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Comparison of Time Trends in Colorectal Cancer Mortality (1990-2006) in the World, from the WHO Mortality DatabaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - November 2, 2009 Category: Cancer & Oncology Authors: Matsuda, T., Zhang, M. Tags: Cancer Statistics Digest Source Type: journals

A Case of Gallbladder Cancer Arising from the Rokitansky-Aschoff SinusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - November 2, 2009 Category: Cancer & Oncology Authors: Matsumoto, T., Shimada, K. Tags: Image of the Month Source Type: journals

Flow Cytometric Detection of Small Cell Lung Cancer Cells with Aberrant CD45 Expression in Micrometastatic Bone MarrowEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe this rare case to arouse an attention that tumors of non-hematolymphoid origin can exhibit exceptional CD45-positvity in metastatic sites. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - November 2, 2009 Category: Cancer & Oncology Authors: Danbara, M., Yoshida, M., Kanoh, Y., Jiang, S.-X., Masuda, N., Akahoshi, T., Higashihara, M. Tags: Short Communications Source Type: journals

Budget Impact Analysis of Chemoprevention of Breast Cancer with Tamoxifen and Raloxifene among High-risk Women in JapanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
‘Cost saving’ was suggested in our recent economic evaluation of chemoprevention of breast cancer targeting women at high risk in Japan. However, this budget impact analysis reveals that the introduction of chemoprevention appears to be not budget saving for ~20 years, whereas the level of budget impact seems affordable. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - November 2, 2009 Category: Cancer & Oncology Authors: Kondo, M., Hoshi, S.-L., Toi, M. Tags: Short Communications Source Type: journals

Elevating Blood Pressure as a Strategy to Increase Tumor-targeted Delivery of Macromolecular Drug SMANCS: Cases of Advanced Solid TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study is to evaluate the improved method of arterial infusion therapy of SMANCS (SX) with lipiodol under the angiotensin-induced hypertensive state for various difficult-to-treat solid tumors. Most patients were unresectable with no other therapeutic options, recurrence after resection, or patients do not respond to common treatments. The new method utilizes angiotensin II (AT) to induce hypertension (e.g. ~15–30 mmHg above norm) for 15–20 min. This method was successfully applied to metastatic liver cancer, cholangiocarcinoma, massive renal cell carcinoma, pancreatic and other abdominal sol...
Source: Japanese Journal of Clinical Oncology - November 2, 2009 Category: Cancer & Oncology Authors: Nagamitsu, A., Greish, K., Maeda, H. Tags: Case Reports Source Type: journals

Four Cases of Pancreatic Acinar Cell Carcinoma Treated with Gemcitabine or S-1 as a Single AgentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pancreatic acinar cell carcinoma (ACC) is a comparatively rare tumor and account for ~1% of all cases of pancreatic cancer. Clinical presentation is usually related to either local spread or metastasis. The clinical features, especially those related to the prognosis and treatment outcomes, have not yet been fully clarified. There are no established treatments for unresectable pancreatic ACC. We administered gemcitabine monotherapy to four patients with ACC; however, the results were not satisfactory. Disease control without obvious tumor shrinkage was observed in one patient. Another patient showed severe renal damage cau...
Source: Japanese Journal of Clinical Oncology - November 2, 2009 Category: Cancer & Oncology Authors: Seki, Y., Okusaka, T., Ikeda, M., Morizane, C., Ueno, H. Tags: Case Reports Source Type: journals

A Case of Bone, Lung, Pleural and Liver Metastases from Renal Cell Carcinoma Which Responded Remarkably Well to Zoledronic Acid MonotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Herein, we report a rare case in which bisphosphonate zoledronic acid (ZA) effectively treated not only multiple bone metastases but also lung, pleural and liver metastases from renal cell carcinoma (RCC). Recently, ZA is used to treat skeletal-related events (SREs) such as bone pain caused by bone metastasis from many kinds of cancer. The patient in the present report had multiple bone metastases from RCC. Remarkable improvement of the bone metastasis was observed following treatment with ZA at a dosage of 4 mg administered once every 4 weeks. Moreover, lung, pleural and liver metastases also diminished markedly in size i...
Source: Japanese Journal of Clinical Oncology - November 2, 2009 Category: Cancer & Oncology Authors: Miwa, S., Mizokami, A., Konaka, H., Izumi, K., Nohara, T., Namiki, M. Tags: Case Reports Source Type: journals

