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Remission of extensive intrahepatic metastasis by C-arm computed tomography guided chemoembolization in uveal melanomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As soon as uveal melanoma has metastasized to the liver, response rates to systemic chemotherapy are low. It can be improved by development of special locoregional procedures. A 24-year-old woman suffered from inoperable hepatic metastases which grew to life-endangering size despite both systemic chemotherapy with gemc-itabine/treosulfan and conventional intrahepatic chemoembolization with fotemustine and starch particles. We subsequently performed two angiographic C-arm CT-guided, superselective chemoembolizations of the hepatic arteries feeding the tumor, using cisplatin, starch microspheres and ethiodized oil. Following...
Source: JDDG - November 18, 2009 Category: Dermatology Authors: Cord Sunderkötter, Mareike Eickelmann, Michael Köhler, Alexander Schmittel, Frank K. Wacker Source Type: journals

Erythema leprosum – after treatment of Lepromatous LeprosyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Leprosy is usually well-controlled by multidrug therapy (MDT). However, in case of noncompliance or leprosy reactions, it may present a therapeutically challenge. A 33-year-old Brazilian woman with lepromatous leprosy was treated with MDT for one year, but then discontinued therapy because she wanted to have children. Eight weeks after stopping her medications, she developed a severe and recalcitrant erythema (nodosum) leprosum (ENL) which presented histologically with thrombosed small veins and neutrophilic inflammation in fat septa, but without arteritis. During her pregnancy and ensuing lactation period, glucocorticoids...
Source: JDDG - November 17, 2009 Category: Dermatology Authors: Mareike Eickelmann, Martin Steinhoff, Dieter Metze, Jane Tomimori-Yamashita, Cord Sunderkötter Source Type: journals

Evidence-based (S3) guideline for the treatment of psoriasis vulgaris – Update: "Therapeutic options" and "Efalizumab"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In February 2009, the European Medicines Agency's (EMEA) Committee for Medicinal Products for Human Use (CHMP) had recommended the suspension of efalizumab's (Raptiva®) marketing authorization, because its benefits in the treatment of psoriasis were modest, while there was a risk of serious side effects in patients receiving the medicine, including the occurrence of progressive multifocal leukoencephalopathy (PML). The guideline group has changed the guideline accordingly. (Source: JDDG)
Source: JDDG - November 13, 2009 Category: Dermatology Authors: Alexander Nast, Matthias Augustin, Wolf-Henning Boehncke, Joachim Klaus, Ulrich Mrowietz, Hans-Michael Ockenfels, Sandra Philipp, Kristian Reich, Thomas Rosenbach, Martin Schlaeger, Michael Sebastian, Wolfram Sterry, Volker Streit, Peter Weisenseel, Berth Source Type: journals

Penicillin and vitamin A as possible therapeutic agents in pityriasis rubra pilarisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pityriasis rubra pilaris (PRP) is a rare skin disorder with versatile clinical presentations. A 62-year-old Caucasian woman with progressive erythroderma and classic adult (type I) PRP is presented. Treatment with systemic steroids and methotrexate produced no improvement. Clinical remission was achieved after systemic therapy with penicillin (both intravenous and intramuscular) and vitamin A. The therapy of PRP is reviewed, focusing on a possible infectious genesis of PRP as well as the role of antibiotics in its management. (Source: JDDG)
Source: JDDG - November 12, 2009 Category: Dermatology Authors: Ludmila Popova, Razvigor Darlenski, Nikolai Tsankov Source Type: journals

Topical treatment of actinic keratoses with low-dose 5-fluorouracil in combination with salicylic acid – pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Treatment was well tolerated and efficient. (Source: JDDG)
Source: JDDG - November 3, 2009 Category: Dermatology Authors: Max Schlaak, Jan C. Simon Source Type: journals

