Journal of Allergy and Clinical ImmunologyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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ReplyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: In response to our recent article, Piippo-Savolainen et al share data from their well studied cohort of 83 subjects followed from early childhood for more than 25 years for asthma and other pulmonary outcomes. Several factors make it difficult to make comparisons to our recent findings from the work highlighted by Piippo-Savolainen et al, including the small sample size, the fact that their study was neither designed nor powered to address our study questions, differences between studies in how exposure and outcome variables were defined, and the lack of both a spectrum of bronchiolitis severity and a compa...
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Kecia N. Carroll, Tebeb Gebretsadik, Marie R. Griffin, Tina V. Hartert Tags: Correspondence Source Type: journals

Long-term outcome after bronchiolitis: No association with the invasiveness of the infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: Carroll et al published in the Journal their interesting results from a retrospective population-based study on the association between the severity of bronchiolitis in infants less than 12 months old and asthma at 4.5 to 5.5 years of age. Among over 90,000 children, 18% had an infant bronchiolitis visit. The adjusted odds ratio for asthma was 1.86 for outpatients, 2.41 in the emergency ward, and 2.82 in the inpatient group, suggesting a dose-response relationship between the severity of bronchiolitis and later asthma. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Eija Piippo-Savolainen, Marja Ruotsalainen, Matti Korppi Tags: Correspondence Source Type: journals

Altered epigenetic regulation and increasing severity of bronchial hyperresponsiveness in atopic asthmatic childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: Environmental influences are believed to shape clinical outcomes in part through epigenetic mechanisms that alter susceptibility to or maintenance of chronic diseases, such as asthma and allergies. Better understanding of the roles of epigenetics in these processes is key to understanding the pathogenesis of chronic inflammatory conditions, as well as to developing prophylactic strategies to reduce their incidence or modulate their intensity. Mechanisms controlling gene expression include methylation of DNA and modifications (eg, acetylation, methylation, and phosphorylation) of histone tails, actively modi...
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Ruey-Chyi Su, Allan B. Becker, Anita L. Kozyrskyj, Kent T. HayGlass Tags: Letters to the Editor Source Type: journals

Predicting outcome of repeat milk, egg, or peanut oral food challengesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: Food allergy affects about 12 million people in the United States, including 3 million children. Frequently, oral food challenges (OFCs) are necessary to obtain a definitive diagnosis or to expand a restricted diet. Clinical guidelines exist to determine who should have initial OFCs, but few data exist regarding the factors that may predict the outcome of repeat OFCs in patients who previously failed an OFC. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Kim Mudd, Melissa Paterakis, Jean Curtin-Brosnan, Elizabeth Matsui, Robert Wood Tags: Letters to the Editor Source Type: journals

Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data indicate that Y145 is the most critical tyrosine supporting SLP-76 function in myeloid cells. Future efforts to dissect how Y145 mediates SLP-76–dependent signaling in MCs and PMNs will increase our understanding of these lineages and provide insights into the treatment of allergy and inflammation. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Laurie E. Lenox, Taku Kambayashi, Mariko Okumura, Christopher Prieto, Karsten Sauer, Ralph M. Bunte, Martha S. Jordan, Gary A. Koretzky, Kim E. Nichols Tags: Mechanisms of allergy and clinical immunology Source Type: journals

Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responsesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Innate cytokine responses are associated with parental allergic or airway disease, somatic fetal growth, ethnicity, and season of birth. Collectively, these findings suggest that urban prenatal exposures and familial factors affect the development of the fetal immune system. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Diane R. Gold, Gordon R. Bloomberg, William W. Cruikshank, Cynthia M. Visness, John Schwarz, Meyer Kattan, George T. O'Connor, Robert A. Wood, Melissa S. Burger, Rosalind J. Wright, Frank Witter, Aviva Lee-Parritz, Rhoda Sperling, Yoel Sadovsky, Alkis Tog Tags: Mechanisms of allergy and clinical immunology Source Type: journals