Innovative Trident Fixation Technique for Allograft Knee Arthrodesis for High-grade Osteosarcoma around the KneeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This straightforward technique was successful in knee arthrodesis with minimized limb length inequality. Accordingly, in light of bone stock preservation and longevity for the young children, it may be a surgical alternative for malignant bone tumors around the knee. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - November 2, 2009 Category: Cancer & Oncology Authors: Su, A. W., Chen, W.-M., Chen, C.-F., Chen, T.-H. Tags: Original Articles Source Type: journals

Five-year Follow-up of Health-related Quality of Life after Intensity-modulated Radiation Therapy for Prostate CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions IMRT can provide the possibility to deliver a high irradiation dose to the prostate with satisfactory functional outcomes for long-term periods. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - November 2, 2009 Category: Cancer & Oncology Authors: Namiki, S., Ishidoya, S., Ito, A., Tochigi, T., Numata, I., Narazaki, K., Yamada, S., Takai, Y., Arai, Y. Tags: Original Articles Source Type: journals

PSA Doubling Time as a Predictive Factor on Repeat Biopsy for Detection of Prostate CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions PSA doubling time was one of the predictive factors for the detection of prostate cancer and was valuable for avoiding unnecessary repeat biopsy in some cases. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - November 2, 2009 Category: Cancer & Oncology Authors: Shimbo, M., Tomioka, S., Sasaki, M., Shima, T., Suzuki, N., Murakami, S., Nakatsu, H., Shimazaki, J. Tags: Original Articles Source Type: journals

Multicenter Phase II Trial of Combination Therapy with Meloxicam, a COX-2 Inhibitor, and Natural Interferon-{alpha} for Metastatic Renal Cell CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The combination of meloxicam and natural IFN- is considered to be an active regimen with tolerable toxicities as a first-line treatment of metastatic renal cell carcinoma. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - November 2, 2009 Category: Cancer & Oncology Authors: Shinohara, N., Kumagai, A., Kanagawa, K., Maruyama, S., Abe, T., Sazawa, A., Nonomura, K. Tags: Original Articles Source Type: journals

Second-line Chemotherapy with Biweekly Paclitaxel after Failure of Fluoropyrimidine-based Treatment in Patients with Advanced or Recurrent Gastric Cancer: a Report from the Gastrointestinal Oncology Group of the Tokyo Cooperative Oncology Group, TCOG GC-0501 TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Biweekly paclitaxel seemed to be one of the useful chemotherapies after failure of fluoropyrimidine-based treatment in patients with advanced or recurrent gastric cancer. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - November 2, 2009 Category: Cancer & Oncology Authors: Koizumi, W., Akiya, T., Sato, A., Yamaguchi, K., Sakuyama, T., Nakayama, N., Tanabe, S., Higuchi, K., Sasaki, T., Sekikawa, T., The Tokyo Cooperative Oncology Group (TCOG GI Group) Tags: Original Articles Source Type: journals

Gender Difference in Treatment Outcomes in Patients with Stage III Non-small Cell Lung Cancer Receiving Concurrent ChemoradiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This study failed to show any gender differences in the survival or toxicity among patients treated by concurrent chemoradiotherapy. These results contrast with the better survival in female patients undergoing surgery for localized disease or chemotherapy for metastatic disease. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - November 2, 2009 Category: Cancer & Oncology Authors: Sekine, I., Sumi, M., Ito, Y., Tanai, C., Nokihara, H., Yamamoto, N., Kunitoh, H., Ohe, Y., Tamura, T. Tags: Original Articles Source Type: journals

Phase II Study of Gemcitabine Monotherapy as a Salvage Treatment for Japanese Metastatic Breast Cancer Patients after Anthracycline and Taxane TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Gemcitabine at 1250 mg/m2 on days 1 and 8 of a 21-day cycle was tolerable and can be a salvage treatment option for Japanese metastatic breast cancer patients previously treated with anthracyclines and taxanes. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - November 2, 2009 Category: Cancer & Oncology Authors: Suzuki, Y., Tokuda, Y., Fujiwara, Y., Iwata, H., Sasaki, Y., Saji, S., Aogi, K., Nambu, Y., Suri, A., Saeki, T., Takashima, S. Tags: Original Articles Source Type: journals

