JAHA:Journal of the American Heart Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Gastric Bypass Surgery Produces a Durable Reduction in Cardiovascular Disease Risk Factors and Reduces the Long-Term Risks of Congestive Heart Failure [Preventive Cardiology]
ConclusionsGastric bypass is associated with a reduced risk of major cardiovascular events and the development of congestive heart failure. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 23, 2017 Category: Cardiology Authors: Benotti, P. N., Wood, G. C., Carey, D. J., Mehra, V. C., Mirshahi, T., Lent, M. R., Petrick, A. T., Still, C., Gerhard, G. S., Hirsch, A. G. Tags: Cardiomyopathy, Heart Failure, Metabolic Syndrome, Remodeling, Cerebrovascular Disease/Stroke Original Research Source Type: research

Changes in Cardiovascular Disease Risk Factors With Immediate Versus Deferred Antiretroviral Therapy Initiation Among HIV-Positive Participants in the START (Strategic Timing of Antiretroviral Treatment) Trial [Preventive Cardiology]
ConclusionsAmong HIV‐positive persons with preserved immunity, immediate ART led to increases in total cholesterol and low‐density lipoprotein cholesterol but also concurrent increases in high‐density lipoprotein cholesterol and decreased use of blood pressure medications. These opposing effects suggest that, in the short term, the net effect of early ART on traditional cardiovascular disease risk factors may be clinically insignificant."Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00867048. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 22, 2017 Category: Cardiology Authors: Baker, J. V., Sharma, S., Achhra, A. C., Bernardino, J. I., Bogner, J. R., Duprez, D., Emery, S., Gazzard, B., Gordin, J., Grandits, G., Phillips, A. N., Schwarze, S., Soliman, E. Z., Spector, S. A., Tambussi, G., Lundgren, J., the INSIGHT (International Tags: Lipids and Cholesterol, Cardiovascular Disease, Risk Factors Original Research Source Type: research

Long–Term Cardiovascular Risk After Radiotherapy in Women With Breast Cancer [Systematic Review and Meta-Analysis]
ConclusionsExposure of the heart to ionizing radiation during radiotherapy for breast cancer increases the subsequent risk of coronary heart disease and cardiac mortality. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 21, 2017 Category: Cardiology Authors: Cheng, Y.-J., Nie, X.-Y., Ji, C.-C., Lin, X.-X., Liu, L.-J., Chen, X.-M., Yao, H., Wu, S.-H. Tags: Cardiovascular Disease, Epidemiology, Primary Prevention, Risk Factors, Women Systematic Review and Meta ‐ Analysis Source Type: research

Quantitative Value of Aldosterone-Renin Ratio for Detection of Aldosterone-Producing Adenoma: The Aldosterone-Renin Ratio for Primary Aldosteronism (AQUARR) Study [Cardiovascular Surgery]
ConclusionsThese results indicate that the ARR conveys key quantitative information that, if properly used, can simplify the diagnostic workup, resulting in saving of money and resources. This can offer the chance of diagnosis and ensuing adrenalectomy to a larger number of hypertensive patients, ultimately resulting in better control of blood pressure. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 21, 2017 Category: Cardiology Authors: Maiolino, G., Rossitto, G., Bisogni, V., Cesari, M., Seccia, T. M., Plebani, M., Rossi, G. P., the PAPY Study Investigators Tags: Hypertension Original Research Source Type: research

Myocardial Metabolism Under Control of a Cytokine Receptor [Editorials]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 20, 2017 Category: Cardiology Authors: Ramos, G., Frantz, S. Tags: Basic Science Research, Inflammation, Metabolism, Myocardial Biology Editorial Source Type: research

Merits of Invasive Strategy in Diabetic Patients With Non-ST Elevation Acute Coronary Syndrome [Editorials]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 20, 2017 Category: Cardiology Authors: Jneid, H. Tags: Percutaneous Coronary Intervention, Revascularization, Treatment, Mortality/Survival, Quality and Outcomes Editorial Source Type: research