Outcomes of patients with severe combined immunodeficiency treated with hematopoietic stem cell transplantation with and without preconditioningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Hematopoietic stem cell transplantation in patients with SCID results in engraftment, long-term survival, and a good quality of life for the majority of patients with or without pretransplantation conditioning. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Niraj C. Patel, Javier Chinen, Howard M. Rosenblatt, I. Celine Hanson, Robert A. Krance, Mary E. Paul, Stuart L. Abramson, Lenora M. Noroski, Carla M. Davis, Filiz O. Seeborg, Samuel B. Foster, Kathryn S. Leung, Betty S. Brown, Jerome Ritz, William T. She Tags: Immune deficiencies, infection, and systemic immune disorders Source Type: journals

Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: Importance of baseline serum tryptase—a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom HypersensitivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In patients with honeybee or vespid venom allergy, baseline serum tryptase concentrations are associated with the risk for severe anaphylactic reactions. Preventive measures should include substitution of angiotensin-converting enzyme inhibitors. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Franziska Ruëff, Bernhard Przybilla, Maria Beatrice Biló, Ulrich Müller, Fabian Scheipl, Werner Aberer, Joëlle Birnbaum, Anna Bodzenta-Lukaszyk, Floriano Bonifazi, Christoph Bucher, Paolo Campi, Ulf Darsow, Cornelia Egger, Gabrielle Haeberli, Thomas H Tags: Food, drug, insect sting allergy, and anaphylaxis Source Type: journals

Maternal peanut exposure during pregnancy and lactation reduces peanut allergy risk in offspringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We show for the first time maternal transmission of susceptibility to first-exposure peanut reactions and active peanut sensitization. Low-dose peanut exposure during pregnancy and lactation reduced this risk. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Iván López-Expósito, Ying Song, Kirsi M. Järvinen, Kamal Srivastava, Xiu-Min Li Tags: Food, drug, insect sting allergy, and anaphylaxis Source Type: journals

CorrectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
With regards to the May 2009 article “Different effects of pimecrolimus and betamethasone on the skin barrier in patients atopic dermatitis” (J Allergy Clin Immunol 2009;123:1124-33), the panels in Figure 5 do not appear in the correct order. Panels A and C should be labeled pimecrolimus and Panels B and D should be betamethasone. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Tags: Correction Source Type: journals

Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although both responders and nonresponders to etanercept inactivated sepsis cascade cytokines, response to etanercept is dependent on inactivation of myeloid dendritic cell genes and inactivation of the TH17 immune response. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Lisa C. Zaba, Mayte Suárez-Fariñas, Judilyn Fuentes-Duculan, Kristine E. Nograles, Emma Guttman-Yassky, Irma Cardinale, Michelle A. Lowes, James G. Krueger Tags: Atopic dermatitis and skin disease Source Type: journals

Targeting Ca2+ release–activated Ca2+ channel channels and leukotriene receptors provides a novel combination strategy for treating nasal polyposisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A drug combination directed against CRAC channels and leukotriene receptor antagonist suppresses the feed-forward loop that leads to aberrant mast cell activation. Hence our results identify a new potential strategy for combating polyposis and mast cell–dependent allergies. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Joseph Di Capite, Charmaine Nelson, Grant Bates, Anant B. Parekh Source Type: journals

Rhinitis with negative skin tests and absent serum allergen-specific IgE: More evidence for local IgE?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The phenomenon of local production of IgE in the nasal mucosa is well documented in subjects with allergic rhinitis who have raised serum specific IgE and positive skin prick tests to clinically relevant allergens. Local IgE has also been detected in high levels in nasal polyps in which Staphylococcus-derived enterotoxins are associated with elevated enterotoxin-specific IgE antibodies and likely act as superantigens, thereby promoting increases in polyclonal IgE. Nonallergic rhinitis in the absence of systemic allergen-specific IgE with/without associated eosinophilia affects approximately 25% of patients who experience ...
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Louisa K. James, Stephen R. Durham Tags: Editorial Source Type: journals

