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Clinical Efficacy of Therapeutic Agents for Clostridioides difficile Infection Based on Four Severity Classifications
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.483. Online ahead of print.ABSTRACTThe Japanese guidelines for the management of Clostridioides difficile infection (CDI) recommend metronidazole (MNZ) for non-severe cases and vancomycin (VCM) for severe cases. Here, we investigated the use of CDI antimicrobials and evaluated their clinical efficacy in four severity classifications and the validity of these classifications. A retrospective chart review was conducted on 137 inpatients with an initial positive C. difficile toxin test and initiation of CDI antimicrobials between April 2015 and March 2019. For the cl...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Mariko Ohtani Sadako Yoshizawa Taito Miyazaki Eri Kumade Shinobu Hirayama Maki Sakamoto Hinako Murakami Tadashi Maeda Yoshikazu Ishii Takahiro Matsumoto Kazuhiro Tateda Source Type: research

Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research

Usefulness of a pluralistic approach in sentinel surveillance: seasonal influenza activity based on case counts per sentinel site in the National Epidemiological Surveillance of Infectious Diseases Program and test counts, case counts, and test positivity from the National Hospital Organization
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.368. Online ahead of print.ABSTRACTIn Japan, based on the National Epidemiological Surveillance of Infectious Diseases (NESID) Program, influenza cases from ~5,000 sentinel sites are monitored weekly as part of influenza surveillance (as number of influenza cases/sentinel site). One limitation is that the number of influenza tests conducted is not reported. Separately, the National Hospital Organization (NHO), with ~140 hospitals, routinely publishes three indicators: number of influenza tests, influenza-positive case counts, and test positivity. We used NESID and...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Takeshi Arashiro Yuzo Arima Takuri Takahashi Kiyosu Taniguchi Hiromasa Horiguchi Motoi Suzuki Source Type: research