Comparison of Time Trends in Lung Cancer Mortality (1990-2006) in the World, from the WHO Mortality DatabaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Marugame, T., Hirabayashi, Y. Tags: Cancer Statistics Digest Source Type: journals

A Case of Gastrointestinal Stromal Tumor of the EsophagusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Miyata, K., Igaki, H. Tags: Image of the Month Source Type: journals

Gender Differences in Stomach Cancer Survival in Osaka, Japan: Analyses Using Relative Survival ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Relative 5-year survival for stomach cancer has increased gradually in Osaka for more than two decades, while women show a small but consistently lower survival for it. We analyzed gender differences in stomach cancer survival, using relative survival model proposed by Dickman et al. Study subjects were reported stomach cancer cases diagnosed in 1975–99. We estimated the excess hazard ratios (EHRs) of death using Poisson's regression model. The crude EHR for women was 1.12 [95% confidence interval (CI): 1.09–1.14] in comparison with men. After adjustments for year and age at diagnosis, the EHR for women decreas...
Source: Japanese Journal of Clinical Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Sato, N., Ito, Y., Ioka, A., Tanaka, M., Tsukuma, H. Tags: Epidemiology Note Source Type: journals

A Phase II Trial of Combined Treatment of Endoscopic Mucosal Resection and Chemoradiotherapy for Clinical Stage I Esophageal Carcinoma: Japan Clinical Oncology Group Study JCOG0508Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Standard treatment for clinical stage I esophageal cancer with submucosal invasion (T1b) has been surgical resection. We conducted a Phase II trial to evaluate the efficacy and the safety of combined treatment of endoscopic mucosal resection (EMR) and chemoradiotherapy for clinical stage I (T1b) esophageal cancer. Patients diagnosed as having clinical stage I (T1b) esophageal cancer which is considered to be resectable by EMR are eligible. When pathological examination of the EMR specimen confirms T1b tumor with negative or positive resection margin, the patient undergoes chemoradiotherapy. The study continues until 82 pat...
Source: Japanese Journal of Clinical Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Kurokawa, Y., Muto, M., Minashi, K., Boku, N., Fukuda, H., for the Gastrointestinal Oncology Study Group of Japan Clinical Oncology Group (JCOG) Tags: Clinical Trial Note Source Type: journals

Idiopathic Plasmacytic Lymphadenopathy with Polyclonal Hypergammaglobulinemia Accompanied with Cutaneous Involvement and Renal DysfunctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Idiopathic plasmacytic lymphadenopathy (IPL) with polyclonal hypergammaglobulinemia has been proposed as a new disease entity resembling the plasma cell type of multicentric Castleman's disease. Here, we report a case of IPL accompanied by renal failure and skin involvement. A 35-year-old man was admitted for advanced renal failure, anemia, systemic lymphadenopathy and skin rashes. Laboratory examinations indicated polyclonal hypergammaglobulinemia and elevated serum interleukin-6 (IL-6). Biopsy of a cervical lymph node revealed follicular hyperplasia with normal germinal centers, sheets of polyclonal proliferating plasma ...
Source: Japanese Journal of Clinical Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Kurosawa, S., Akiyama, N., Ohwada, A., Warabi, M., Suenaga, M., Kojima, M., Tomiyama, J. Tags: Case Reports Source Type: journals

Unusual Appearance of Perirenal Fibrosis in Renal Cell Carcinoma Simulating a TumourEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we present a unique case of a 78-year-old male patient with clear cell renal carcinoma (CCRC) who presented with a lump in the right loin. On magnetic resonance imaging scan, the mass was arising from the middle part of the right kidney. The nephrectomy was done and specimen on examination revealed a variegated tumour with another whitish solid mass in the surrounding perirenal fat. The kidney tumour showed features of CCRC, whereas whitish mass was entirely composed of proliferating spindle cells. Therefore, the mass mimicked a second tumour not only on gross but even on microscopy. The special stains (Ela...
Source: Japanese Journal of Clinical Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Kumar, Y., Bhatia, A., Das, A., Kathpalia, A. S. Tags: Case Reports Source Type: journals

Health-related Quality of Life Evaluation in Patients Undergoing Cavernous Nerve Reconstruction During Radical ProstatectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Cavernous nerve reconstruction provided recovery of erectile dysfunction in substantial proportion of patients, which resulted in favorable physical HRQOL. Majority of these patients, however, did not seem to be satisfied with their sexual function, which caused sustained sexual bother feeling. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Sugimoto, M., Tsunemori, H., Kakehi, Y. Tags: Original Articles Source Type: journals

