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1741 records returned

Response: Re: Antitumor Efficacy Testing in RodentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Authors: Hollingshead, M. G. Tags: CORRESPONDENCE Source Type: journals

Re: Antitumor Efficacy Testing in RodentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Authors: Poggesi, I., de Nicolao, G., Germani, M., Rocchetti, M. Tags: CORRESPONDENCE Source Type: journals

Recent Changes in Breast Cancer Incidence in Spain, 1980-2004Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The recent downturn in breast cancer incidence among Spanish women older than 45 years is best explained by a period effect linked to screening saturation. (Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Authors: Pollan, M., Pastor-Barriuso, R., Ardanaz, E., Arguelles, M., Martos, C., Galceran, J., Sanchez-Perez, M.-J., Chirlaque, M.-D., Larranaga, N., Martinez-Cobo, R., Tobalina, M.-C., Vidal, E., Marcos-Gragera, R., Mateos, A., Garau, I., Rojas-Martin, M.-D., Ji Tags: ARTICLES Source Type: journals

Papillary Thyroid Cancer Incidence in the Volcanic Area of SicilyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Residents of Catania province with its volcanic region appear to have a higher incidence of papillary thyroid cancer than elsewhere in Sicily. (Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Authors: Pellegriti, G., De Vathaire, F., Scollo, C., Attard, M., Giordano, C., Arena, S., Dardanoni, G., Frasca, F., Malandrino, P., Vermiglio, F., Previtera, D. M., D'Azzo, G., Trimarchi, F., Vigneri, R. Tags: ARTICLES Source Type: journals

Antitumor Activity of the Selective MDM2 Antagonist Nutlin-3 Against Chemoresistant Neuroblastoma With Wild-Type p53Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Nutlin-3 activates the p53 pathway and suppresses tumor growth in this model system of chemoresistant neuroblastoma, provided that wild-type p53 is present. (Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Authors: Van Maerken, T., Ferdinande, L., Taildeman, J., Lambertz, I., Yigit, N., Vercruysse, L., Rihani, A., Michaelis, M., Cinatl, J., Cuvelier, C. A., Marine, J.-C., De Paepe, A., Bracke, M., Speleman, F., Vandesompele, J. Tags: ARTICLES Source Type: journals

A Case-Control Study of Smoking and Bladder Cancer Risk: Emergent Patterns Over TimeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Smoking-related risks of bladder cancer appear to have increased in New Hampshire since the mid-1990s. Based on our modeling of pack-years and intensity, smoking fewer cigarettes over a long time appears more harmful than smoking more cigarettes over a shorter time, for equal total pack-years of cigarettes smoked. (Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Authors: Baris, D., Karagas, M. R., Verrill, C., Johnson, A., Andrew, A. S., Marsit, C. J., Schwenn, M., Colt, J. S., Cherala, S., Samanic, C., Waddell, R., Cantor, K. P., Schned, A., Rothman, N., Lubin, J., Fraumeni, J. F., Hoover, R. N., Kelsey, K. T., Silverman Tags: ARTICLES Source Type: journals

Pharmacokinetically Guided Dose Adjustment of 5-Fluorouracil: A Rational Approach to Improving Therapeutic OutcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chemotherapy dosing of the fluoropyrimidine 5-fluorouracil (5-FU) is currently based on body surface area. However, body surface area–based dosing has been associated with clinically significant pharmacokinetic variability, and as such, dosing based on body surface area may be of limited use. The clinical activity of 5-FU is modest at standard doses, and in general, dosing is limited by the safety profile, with myelosuppression and gastrointestinal toxicity being the most commonly observed side effects. Various strategies have been developed to enhance the clinical activity of 5-FU, such as biochemical modulation, al...
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Authors: Saif, M. W., Choma, A., Salamone, S. J., Chu, E. Tags: REVIEW Source Type: journals

Putting Risk Prediction in Perspective: Relative Utility CurvesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Risk prediction models based on medical history or results of tests are increasingly common in the cancer literature. An important use of these models is to make treatment decisions on the basis of estimated risk. The relative utility curve is a simple method for evaluating risk prediction in a medical decision-making framework. Relative utility curves have three attractive features for the evaluation of risk prediction models. First, they put risk prediction into perspective because relative utility is the fraction of the expected utility of perfect prediction obtained by the risk prediction model at the optimal cut point...
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Authors: Baker, S. G. Tags: COMMENTARY Source Type: journals

Search for New Treatments Intensifies for Triple-Negative Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Authors: Brower, V. Tags: NEWS Source Type: journals

Increase in Oral Cancer Drugs Raises Thorny Issues for Oncology PracticesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Authors: Hede, K. Tags: NEWS Source Type: journals

StatBite: A Look at Bladder Cancer in the United StatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Tags: NEWS Source Type: journals

Are Smokers Now at Higher Risk of Bladder Cancer? Are Changes in Cigarettes To Blame?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Authors: Tuma, R. S. Tags: NEWS Source Type: journals

Why Do Tumors Become Resistant to Antiangiogenesis Drugs?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Authors: Schmidt, C. Tags: NEWS Source Type: journals