Morgellons in dermatologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Delusional parasitosis (DP) is the most frequent delusional disorder in dermatology. In DP there is a fixed belief of a usually skin-related invasion or infestation by a number of alleged infectious species (usually parasites and bacteria), whose identity has varied over the decades. Since 2002 worldwide an increasing number of patients have complained of unverifiable fibers and filaments in or on the skin, associated with numerous nonspecific complaints (arthralgias, altered cognitive function and extreme fatigue). This entity has been named "Morgellons disease" by the patients themselves, although medical evidence for it...
Source: JDDG - October 30, 2009 Category: Dermatology Authors: Wolfgang Harth, Barbara Hermes, Roland W. Freudenmann Source Type: journals

Allergy preventionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The further increase of allergies in industrialized countries demands evidence-based measures of primary prevention. The recommendations as published in the guideline of 2004 were updated and consented on the basis of a systematic literature search. Evidence from the period February 2003[ndash]May 2008 was searched in the electronic databases Cochrane and MEDLINE as well as in reference lists of recent reviews and by contacting experts. The retrieved citations were screened for relevance first by title and abstract and in a second step as full paper. Levels of evidence were assigned to each included study and the methodolo...
Source: JDDG - October 29, 2009 Category: Dermatology Authors: Cathleen Muche-Borowski, Matthias Kopp, Imke Reese, Helmut Sitter, Thomas Werfel, Torsten Schäfer Source Type: journals

Clinical, histological and immunpathological findings in 32 patients with dermatitis herpetiformis DuhringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The detection of IgA autoantibodies against epidermal transglut-aminase is the most sensitive serological test in the diagnosis of dermatitis herpetiformis. Our observations confirm that patients with dermatitis herpetiformis usually do not demonstrate apparent gastrointestinal symptoms. (Source: JDDG)
Source: JDDG - October 28, 2009 Category: Dermatology Authors: Christian Rose, Eva-Bettina Bröcker, Detlef Zillikens Source Type: journals

Basic measures and systemic medical treatment of patients with toxic epidermal necrolysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Immediate beginning of therapy is essential for a successful treatment of toxic epidermal necrolysis. Besides systemic therapy with corticosteroids, certain basic measures such as isolation of patients at adequate room temperature to prevent hypothermia, strict control of circulation, temperature and laboratory parameters, daily smears of skin and mucous membranes and a diet rich in calories due to the catabolic metabolic status are very important for successful outcome. (Source: JDDG)
Source: JDDG - October 21, 2009 Category: Dermatology Authors: Imke Hanken, Melanie Schimmer, Christian A. Sander Source Type: journals

Myiasis after study trip to French GuianaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cutaneous myiasis is usually a harmless tropical disease caused by infestation with larvae from a variety of flies. Because of its rare occurrence in Europe, it is often misdiagnosed. Increased travel to tropical regions has correspondingly increased the number of cases observed in Europe. The furuncular type of cutaneous myiasis in a 31-year-old biology student was diagnosed upon his return from French Guiana. The student cultured one of the larvae to obtain a botfly. This case is discussed in the light of the current literature on pathogenesis, incidence and therapy of cutaneous myiasis. (Source: JDDG)
Source: JDDG - October 12, 2009 Category: Dermatology Authors: Heike A. Schreiber, Andreas C. Renkl, Witold Lapinski, Karin Scharffetter-Kochanek, Johannes M. Weiss Source Type: journals

Primary mucinous eccrine carcinoma of the skin – a rare clinical tumor with many differential diagnosesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary mucinous eccrine carcinoma of the skin is an extremely rare tumor most frequently occurring in the face or capillitium. It is felt to be an eccrine carcinoma, characterized by slow progress and unpredictable locally infiltrative growth. Therefore micrographic surgery is important to avoid local recurrence. It can be difficult to differentiate this carcinoma histologically from cutaneous metastases of breast or gastrointestinal tumors. Because of this, a primary staging in affected patients is essential. (Source: JDDG)
Source: JDDG - October 12, 2009 Category: Dermatology Authors: Ina M. Scholz, Wolfgang Hartschuh Source Type: journals

Occupational exposure to non-artificial UV-light and non-melanocytic skin cancer – a systematic review concerning a new occupational diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The association between occupational UV exposure and SCC is well and consistently documented epidemiologically (approximately 2-fold increased risk), so that the criteria for a new occupational disease are fulfilled. The association with BCC is unclear due to significant methodological limitations in the published studies. (Source: JDDG)
Source: JDDG - October 12, 2009 Category: Dermatology Authors: Jochen Schmitt, Thomas Diepgen, Andrea Bauer Source Type: journals