New Role for Interleukin-13 Receptor {alpha}1 in Myocardial Homeostasis and Heart Failure [Heart Failure]
ConclusionsThe results of our studies in humans and mice indicate, for the first time, a role of interleukin‐13 receptor α1 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 20, 2017 Category: Cardiology Authors: Amit, U., Kain, D., Wagner, A., Sahu, A., Nevo-Caspi, Y., Gonen, N., Molotski, N., Konfino, T., Landa, N., Naftali-Shani, N., Blum, G., Merquiol, E., Karo-Atar, D., Kanfi, Y., Paret, G., Munitz, A., Cohen, H. Y., Ruppin, E., Hannenhalli, S., Leor, J. Tags: Growth Factors/Cytokines Original Research Source Type: research

C-GRApH: A Validated Scoring System for Early Stratification of Neurologic Outcome After Out-of-Hospital Cardiac Arrest Treated With Targeted Temperature Management [Resuscitation Science]
BackgroundOut‐of‐hospital cardiac arrest (OHCA) results in significant morbidity and mortality, primarily from neurologic injury. Predicting neurologic outcome early post‐OHCA remains difficult in patients receiving targeted temperature management.Methods and ResultsRetrospective analysis was performed on consecutive OHCA patients receiving targeted temperature management (32–34°C) for 24 hours at a tertiary‐care center from 2008 to 2012 (development cohort, n=122). The primary outcome was favorable neurologic outcome at hospital discharge, defined as cerebral performance category 1 to 2 (poor 3–5). Patient ...
Source: JAHA:Journal of the American Heart Association - May 20, 2017 Category: Cardiology Authors: Kiehl, E. L., Parker, A. M., Matar, R. M., Gottbrecht, M. F., Johansen, M. C., Adams, M. P., Griffiths, L. A., Dunn, S. P., Bidwell, K. L., Menon, V., Enfield, K. B., Gimple, L. W. Tags: Sudden Cardiac Death, Clinical Studies, Cardiopulmonary Arrest, Quality and Outcomes Original Research Source Type: research

T-Wave Morphology Restitution Predicts Sudden Cardiac Death in Patients With Chronic Heart Failure [Health Services and Outcomes Research]
BackgroundPatients with chronic heart failure are at high risk of sudden cardiac death (SCD). Increased dispersion of repolarization restitution has been associated with SCD, and we hypothesize that this should be reflected in the morphology of the T‐wave and its variations with heart rate. The aim of this study is to propose an electrocardiogram (ECG)‐based index characterizing T‐wave morphology restitution (TMR), and to assess its association with SCD risk in a population of chronic heart failure patients.Methods and ResultsHolter ECGs from 651 ambulatory patients with chronic heart failure from the MUSIC (MUerte S...
Source: JAHA:Journal of the American Heart Association - May 19, 2017 Category: Cardiology Authors: Ramirez, J., Orini, M., Minchole, A., Monasterio, V., Cygankiewicz, I., Bayes de Luna, A., Martinez, J. P., Pueyo, E., Laguna, P. Tags: Arrhythmias, Sudden Cardiac Death, Biomarkers, Heart Failure, Mortality/Survival Original Research Source Type: research

Netrin-1 Preserves Blood-Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats [Imaging]
ConclusionsNTN‐1 treatment preserved BBB integrity and improved neurological functions through a Deleted in Colorectal Cancer/focal adhesion kinase/RhoA signaling pathway after SAH. Thus, NTN‐1 may serve as a promising treatment to alleviate early brain injury following SAH. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 19, 2017 Category: Cardiology Authors: Xie, Z., Enkhjargal, B., Reis, C., Huang, L., Wan, W., Tang, J., Cheng, Y., Zhang, J. H. Tags: Animal Models of Human Disease, Basic Science Research, Ischemia Original Research Source Type: research