Is there a Role of the Histologic Subtypes of Papillary Renal Cell Carcinoma as a Prognostic Factor?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In the present study, the type of papillary RCC does not reach independent prognostic significance. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Ku, J. H., Moon, K. C., Kwak, C., Kim, H. H., Lee, S. E. Tags: Original Articles Source Type: journals

Narrow Band Imaging Videobronchoscopy Improves Assessment of Lung Cancer Extension and Influences Therapeutic StrategyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions NBI showed significantly better specificity and sensitivity in the assessment of lung cancer extension. NBI proved that it might have potential influence on therapeutic decision, making it more accurate. The procedure is safe and easily deployed in everyday practice. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Zaric, B., Becker, H. D., Perin, B., Jovelic, A., Stojanovic, G., Ilic, M. D., Eri, Z., Panjkovic, M., Obradovic, D., Antonic, M. Tags: Original Articles Source Type: journals

No Association Between CYP2D6*10 Genotype and Survival of Node-negative Japanese Breast Cancer Patients Receiving Adjuvant Tamoxifen TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our results suggest that the CYP2D6*10 genotype is unlikely to have any clinical significance for prognosis of node-negative Japanese breast cancer patients receiving adjuvant tamoxifen alone. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Toyama, T., Yamashita, H., Sugiura, H., Kondo, N., Iwase, H., Fujii, Y. Tags: Original Articles Source Type: journals

Expression of VEGF-C Correlates with a Poor Prognosis Based on Analysis of Prognostic Factors in 73 Patients with Esophageal Squamous Cell CarcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Expression of VEGF-C is related to histological grade, pT, pN and lymphatic invasion, and is a prognostic indicator for ESCC. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Liu, P., Chen, W., Zhu, H., Liu, B., Song, S., Shen, W., Wang, F., Tucker, S., Zhong, B., Wang, D. Tags: Original Articles Source Type: journals

A Phase II Trial of Chemoradiotherapy for Stage I Esophageal Squamous Cell Carcinoma: Japan Clinical Oncology Group Study (JCOG9708)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions High CR proportion and survival proportion with mild toxicity suggest that this regimen could be considered as a candidate of new standard treatment to be compared with surgery in patients with Stage I ESCC. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Kato, H., Sato, A., Fukuda, H., Kagami, Y., Udagawa, H., Togo, A., Ando, N., Tanaka, O., Shinoda, M., Yamana, H., Ishikura, S. Tags: Original Articles Source Type: journals

Significance of Retropharyngeal Lymph Node Dissection in Hypopharyngeal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We recommend RPLN dissection at the time primary of treatment of hypopharyngeal cancer, especially in cases with cancer at subsites PC/PW, as RPLN dissection is expected to improve prognosis. The primary subsites PC/PW are associated with a risk of RPLN metastasis. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Kamiyama, R., Saikawa, M., Kishimoto, S. Tags: Original Articles Source Type: journals

Expression Pattern and Clinical Prognostic Relevance of Bone Morphogenetic Protein-2 in Human GliomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These results indicate that BMP-2 is a highly sensitive marker for gliomas prognosis and suggest that the expression level of BMP-2 may be a potent tool for the clinical prognosis of gliomas patients. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Liu, C., Tian, G., Tu, Y., Fu, J., Lan, C., Wu, N. Tags: Original Articles Source Type: journals

Comparison of Time Trends in Stomach Cancer Mortality (1990-2006) in the World, from the WHO Mortality DatabaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 26, 2009 Category: Cancer & Oncology Authors: Yako-Suketomo, H., Katanoda, K. Tags: Cancer Statistics Digest Source Type: journals

A Case of Metastatic Intracranial Malignant Melanoma Mimicking Simple Subcortical Hemorrhage in an Elderly WomanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 26, 2009 Category: Cancer & Oncology Authors: Miyakita, Y., Shibui, S. Tags: Image of the Month Source Type: journals