Cutaneous side effects of inhibition of VEGF signal transductionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The VEGF signaling pathway (including ligands, surface-bound receptors and intracellular downstream signaling cascades) is critically involved in angiogenesis under normal and pathological conditions, in particular in malignant tumors. As a consequence, several therapies that target specific components of this pathway have been approved for clinical use or are in various stages of clinical development. Currently, the monoclonal antibodies bevacizumab and ranibizumab, as well as the small-molecule kinase inhibitors sorafenib and sunitinib, have been approved for cancer therapy. The spectrum of cutaneous side effects elicite...
Source: JDDG - October 12, 2009 Category: Dermatology Authors: Gottfried Wozel, Michael Sticherling, Michael P. Schön Source Type: journals

Tinea of glabrous skinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JDDG)
Source: JDDG - October 11, 2009 Category: Dermatology Authors: Claus Seebacher, Hans Christian Korting, Dietrich Abeck, Jochen Brasch, Oliver Cornely, Isaak Effendy, Gabriele Ginter-Hanselmayer, Norbert Haake, Gudrun Hamm, Uta-Christina Hipler, Herbert Hof, Peter Mayser, Markus Ruhnke, Kurt-Heiner Schlacke, Hans-Jür Source Type: journals

Impact of the surgeon's experience on the postoperative outcome – a retrospective analysis of non-melanoma skin cancers of the head and neck regionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Micrographically-controlled surgery followed by plastic reconstruction is the treatment of choice for non-melanoma skin tumors of the head and neck area. Cosmetic results are excellent. Minor procedures can be performed by residents during their training; larger defects require more experience in dermatosurgery. (Source: JDDG)
Source: JDDG - October 8, 2009 Category: Dermatology Authors: Moritz Felcht, Jörg Faulhaber, Anna Sophie Maria Linder, Sergij Goerdt, Wolfgang Koenen Source Type: journals

Hand augmentation with stabilized hyaluronic acid (Macrolane™ VRF20 and Restylane® Vital, Restylane® Vital Light)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the treatment of two patients who received hyaluronic acid products produced by Q-Med (Macrolane[trade] VRF20, Restylane® Vital and Vital Light). The injections of Macrolane[trade] VRF 20 were done by feathering technique using a long and blunt 18 gauge canula while Restylane® was injected by tunneling or tenting technique with a 30 gauge needle. Significant adverse events did not occur. After injection of the hyaluronic acid fillers, the appearance of the back of the hands was improved. Both patients were very satisfied with the result. (Source: JDDG)
Source: JDDG - October 8, 2009 Category: Dermatology Authors: Vanessa Hartmann, Frank Bachmann, Martina Plaschke, Tobias Gottermeier, Alexander Nast, Berthold Rzany Source Type: journals

Three years after the publication of the German (S3) evidence based Psoriasis Guidelines – Was it worth the effort?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The S3 (evidence-based) psoriasis guidelines were an important milestone in German dermatology. Three years after their publication, a review and evaluation of their success is important. Since the publication of the guidelines, the quality of care of psoriasis patients has improved. The proportion of patients with a PASI above 20 in the general patient population has decreased, there are less days of work lost due to psoriasis, uncertainties in administering systemic therapies have been decreased and the proportion of patients with severe psoriasis receiving a systemic treatment has increased. The guidelines' website as w...
Source: JDDG - October 8, 2009 Category: Dermatology Authors: Alexander Nast, Berthold Rzany Source Type: journals

Successful treatment of a large hemangioma with propranololEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hemangiomas are the most common vascular tumors in children. They occur in 8[ndash]12% of all infants and in 22% of premature infants (female: male = 3: 1). Hemangiomas are usually sporadic; their etiology is unknown [1]. A premature female infant, born at 28 weeks of gestation, presented with a large hemangioma of the right thoracic wall. Within the first few weeks, the hemangioma showed rapid horizontal and vertical growth as well as ulceration, which led us to initiate systemic therapy. The effectiveness of propranolol (non-selective ß-blocker) in the management of severe cases of hemangioma has been shown in a recent ...
Source: JDDG - September 25, 2009 Category: Dermatology Authors: Waseem Mousa, Kirsten Kues, Ellen Haas, Peter Lauerer, Helena Pavlakovic, Michael P. Schön, Markus Zutt Source Type: journals