Systolic Blood Pressure Within 24 Hours After Thrombectomy for Acute Ischemic Stroke Correlates With Outcome [Stroke]
ConclusionsHigher peak values of systolic blood pressure independently correlated with worse 90‐day modified Rankin scale and a higher rate of hemorrhagic complications. Further prospective studies are warranted to identify whether systolic blood pressure is a therapeutic target to improve outcomes. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 18, 2017 Category: Cardiology Authors: Mistry, E. A., Mistry, A. M., Nakawah, M. O., Khattar, N. K., Fortuny, E. M., Cruz, A. S., Froehler, M. T., Chitale, R. V., James, R. F., Fusco, M. R., Volpi, J. J. Tags: High Blood Pressure, Revascularization, Complications, Quality and Outcomes, Ischemic Stroke Original Research Source Type: research

Risk of Ischemic Stroke Associated With Calcium Supplements With or Without Vitamin D: A Nested Case-Control Study [Stroke]
BackgroundThere is controversy surrounding the risk of ischemic stroke associated with the use of calcium supplements either in monotherapy or in combination with vitamin D.Methods and ResultsA nested case‐control study was performed with patients aged 40 to 89 years old, among whom a total of 2690 patients had a first episode of nonfatal ischemic stroke and for which 19 538 controls were randomly selected from the source population and frequency‐matched with cases for age, sex, and calendar year. Logistic regression provided the odds ratios while adjusting for confounding factors. A sensitivity analysis was performe...
Source: JAHA:Journal of the American Heart Association - May 18, 2017 Category: Cardiology Authors: de Abaȷo, F. J., Rodriguez-Martin, S., Rodriguez-Miguel, A., Gil, M. J. Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Original Research Source Type: research

Effects of Sodium–Glucose Cotransporter 2 Inhibitors on 24–Hour Ambulatory Blood Pressure: A Systematic Review and Meta–Analysis [Systematic Review and Meta-Analysis]
ConclusionsThis meta‐analysis shows that the reduction in 24‐hour ambulatory BP observed with SGLT2 inhibitors is a class effect. The diurnal effect of SGLT2 inhibitors on 24‐hour ambulatory BP may contribute to their favorable effects on cardiovascular outcomes. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 18, 2017 Category: Cardiology Authors: Baker, W. L., Buckley, L. F., Kelly, M. S., Bucheit, J. D., Parod, E. D., Brown, R., Carbone, S., Abbate, A., Dixon, D. L. Tags: Diabetes, Type 2, High Blood Pressure, Hypertension, Meta Analysis Systematic Review and Meta ‐ Source Type: research

Midlife and Late-Life Vascular Risk Factors and White Matter Microstructural Integrity: The Atherosclerosis Risk in Communities Neurocognitive Study [Epidemiology]
ConclusionsHypertension in both midlife and late life and elevated glucose in midlife are related to worse WM microstructural integrity in late life. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 18, 2017 Category: Cardiology Authors: Power, M. C., Tingle, J. V., Reid, R. I., Huang, J., Sharrett, A. R., Coresh, J., Griswold, M., Kantarci, K., Jack, C. R., Knopman, D., Gottesman, R. F., Mosley, T. H. Tags: Lipids and Cholesterol, Diabetes, Type 2, Epidemiology, Risk Factors, High Blood Pressure Original Research Source Type: research

Synergistic Effect of Dofetilide and Mexiletine on Prevention of Atrial Fibrillation [Arrhythmia and Electrophysiology]
This study was done to test whether combined use of dofetilide and mexiletine exhibits not only a synergistic effect on AF suppression but also a safer profile in drug‐induced ventricular proarrhythmias.Methods and ResultsThe effects of dofetilide plus mexiletine on atrial effective refractory period (ERP), AF inducibility, QT, and QT‐related ventricular arrhythmias were studied using the isolated arterially perfused rabbit atrial and ventricular wedge preparations. Dofetilide or mexiletine alone mildly to moderately prolonged atrial ERP, but their combined use produced a markedly rate‐dependent increase in atrial ER...
Source: JAHA:Journal of the American Heart Association - May 18, 2017 Category: Cardiology Authors: Liu, G., Xue, X., Gao, C., Huang, J., Qi, D., Zhang, Y., Dong, J.-Z., Ma, C.-S., Yan, G.-X. Tags: Arrhythmias, Basic Science Research Original Research Source Type: research