Allergic Reactions to Oxaliplatin in a Single Institute in JapanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Allergic reactions to oxaliplatin can be severe and are an important cause of discontinuation of treatment. A retrospective review was performed for 105 patients who received FOLFOX regimens between May 2005 and June 2007. Twenty-five cases (23.8%) of allergic reactions were identified, including 9 late onset reactions (8.6%) and 16 immediate reactions (15.2%). Severe allergy (Grades 3 and 4) occurred in seven patients (6.7%). Re-introduction of FOLFOX was attempted for seven immediate onset patients with a severity grade of 1 or 2, and three of these patients (42.9%) showed relapse of allergy. In ~10% of the patients, FOL...
Source: Japanese Journal of Clinical Oncology - August 26, 2009 Category: Cancer & Oncology Authors: Ichikawa, Y., Goto, A., Hirokawa, S., Kijima, M., Ishikawa, T., Chishima, T., Suwa, H., Yamamoto, H., Yamagishi, S., Osada, S., Ota, M., Fujii, S. Tags: Short Communication Source Type: journals

Cardiac Angiosarcoma with Cardiac Tamponade Diagnosed as a Ruptured Aneurysm of the Sinus ValsalvaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we describe the case of a 56-year-old woman with a right atrial angiosarcoma. The patient presented with impending cardiac tamponade caused by right atrial perforation, but was misdiagnosed as a ruptured aneurysm of the sinus valsalva based on findings of a continuous murmur and an aorta to right atrium shunt by echocardiography. In the emergent operation that ensued, we found a right atrial perforation and a right coronary artery fistula to the right atrium. Coronary artery fistula is a rare complication of primary cardiac angiosarcoma, and a continuous murmur is also extremely rare as a clinical finding o...
Source: Japanese Journal of Clinical Oncology - August 26, 2009 Category: Cancer & Oncology Authors: Yoshitake, I., Hata, M., Sezai, A., Niino, T., Unosawa, S., Shimura, K., Kasamaki, Y., Minami, K. Tags: Case Report Source Type: journals

Retrospective Study on Home Care for Patients with Hematologic MalignanciesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Even patients with hematologic malignancies could be candidates for home care if their underlying diseases are slowly progressive, and they can sustain themselves by oral intakes. Dementia and poor PS are not contraindicated to it. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 26, 2009 Category: Cancer & Oncology Authors: Kodama, Y., Takita, M., Kawagoe, S., Hirahara, S., Kimura, Y., Onozawa, S., Wada, T., Nakano, K., Kami, M., Matsumura, T., Yuji, K. Tags: Original Articles Source Type: journals

A Feasibility Study of UFT/LV and Irinotecan (TEGAFIRI) in Advanced or Metastatic Colorectal Cancer: Osaka Gastrointestinal Cancer Chemotherapy Study Group (OGSG) PROG 0304Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Approved dose of CPT-11 is 150 mg/m2 in Japan. As is lower dose with CPT-11, TEGAFIRI for patients with advanced or metastatic CRC in Japan seems to have the similar effect with that reported abroad and indicates prolonged PFS and MST in cases with CR or PR. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 26, 2009 Category: Cancer & Oncology Authors: Ishida, H., Miyake, Y., Fukunaga, M., Watanabe, Y., Kato, T., Takemoto, H., Furukawa, H. Tags: Original Articles Source Type: journals

Vascular Endothelial Growth Factor Receptor Expression as a Prognostic Marker for Survival in Colorectal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions VEGF-R1, -R2 and -R3 were highly expressed in CRC cells and stromal vessels. VEGF-R1 strong positive staining correlated with shorter survival after CRC surgery. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 26, 2009 Category: Cancer & Oncology Authors: Okita, N. T., Yamada, Y., Takahari, D., Hirashima, Y., Matsubara, J., Kato, K., Hamaguchi, T., Shirao, K., Shimada, Y., Taniguchi, H., Shimoda, T. Tags: Original Articles Source Type: journals

Clinical Impact of the Presence of the Worst Nucleolar Grade in Renal Cell Carcinoma SpecimensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Regardless of dominancy, the presence of the worst grade component has a significant clinical impact in RCC patients. N0M0 patients whose RCC has worst-grade components but whose CRP levels are <1 are expected to have longer recurrence-free intervals and to survive longer than those whose CRP levels are higher. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 26, 2009 Category: Cancer & Oncology Authors: Ito, K., Yoshii, H., Asakuma, J., Sato, A., Horiguchi, A., Sumitomo, M., Hayakawa, M., Asano, T. Tags: Original Articles Source Type: journals