Microcystic adnexal carcinoma – aggressive infiltrative tumor often with innocent clinical appearanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report two patients with microcystic adnexal carcinoma, using them as a basis to discuss, pathogenesis, diagnosis, histology and therapy of the tumor. (Source: JDDG)
Source: JDDG - September 24, 2009 Category: Dermatology Authors: Corinna Hamsch, Wolfgang Hartschuh Source Type: journals

Disorders of PigmentationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Skin color is highly individual and the variations are controlled by numerous genes. The different skin colors result from the size and number of melanosomes and do not mirror the amount of melanocytes. Disorders of pigmentation can result from migration abnormalities of melanocytes from the neural crest to the skin during embryogenesis. In addition, impairment of melanosome transfer to the surrounding keratinocytes, an alteration in melanin synthesis and a defective degradation or removal of melanin may lead to abnormal skin pigmentation. Immunologic or toxic mediated destructions of melanocytes can end in pigmentation di...
Source: JDDG - September 24, 2009 Category: Dermatology Authors: Susanna K. Fistarol, Peter H. Itin Source Type: journals

Successful treatment of hereditary angioedema with bradykinin B2-receptor antagonist icatibantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The bradykinin B2 receptor antagonist icatibant has recently become available for treating hereditary angioedema. Our observations demonstrate icatibant to be effective and safe for the treatment of both, abdominal and cutaneous attacks in a practice setting beyond clinical studies. (Source: JDDG)
Source: JDDG - September 15, 2009 Category: Dermatology Authors: Karoline Krause, Martin Metz, Torsten Zuberbier, Marcus Maurer, Markus Magerl Source Type: journals

Periorbital dermatitis: Causes, differential diagnoses and therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the causes of periorbital dermatitis and compared the data of 88 patients from the Department of Dermatology, University Hospital Erlangen to those of the German IVDK (Information Network of the Departments of Dermatology). Between 1999 and 2004, predominant causes of periorbital dermatitis were allergic contact dermatitis (Erlangen 44 %, IVDK 32 %), atopic eczema (Erlangen 25 %, IVDK 14 %), airborne contact dermatitis (Erlangen 10 %, IVDK 2 %) and irritant contact dermatitis (Erlangen 9 %, IVDK 8 %). Less frequent causes for secondary eczematous periocular skin lesions were periorbital rosacea, allergic conjun...
Source: JDDG - September 14, 2009 Category: Dermatology Authors: Alexandra Feser, Vera Mahler Source Type: journals

The role and duties of scientific medical societies: The German Society of Dermatology from the member's perspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A scientific society in general acts in a permanent area of conflict and has to deal with multiple positions and interests.Thereby members' needs and demands may vary dependent on individual and professional backgrounds. Members who are not scientifically active should be more integrated in the society while at the same time the society's aims should be coordinated with that of the Berufsverband (organization of practicing dermatologists). Better networking is required both within the society and with outside groups. In addition, the primary aims and objectives of the society should be made even clearer to all...
Source: JDDG - September 13, 2009 Category: Dermatology Authors: Peter Hensen, Rudolf Stadler, Thomas A. Luger Source Type: journals

Photopheresis in pediatric patients with low-body weight using the UVAR® XTS™ systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: It is possible to run ECP in low-body weight patients with the UVAR® XTS[trade] system. (Source: JDDG)
Source: JDDG - September 13, 2009 Category: Dermatology Authors: Uwe Hillen, Sabine Meyer, Dirk Schadendorf, Bernhard Kremens Source Type: journals

