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Acknowledgement to refereesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Tags: Acknowledgement to referees Source Type: journals

Comment on: Developments in outpatient parenteral antimicrobial therapy (OPAT) for Gram-positive infections in Europe, and the potential impact of daptomycinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Adriaenssens, N., Goossens, H., Coenen, S., on behalf of the ESAC Project Group Tags: Letter to the Editor Source Type: journals

Off-label use of antibiotics in hospitalized patients: focus on tigecyclineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Curcio, D. Tags: Research letters Source Type: journals

Sustained HIV RNA suppression after switching from enfuvirtide to etravirine in the early access programmeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Loutfy, M., Ribera, E., Florence, E., De Wit, S., Castagna, A., Ryan, R., Hill, A., Vanaken, H., van Delft, Y., Marks, S. Tags: Research letters Source Type: journals

Use of therapeutic drug monitoring in the long-term valaciclovir therapy of relapsing herpes simplex virus encephalitis in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Lim, M., Menson, E., Tong, C. Y. W., Lin, J.-P. Tags: Research letters Source Type: journals

Susceptibility of pneumococci causing meningitis in Spain and prevalence among such isolates of serotypes contained in the 7-valent pneumococcal conjugate vaccineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Fenoll, A., Gimenez, M.-J., Vicioso, M.-D., Granizo, J.-J., Robledo, O., Aguilar, L. Tags: Research letters Source Type: journals

In vitro activity of the new quinolone derivative RD-3 against clinical isolates of Mycoplasma pneumoniae and Mycoplasma hominisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Sainath Rao, S., Raghunathan, M. Tags: Research letters Source Type: journals

Novel genetic environment of qnrB2 associated with TEM-1 and SHV-12 on pB1004, an IncHI2 plasmid, in Salmonella Bredeney BB1047 from SpainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Gutierrez, B., Herrera-Leon, S., Escudero, J. A., Hidalgo, L., Gonzalez-Sanz, R., Arroyo, M., San Millan, A., Echeita, M. A., Gonzalez-Zorn, B. Tags: Research letters Source Type: journals

Novel genetic environment of plasmid-mediated quinolone resistance gene qnrB2 in Salmonella Bredeney from poultryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Fortini, D., Garcia-Fernandez, A., Veldman, K., Mevius, D., Carattoli, A. Tags: Research letters Source Type: journals

Dominance of CTX-M-2 and CTX-M-56 among extended-spectrum {beta}-lactamases produced by Klebsiella pneumoniae and Escherichia coli isolated in hospitals in ParaguayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Khan, M. A., Lemmens, N., Riera, E., Blonk, T., Goedhart, J., Van Belkum, A., Goessens, W., Hays, J. P., Van Westreenen, M. Tags: Research letters Source Type: journals

Plasmid-mediated ArmA and RmtB 16S rRNA methylases in Escherichia coli isolated from chickensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Du, X.-D., Wu, C.-M., Liu, H.-B., Li, X.-S., Beier, R. C., Xiao, F., Qin, S.-S., Huang, S.-Y., Shen, J.-Z. Tags: Research letters Source Type: journals

Molecular characterization of group B streptococci with reduced penicillin susceptibility recurrently isolated from a sacral decubitus ulcerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Nagano, N., Kimura, K., Nagano, Y., Yakumaru, H., Arakawa, Y. Tags: Research letters Source Type: journals

Detection of methicillin-resistant Staphylococcus aureus ST398 in food samples of animal origin in SpainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Lozano, C., Lopez, M., Gomez-Sanz, E., Ruiz-Larrea, F., Torres, C., Zarazaga, M. Tags: Research letters Source Type: journals

Clinical efficacy and cost-effectiveness of outpatient parenteral antibiotic therapy (OPAT): a UK perspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Using this service model, OPAT is safe and clinically effective, with low rates of complications/readmissions and high levels of patient satisfaction. OPAT is cost-effective when compared with equivalent inpatient care in the UK healthcare setting. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Chapman, A. L. N., Dixon, S., Andrews, D., Lillie, P. J., Bazaz, R., Patchett, J. D. Tags: Original research Source Type: journals

Non-compliance with recommendations for the practice of antibiotic prophylaxis and risk of surgical site infection: results of a multilevel analysis from the INCISO Surveillance NetworkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A too-short SAP duration was the most important SAP malpractice associated with an increased risk of SSI. Information directed at practitioners should be reinforced based on standard recommendations. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Miliani, K., L'Heriteau, F., Astagneau, P., on behalf of the INCISO Network Study Group Tags: Original research Source Type: journals

Epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) among residents of nursing homes in BelgiumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A high prevalence of MRSA carriage in NH residents was associated with hospital care, co-morbidities and less-developed coordination of institutional care. The predominant MRSA strains from NH residents and hospitalized patients of the same area were identical. Strengthening and coordination of MRSA surveillance and control activities are warranted within and between NHs and hospitals. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Denis, O., Jans, B., Deplano, A., Nonhoff, C., De Ryck, R., Suetens, C., Struelens, M. J. Tags: Original research Source Type: journals

Prevalence of antimicrobial-resistant bacteria isolated from older versus younger hospitalized adults: results of a two-centre studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Overall, advanced patient age was not uniformly associated with a greater likelihood of antimicrobial resistance among all bacterial pathogens. Moreover, the frequency of resistance in older and younger patients varied considerably at the two sites over the study period. Variability in the frequency of resistance precludes simplistic conclusions regarding the relationship between age and resistance. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Weber, S. G., Miller, R. R., Perencevich, E. N., Tolentino, J., Meltzer, D., Pitrak, D., McGregor, J. C., Sachs, G. A., Harris, A. D., Furuno, J. P. Tags: Original research Source Type: journals

Clinical efficacy of first- and second-line treatments for HIV-associated Pneumocystis jirovecii pneumonia: a tri-centre cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Pentamidine was associated with a greater risk of death when used as first- and second-line therapy for HIV-associated PCP, and was associated with more treatment changes. Clindamycin/primaquine appeared superior to pentamidine as second-line therapy for PCP in patients failing or developing toxicity with trimethoprim/sulfamethoxazole. In patients failing first-line treatment with non-trimethoprim/sulfamethoxazole regimens, second-line therapy should be trimethoprim/sulfamethoxazole. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Helweg-Larsen, J., Benfield, T., Atzori, C., Miller, R. F. Tags: Original research Source Type: journals

An EORTC Phase II study of caspofungin as first-line therapy of invasive aspergillosis in haematological patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Caspofungin provided an observed response rate compatible with the null hypothesis of a true response rate of ≤35%. Underlying disease-related factors had a major impact on results. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Viscoli, C., Herbrecht, R., Akan, H., Baila, L., Sonet, A., Gallamini, A., Giagounidis, A., Marchetti, O., Martino, R., Meert, L., Paesmans, M., Ameye, L., Shivaprakash, M., Ullmann, A. J., Maertens, J., on behalf of the Infectious Disease Group of the EO Tags: Original research Source Type: journals

Influence of CYP2B6 polymorphisms on the persistence of plasma nevirapine concentrations following a single intra-partum dose for the prevention of mother to child transmission in HIV-infected Thai womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The CYP2B6 516G>T impact on nevirapine concentrations was less pronounced after intra-partum single-dose nevirapine than reported under steady-state conditions, perhaps due to lack of enzyme auto-induction at the time of dosing. Although the TGATC CYP2B6 haplotype may shorten the persistence of nevirapine post-partum, its practical implications for the prevention of HIV transmission or selection of resistance mutations are likely limited. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Chantarangsu, S., Cressey, T. R., Mahasirimongkol, S., Capparelli, E., Tawon, Y., Ngo-Giang-Huong, N., Jourdain, G., Lallemant, M., Chantratita, W. Tags: Original research Source Type: journals

Once-daily treatment with saquinavir mesylate (2000 mg) and ritonavir (100 mg) together with a fixed-dose combination of abacavir/lamivudine (600/300 mg) or tenofovir/emtricitabine (245/200 mg) in HIV-1-infected patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Once-daily treatment with ritonavir-boosted saquinavir was well tolerated and resulted in similar saquinavir drug exposure despite much lower ritonavir concentrations when compared with a twice-daily dosing schedule. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Bickel, M., Bodtlander, A., Knecht, G. K., Stephan, C., von Hentig, N., Kurowski, M., Gute, P., Klauke, S., Lutz, T. Tags: Original research Source Type: journals

Pharmacokinetics of nevirapine in HIV-infected children with and without malnutrition receiving divided adult fixed-dose combination tabletsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Use of divided adult Triomune®30 tablets in treating young children results in significant underdosing. No independent effect of malnutrition on total and unbound nevirapine exposures was observed. These data support the use of bespoke paediatric antiretroviral formulations. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Pollock, L., Else, L., Poerksen, G., Molyneux, E., Moons, P., Walker, S., Fraser, W., Back, D., Khoo, S. Tags: Original research Source Type: journals

Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A significant reduction in the number of bacteria was observed when initiating treatment 1 h post-infection compared with initiating treatment after 24 h, although the latest isolate avoided complete clearance. Early antibiotic treatment directed at the mucoid phenotype in mice also reduced the inflammation and, thereby, the lung tissue damage. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: van Gennip, M., Moser, C., Christensen, L. D., Bjarnsholt, T., Calum, H., Jensen, P. O., Christophersen, L., Hougen, H. P., Ciofu, O., Molin, S., Givskov, M., Hoiby, N. Tags: Original research Source Type: journals

Combined topical paromomycin and oral miltefosine treatment of mice experimentally infected with Leishmania (Leishmania) major leads to reduction in both lesion size and systemic parasite burdensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The combination of topical paromomycin gel and oral miltefosine provides an enhanced efficacy in the treatment of L. (L.) major-infected mice, thus presenting a significantly higher activity than that observed for the monotherapeutic regimens. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Aguiar, M. G., Silva, D. L., Nunan, F. A., Nunan, E. A., Fernandes, A. P., Ferreira, L. A. M. Tags: Original research Source Type: journals

In vitro effect of physiological concentrations of human albumin on the antibacterial activity of tigecyclineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Correcting the total concentration for the reported literature binding values is unreliable since tigecycline antibacterial activity was greater than that suggested by the free fraction of the drug. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Alou, L., Gimenez, M.-J., Cafini, F., Aguilar, L., Sevillano, D., Gonzalez, N., Torrico, M., Prieto, J., Garcia-Rey, C., Garcia-Escribano, N. Tags: Original research Source Type: journals

In vitro activity of nemonoxacin (TG-873870), a novel non-fluorinated quinolone, against clinical isolates of Staphylococcus aureus, enterococci and Streptococcus pneumoniae with various resistance phenotypes in TaiwanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our findings point to a potentially useful role for nemonoxacin in the treatment of infections caused by MSSA, ciprofloxacin-susceptible MRSA and S. pneumoniae with various resistance phenotypes. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Chen, Y.-H., Liu, C.-Y., Lu, J.-J., King, C.-H. R., Hsueh, P.-R. Tags: Original research Source Type: journals

Antimicrobial efficacy of eucalyptus oil and 1,8-cineole alone and in combination with chlorhexidine digluconate against microorganisms grown in planktonic and biofilm culturesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In conclusion, CHG may be combined with either crude EO or its major component 1,8-cineole for enhanced, synergistic antimicrobial activity against a wide range of microorganisms in planktonic and biofilm modes of growth; however, the superior antimicrobial efficacy associated with crude EO alone, compared with 1,8-cineole, favours its combination with CHG. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Hendry, E. R., Worthington, T., Conway, B. R., Lambert, P. A. Tags: Original research Source Type: journals

Restricting ciprofloxacin-induced resistant variant formation in biofilm of Klebsiella pneumoniae B5055 by complementary bacteriophage treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The combination treatment not only killed the bacteria, but also restricted the formation of resistant variants significantly as compared with individual treatments. Hence, a combination of bacteriophage and ciprofloxacin offers an effective strategy to combat the emergence of treatment-associated resistance. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Verma, V., Harjai, K., Chhibber, S. Tags: Original research Source Type: journals

Enhancing antibiotic activity: a strategy to control Acinetobacter infectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Susceptibility of MDR A. baumannii to a variety of antibiotics was enhanced in the presence of ellagic and tannic acids. The use of such plant compounds might provide effective treatments for resistant Gram-negative bacterial infections. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Chusri, S., Villanueva, I., Voravuthikunchai, S. P., Davies, J. Tags: Original research Source Type: journals

The Enterococcus faecalis superoxide dismutase is essential for its tolerance to vancomycin and penicillinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions SodA is central to the intrinsic ability of E. faecalis to withstand drug-induced killing, and the superoxide anion seems to be the key effector of bacterial death. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Bizzini, A., Zhao, C., Auffray, Y., Hartke, A. Tags: Original research Source Type: journals

In vitro synergistic activity against CCR5-tropic HIV-1 with combinations of potential candidate microbicide molecules HHA, KRV2110 and enfuvirtide (T20)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These observations provide a rational basis for in vitro testing of microbicide candidate molecule combinations, including anti-HIV-1 and cytotoxic cellular assays. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Jenabian, M.-A., Saidi, H., Charpentier, C., Van Herrewege, Y., Son, J. C., Schols, D., Balzarini, J., Vanham, G., Belec, L., on behalf of the ANRS Multi-Micro Project Study Group Tags: Original research Source Type: journals