Epicutaneous allergen administration: A novel approach for allergen-specific immunotherapy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Specific allergen immunotherapy was first used nearly 100 years ago and is now administered worldwide to treat patients with allergic rhinitis, asthma, or venom hypersensitivity. It is considered to be the only effective, specific treatment for IgE-mediated allergic diseases; recent systemic reviews of controlled clinical studies of specific allergen immunotherapy led to it being recommended for the treatment of respiratory allergy because of its efficacy in reducing asthma and rhinitis symptoms. In addition to its proven clinical efficacy, it can alter the natural history of allergic disease and produce sustained clinica...
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Thomas Werfel Tags: Editorial Source Type: journals

Celebrating JACI's 80th Anniversary-Francis M. Rackemann, Editorial Board MemberEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Source Type: journals

Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: NO oxidation products are increased in the ELF of asthmatic children. The relationship between FENO values and airway nitrosative stress is complicated and requires further study. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Anne M. Fitzpatrick, Lou Ann S. Brown, Fernando Holguin, W. Gerald Teague, National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program Source Type: journals

Antibiotic use in infancy and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old: International Study of Asthma and Allergies in Childhood Phase IIIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: There is an association between antibiotic use in the first year of life and current symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old. Further research is required to determine whether the observed associations are causal or are a result of confounding by indication or reverse causation. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Sunia Foliaki, Neil Pearce, Bengt Björkstén, Javier Mallol, Stephen Montefort, Erika von Mutius, International Study of Asthma and Allergies in Childhood Phase III Study Group Source Type: journals

Long-term pathologic consequences of acute irritant-induced asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study provides evidence of a significant eosinophilic and neutrophilic inflammation as well as remodeling in IrIa many years after an inhalational accident. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Naoya Takeda, Karim Maghni, Sylvie Daigle, Jocelyne L'Archevêque, Lucero Castellanos, Wisam Al-Ramli, Jean-Luc Malo, Qutayba Hamid Source Type: journals

Celebrating JACI's 80th Anniversary-Alfred H. W. Caulfeild, Editorial Board MemberEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Source Type: journals

Celebrating JACI's 80th Anniversary-Arthur F. Coca, Editorial Board MemberEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Source Type: journals

Celebrating JACI's 80th Anniversary-Albert H. Rowe, Editorial Board MemberEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Source Type: journals

Recent asthma exacerbations predict future exacerbations in children with severe or difficult-to-treat asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Recent severe asthma exacerbations are an important independent predictor of FSE in children with severe/difficult-to-treat asthma and should be considered when establishing asthma management plans. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Tmirah Haselkorn, Robert S. Zeiger, Bradley E. Chipps, David R. Mink, Stanley J. Szefler, F. Estelle R. Simons, Marc Massanari, James E. Fish Source Type: journals

Celebrating JACI's 80th Anniversary-Warren T. Vaughan, Associate EditorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Source Type: journals

Tissue remodeling induced by hypersecreted epidermal growth factor and amphiregulin in the airway after an acute asthma attackEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Acute asthma attacks are associated with hypersecretion of EGF and amphiregulin in the airway. Recurrent acute attacks may aggravate airway remodeling. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Yukinori Enomoto, Kanami Orihara, Tetsuya Takamasu, Akio Matsuda, Yasuhiro Gon, Hirohisa Saito, Chisei Ra, Yoshimichi Okayama Source Type: journals

Predicting the long-term outcome of preschool wheeze: Are we there yet?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Asthma is one of the more difficult diagnoses for doctors to make in the preschool age group. Wheeze as a symptom is often inaccurately reported by parents, and many children with wheeze have diagnoses other than asthma. In this month's issue of the Journal, Caudri et al present a clinical risk score to improve the diagnosis of asthma in preschool children. They have used data from the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort, in which participants were assessed on a yearly basis to the age of 8 years. The cohort study enrolled 3963 children and has achieved excellent follow-up rates, with 8...
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Graham Roberts Tags: Editorial Source Type: journals