Research in practice: the second barrier of the human skinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A major function of human skin is to form an effective barrier between the environment and the inside of the organism. Especially important for this function is the activity of the physical barrier of the skin, which is mainly located in the stratum corneum. To improve this barrier function of the skin, skin protection agents are used. Recent studies have revealed that application of skin protection agents before exposition to xenobiotics does not generally reduce the percutaneous uptake of these compounds. These findings indicate that besides new study designs and improved test systems, there seems to be a need for new th...
Source: JDDG - September 13, 2009 Category: Dermatology Authors: Jens Malte Baron, Claudia Skazik Source Type: journals

Hymenoptera venom allergyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Allergic reactions to Hymenoptera stings usually present as large local reactions or systemic reactions with symptoms of immediate type allergy (anaphylaxis). In Central Europe they are predominantly elicited by stings of the honeybee or Vespula spp. Acute reactions are managed by symptomatic treatment. Long-term care includes patient education (allergen avoidance, course of action at re-sting) and prescription of an emergency kit for self-treatment. Venom immunotherapy is established as specific treatment for Hymenoptera venom allergic patients. Diagnosis of Hymenoptera venom anaphylaxis is based on history, skin tests an...
Source: JDDG - September 13, 2009 Category: Dermatology Authors: Bernhard Przybilla, Franziska Ruëff Source Type: journals

Adjuvant topical therapy with a cannabinoid receptor agonist in facial postherpetic neuralgiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Topical cannabinoid receptor agonists are an effective and well-tolerated adjuvant therapy option in postherpetic neuralgia. (Source: JDDG)
Source: JDDG - September 10, 2009 Category: Dermatology Authors: Ngoc Quan Phan, Dorothee Siepmann, Ingrid Gralow, Sonja Ständer Source Type: journals

Dermatology in the Darwin anniversary. Part 2: Evolution of the skin-associated immune systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The present review highlights the evolution of the skin-associated immune system from the invertebrates to the vertebrates and man. In the invertebrates a non-specific humoral immune response dominates. It includes antimicrobial peptides, oxidases, lysozyme, agglutinins, coagulins and melanin. The cellular immune system initially consists of undifferentiated mesenchymal stem cells. Later migrating phagocytes and natural killer cells occur. From the fishes on, dendritic cells are present, linking innate and adaptive immune responses. In addition to this unspecific but highly effective immune system, the specific immune resp...
Source: JDDG - August 31, 2009 Category: Dermatology Authors: Ute Wölfle, Stefan Martin, Matthias Emde, Christoph Schempp Source Type: journals

Pemphigus vegetans – immunopathological findings in a rare variant of pemphigus vulgarisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A patient with painful erosions of the oral cavity and the labia minora developed multifocal blisters in inter-triginous areas. These blisters eroded and evolved into papillomatous erosive vegetations. Histopathology and immunopathological investigations confirmed the diagnosis of pemphigus vegetans, mediated by IgG autoantibodies. The circulating IgG1 and IgG4 autoantibodies were exclusively directed against desmoglein 3, as shown by ELISA and indirect immunofluorescence studies. These IgG1 and IgG4 isotypes were also in vivo bound, as demonstrated with immunoperoxidase staining of perilesional skin. Our clinical, biochem...
Source: JDDG - August 31, 2009 Category: Dermatology Authors: Babak Monshi, Michael Marker, Hans Feichtinger, Grazyna Schmid, Ernst Kriehuber, Dagmar Födinger, Klemens Rappersberger Source Type: journals

Recommendations for tap water iontophoresisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JDDG)
Source: JDDG - August 31, 2009 Category: Dermatology Authors: Erhard Hölzle, Martina Hund, Kerstin Lommel, Bodo Melnik Source Type: journals

Cutaneous gamma/delta T-cell lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a patient treated with surgery, immunomodulatory therapy, and polychemotherapy. He then received hematopoietic stem cell transplantation and has been in complete remission since. Allogeneic stem cell transplantation appears to be a promising therapeutic option for aggressive and generally fatal lymphomas like GD-TCL. (Source: JDDG)
Source: JDDG - August 19, 2009 Category: Dermatology Authors: Richard Koch, Elaine S. Jaffe, Christian Mensing, Matthias Zeis, Norbert Schmitz, Christian A. Sander Source Type: journals

