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Current status of fast-track recovery pathways in pancreatic surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Implementation of an enhanced recovery pathway is feasible and can achieve shorter hospital stay and reduced costs, with no increase in re-admission or peri-operative mortality rates. There is, however, conflicting evidence on the physiological mechanisms that contribute to accelerated patient recovery. Certain safety issues associated with post-operative morbidity warrant rigorous evaluation in further prospective studies. PMID: 19890186 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Ypsilantis E, Praseedom RK Tags: JOP Source Type: journals

Zinc status in chronic pancreatitis and its relationship with exocrine and endocrine insufficiency.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study demonstrates zinc deficiency in chronic pancreatitis patients, and that zinc deficiency correlates with exocrine and endocrine insufficiency. Further studies may clarify the possible benefits of zinc supplementation in chronic pancreatitis. PMID: 19890187 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Girish BN, Rajesh G, Vaidyanathan K, Balakrishnan V Tags: JOP Source Type: journals

Management of pancreatic injuries after blunt abdominal trauma. Experience at a single institution.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Blunt pancreatic trauma continues to pose significant diagnostic and therapeutic challenges. In view of the numerous associated injuries, priority must be given to stabilizing the patient before any definitive management of the pancreatic injuries is carried out. Mortality in these patients is usually a result of the magnitude of their associated injuries. PMID: 19890188 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Tan KK, Chan DX, Vijayan A, Chiu MT Tags: JOP Source Type: journals

An epithelial splenic cyst in an intrapancreatic accessory spleen. A case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Although great progress has been made with modern imaging techniques, it is still difficult to make a definitive diagnosis of cystic lesions in the pancreas. PMID: 19890189 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Zhang Z, Wang JC Tags: JOP Source Type: journals

Successful pancreaticoduodenectomy with immediate vascular reconstruction in a patient with cancer of the pancreatic head and celiac artery stenosis. A case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A careful evaluation of abdominal CT scan is required to preoperatively identify this not uncommon vascular obstructive disease, especially in asymptomatic patients. Otherwise, the astute surgeon should suspect celiac artery stenosis based on intraoperative findings/changes immediately following ligation of the gastroduodenal artery during a PD. PMID: 19890190 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Peros G, Sakorafas GH, Giannopoulos GA, Manikis D, Vassiliu P, Brountzos EN Tags: JOP Source Type: journals

Pancreaticopleural fistula: an unusual complication of pancreatitis diagnosed with magnetic resonance cholangiopancreatography.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: MRCP is a useful modality for diagnosing a pancreaticopleural fistula. PMID: 19890191 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Vyas S, Gogoi D, Sinha SK, Singh P, Yadav TD, Khandelwal N Tags: JOP Source Type: journals

Some reflexions on the modified Appleby procedure.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: CT vascular encasement is not always synonymous with real tumoral vascular invasion. Improvement in the quality of anesthesiological and surgical techniques has allowed vascular resections with lower morbidity. A cholecystectomy should always be performed using the modified Appleby procedure. PMID: 19890192 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Morera-Ocon FJ, Cárcel-Cárcel I, Ballestín Vicente J, Iranzo González-Cruz V Tags: JOP Source Type: journals

Pancreatic PEComa (sugar tumor): MDCT and EUS features.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Although three pancreatic PEComas (sugar tumors) have been described previously, to the best of our knowledge, this is the first report of a pancreatic PEComa with illustration of its multidetector-row CT and endoscopic ultrasound features in the radiological literature. PMID: 19890193 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Baez JC, Landry JM, Saltzman JR, Qian X, Zinner MJ, Mortelé KJ Tags: JOP Source Type: journals

EUS diagnosis of a primary pancreatic metastasis of alveolar rhabdomyosarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: To our knowledge this is the first reported case of EUS guided FNA diagnosis of alveolar rhabdomyosarcoma metastatic to the pancreas. This is also the only case report of a primary pancreatic metastasis of this type of tumor in a male patient (which occurs less commonly than in females). PMID: 19890194 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Vanwoerkom RC, Bentz J, Chen L, Adler DG Tags: JOP Source Type: journals