Stable expression of Escherichia coli {beta}-glucuronidase A (GusA) in Giardia lamblia: application to high-throughput drug susceptibility testingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions G. lamblia WB C6 GusA is a suitable tool for high-throughput anti-giardial drug screening. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Muller, J., Nillius, D., Hehl, A., Hemphill, A., Muller, N. Tags: Original research Source Type: journals

Emergence of extended-spectrum {beta}-lactamases and AmpC-type {beta}-lactamases in human Salmonella isolated in Spain from 2001 to 2005Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This study demonstrates the emergence of a public health risk related to resistance to β-lactams in Salmonella. The resistance trends need to be monitored carefully. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Gonzalez-Sanz, R., Herrera-Leon, S., de la Fuente, M., Arroyo, M., Echeita, M. A. Tags: Original research Source Type: journals

Decreased fluoroquinolone susceptibility in mutants of Salmonella serovars other than Typhimurium: detection of novel mutations involved in modulated expression of ramA and soxSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Changes in the ramR-ramA region as well as in the soxR gene occur in mutants of Salmonella serovars other than Typhimurium and seem to be involved in the up-regulation of efflux activity. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Kehrenberg, C., Cloeckaert, A., Klein, G., Schwarz, S. Tags: Original research Source Type: journals

Dissemination of transposon Tn6001 in carbapenem-non-susceptible and extensively drug-resistant Pseudomonas aeruginosa in TaiwanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Tn6001 and In450 play an important role in the dissemination of CNSPA and XDRPA. The prevalence of these genetic constituents was higher in XDRPA than in non-XDRPA isolates, suggesting that the mobile element Tn6001 might have transferred horizontally. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Tseng, S.-P., Tsai, J.-C., Teng, L.-J., Hsueh, P.-R. Tags: Original research Source Type: journals

High clonal diversity in erythromycin-resistant Streptococcus pneumoniae invasive isolates in Madrid, Spain (2000-07)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The resistance determinants erm(B) and the combination of erm(B) plus mef(A) were observed within multiple S. pneumoniae bacteraemic clones. The preservation of a polyclonal structure might provide a suitable background for further evolution of antibiotic resistance. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: de la Pedrosa, E. G. G., Baquero, F., Loza, E., Nadal-Serrano, J.-M., Fenoll, A., del Campo, R., Canton, R. Tags: Original research Source Type: journals

Diversity of antimicrobial resistance pheno- and genotypes of methicillin-resistant Staphylococcus aureus ST398 from diseased swineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions MRSA ST398 isolates varied slightly in their virulence properties and spa types but differed distinctly in their antimicrobial resistance pheno- and genotypes as well as their ApaI-PFGE patterns. These data underline the ability of ST398 to acquire genetic material that might increase antimicrobial resistance and virulence. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Kadlec, K., Ehricht, R., Monecke, S., Steinacker, U., Kaspar, H., Mankertz, J., Schwarz, S. Tags: Original research Source Type: journals

Characterization of methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative Staphylococcus spp. isolated from US West Coast public marine beachesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This is the first report of MRSA and MRCoNS isolated from marine water and intertidal beach sand. The MLST types and antibiotic carriage of five MRSA isolates were similar to hospital MRSA isolates rather than US community-acquired MRSA isolates. Our results suggest that public marine beaches may be a reservoir for transmission of MRSA to beach visitors as well as an ecosystem for exchange of antibiotic resistance genes among staphylococci and related genera. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Soge, O. O., Meschke, J. S., No, D. B., Roberts, M. C. Tags: Original research Source Type: journals

Use of benznidazole to treat chronic Chagas' disease: a systematic review with a meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Analysis of available information reveals that the efficacy of treatment in late chronic infection is doubtful. Although data generally point to a beneficial effect, this could be marginal. This uncertainty is largely the result of differences in the study populations, endpoints and follow-up periods, and the fact that almost all of the information on treatment in the late chronic phase comes from non-randomized studies. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Perez-Molina, J. A., Perez-Ayala, A., Moreno, S., Fernandez-Gonzalez, M. C., Zamora, J., Lopez-Velez, R. Tags: Systematic review Source Type: journals