A Phase II Study of Paclitaxel and Nedaplatin as First-line Chemotherapy in Patients with Advanced Esophageal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Combination of paclitaxel and nedaplatin is a tolerated treatment modality with promising activity in previously untreated advanced esophageal cancer. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 26, 2009 Category: Cancer & Oncology Authors: Cao, W., Xu, C., Lou, G., Jiang, J., Zhao, S., Geng, M., Xi, W., Li, H., Jin, Y. Tags: Original Articles Source Type: journals

A Phase I Study of Gemcitabine and Carboplatin in Patients with Advanced Non-small Cell Lung Cancer and a Performance Status of 2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The MTD and the recommended dose for Phase II studies of this regimen were determined to be GEM 1000 mg/m2 and CBDCA AUC of 4. Additional objective measures are needed to evaluate patients’ risk and benefit in future clinical trials for PS 2 patients. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 26, 2009 Category: Cancer & Oncology Authors: Kim, Y. H., Kubota, K., Goto, K., Yoh, K., Niho, S., Ohmatsu, H., Saijo, N., Nishiwaki, Y. Tags: Original Articles Source Type: journals

Dose-escalating and Pharmacokinetic Study of a Weekly Combination of Paclitaxel and Carboplatin for Inoperable Non-small Cell Lung Cancer: JCOG 9910-DIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Weekly combined paclitaxel (up to 90 mg/m2) and carboplatin (AUC = 2 mg/ml min) was well tolerated. A higher dose intensity of paclitaxel can be given, and RR and survival are not less than the every-3-week protocol. The weekly regimen is an alternative for untreated inoperable NSCLC patients. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 26, 2009 Category: Cancer & Oncology Authors: Naoki, K., Kunikane, H., Fujii, T., Tsujimura, S., Hida, N., Okamoto, H., Watanabe, K. Tags: Original Articles Source Type: journals

The Predictive Role of E-cadherin and Androgen Receptor on In Vitro Chemosensitivity in Triple-negative Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions E-cadherin and AR could be candidate predictive factors for chemotherapy response in TNBC. Further in vivo study is required to clarify their roles. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 26, 2009 Category: Cancer & Oncology Authors: Koo, J. S., Jung, W., Jeong, J. Tags: Original Articles Source Type: journals

Fusion of MRI and Sonography Image for Breast Cancer Evaluation Using Real-time Virtual Sonography with Magnetic Navigation: First ExperienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our results suggest that the RVS system can identify enhancing breast lesions with excellent accuracy. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 26, 2009 Category: Cancer & Oncology Authors: Nakano, S., Yoshida, M., Fujii, K., Yorozuya, K., Mouri, Y., Kousaka, J., Fukutomi, T., Kimura, J., Ishiguchi, T., Ohno, K., Mizumoto, T., Harao, M. Tags: Original Articles Source Type: journals

Anti-angiogenic Therapy Against Gastrointestinal Tract CancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gastrointestinal tract cancers constitute a group of highest morbidity both in and outside Japan, and the prognosis still remains unfavorable when the disease has progressed to the unresectable stage. Since the late 1990s, a novel category of anti-cancer drugs, ‘molecular-targeted drugs’, has become available, and angiogenesis has been considered as one of the most important molecular targets for antitumor therapy since it is essential for tumor growth. Anti-angiogenic therapy inhibits tumor angiogenesis and promotes apoptosis of existing tumor blood vessels, thereby intercepting the supply of oxygen and nutrit...
Source: Japanese Journal of Clinical Oncology - August 26, 2009 Category: Cancer & Oncology Authors: Iwasaki, J., Nihira, S.-i. Tags: Review Article Source Type: journals

Comparison of Time Trends in Cancer Mortality (1990-2006) in the World, from the WHO Mortality DatabaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - July 28, 2009 Category: Cancer & Oncology Authors: Saika, K., Matsuda, T. Tags: Cancer Statistics Digest Source Type: journals

A Case of Gallbladder Metastasis from Hepatocellular CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - July 28, 2009 Category: Cancer & Oncology Authors: Ando, K., Sakamoto, Y. Tags: Image of the Month Source Type: journals