A rare case of primary pancreatic Burkitt lymphoma in a young Indian male. Case report and review of the literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Early diagnosis of this aggressive tumor and prompt induction of chemotherapy dramatically improved the patient's condition and avoided unnecessary surgical intervention. PMID: 19890195 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Nistala SS, Sawalakhe NR, Thiruvengadam NR, Rathi PM Tags: JOP Source Type: journals

Signet ring cell carcinoma of the ampulla of vater. A case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Although several cases have been reported, the detailed clinicopathological features and prognosis are not clear. Additional reports are warranted. PMID: 19890196 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Ishibashi Y, Ito Y, Omori K, Wakabayashi K Tags: JOP Source Type: journals

Pancreatic lymphoepithelial cyst with an intracystic papillary projection. Report of a case.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Resection is inevitable when a true pancreatic neoplasm cannot be excluded. PMID: 19890197 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Maekawa H, Yoneyama H, Komatsu Y, Orita H, Sakurada M, Sato K, Yamano M Tags: JOP Source Type: journals

Surgical relevance of liver arterial blood supply reconstruction by CT scan before a Whipple procedure.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19890198 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Ben-Ishay O, Kluger Y Tags: JOP Source Type: journals

Splenic infarction in pancreatic cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19890199 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Shiroma J, Hokama A, Maeshiro T, Shibata D, Arakaki S, Kinjo F, Fujita J Tags: JOP Source Type: journals

Early ERCP in acute gallstone pancreatitis without cholangitis: a need for systematic biliary sphincterotomy!Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19890200 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Shrode CW, Kahaleh M Tags: JOP Source Type: journals

Is type 2 diabetes a risk factor for pancreatic cancer?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19890202 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Pezzilli R, Casadei R, Morselli-Labate AM Tags: JOP Source Type: journals

Abstracts of the Italian Association for the Study of the Pancreas (AISP) 33rd National Congress. Rozzano, Italy. October 15-17, 2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19779270 [PubMed - indexed for MEDLINE] (Source: JOP)
Source: JOP - October 7, 2009 Category: Gastroenterology Tags: JOP Source Type: journals

Italian Association for the Study of the Pancreas (AISP) 33rd National Congress, Rozzano, MI (Italy). October 15-17, 2009. Abstracts.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19779270 [PubMed - in process] (Source: JOP)
Source: JOP - October 3, 2009 Category: Gastroenterology Tags: JOP Source Type: journals

Lung injury in acute pancreatitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19734621 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Pezzilli R, Bellacosa L, Felicani C Tags: JOP Source Type: journals

The effect of a heavy exercise program on the distribution of pancreatic hormones in the streptozotocin-induced diabetic rat.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Alterations in the distribution of pancreatic hormones in streptozotocin-induced diabetic rats, a model of type 1 diabetes, are not improved with heavy exercise. PMID: 19734622 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Howarth FC, Marzouqi FM, Al Saeedi AM, Hameed RS, Adeghate E Tags: JOP Source Type: journals

Pancreatic leak related hemorrhage following pancreaticoduodenectomy. A case series.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The severity of the underlying sepsis and the prompt identification of the sentinel bleed determine surgical and angiographic intervention and define the outcome in the treatment of a pancreatic leak-related hemorrhage. Endoscopy has no role in this setting. PMID: 19734623 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Tsirlis T, Vasiliades G, Koliopanos A, Kopanakis N, Katseli A, Tsipras H, Margaris H Tags: JOP Source Type: journals

Are large side holes associated with reduced rates of pancreatic stent occlusion? Results of a prospective study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Pancreatic stents are mostly occluded as early as 1 month after insertion. Larger side holes may prevent stents within the pancreas from becoming clogged. PMID: 19734624 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Buscaglia JM, DiMaio CJ, Pollack MJ, Shin EJ, Harris MD, Richards R, Chak A, Kantsevoy SV, Jagannath SB, Okolo PI Tags: JOP Source Type: journals

BACE1 is a newly discovered protein secreted by the pancreas which cleaves enteropeptidase in vitro.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DISCUSSION: We hypothesize that enteropeptidase is a BACE1 substrate in vivo. If so, BACE1 could protect the pancreas from premature trypsinogen activation due to the occasionally occurring reflux of enteropeptidase. PMID: 19734625 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Hoffmeister A, Dietz G, Zeitschel U, Mössner J, Rossner S, Stahl T Tags: JOP Source Type: journals