Targeted Molecular Therapy for Neuroblastoma: The ARF/MDM2/p53 AxisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Authors: Kim, E., Shohet, J. Tags: EDITORIALS Source Type: journals

Cigarette Smoking and Bladder Cancer: A New Twist in an Old Saga?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Authors: Alberg, A. J., Hebert, J. R. Tags: EDITORIALS Source Type: journals

In this issueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Tags: IN THIS ISSUE Source Type: journals

Table of ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Tags: TABLE OF CONTENTS Source Type: journals

Japanese journal of clinical oncologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Tags: BACK MATTER Source Type: journals

Editorial boardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Tags: EDITORIAL BOARD Source Type: journals

CoverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Tags: COVER Source Type: journals

Higher Incidence of Thyroid Cancer in Volcanic Area of SicilyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Tags: MEMO TO THE MEDIA Source Type: journals

Bladder Cancer Risks Increase Over Time For SmokersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Tags: MEMO TO THE MEDIA Source Type: journals

Association of Merkel Cell Polyomavirus-Specific Antibodies With Merkel Cell CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Infection with MCPyV is common in the general population. MCPyV, but not other human polyomaviruses, appears to be associated with Merkel cell carcinoma. (Source: JNCI)
Source: JNCI - November 3, 2009 Category: Cancer & Oncology Authors: Carter, J. J., Paulson, K. G., Wipf, G. C., Miranda, D., Madeleine, M. M., Johnson, L. G., Lemos, B. D., Lee, S., Warcola, A. H., Iyer, J. G., Nghiem, P., Galloway, D. A. Tags: ARTICLES Source Type: journals

Prospective Case-Control Study of Serum Mullerian Inhibiting Substance and Breast Cancer RiskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion MIS may be a novel biomarker of increased breast cancer risk. Additional research including confirmatory epidemiological studies and mechanistic studies is needed. (Source: JNCI)
Source: JNCI - November 3, 2009 Category: Cancer & Oncology Authors: Dorgan, J. F., Stanczyk, F. Z., Egleston, B. L., Kahle, L. L., Shaw, C. M., Spittle, C. S., Godwin, A. K., Brinton, L. A. Tags: ARTICLES Source Type: journals

Cancer Incidence in Israeli Jewish Survivors of World War IIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Incidence of all cancers, particularly breast and colorectal cancer, was higher among Israeli Jews who were potentially exposed to the Holocaust than among those who were not. (Source: JNCI)
Source: JNCI - November 3, 2009 Category: Cancer & Oncology Authors: Keinan-Boker, L., Vin-Raviv, N., Liphshitz, I., Linn, S., Barchana, M. Tags: ARTICLES Source Type: journals

Screening for Emotional Distress in Cancer Patients: A Systematic Review of Assessment InstrumentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Screening for emotional distress is becoming increasingly common in cancer care. This systematic review examines the psychometric properties of the existing tools used to screen patients for emotional distress, with the goal of encouraging screening programs to use standardized tools that have strong psychometrics. Systematic searches of MEDLINE and PsycINFO databases for English-language studies in cancer patients were performed using a uniform set of key words (eg, depression, anxiety, screening, validation, and scale), and the retrieved studies were independently evaluated by two reviewers. Evaluation criteria included ...
Source: JNCI - November 3, 2009 Category: Cancer & Oncology Authors: Vodermaier, A., Linden, W., Siu, C. Tags: REVIEW Source Type: journals

A Perspective on Challenges and Issues in Biomarker Development and Drug and Biomarker CodevelopmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A workshop sponsored by the National Cancer Institute and the US Food and Drug Administration addressed past lessons learned and ongoing challenges faced in biomarker development and drug and biomarker codevelopment. Participants agreed that critical decision points in the product life cycle depend on the level of understanding of the biology of the target and its interaction with the drug, the preanalytical and analytical factors affecting biomarker assay performance, and the clinical disease process. The more known about the biology and the greater the strength of association between an analytical signal and clinical res...
Source: JNCI - November 3, 2009 Category: Cancer & Oncology Authors: Taube, S. E., Clark, G. M., Dancey, J. E., McShane, L. M., Sigman, C. C., Gutman, S. I. Tags: COMMENTARIES Source Type: journals

Use of Archived Specimens in Evaluation of Prognostic and Predictive BiomarkersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The development of tumor biomarkers ready for clinical use is complex. We propose a refined system for biomarker study design, conduct, analysis, and evaluation that incorporates a hierarchal level of evidence scale for tumor marker studies, including those using archived specimens. Although fully prospective randomized clinical trials to evaluate the medical utility of a prognostic or predictive biomarker are the gold standard, such trials are costly, so we discuss more efficient indirect "prospective–retrospective" designs using archived specimens. In particular, we propose new guidelines that stipulate that 1) ade...
Source: JNCI - November 3, 2009 Category: Cancer & Oncology Authors: Simon, R. M., Paik, S., Hayes, D. F. Tags: COMMENTARIES Source Type: journals

