Common and Disparate Clinical Presentations and Mechanisms in Different Eosinophilic Gastrointestinal Diseases
Eosinophilic gastrointestinal diseases (EGIDs) are a group of diseases characterized by selective eosinophil infiltration of the gastrointestinal tract in the absence of other causes of eosinophilia. These diseases are generally driven by type 2 inflammation often in response to food allergen exposure. Common among all EGIDs is a clinical presentation characterized by a history of atopic disease with a variety of gastrointestinal symptoms. EGIDs are traditionally separated into eosinophilic esophagitis (EoE) and non-EoE EGIDs. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 27, 2024 Category: Allergy & Immunology Authors: Tetsuo Shoda, Richard J. Taylor, Naoya Sakai, Marc E. Rothenberg Source Type: research

Metabolomic Profiles during Early Childhood and Risk of Food Allergies and Asthma in Multi-ethnic Children from a Prospective Birth Cohort
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 26, 2024 Category: Allergy & Immunology Authors: Xiumei Hong, Kari Nadeau, Guoying Wang, Ben Larman, Kellie N. Smith, Colleen Pearson, Hongkai Ji, Pamela Frischmeyer-Guerrerio, Liming Liang, Frank B. Hu, Xiaobin Wang Source Type: research

Metabolomics identifies phenotypic biomarkers of amino acid metabolism in milk allergy and sensitized tolerance
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Qiaozhi Zhang, Hui Wang, Shenyu Zhang, Mingwu Chen, Zhongshan Gao, Jinlyu Sun, Jizhou Wang, Linglin Fu Source Type: research

Autoimmune adverse event following COVID-19 vaccination in Seoul, South Korea
There is growing evidence that the coronavirus disease 2019 (COVID-19) vaccination can affect the regulation of the immune system, leading to the development of autoimmune diseases. However, the autoimmune adverse events (AEs) after COVID-19 vaccination remain largely unclear. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 21, 2024 Category: Allergy & Immunology Authors: Hong Jin Kim, Min-Ho Kim, Seong Jun Park, Myeong Geun Choi, Eun Mi Chun Source Type: research

Prevention of allergic reactions during oxaliplatin desensitization through inhibition of Bruton ’s tyrosine kinase
Capsule Summary: Acalabrutinib 100 mg orally twice daily starting in the evening 2 days before and continuing through a rapid drug desensitization protocol allowed a sensitized patient to successfully and safely receive oxaliplatin. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 21, 2024 Category: Allergy & Immunology Authors: Kristin A. Erickson, James E. Norton, Jennifer Law, Nicole Soriano, Malgorzata Strojny, Nicole Gentry, Morgan Fried, Bruce S. Bochner, Sheetal Kircher, Whitney W. Stevens Source Type: research

The 2024 AAAAI Foundation Faculty Development awardees
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 20, 2024 Category: Allergy & Immunology Authors: Zuhair K. Ballas Source Type: research

Landscape fire smoke airway exposure impairs respiratory and cardiac function and worsens experimental asthma
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 19, 2024 Category: Allergy & Immunology Authors: Henry M. Gomez, Tatt J. Haw, Dusan Ilic, Peter Robinson, Chantal Donovan, Amanda J. Croft, Kanth S. Vanka, Ellen Small, Olivia R. Carroll, Richard Y. Kim, Jemma R. Mayall, Tesfalidet Beyene, Thava Palanisami, Doan TM. Ngo, Graeme R. Zosky, Elizabeth G. Ho Source Type: research

IgE to cyclophilins in pollen allergic children: epidemiological, clinical and diagnostic relevance of a neglected panallergen.
Capsule summary: Plant cyclophilins, panallergens known since decades, are still neglected. However, among Italian children with seasonal allergic rhino-conjunctivitis, cyclophilin-sIgE antibodies cause false positive reactions to pollen extracts of many clinically relevant species, mainly trees and weeds. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 18, 2024 Category: Allergy & Immunology Authors: Paolo Maria Matricardi, Ekaterina Potapova, Valentina Panetta, Jonas Lidholm, Lars Mattsson, Enrico Scala, Roberto Bernardini, Carlo Caffarelli, Antonella Casani, Rosa Cervone, Loredana Chini, Pasquale Comberiati, Giovanna De Castro, Michele Miraglia Del Source Type: research