Incidental pancreatic cysts: a frequent finding in liver-transplanted patients as assessed by 3D T2-weighted turbo spin echo magnetic resonance cholangiopancreatography.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Incidental pancreatic cysts are frequent in liver-transplanted patients. Clinical significance, relation to transplant, impact on patient management before and after transplant are still under debate and a matter for further investigation. PMID: 19734626 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Girometti R, Intini SG, Cereser L, Bazzocchi M, Como G, Del Pin M, Baccarani U, Toniutto P, Zuiani C Tags: JOP Source Type: journals

Pancreatic neuroendocrine tumors among patients with intraductal papillary mucinous neoplasms: real association or just a coincidence?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: IPMN and PNT can coexist. The prevalence of PNT among IPMN patients is low (3.8%). Our study is limited by small sample size. Large studies with large number of patients are needed to further explore this association. PMID: 19734627 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Gill KR, Scimeca D, Stauffer J, Krishna M, Woodward TA, Jamil LH, Wallace MB, Nguyen JH, Raimondo M Tags: JOP Source Type: journals

A pilot study of Octreotide LAR vs. octreotide tid for pain and quality of life in chronic pancreatitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Octreotide LAR(R) may be a reasonable substitute for tid octreotide in treating chronic pancreatitis pain. Further, larger studies would be useful to better characterize the role of Octreotide LAR(R) in the management of chronic pancreatitis pain. PMID: 19734628 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Lieb JG, Shuster JJ, Theriaque D, Curington C, Cintrón M, Toskes PP Tags: JOP Source Type: journals

Metastatic pancreatic adenocarcinoma and renal cell carcinoma treated with gemcitabine and sunitinib malate. A case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This encouraging response, safety profile and progression free survival response suggest that we should further examine this and other such regimens to improve clinical outcomes for maximum efficacy with minimal side-effects. PMID: 19734629 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Bharthuar A, Pearce L, Litwin A, LeVea C, Kuvshinoff B, Iyer R Tags: JOP Source Type: journals

Successful preoperative localization of a small pancreatic insulinoma by diffusion-weighted MRI.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Diffusion-weighted imaging can be useful in detecting and localizing small insulinomas, especially for those with no hypervascular pattern. PMID: 19734630 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Anaye A, Mathieu A, Closset J, Bali MA, Metens T, Matos C Tags: JOP Source Type: journals

Heterotopic pancreatic tissue obstructing the gallbladder neck: a case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Although heterotopic pancreatic tissue is usually an incidental finding on pathologic exam, one should not exclude it in the differential diagnosis of symptomatic gallbladder disease of indefinite etiology. PMID: 19734631 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Weppner JL, Wilson MR, Ricca R, Lucha PA Tags: JOP Source Type: journals

Surgical resection after TNFerade therapy for locally advanced pancreatic cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Neoadjuvant TNFerade based chemoradiation therapy may be a useful adjunct to treatment of locally advanced pancreatic cancer. PMID: 19734632 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Chadha MK, Litwin A, Levea C, Iyer R, Yang G, Javle M, Gibbs JF Tags: JOP Source Type: journals

Autoimmune pancreatitis with multiorgan involvement. A case of pericardial involvement.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In such cases more intensive immunosuppressive therapy may be necessary to get better control of the disease as is apparent from this case. PMID: 19734633 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Nayar M, Charnley R, Scott J, Haugk B, Oppong K Tags: JOP Source Type: journals

Solid appearance of pancreatic serous cystadenoma diagnosed as cystic at ultrasound acoustic radiation force impulse imaging.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The "XXXX" values always measured at Virtual Touch tissue quantification allow the diagnosis of a pancreatic cystic lesion with simple fluid content suggesting the diagnosis of serous cystadenoma. PMID: 19734634 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: D'Onofrio M, Gallotti A, Martone E, Pozzi Mucelli R Tags: JOP Source Type: journals

Managing arterial collaterals due to coeliac axis stenosis during pancreaticoduodenectomy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Management of coeliac artery stenosis during pancreaticoduodenectomy depends on identifying the cause and dealing with it accordingly, intraoperatively. PMID: 19734635 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Harb Sel-G, O'Sullivan AW, Marangoni G, Heaton ND, Rela M Tags: JOP Source Type: journals

