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Publication date: November 2018Source: Journal of Applied Biomedicine, Volume 16, Issue 4Author(s): (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - October 11, 2018 Category: Biotechnology Source Type: research
Evaluation of hypotesticular activities of different solvent fractions of hydro-methanolic extract of the fruit of Terminalia chebula in Wistar strain adult albino rat: Genomic and flow cytometric approaches
Publication date: Available online 19 September 2018Source: Journal of Applied BiomedicineAuthor(s): Prabal Ghosh, Priety Gupta, Adrija Tripathy, Barnali Das, Debidas GhoshAbstractFruit of Terminalia chebula Retz. (Combretaceae) has male contraceptive folk medicine reputation but its molecular aspect regarding hypotesticular activity is still in dark. The study focused the hypotesticular efficacy of the most potent fraction out of n-hexane, chloroform and ethyl acetate fractions of hydro-methanolic (3:2) extract of Terminalia chebula in connection with male herbal contraceptive development.Treatment with above fractions of...
Source: Journal of Applied Biomedicine - September 21, 2018 Category: Biotechnology Source Type: research
Phytochemical analysis and assessment of antioxidant and antimicrobial activities of some medicinal plant species from Egyptian flora
Publication date: Available online 3 September 2018Source: Journal of Applied BiomedicineAuthor(s): Rania Al-Tohamy, Sameh Samir Ali, Khalil Saad-Allah, Mervat Fareed, Asmaa Ali, Anwer El-Badry, Nessma Ahmed El-Zawawy, Jian Wu, Jianzhong Sun, Guang-Hua Mao, Parveen Fatemeh RupaniAbstractPlants offer unlimited source of bioactive compounds that have tremendous applications in pharmaceutical industry. To find new sources of antioxidants and antimicrobial agents against pan-drug resistant (PDR) pathogens of skin burn infections, methanolic extracts of nine Egyptian plants were evaluated. Total phenolic content varied from 19....
Source: Journal of Applied Biomedicine - September 3, 2018 Category: Biotechnology Source Type: research
Pre-pregnancy stress suppressed the reproductive systems in parents and changed sex ratio in offspring
This study aimed to investigate the effect of stress during spermatogenesis and oogenesis on reproductive performance in adult rats and sex ratio in offspring. The rats were subjected to predatory stress (exposed to a cat) twice a day for 50 (male) and 15 (female) consecutive days. At the end of the stress procedure, a number of control and stressed rats were considered to examine reproductive parameters and the rest was coupled as follows: both male and female control, male stressed/female control, male control/female stressed, and both male and female stressed. After parturition, the pups were counted, weighed, and gende...
Source: Journal of Applied Biomedicine - August 28, 2018 Category: Biotechnology Source Type: research
Contents
Publication date: August 2018Source: Journal of Applied Biomedicine, Volume 16, Issue 3Author(s): (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - July 27, 2018 Category: Biotechnology Source Type: research
Positive association between the progression of idiopathic scoliosis and the common variant near the LBX1 gene in Southeast European population
This report investigates the positive association between curve progression of Southeast European population and one of the most significant polymorphisms of idiopathic scoliosis (IS). The association between rs11190870 near the ladybird homeobox 1 (LBX1) gene, the curve severity (case-control study) and the curve pattern (case-only study) was explored among 155 IS Caucasian patients and 254 unrelated controls. The genotyping of rs11190870 was carried out by the TaqMan real-time amplification technology. The results revealed the existence of a statistically significant association between rs11190870, downstream of the LBX1...
Source: Journal of Applied Biomedicine - July 25, 2018 Category: Biotechnology Source Type: research
Influence of skin permeation enhancers on the transdermal delivery of palonosetron: An in vitro evaluation
This study reveals that the optimized transdermal system with propylene glycol as permeation enhancers can provide effective therapeutic level of palonosetron.Graphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
NTPDase, 5′-nucleotidase and adenosine deaminase activities and purine levels in serum of sickle cell anemia patients
Publication date: Available online 26 December 2017Source: Journal of Applied BiomedicineAuthor(s): Lívia G. Castilhos, Stephen A. Adefegha, Pedro H. Doleski, Tatiana M.D. Bertoldo, Cesar Eduardo J. Moritz, Emerson A. Casali, Daniela B.R. LealAbstractSickle cell anemia (SCA) is a hereditary disorder that is characterized by tendency of hemoglobin molecules within the erythrocytes to polymerize under hypoxia conditions, deform the red cells, and promote vaso-occlusion and endothelial damage. This disease may be associated with the extracellular release of nucleotides, particularly ATP, ADP and adenosine into the circulatio...