Bio-repository of Post-clinical Test Samples at the National Cancer Center Hospital (NCCH) in TokyoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We established the Bio-repository at the National Cancer Center Hospital in October 2002. The main purpose of this article is to show the importance and usefulness of a bio-repository of post-clinical test samples not only for translational cancer research but also for routine clinical oncology by introducing the experience of setting up such a facility. Our basic concept of a post-clinical test sample is not as left-over waste, but rather as frozen evidence of a patient's pathological condition at a particular point. We can decode, if not all, most of the laboratory data from a post-clinical test sample. As a result, the ...
Source: Japanese Journal of Clinical Oncology - July 28, 2009 Category: Cancer & Oncology Authors: Furuta, K., Yokozawa, K., Takada, T., Kato, H. Tags: Technical Note Source Type: journals

A Case Report of Pathologically Complete Response of a Huge Rectal Cancer after Systemic Chemotherapy with mFOLFOX6Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 54-year-old man was referred to our hospital because of a huge, unresectable rectal cancer occupying his entire pelvic space with a solitary liver metastasis. He had undergone a laparotomy for surgical resection, but ended up with a sigmoid colostomy due to possible invasion into the urinary bladder and pelvic wall. At the completion of seven cycles of FOLFOX regimen, radiographic examination revealed remarkable reduction of the primary rectal tumor and regional lymph nodes, and also a complete response (CR) of the liver metastasis. The tumor was extirpated without any macroscopic residues by a low anterior resection of ...
Source: Japanese Journal of Clinical Oncology - July 28, 2009 Category: Cancer & Oncology Authors: Okoshi, K., Nagayama, S., Furu, M., Mori, Y., Yoshizawa, A., Toguchida, J., Sakai, Y. Tags: Case Reports Source Type: journals

Pedunculated Polyp of Early Sigmoid Colon Cancer with Invasive Micropapillary CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 64-year-old man was admitted to Dongo Hospital (Nara, Japan) with colonic cancer, following the onset of abdominal pain, diarrhea and fever. A pedunculated polyp was detected in the sigmoid colon by colonoscopy, and laparoscopy-assisted sigmoidectomy with regional lymph node resection was performed. Histopathologically, the tumor exhibited massive invasion of the submucosa, and multiple lymph node metastases were detected. The tumor mainly consisted of a micropapillary component. Immunohistochemically, MUC1 was expressed at the stromal edge of the micropapillary component and showed the characteristic ‘inside-out&r...
Source: Japanese Journal of Clinical Oncology - July 28, 2009 Category: Cancer & Oncology Authors: Sonoo, H., Kameyama, M., Inatugi, N., Nonomura, A., Enomoto, Y. Tags: Case Reports Source Type: journals

Primary Osteogenic Sarcoma with Pulmonary Metastasis: Clinical Results and Prognostic Factors in 91 PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The prognosis of osteosarcoma with pulmonary metastases is dismal, especially for patients who have primary pulmonary metastases, more than three pulmonary metastatic nodules or involvement of more than one lobe. Factors such as older age, larger tumor volume and elevated LDH may reflect high metastatic rate. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - July 28, 2009 Category: Cancer & Oncology Authors: Wu, P. K., Chen, W. M., Chen, C. F., Lee, O. K., Haung, C. K., Chen, T. H. Tags: Original Articles Source Type: journals

Detection of Low Allele Burden of JAK2 Exon 12 Mutations Using TA-cloning in Patients with ErythrocytosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We found clonal mutations (i.e. H538-K539delinsL and D544G) in 3 of 7 JAK2-V617F-negative PV patients, however, unlike JAK2-V617F, allele burden of JAK2 exon 12 mutation was low. Since allele-specific PCR is able to amplify only the limited region which contains known mutations with gain-of-function, we need to clarify the biological implications of unknown single nucleotide substitution of the JAK2 exon 12 with low clonal burden in erythrocytosis patients. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - July 28, 2009 Category: Cancer & Oncology Authors: Ohyashiki, J. H., Hisatomi, H., Shimizu, S., Sugaya, M., Ohyashiki, K. Tags: Original Articles Source Type: journals

Health-related Quality of Life using SF-8 and EPIC Questionnaires after Treatment with Radical Retropubic Prostatectomy and Permanent Prostate BrachytherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This prospective study revealed the differences in the HRQOL after an RRP and PPB. Disease-specific HRQOL is clarified by using EPIC survey. These results will be helpful for making treatment decisions. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - July 28, 2009 Category: Cancer & Oncology Authors: Hashine, K., Kusuhara, Y., Miura, N., Shirato, A., Sumiyoshi, Y., Kataoka, M. Tags: Original Articles Source Type: journals