Acetaminophen-induced acute pancreatitis. A case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Drug-induced acute pancreatitis is often challenging for clinicians and a detailed mechanism is unknown. It is very important to rule out drug-induced pancreatitis when treating pancreatitis with an unknown etiology. PMID: 19734636 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Igarashi H, Ito T, Yoshinaga M, Oono T, Sakai H, Takayanagi R Tags: JOP Source Type: journals

Adenocarcinoma of the pancreas undetected by multidetector CT, endoscopic ultrasound, or intraoperative ultrasound.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Some pancreatic adenocarcinomas may defy detection using modern imaging modalities. This case illustrates how extensive imaging failed to detect a malignancy prior to surgery. Patients with a high clinical suspicion for malignancy but no visualized mass should undergo operative evaluation with definitive tissue sampling. PMID: 19734637 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Chan M, Scaife C, Thaker HM, Adler DG Tags: JOP Source Type: journals

Metastasis-induced acute pancreatitis in a patient with small cell carcinoma of the lungs.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: When cases of acute pancreatitis in patients with small cell lung carcinoma are encountered, we must consider the possibility of metastasis-induced acute pancreatitis and that, should pancreatic metastases be found in these patients, chemotherapy may provide substantial benefit. PMID: 19734638 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Tanaka H, Nakazawa T, Yoshida M, Miyabe K, Okumura F, Naitoh I, Hayashi K, Ando T, Ohara H, Joh T Tags: JOP Source Type: journals

Late recurrence after surgical resection of a pancreatic tumor in von Hippel-Lindau disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Although no local and/or distant tumor recurrences are usually reported in radically operated on von Hippel-Lindau pancreatic neuroendocrine tumor patients after a median time of five years of follow-up, the present patient had a recurrence after a very long period of time, suggesting that a pancreatic neuroendocrine tumor associated with von Hippel-Lindau syndrome may behave more aggressively than that has previously been described, thus requiring a life-long follow-up. PMID: 19734639 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Corleto VD, Cotesta D, Petramala L, Panzuto F, Pagnini C, Masoni L, Verrienti A, Delle Fave G, Filetti S, Letizia C Tags: JOP Source Type: journals

Catastrophic antiphospholipid syndrome presenting as ischemic pancreatitis in systemic lupus erythematosus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Awareness of this rare, rapidly fatal medical condition prompts vital, early intervention to improve patients' survival. This case report aims to add to the limited therapeutic data available as well as suggest a possible approach to treating this rare syndrome with very high morbidity and mortality. PMID: 19734640 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Vyas A, Kadikoy H, Haque W, Abdellatif A Tags: JOP Source Type: journals

Ascaris lumbricoides-induced acute pancreatitis: diagnosis during EUS for a suspected small pancreatic tumor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In non endemic countries, acute pancreatitis induced by Ascaris lumbricoides is an unusual diagnosis, and should be suspected especially in patients with history of traveling in endemic areas. PMID: 19734641 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Mangiavillano B, Carrara S, Petrone MC, Arcidiacono PG, Testoni PA Tags: JOP Source Type: journals

Gemcitabine-induced hepatitis in a pancreatic cancer patient receiving adjuvant therapy following metastasectomy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19734642 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Saadati H, Peccerillo J, Kaley K, Schilsky ML, Saif MW Tags: JOP Source Type: journals

Small intestine bacterial overgrowth: an underdiagnosed cause of diarrhea in patients with pancreatic cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19734643 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Bustillo I, Larson H, Saif MW Tags: JOP Source Type: journals

Bisphosphonate-related osteonecrosis of the jaw in cancer patients and hyperbaric oxygen therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19734644 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Erkan M, Bilgi O, Mutluoğlu M, Uzun G Tags: JOP Source Type: journals

Do we really need a new category of severity for patients with acute pancreatitis?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19734646 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Uomo G Tags: JOP Source Type: journals

The use of real-time online updates for physicians.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19581732 [PubMed - in process] (Source: JOP)
Source: JOP - July 9, 2009 Category: Gastroenterology Authors: Gaudette R, Yarcusko J, Saif MW Tags: JOP Source Type: journals