Capsule Endoscopy To Screen for Colon Cancer Scores Low on Sensitivity, High on ControversyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 3, 2009 Category: Cancer & Oncology Authors: Schmidt, C. Tags: NEWS Source Type: journals

StatBite: Survey: Oncologists on Costs and TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 3, 2009 Category: Cancer & Oncology Tags: NEWS Source Type: journals

ASCO Rx for High Drug Costs: Doctors and Patients Need To TalkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 3, 2009 Category: Cancer & Oncology Authors: Nicholas, J. Tags: NEWS Source Type: journals

Progression-Free Survival Remains Debatable Endpoint in Cancer TrialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 3, 2009 Category: Cancer & Oncology Authors: Tuma, R. Tags: NEWS Source Type: journals

High-Throughput Screening Finds Potential Killer of Cancer Stem CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 3, 2009 Category: Cancer & Oncology Authors: Rowan, K. Tags: NEWS Source Type: journals

Cancer Risk From Extreme Stressors: Lessons From European Jewish Survivors of World War IIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 3, 2009 Category: Cancer & Oncology Authors: Hursting, S. D., Forman, M. R. Tags: EDITORIAL Source Type: journals

In this issueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 3, 2009 Category: Cancer & Oncology Tags: IN THIS ISSUE Source Type: journals

Table of ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 3, 2009 Category: Cancer & Oncology Tags: TABLE OF CONTENTS Source Type: journals

Japanese journal of clinical oncologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 3, 2009 Category: Cancer & Oncology Tags: BACK MATTER Source Type: journals

Editorial boardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 3, 2009 Category: Cancer & Oncology Tags: EDITORIAL BOARD Source Type: journals

CoverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 3, 2009 Category: Cancer & Oncology Tags: COVER Source Type: journals

Holocaust Survivors at Higher Risk for All CancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 3, 2009 Category: Cancer & Oncology Tags: MEMO TO THE MEDIA Source Type: journals

Tenth Biannual Report of the Cochrane Haematological Malignancies Group--Focus on Acute Myeloid LeukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - October 21, 2009 Category: Cancer & Oncology Authors: Bauer, K., Skoetz, N., Brillant, C., Herbst, C., Monsef, I., Kluge, S., Engert, A. Tags: ONLINE COMMENTARY Source Type: journals

ErratumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - October 21, 2009 Category: Cancer & Oncology Tags: CORRESPONDENCE Source Type: journals

Editor's Note:Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - October 21, 2009 Category: Cancer & Oncology Tags: CORRESPONDENCE Source Type: journals

Response: Re: Tandem vs Single Autologous Hematopoietic Cell Transplantation for the Treatment of Multiple Myeloma: A Systematic Review and Meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - October 21, 2009 Category: Cancer & Oncology Authors: Kumar, A., Kharfan-Dabaja, M., Djulbegovic, B. Tags: CORRESPONDENCE Source Type: journals

Re: Tandem vs Single Autologous Hematopoietic Cell Transplantation for the Treatment of Multiple Myeloma: A Systematic Review and Meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - October 21, 2009 Category: Cancer & Oncology Authors: Mehta, J. Tags: CORRESPONDENCE Source Type: journals

Re: Cervical Intraepithelial Neoplasia Outcomes After Treatment: Long-term Follow-up From the British Columbia Cohort StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - October 21, 2009 Category: Cancer & Oncology Authors: Cecchini, S., Ciatto, S., Iossa, A., Ventura, L., Zappa, M. Tags: CORRESPONDENCE Source Type: journals

Response: Re: Incidence of Adenocarcinoma of the Esophagus Among White Americans by Sex, Stage, and AgeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - October 21, 2009 Category: Cancer & Oncology Authors: Brown, L. M., Devesa, S. S., Chow, W.-H. Tags: CORRESPONDENCE Source Type: journals

Re: Incidence of Adenocarcinoma of the Esophagus Among White Americans by Sex, Stage, and AgeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - October 21, 2009 Category: Cancer & Oncology Authors: Chien, C.-R., Lin, C.-Y., Chen, C.-Y. Tags: CORRESPONDENCE Source Type: journals

Polyclonality of BRAF Mutations in Acquired Melanocytic NeviEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Melanocytic nevi are thought to be senescent clones of melanocytes that have acquired an oncogenic BRAF mutation. BRAF mutation is considered to be a crucial step in the initiation of melanocyte transformation. However, using immunomagnetic separation or laser-capture microdissection, we examined BRAF mutations in sets of approximately 50 single cells isolated from acquired melanocytic nevi from 13 patients and found a substantial number of nevus cells that contained wild-type BRAF mixed with nevus cells that contained BRAFV600E. Furthermore, we simultaneously amplified BRAF exon 15 and a neighboring single nucleotide poly...
Source: JNCI - October 21, 2009 Category: Cancer & Oncology Authors: Lin, J., Takata, M., Murata, H., Goto, Y., Kido, K., Ferrone, S., Saida, T. Tags: BRIEF COMMUNICATION Source Type: journals