A murine model of eosinophilic chronic rhinosinusitis with nasal polyposis inducing neuroinflammation and olfactory dysfunction
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Wei-Hao Huang, Yu-Wen Hung, Wei Hung, Ming-Ying Lan, Chien-Fu Yeh Source Type: research

Association between polymorphisms on chromosome 17q12-q21 and rhinovirus-induced interferon responses
Single nucleotide polymorphisms (SNPs) in genes on chromosome 17q12-q21 are associated with childhood-onset asthma and rhinovirus-induced wheezing. There is little mechanistic data linking chromosome 17q12-q21 to wheezing illness. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Eteri Regis, Sara Fontanella, John A. Curtin, Angela Pinot de Moira, Michael R. Edwards, Clare S. Murray, Angela Simpson, Sebastian L. Johnston, Adnan Custovic Source Type: research

Deucrictibant for angioedema due to acquired C1-inhibitor deficiency: a randomized-controlled trial
Angioedema due to acquired C1-inhibitor deficiency is a very rare but serious disease, with an estimated prevalence of 1 per 500,000 persons. There are no approved therapies to treat or prevent angioedema swellings in patients with this condition. Deucrictibant is a specific, orally bioavailable, competitive antagonist of the bradykinin B2 receptor currently under investigation for hereditary angioedema. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Remy S. Petersen, Laur é M. Fijen, Johannes P. Kelder, Danny M. Cohn Source Type: research

Interactions between skin-resident dendritic and Langerhans cells and pain-sensing neurons
Various immune cells in the skin contribute to its function as a first line of defence against infection/disease, while its dense innervation by pain-sensing sensory neurons protects the host from injury/damage signals. Dendritic cells (DCs) are a heterogeneous population of cells that link the innate immune response to the adaptive response by capturing, processing, and presenting antigens to promote T-cell differentiation and activation. DCs are abundant across peripheral tissues, including the skin, where they are found in the dermis and epidermis. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 14, 2024 Category: Allergy & Immunology Authors: Natalie C. Wilcox, Golnar Taheri, Katherine Halievski, Sebastien Talbot, Jaqueline R. Silva, Nader Ghasemlou Source Type: research

A health inequality analysis of childhood asthma prevalence in urban Australia
Long-standing health inequalities in Australian society that were exposed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic were described as “fault lines” in a recent call to action by a consortium of philanthropic organizations. With asthma a major contributor to childhood disease burden, studies of its spatial epidemiology can provide valuable insights into the emergence of health inequalities early in life. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Ewan Cameron, Joyce Mo, Charles Yu Source Type: research

Activated sputum eosinophils associated with exacerbations in children on mepolizumab
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Gabriella E. Wilson, James Knight, Qing Liu, Ashish Shelar, Emma Stewart, Xiaomei Wang, Xiting Yan, Joshua Sanders, Cynthia Visness, Michelle Gill, Rebecca Gruchalla, Andrew H. Liu, Meyer Kattan, Gurjit K. Khurana Hershey, Alkis Togias, Patrice M. Becker, Source Type: research

Hematopoietic stem cell gene editing rescues B cell development in X-linked agammaglobulinemia
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 11, 2024 Category: Allergy & Immunology Authors: Sameer Bahal, Marta Zinicola, Shefta E. Moula, Thomas E. Whittaker, Andrea Schejtman, Asma Naseem, Elena Blanco, Winston Vetharoy, Yi-Ting Hu, Rajeev Rai, Eduardo Gomez-Castaneda, Catarina Cunha Santos, Siobhan O. Burns, Emma C. Morris, Claire Booth, Gian Source Type: research