Biomarkers for early detection and screening in pancreatic cancer. Highlights from the 45th ASCO annual meeting. Orlando, FL, USA. May 29-June 2, 2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pancreatic cancer is the second most frequent gastrointestinal malignancy with an unabated mortality that reflects the advanced stage of presentation. Detection of early disease through screening likely is the best way to meaningfully prolong survival. The development of biomarkers for screening holds enormous promise for increasing early detection and impacting mortality. Many biomarkers have been studied including the serum protein carbohydrate antigen 19-9, vascular endothelial growth factor, and nuclear factor kappa B, however, still no blood test or other fluid analysis reliably predicts patients with disease. The...
Source: JOP - July 9, 2009 Category: Gastroenterology Authors: Hoimes CJ, Moyer MT, Saif MW Tags: JOP Source Type: journals

Pharmacogenetics in pancreatic cancer. Highlights from the 45th ASCO annual meeting. Orlando, FL, USA. May 29-June 2, 2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cancer pharmacogenetics is a popular and evolving field in medicine with applications in various types of tumours helping clinicians to apply a more personalized medicine by providing information of prognostic, predictive and therapeutic value. Such evidence of pharmacogenetic applications is been already available in colon cancer (e.g. KRAS status, mismatch repair genes status, UGT1A1 polymorphisms), lung cancer (EGFR mutations, ERCC1 mutations), breast cancer (HER2/neu overexpression) and many others. In all these tumors, the genetic information is rendering the management of the involved patients safer and more effe...
Source: JOP - July 9, 2009 Category: Gastroenterology Authors: Strimpakos AS, Syrigos KN, Saif MW Tags: JOP Source Type: journals

Any progress in the management of advanced pancreatic cancer? Highlights from the 45th ASCO annual meeting. Orlando, FL, USA. May 29-June 2, 2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Majority of the patients with pancreatic cancer present with advanced disease that is lethal and notoriously difficult to treat. Survival has not improved dramatically despite routine use of chemotherapy and radiotherapy; this situation signifies an urgent need for novel therapeutic approaches. The treatment of advanced disease with gemcitabine has only a modest activity on survival with a favorable impact on quality of life. So far, the current targeted agents that have been used in combination with gemcitabine have failed to improve clinical outcomes. This failure may stem from the heterogeneous molecular pathogenesi...
Source: JOP - July 9, 2009 Category: Gastroenterology Authors: Li J, Saif MW Tags: JOP Source Type: journals

New developments in the treatment of locally advanced pancreatic cancer. Highlights from the 45th ASCO annual meeting. Orlando, FL, USA. May 29-June 2, 2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The results of the trials presented at this year's ASCO annual meeting underline the challenges of not only treating but also studying locally advanced pancreatic cancer, with any appreciable effect of treatment gained at the cost of considerable toxicity. That response was observed in small numbers of patients in the presented trials speaks to the importance of rational selection of treatment in individual patients in order to achieve maximal survival with minimal treatment-associated morbidity. Further understanding of tumor biology and identification of both prognostic and predictive factors will help define persona...
Source: JOP - July 9, 2009 Category: Gastroenterology Authors: Triano LR, Chang BW, Saif MW Tags: JOP Source Type: journals

Adjuvant treatment of pancreatic cancer in 2009: where are we? Highlights from the 45th ASCO annual meeting. Orlando, FL, USA. May 29-June 2, 2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite attempted curative resection of localized pancreatic adenocarcinoma, most patients succumb a recurrence and die of their disease. The Gastrointestinal Tumor Study Group, European Organization for Research and Treatment of Cancer, and European Study Group for Pancreatic Cancer trials have suggested the benefit of adjuvant therapy. However, the relatively few randomized trials available have not established a definite standard of care due to study limitations. Although these trials, and the recently published Charité Onkologie (CONKO)-001 trial, have shown a definite advantage of adjuvant chemotherapy, the m...
Source: JOP - July 9, 2009 Category: Gastroenterology Authors: Saif MW Tags: JOP Source Type: journals

Syndecan-1 and tenascin expression in cystic tumors of the pancreas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our findings suggest that low syndecan-1 expression might serve as a predictive factor for malignancy in cystic tumors of the pancreas. PMID: 19581738 [PubMed - in process] (Source: JOP)
Source: JOP - July 9, 2009 Category: Gastroenterology Authors: Kylänpää L, Hagström J, Lepistö A, Linjama T, Kärkkäinen P, Kiviluoto T, Haglund C Tags: JOP Source Type: journals