Successful treatment of pityriasis rubra pilaris (type 1) under combination of infliximab and methotrexateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report for the first time the successful combination of infliximab and MTX for the treatment of PRP. (Source: JDDG)
Source: JDDG - August 18, 2009 Category: Dermatology Authors: Dietrich Barth, Wolfgang Harth, Regina Treudler, Jan C. Simon Source Type: journals

Role of the epidermal barrier in atopic dermatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The skin's permeability barrier protects against extensive water loss and prevents the entry into the skin of harmful substances like irritants, allergens and microorganisms. The permeability barrier is mainly located in the stratum corneum and consists of corneocytes and a lipid-enriched intercellular domain. The barrier is formed during epidermal differentiation. In atopic dermatitis the skin barrier is disturbed already in non-lesional skin. The disturbed skin barrier allows the entry of environmental allergens from house dust mites, animal dander and grass pollen into the skin. In predisposed individuals these allergen...
Source: JDDG - August 14, 2009 Category: Dermatology Authors: Ehrhardt Proksch, Regina Fölster-Holst, Matthias Bräutigam, Marjan Sepehrmanesh, Stephan Pfeiffer, Jens-Michael Jensen Source Type: journals

What do we know of post-thrombotic syndrome? Current status of post-thrombotic syndrome in adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The post-thrombotic syndrome (PTS) is a common but not completely understood and rarely studied sequela of an acute deep vein thrombosis. The influence of several risk factors on the incidence or severity of PTS is controversial. The therapeutic options for PTS are still limited. Appropriate medical compression stockings can reduce the incidence ([ndash]50 %) as well as the severity of PTS. In the case of severe, symptomatic PTS, they should be worn lifelong. As PTS is a chronic and often progressive disease, patients need regular clinical follow-up and encouragement to continuously wear their compression therapy. New stra...
Source: JDDG - August 11, 2009 Category: Dermatology Authors: Stefanie Reich-Schupke, Peter Altmeyer, Markus Stücker Source Type: journals

Folliculotropic mycosis fungoides in a psoriatic patient under methotrexate treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of folliculotropic mycosis fungoides developing in the months following methotrexate therapy in a psoriatic patient. This lymphoma did not regress after stopping the antipsoriatic treatment. There is a known relationship between the use of immunosuppressive therapies and the development of lymphoproliferative malignancies. However these lymphomas are mainly B-cell non-Hodgkin lymphomas associated with Epstein-Barr virus. In our patient the short period of time from the beginning of the immunosuppressive treatment to the occurrence of the T-cell lymphoma does not support a strong causal relationship between...
Source: JDDG - August 2, 2009 Category: Dermatology Authors: Vito Di Lernia, Cinzia Ricci, Laura Grenzi, Elisabetta Froio, Simonetta Piana Source Type: journals

New mutation in the CYLD gene within a family with Brooke-Spiegler syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a family, in which we performed a molecular-genetic examination and found a new mutation in exon 19 in the CYLD gene leading to a frameshift. It is important to be aware of this syndrome and its pathogenesis as its phenotypic features can vary so that apparently different diseases are caused by the same genetic defect. In addition, there may be malignant transformation of the generally benign tumors, so that a timely diagnosis is essential for appropriate monitoring and therapy. (Source: JDDG)
Source: JDDG - July 24, 2009 Category: Dermatology Authors: Ina M. Scholz, Astrid Nümann, Ursula G. Froster, Peter Helmbold, Alexander H. Enk, Helmut Näher Source Type: journals

RosaceaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JDDG)
Source: JDDG - July 23, 2009 Category: Dermatology Authors: Katharina Gauwerky, Winfried Klövekorn, Hans Christian Korting, Percy Lehmann, Eva-Maria Meigel, Dieter Reinel, Thomas Ruzicka, Martin Schaller, Helmut Schöfer, Julia Tietze Source Type: journals

How to run an effective and efficient dermato-oncology unit: a Dutch approachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The worldwide incidence of skin cancer (especially non-melanoma skin cancer) has risen dramatically over the last decades. Skin cancer, including pre-malignant lesions, is becoming a chronic disease. Adjustments in skin cancer health care need to be made. A disease management system for skin cancer is mandatory in order to avoid waiting lists and insure adequate treatment quality with ever growing numbers of patients requiring treatment. At the Catharina Hospital Eindhoven adjustments are being made on several levels of the dermato-oncology unit in collaboration with Eindhoven University of Technology. The model combines t...
Source: JDDG - July 23, 2009 Category: Dermatology Authors: Simone van der Geer, Hajo Reijers, Gertruud Krekels Source Type: journals