Celebrating JACI's 80th Anniversary-Harry L. Alexander, EditorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Tags: Asthma and lower airway disease Source Type: journals

The Editors' ChoiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mast cells are tightly linked to the development of allergies and nasal polyposis, the latter affecting up to 2% of the population. In this issue of the Journal, Di Capite et al (p 1014) report the presence of a novel positive feedback cycle in mast cells that might sustain activation in diseased states. This positive feedback cycle involves interplay between Ca2+ release–activated Ca2+ (CRAC) channels and cysteinyl leukotriene type I receptors. In both rodent and human mast cells, Ca2+ entry through open CRAC channels drives the synthesis and secretion of leukotriene C4, which then acts in a paracrine manner to generate...
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Donald Y.M. Leung, Stanley J. Szefler, Associate Editors of the JACI Tags: The Editors' choice Source Type: journals

The irreversible component of persistent asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Tags: Continuing Medical Education examination Source Type: journals

The irreversible component of persistent asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Irreversible airflow obstruction or limitation occurs in some patients with asthma, can develop early in life, and becomes more common as asthma becomes more severe. Efforts to understand irreversible airflow obstruction or limitation have been hampered by the lack of a standardized definition of the phenotype and by the lack of appropriate research models. Unfortunately, it appears that currently available asthma treatments do not prevent this important asthma complication. Herein, the evidence of an irreversible component of asthma, its underlying pathology, and the limitations of current asthma treatments are reviewed. ...
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Rodolfo M. Pascual, Stephen P. Peters Tags: Mechanisms of allergic diseases Source Type: journals

Management of chronic obstructive pulmonary disease: Moving beyond the asthma algorithmEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Tags: Continuing Medical Education examination Source Type: journals

Management of chronic obstructive pulmonary disease: Moving beyond the asthma algorithmEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For many years, chronic obstructive pulmonary disease (COPD) was considered a disease of fixed airflow obstruction for which there was no good treatment. Out of desperation and frustration, health care providers extrapolated from asthma to COPD, and standard asthma therapy was adopted without evidence for efficacy. In recent years, we have gained a better understanding of the pathophysiologic differences between asthma and COPD, and prospective controlled trials have provided a rationale for therapy. Smoking cessation is critically important, both as primary prevention and as an effective way to slow the decrease in lung f...
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Erin Gordon, Stephen C. Lazarus Tags: Clinical reviews in allergy and immunology Source Type: journals

News Beyond Our PagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The widely accepted view of asthma is that it is a TH2-driven disease mediated by the TH2 cytokines, including IL-4, IL-5, and IL-13. Recent studies, however, have suggested significant heterogeneity in asthma phenotypes. Microarray and PCR analyses were conducted by Woodruff and collaborators (Am J Respir Crit Care med 2009;180:388-95) on bronchial epithelial brushings from 42 patients with mild-to-moderate asthma and 28 healthy control subjects to assess the role of TH2 cells in asthma. Only half (n = 22) of the asthmatic subjects proved to have increased levels of IL-13–inducible genes. These high-TH2 asthmatic subjec...
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Marc E. Rothenberg, Harold S. Nelson Tags: News beyond our pages Source Type: journals

CME Activities CalendarEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
▪ 2009 Virtual Annual Meeting: Unable to attend all of the sessions that you wanted to at the 2009 Annual Meeting? Couldn't make it to Washington, DC? The 2009 Virtual Annual Meeting offers Webcasts and audio recordings of most Annual Meeting sessions, and offers more than 100 CME/CE credits. For additional information or to place an order, visit annualmeeting.aaaai.org and select “2009 Annual Meeting” from the Attendees tab. Funded through an educational grant from GlaxoSmithKline. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Tags: Reader services Source Type: journals