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
A survey on applying machine learning techniques for management of diseases
Publication date: Available online 19 January 2018Source: Journal of Applied BiomedicineAuthor(s): Enas M.F. El HoubyAbstractDuring the past years, the increase in scientific knowledge and the massive data production have caused an exponential growth in databases and repositories. Biomedical domain represents one of the rich data domains. An extensive amount of biomedical data is currently available, ranging from details of clinical symptoms to various types of biochemical data and outputs of imaging devices. Manually extracting biomedical patterns from data and transforming them into machine-understandable knowledge is a ...
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
Effect of gender, age, diet and smoking status on the circadian rhythm of ascorbic acid (vitamin C) of healthy Indians
ConclusionThe present observations confirm a definite circadian rhythm in ascorbic acid concentrations with significant effects of age, diet and smoking status in clinical health. Mapping the circadian rhythm of serum ascorbic acid in health can help explore its role in different pathophysiological conditions as pre-disease conditions may be characterized by alterations in the circadian amplitude and/or phase before there is a change in mean value.Graphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
Oral melatonin administration improves the objective and subjective sleep quality, increases 6-sulfatoxymelatonin levels and total antioxidant capacity in patients with fibromyalgia
ConclusionThe daily intake of melatonin improved the sleep quality, increased the aMT6-s levels and the total antioxidant capacity in patients with fibromyalgia. (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
Sinomenine inhibits the growth of glioma cells through STAT3 signal pathway
Publication date: February 2018Source: Journal of Applied Biomedicine, Volume 16, Issue 1Author(s): Yi-ting Wei, Qun-ying Yang, Shuang-bo Fan, Liang-Wang, Dong-Xia Hu, Ping ShuaiAbstractThe present study was designed to examine effects of Sinomenine (SM) on glioma cells growth in vivo and in vitro. Cells growth and apoptosis were detected by MTT assay, TUNEL assay and flow cytometric analysis. In the study, SM treatment led to growth inhibition on a series of glioma cell lines, including U87, U373, U251, Hs683 and T98G. SM prevented U87 growth in the nude mice as well. Inhibitory effects of SM on U87 cells proliferation in...
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
Apigenin inhibits ethanol-induced oxidative stress and LPS-induced inflammatory cytokine production in cultured rat hepatocytes
In this study, the effects of apigenin on ethanol-induced oxidative stress and lipopolysaccharide (LPS)-induced inflammatory cytokine production were examined in cultured rat hepatocytes. Following pretreatment of ethanol-stimulated hepatocytes with apigenin 6–24 mM for 2 h, the levels of cytochrome P450 2E1 (CYP2E1) protein expression and supernatant alanine aminotransferase and malondialdehyde were reduced (P < 0.05 or P < 0.01), while the activities of glutathione reductase and glutathione peroxidase were increased (P < 0.05 or P < 0.01). Likewise, the ...
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
DNA repair inhibitors as radiosensitizers in human lung cells
Publication date: February 2018Source: Journal of Applied Biomedicine, Volume 16, Issue 1Author(s): Kamila Ďurišová, Lucie Čecháková, Petr Jošt, Zuzana Šinkorová, Adéla Kmochová, Jaroslav Pejchal, Martin Ondrej, Jiřina Vávrová, Aleš TichýAbstractThe aim of this study was to compare the effects of DNA repair inhibitors in the context of radio-sensitization of human lung cells. The radio-sensitizing effects of NU7441 (1 mM), an inhibitor of DNA-dependent protein kinase (DNA-PK); KU55933 (10 μM), an inhibitor of ataxia-telangiectasia mutated kinase (ATM); and VE-821 (10 μM), an inhibitor of ATM-related kinas...
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
Antibacterial and cytotoxicity effects of biogenic palladium nanoparticles synthesized using fruit extract of Couroupita guianensis Aubl.
Publication date: February 2018Source: Journal of Applied Biomedicine, Volume 16, Issue 1Author(s): Sathishkumar Gnanasekar, Jeyaraj Murugaraj, Balakrishnan Dhivyabharathi, Varunkumar Krishnamoorthy, Pradeep K Jha, Prabukumar Seetharaman, Ravikumar Vilwanathan, Sivaramakrishnan SivaperumalAbstractHerein, we report a facile route to synthesize palladium nanoparticles (CGPdNPs) using the aqueous fruit extract of C. guianensis Aubl. as a potent biological reducing agent. Reduction of PdCl2 solution into their nano scale was confirmed with the formation of a black precipitate which gives a reduced absorbance in UV–vis spectr...
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