Reticular erythematous mucinosis – (REM syndrome) in twinsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present female twins with reticular erythematous mucinosis (REM syndrome). Remarkably, the lesions developed in both sisters almost at the same time in the same locations after UV exposure. Reports of familial manifestations of REM syndrome are very rare and an association to a distinct HLA constellation has not been proven. Our report clearly suggests a genetic predisposition. (Source: JDDG)
Source: JDDG - July 23, 2009 Category: Dermatology Authors: Maren Fühler, Karl Ottmann, Michael Tronnier Source Type: journals

Topical use of pimecrolimus in atopic dermatitis: Update on the safety and efficacyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pimecrolimus has been approved for more than five years for the treatment of atopic dermatitis in Germany. An important difference in the safety profile of this drug compared with topical corticosteroids is the lack of potential side effects which are often observed upon prolonged use of topical corticosteroids (skin atrophy, steroid-induced rosacea or perioral dermatitis). Even after prolonged use in sensitive skin areas, no tolerance to this drug is induced, in contrast to that seen with topical corticosteroids. The most common side effect of pimecrolimus is burning. Placebo-controlled studies suggest that pimecrolimus i...
Source: JDDG - July 23, 2009 Category: Dermatology Authors: Thomas Werfel Source Type: journals

Current therapy of HIVEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antiretroviral therapy has improved continuously. Almost every year a new drug has been approved. Nucleoside analogs still build the backbone of antiretroviral therapy. They inhibit reverse transcriptase and thus the transcription of RNA to DNA. They are combined with non-nucleoside reverse transcriptase inhibitors or protease inhibitors. New therapeutic approaches are attachment or entry inhibitors, integrase inhibitors and maturation inhibitors. Multiple prospective multicenter studies have proven the life prolonging effect of antiretroviral therapy. With the optimal therapy life expectancy of HIV patients is only slight...
Source: JDDG - July 23, 2009 Category: Dermatology Authors: Anja Verena Potthoff, Norbert H. Brockmeyer Source Type: journals

The strip patch test – indication in occupational dermatology demonstrated with a case historyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on a 30-year-old man working as an industrial mechanic from 1995 to 2006. After approval of an occupational disease no. 5101 of the German ordinance on industrial disease in 2007, he went to court claiming compensation. The sensitization with clinical and occupational relevance to potassium dichromate that was decisive for the evaluation for insurance purposes was first confirmed in a patch test in 2005. Succeeding tests in 2006 in the context of an expert opinion and in 2008 in the context of our decisive expert opinion remained negative. We could reconfirm the potassium dichromate sensitization only by the SPT ...
Source: JDDG - July 21, 2009 Category: Dermatology Authors: Heinrich Dickel, Nina Scola, Peter Altmeyer Source Type: journals

Perineal extramammary Paget disease responsive to topical imiquimodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Extramammary Paget disease (EMPD) is a rare neoplasm that arises in skin rich in apocrine glands, such as the axillae and anogenital region and usually affects the elderly. In most cases, EMPD is an apocrine carcinoma in situ, but it can be associated with internal malignancy spreading to overlying skin. Surgical excision with margin control is the generally accepted standard of care. A 74-year-old woman presented with a 1 year history of a pruritic eczematous eruption in perineum which on biopsy was diagnosed as EMPD. Because of the location and extent of the tumor, any surgical approach would have been problematic. Imiqu...
Source: JDDG - July 18, 2009 Category: Dermatology Authors: Roberto Cecchi, Mario Pavesi, Laura Bartoli, Luigi Brunetti, Valentina Rapicano Source Type: journals

Use of high-dose immunoglobulins in dermatologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JDDG)
Source: JDDG - July 16, 2009 Category: Dermatology Authors: Alexander Enk, Gerhard Fierlbeck, Lars French, Michael Hertl, Gerald Messer, Michael Meurer, Kerstin Steinbrink, Georg Stingl, Beatrice Volc-Platzer, Detlef Zillikens Source Type: journals

