Jama
(Source: JAMA)
Source: JAMA - April 16, 2024 Category: General Medicine Source Type: research
Audio Highlights
Listen to the JAMA Editor ’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA. (Source: JAMA)
Source: JAMA - April 16, 2024 Category: General Medicine Source Type: research
Jama
(Source: JAMA)
Source: JAMA - April 9, 2024 Category: General Medicine Source Type: research
Does This Patient Have Alcohol Use Disorder?
This Rational Clinical Examination systematic review summarizes studies that examined the diagnostic accuracy of brief screening tools to identify individuals with alcohol use disorder. (Source: JAMA)
Source: JAMA - April 9, 2024 Category: General Medicine Source Type: research
Trading Places, Becoming One
“Hey Doc” calls to us in an almost cheeky tone, its colloquial informality at first seeming to challenge the stereotypically aloof physician. Common-man “John,” as the speaker of the poem declares he prefers to be called, seeks to commune on more humanistic terms with his physician-interlocu tor, invoking Aristotle and Ptolemy, classical thinkers whose writings bridge high-minded science and universalizing art. A twist in the poem occurs midway, where the speaker and the physician trade places, becoming one: “When you descended into//hell, whose heavenly hand reached you?” (note the plunge to hell across the st...
Source: JAMA - April 9, 2024 Category: General Medicine Source Type: research
Hey Doc
I would like to be known as John. It ’s not that I’m against utilitarian exchanges; I simply don’t want every foundation (Source: JAMA)
Source: JAMA - April 9, 2024 Category: General Medicine Source Type: research
Acetaminophen Use During Pregnancy and Children ’s Risk of Autism, ADHD, and Intellectual Disability
This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children ’s risk of autism, ADHD, and intellectual disability. (Source: JAMA)
Source: JAMA - April 9, 2024 Category: General Medicine Source Type: research
Affiliation Bias in Peer Review of Abstracts —Reply
In Reply We thank Dr Gallo and colleagues for their interest in our study and for raising awareness about the statistical considerations when investigating LLMs. (Source: JAMA)
Source: JAMA - April 9, 2024 Category: General Medicine Source Type: research
Breast Cancer and Pregnancy in Young BRCA Carriers —Reply
In Reply We thank Dr Narod for his comment on our recent research article evaluating the safety of pregnancy following breast cancer in young women with germline BRCA pathogenic or likely pathogenic variants. In his Letter, Narod noted that our primary analysis did not control for the potentially protective effect of risk-reducing bilateral salpingo-oophorectomy in this patient cohort. (Source: JAMA)
Source: JAMA - April 9, 2024 Category: General Medicine Source Type: research
ECMO and Prone Position in Patients With Severe ARDS —Reply
In Reply In their Letter about our recent study, Drs Wiener and Albert suggest that incorporating periodic sigh breaths into ultraprotective lung ventilation during ECMO could potentially enhance the efficacy of prone positioning. They suggest that this approach may help expand atelectatic regions, improve lung compliance, reduce cyclical airspace opening and closing, and subsequently facilitate earlier ECMO weaning. While we acknowledge the potential appeal of this mechanical ventilation strategy, the literature currently lacks data on the utilization of periodic sigh breaths in conjunction with very low tidal volume, red...
Source: JAMA - April 9, 2024 Category: General Medicine Source Type: research
Affiliation Bias in Peer Review of Abstracts
This study demonstrates an important issue in current LLM research studies that urgently needs addressing: how to handle the proba bilistic nature of LLMs. (Source: JAMA)
Source: JAMA - April 9, 2024 Category: General Medicine Source Type: research
Breast Cancer and Pregnancy in Young BRCA Carriers
To the Editor In the article by Dr Lambertini and colleagues on pregnancy after breast cancer in young BRCA carriers, the authors compared the outcomes of patients with breast cancer and BRCA1 or BRCA2 variants according to whether or not they had a pregnancy after having breast cancer. They found no effect of pregnancy on the outcome of disease-free survival (local recurrence, contralateral breast cancer, distant recurrence) (hazard ratio, 0.99; 95% CI, 0.81-1.20) but found a significant improvement in breast cancer –specific survival (death due to breast cancer) with pregnancy (hazard ratio, 0.53; 95% CI, 0.37-0.74; P...
Source: JAMA - April 9, 2024 Category: General Medicine Source Type: research
ECMO and Prone Position in Patients With Severe ARDS
To the Editor The PRONECMO study on the effects of prone positioning during ECMO concluded that prone positioning did not significantly reduce the time to successful weaning of ECMO. However, we find the presentation of this conclusion unclear. (Source: JAMA)
Source: JAMA - April 9, 2024 Category: General Medicine Source Type: research
ECMO and Prone Position in Patients With Severe ARDS
To the Editor Use of prone ventilation in patients with acute respiratory distress syndrome (ARDS) decreases pulmonary arterial to venous shunt, improves respiratory system compliance, and reduces cyclical airspace opening/closing in dependent lung regions. In their randomized clinical trial of prone positioning in conjunction with extracorporeal membrane oxygenation (ECMO), Dr Schmidt and colleagues used ultraprotective lung ventilation (tidal volume ≤4 mL/kg) to achieve low airspace opening pressures. There were no attempts to vary either the tidal volume or the level of positive end-expiratory pressure to optimize res...
Source: JAMA - April 9, 2024 Category: General Medicine Source Type: research
The Private Physician and Preventive Medicine
The fields of preventive medicine and public health have to a large degree been commingled, so that in the minds of many the terms are more or less synonymous. Some, however, wish to draw a clearcut line between the two. Many physicians seldom stop to think how much of their activity, and how many services they render to patients, are actually preventive in character. These services are usually rendered as remedial of illness and are, therefore, looked on as curative. It is difficult to differentiate clearly among public health, preventive medicine and curative medicine; indeed, it is neither necessary nor really desirable...
Source: JAMA - April 9, 2024 Category: General Medicine Source Type: research