Effects of daptomycin in combination with other antimicrobial agents: a review of in vitro and animal model studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review summarizes the in vitro and animal model data available on antibiotic combinations with daptomycin. The majority of studies focus on the clinically relevant combinations of daptomycin with rifampicin or with gentamicin. These studies demonstrate that daptomycin does not adversely affect the activity of other antimicrobial agents that may be administered concomitantly. Overall, additive or indifferent effects with daptomycin combinations were observed; however, synergy was observed for certain isolates of vancomycin-resistant enterococci when exposed to daptomycin and rifampicin. Unexpected synergy was demonstra...
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Steenbergen, J. N., Mohr, J. F., Thorne, G. M. Tags: Review Source Type: journals

Dried blood spots can expand access to virological monitoring of HIV treatment in resource-limited settingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The global scale-up of antiretroviral treatment in past years has, unfortunately, not been accompanied by adequate strengthening of laboratory capacity. Monitoring of treatment with HIV viral load and resistance testing, as recommended in industrialized countries, is rarely available in resource-limited settings due to high costs and stringent requirements for storage and transport of plasma. Consequently, treatment failure usually passes unnoticed until severe symptoms occur, when resistance mutations have accumulated and second-line drug options are restricted. Dried blood spots (DBS) are easy to collect and store, and c...
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Johannessen, A., Troseid, M., Calmy, A. Tags: Leading articles Source Type: journals

Antibiotics for community-acquired pneumoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antibiotic guidelines for community-acquired pneumonia (CAP) often recommend broad-spectrum agents for severe pneumonia. While these may be entirely appropriate in terms of their spectrum of activity and efficacy, there is a risk that such recommendations could result in over-prescribing of broad-spectrum agents with consequent ‘collateral damage’, meaning superinfection by resistant pathogens, or selection of antibiotic resistance. Narrow-spectrum agents are often as effective and result in less collateral damage. National and local antibiotic guidance should promote choices of agents for narrow-spectrum presc...
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Dryden, M., Hand, K., Davey, P., on behalf of the BSAC Council Tags: Leading articles Source Type: journals

Oxford Handbook of Infectious Diseases and MicrobiologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - October 12, 2009 Category: Microbiology Authors: Dryden, M. Tags: Book review Source Type: journals

Daily 300 mg dose of linezolid for the treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis--authors' responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - October 12, 2009 Category: Microbiology Authors: Koh, W.-J., Shim, T. S. Tags: Letters to the Editor Source Type: journals

Comment on: Daily 300 mg dose of linezolid for the treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - October 12, 2009 Category: Microbiology Authors: Yew, W. W., Chang, K. C., Chau, C. H. Tags: Letters to the Editor Source Type: journals

Potentially dangerous misuse of the Hartford once-daily nomogram for gentamicinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - October 12, 2009 Category: Microbiology Authors: Lovering, A. M., Reeves, D. S. Tags: Research letters Source Type: journals

In vitro synergy studies based on tazobactam/piperacillin against clinical isolates of metallo-{beta}-lactamase-producing Pseudomonas aeruginosaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - October 12, 2009 Category: Microbiology Authors: Fujimura, S., Takane, H., Nakano, Y., Watanabe, A. Tags: Research letters Source Type: journals

Reduced biofilm production associated with increasing linezolid MICs among linezolid-resistant staphylococciEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - October 12, 2009 Category: Microbiology Authors: Dandache, P., Moise, P. A., Orsini, J., Montecalvo, M., Sakoulas, G. Tags: Research letters Source Type: journals

Has the publication of methicillin-resistant Staphylococcus aureus (MRSA) treatment guidelines increased the survival associated with MRSA bacteraemia?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions No significant difference in survival in relation to local practice review or the publication of national guidelines was detected. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - October 12, 2009 Category: Microbiology Authors: Brindle, R., on behalf of Wessex Microbiologists Tags: Original research Source Type: journals

Emergence of blaKPC-containing Klebsiella pneumoniae in a long-term acute care hospital: a new challenge to our healthcare systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The detection of KPC-Kp in an LTACH represents a serious infection control and therapeutic challenge in a new clinical setting. The speed at which the epidemic of KPC-Kp is spreading in our healthcare system mandates urgent action. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - October 12, 2009 Category: Microbiology Authors: Endimiani, A., DePasquale, J. M., Forero, S., Perez, F., Hujer, A. M., Roberts-Pollack, D., Fiorella, P. D., Pickens, N., Kitchel, B., Casiano-Colon, A. E., Tenover, F. C., Bonomo, R. A. Tags: Original research Source Type: journals