Effects of the introduction of the German "Praxisgebühr" on outpatient care and treatment of patients with atopic eczemaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: After the introduction of the German "Praxisgebühr" fewer patients with AE received dermatological treatment. Simultaneously, an unexpectedly significant increase in the (non evidence-based) treatment of AE with systemic steroids was observed, of which patients with relatively lower consultation frequency after the introduction of the co-payment were particularly affected. (Source: JDDG)
Source: JDDG - July 15, 2009 Category: Dermatology Authors: Jochen Schmitt, Wilhelm Kirch, Michael Meurer Source Type: journals

Uncombable hair and atopic dermatitis in a case of tricho-dento-osseous syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on an 8-year-old girl with tricho-dento-osseous syndrome, who presented in our allergy center with severe atopic dermatitis. Additional clinical findings included light, kinky hair reminiscent of pili trianguli et canaliculi (uncombable hair), enamel hypoplasia and enlarged pulp chambers of the molar teeth (tau-rodontism). A genetic investigation revealed a de-novo mutation in the DLX3 gene on chromosome 17q21. Electron microscopic examination of the curly hair showed a flattened hair shaft with longitudinal grooves. (Source: JDDG)
Source: JDDG - July 14, 2009 Category: Dermatology Authors: Dagmara E. Y. Mayer, Christian Baal, Margaritha Litschauer-Poursadrollah, Wolfgang Hemmer, Reinhart Jarisch Source Type: journals

Quality of medical care of patients with acne vulgaris in Germany – nationwide survey of pharmacy clientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Acne vulgaris is a burdensome, socio-economically relevant illness, and dermatologists treat most cases in Germany. Surveying across a network of pharmacies offers a unique access to relevant treatment data. Selection effects, particularly by choice of doctors and self-medication, were minimized. (Source: JDDG)
Source: JDDG - June 30, 2009 Category: Dermatology Authors: Nadine Franzke, Lisa Zimmer, Ines Schäfer, Christian Radermacher, Joachim Kresken, Matthias Augustin Source Type: journals

Cutaneous metastases as the first clinical sign of metastatic gastric carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cutaneous metastases from gastric cancer are uncommon with a frequency of 7 % but can rarely be the presenting sign. A 54-year-old man complained of multiple pea-sized scalp nodules which had been present for four months. Histology showed a metastatic adenocarcinoma. Initial evaluation revealed liver metastases and gastroscopy then identified a tumor involving the distal esophagus and gastric cardia that was diagnosed as a gastric tubular carcinoma. The patient had a good response to polychemotherapy. While gastric carcinoma generally metastasizes to the abdominal wall or lymph nodes, our patient showed an exceptional vari...
Source: JDDG - June 16, 2009 Category: Dermatology Authors: Lidia Frey, Claudia Vetter-Kauczok, Anja Gesierich, Eva-B. Bröcker, Selma Ugurel Source Type: journals

Multiple clustered dermatofibroma with overlying sebaceous hyperplasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the first case of a multiple clustered dermatofibroma with overlying sebaceous hyperplasia. (Source: JDDG)
Source: JDDG - June 16, 2009 Category: Dermatology Authors: Øyvind Bakken Rognstad, Norbert Haas, Wolfram Sterry, Susanne Astner Source Type: journals

Tropical rat mites (Ornithonyssus bacoti) – serious ectoparasitesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In Germany there is limited information available about the distribution of the tropical rat mite (Ornithonyssus bacoti) in rodents. A few case reports show that this hematophagous mite species may also cause dermatitis in man. Having close body contact to small rodents is an important question for patients with pruritic dermatoses. The definitive diagnosis of this ectopara-sitosis requires the detection of the parasite, which is more likely to be found in the environment of its host (in the cages, in the litter or in corners or cracks of the living area) than on the hosts' skin itself. A case of infestation with tropical ...
Source: JDDG - June 15, 2009 Category: Dermatology Authors: Wieland Beck, Regina Fölster-Holst Source Type: journals