis was performed 30 mm from the ostium of each coronary artery. VH-IVUS revealed 11 early FAs (34.5+/-8.3 yr), 12 late FAs (42.6+/-16.6 yr), 8 thick-cap FAs (TkCFAs) (46.4+/-11.1 yr), and 6 thin-cap FAs (TCFAs) (51.8+/-6.8 yr). TkCFAs and TCFAs were defined as advanced FA. ...
Source: J Korean Med Sci - July 31, 2009 Category: Journals (General) Authors: Lee WS, Kim SW, Hong SA, Lee TJ, Park ES, Kim HJ, Lee KJ, Kim TH, Kim CJ, Ryu WS Tags: J Korean Med Sci Source Type: journals

Overexpression of X-linked inhibitor of apoptosis protein (XIAP) is an independent unfavorable prognostic factor in childhood de novo acute myeloid leukemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was performed to investigate the prognostic relevance of XIAP expression in childhood acute myeloid leukemia (AML). In 53 children with de novo AML, the level of XIAP expression was determined by using quantitative reverse transcriptase-polymerase chain reaction and was analyzed with respect to the clinical characteristics at diagnosis and treatment outcomes. As a result, the XIAP expression was found to be higher in patients with extramedullary disease than in those without (P=0.014). In addition, XIAP overexpression (>or=median expression) was associated with an unfavorable day 7 response to induction chemo...
Source: J Korean Med Sci - July 31, 2009 Category: Journals (General) Authors: Sung KW, Choi J, Hwang YK, Lee SJ, Kim HJ, Kim JY, Cho EJ, Yoo KH, Koo HH Tags: J Korean Med Sci Source Type: journals