Footnotes1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This month, Gillian Shepherd, MD, FAAAAI, took time to answer a few questions. Shepherd is the new Chair of the Allergy, Asthma & Immunology Education and Research Trust (AR Trust). (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Tags: Reader services Source Type: journals

Information for ReadersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Communications regarding original articles and editorial management should be addressed to Donald Y. M. Leung, MD, PhD, Editor in Chief, The Journal of Allergy and Clinical Immunology, National Jewish Medical and Research Center, 1400 Jackson St (J324), Denver, CO 80206; phone 303-398-1963; fax 303-270-2269. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Tags: Reader services Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Editor in Chief DONALD Y. M. LEUNG, MD, PhD Denver, Colo Deputy Editor STANLEY J. SZEFLER, MD Denver, Colo (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Source Type: journals

Table of ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Source Type: journals

A Brief Overview of This Month's JACIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Source Type: journals

Cover 1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2009 Category: Allergy & Immunology Source Type: journals

Clinical pearls for preventing, diagnosing, and treating seasonal and 2009 H1N1 influenza infection in patients with asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Concern about infection with influenza has heightened after the initial and ongoing circulation of a 2009 H1N1 influenza strain. The goal of this article is to discuss clinical pearls that will assist clinicians in preventing, diagnosing, and managing influenza infections. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 12, 2009 Category: Allergy & Immunology Authors: Matthew A. Rank, James T. Li Tags: Clinical pearls Source Type: journals

Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Consistently VPC asthma, as defined by the impairment domain of the 2007 asthma guidelines, is strongly predictive of future asthma exacerbations. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 8, 2009 Category: Allergy & Immunology Authors: Tmirah Haselkorn, James E. Fish, Robert S. Zeiger, Stanley J. Szefler, Dave P. Miller, Bradley E. Chipps, F. Estelle R. Simons, Scott T. Weiss, Sally E. Wenzel, Larry Borish, Eugene R. Bleecker, TENOR Study Group Tags: Asthma and lower airway disease Source Type: journals

Comparison of asthma exacerbations in pediatric and adult patients with severe or difficult-to-treat asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: Optimally controlled asthma remains elusive in many children, as suggested by the high frequency of exacerbations requiring oral corticosteroid courses in those taking long-term controller medications. Although lower than the rate of 122 per 100 person-years in children taking placebo, children with mild-to-moderate asthma taking inhaled corticosteroids in the Childhood Asthma Management Program study demonstrated an oral corticosteroid–treated exacerbation rate of 70 per 100 person-years. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 5, 2009 Category: Allergy & Immunology Authors: Robert S. Zeiger, Bradley E. Chipps, Tmirah Haselkorn, Lawrence Rasouliyan, F. Estelle R. Simons, James E. Fish Tags: Letters to the Editor Source Type: journals

Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results demonstrate that patients with LAR had local production of sIgE and mast cell/eosinophil activation induced by nasal exposure to grass pollen. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 5, 2009 Category: Allergy & Immunology Authors: Carmen Rondón, Javier Fernández, Soledad López, Paloma Campo, Inmaculada Doña, Maria J. Torres, Cristobalina Mayorga, Miguel Blanca Tags: Rhinitis, sinusitis, and upper airway disease Source Type: journals

Novel relationship of serum cholesterol with asthma and wheeze in the United StatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Serum TC and non–HDL-C are inversely related to asthma in the US population, chiefly reflecting a relationship among MAs. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 5, 2009 Category: Allergy & Immunology Authors: Michael B. Fessler, Mark W. Massing, Brian Spruell, Renee Jaramillo, David W. Draper, Jennifer H. Madenspacher, Samuel J. Arbes, Agustin Calatroni, Darryl C. Zeldin Source Type: journals

Discovering anaphylaxis: Elucidation of a shocking phenomenonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Systemic reactions in experimental animals given small doses of otherwise well tolerated foreign species-derived substances were first noted in Magendie's nutritional studies in which rabbits after repeat injections of egg albumin developed immediate fatal collapse. Subsequently, Magendie's experience was duplicated by Behring in 1893 with diphtheria toxins, Flexner with dog serum in rabbits in 1894, and Héricort and Richet with eel serum in dogs in 1898. Regardless of species differences or sources of foreign materials, laboratory animals developed systemic manifestations and fatalities to second doses too small to effec...
Source: Journal of Allergy and Clinical Immunology - September 30, 2009 Category: Allergy & Immunology Authors: Sheldon G. Cohen, Joy C. Mazzullo Tags: The allergy archives: Pioneers and milestones Source Type: journals

Induction of long-lived allergen-specific plasma cells by mucosal allergen challengeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results show that inhalation of aerosolized allergen generates long-lived, allergen-specific IgG1-secreting, IgA-secreting, and IgE-secreting plasma cells that survive cytostatic treatment. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 30, 2009 Category: Allergy & Immunology Authors: Elke O. Luger, Verena Fokuhl, Michael Wegmann, Melanie Abram, Kati Tillack, Gernot Achatz, Rudolf A. Manz, Margitta Worm, Andreas Radbruch, Harald Renz Tags: Mechanisms of allergy and clinical immunology Source Type: journals

Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Epicutaneous sensitization in the absence of IL-4/IL-13 induces an exaggerated TH17 response systemically and in lungs after antigen challenge that results in airway inflammation and airway hyperresponsiveness. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 30, 2009 Category: Allergy & Immunology Authors: Rui He, Hye Young Kim, Juhan Yoon, Michiko K. Oyoshi, Andrew MacGinnitie, Sho Goya, Eva-Jasmin Freyschmidt, Paul Bryce, Andrew N.J. McKenzie, Dale T. Umetsu, Hans C. Oettgen, Raif S. Geha Tags: Atopic dermatitis and skin disease Source Type: journals

Does exposure to cats and dogs decrease the risk of allergic sensitization and disease?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sensitization to domestic pets, particularly cats and dogs, is an important risk factor for allergic diseases, such as asthma and allergic rhinitis. Although cat and dog allergens are known asthma triggers and can influence disease severity among sensitized individuals, their role in the development of sensitization and allergic disease is less clear and has remained a subject of debate. Recent studies suggest that pet exposure, particularly in early childhood, can have beneficial effects and might actually prevent the development of atopic disorders. In this issue of the Journal, the longitudinal investigation by Mandhane...
Source: Journal of Allergy and Clinical Immunology - September 30, 2009 Category: Allergy & Immunology Authors: Päivi M. Salo, Darryl C. Zeldin Tags: Editorial Source Type: journals

Analysis of behavior-related adverse experiences in clinical trials of montelukastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Reports of BRAEs were infrequent in clinical trials of montelukast. Those leading to study discontinuation or considered serious were rare. Frequencies were similar regardless of treatment group. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 30, 2009 Category: Allergy & Immunology Authors: George Philip, Carolyn M. Hustad, Marie-Pierre Malice, Gertrude Noonan, Alan Ezekowitz, Theodore F. Reiss, Barbara Knorr Tags: Editorial Source Type: journals

Assessing risk: Data from montelukast clinical trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The US Food and Drug Administration (FDA)'s most recent updated information on leukotriene inhibitors dated August 28, 2009, states that postmarket cases of neuropsychiatric events have been reported for the leukotriene inhibitors montelukast, zafirlukast, and zileuton. Cases included agitation, aggression, anxiousness, dream abnormalities, hallucination, depression, insomnia, irritability, restlessness, suicidal thinking and behavior, and tremor. The FDA recommends that patients should be informed of the potential for these events. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 30, 2009 Category: Allergy & Immunology Authors: Kimberly Kelsay Tags: Editorial Source Type: journals