Machine Learning and Bioinformatics Approaches to Identify the Candidate Biomarkers in Severe Asthma
J Asthma. 2024 Apr 22:1-31. doi: 10.1080/02770903.2024.2335562. Online ahead of print.ABSTRACTSevere asthma is characterized by a poor level of control that severely affects the patient's life and prognosis. However, the underlying pathogenic mechanisms remain unknown. Here, we identified differentially expressed genes from the microarray datasets(GSE130499 and GSE63142) of severe asthma, and then constructed models to screen the most relevant biomarkers to severe asthma by machine learning algorithms(LASSO and SVM-RFE), with further validation of the results by GSE43696. Three genes (BCL3, DDIT4 and S100A14) are considere...
Source: Journal of Asthma - April 22, 2024 Category: Respiratory Medicine Authors: Fuying Zhang Xiang Weng Jiabao Zhu Qin Tang Mingsheng Lei Weimin Zhou Source Type: research
YiQi GuBen capsule alleviates OVA-induced asthma through improving mitochondrial dysfunction
Conclusion: This study suggests YiQi GuBen capsule can effectively improve mitochondrial dysfunction in the OVA-induced mouse model.PMID:38647486 | DOI:10.1080/02770903.2024.2303755 (Source: Journal of Asthma)
Source: Journal of Asthma - April 22, 2024 Category: Respiratory Medicine Authors: Xiaoting Ren Yibu Kong Hongjun Yu Aiai Dong Yongji Wang Lina Wei Yongfu Song Zhongtian Wang Lie Wang Yinan Guo Liping Sun Source Type: research
Machine Learning and Bioinformatics Approaches to Identify the Candidate Biomarkers in Severe Asthma
J Asthma. 2024 Apr 22:1-31. doi: 10.1080/02770903.2024.2335562. Online ahead of print.ABSTRACTSevere asthma is characterized by a poor level of control that severely affects the patient's life and prognosis. However, the underlying pathogenic mechanisms remain unknown. Here, we identified differentially expressed genes from the microarray datasets(GSE130499 and GSE63142) of severe asthma, and then constructed models to screen the most relevant biomarkers to severe asthma by machine learning algorithms(LASSO and SVM-RFE), with further validation of the results by GSE43696. Three genes (BCL3, DDIT4 and S100A14) are considere...
Source: Journal of Asthma - April 22, 2024 Category: Respiratory Medicine Authors: Fuying Zhang Xiang Weng Jiabao Zhu Qin Tang Mingsheng Lei Weimin Zhou Source Type: research
YiQi GuBen capsule alleviates OVA-induced asthma through improving mitochondrial dysfunction
Conclusion: This study suggests YiQi GuBen capsule can effectively improve mitochondrial dysfunction in the OVA-induced mouse model.PMID:38647486 | DOI:10.1080/02770903.2024.2303755 (Source: Journal of Asthma)
Source: Journal of Asthma - April 22, 2024 Category: Respiratory Medicine Authors: Xiaoting Ren Yibu Kong Hongjun Yu Aiai Dong Yongji Wang Lina Wei Yongfu Song Zhongtian Wang Lie Wang Yinan Guo Liping Sun Source Type: research
Mounier-Kuhn Syndrome in poorly controlled asthma
CONCLUSIONS: Despite its rarity, this syndrome significantly impacts patients' quality of life. Diagnosis and management involve comprehensive evaluations including computed tomography, with a multidisciplinary approach including pulmonologists and radiologists. Exploring its clinical features, associations with other respiratory diseases and treatment options is crucial in managing this rare respiratory condition.PMID:38639468 | DOI:10.1080/02770903.2024.2344168 (Source: Journal of Asthma)
Source: Journal of Asthma - April 19, 2024 Category: Respiratory Medicine Authors: Marta Sol ís García Carolina Cisneros Serrano Ana Sof ía Martín Hernández Jose Mar ía Eiros Bachiller Celeste Marcos Source Type: research
Spontaneous pneumomediastinum and pneumopericardium in a young male with asthma
Conclusion: This case outlines the presentation, diagnosis, and management of concurrent spontaneous pneumomediastinum and pneumopericardium.PMID:38639651 | DOI:10.1080/02770903.2024.2346151 (Source: Journal of Asthma)
Source: Journal of Asthma - April 19, 2024 Category: Respiratory Medicine Authors: Ivy M Fan Sarah Goh Joe Choi Daniel J Tan Source Type: research
Urinary Metabolomic Profiles Uncover Metabolic Pathways in Children with Asthma
Conclusions: This study suggests that there are significant metabolic differences in the urine of asthmatic children and healthy controls, and alpha-linolenic acid metabolic pathways may be involved in the pathogenesis of asthma.PMID:38634666 | DOI:10.1080/02770903.2024.2338865 (Source: Journal of Asthma)
Source: Journal of Asthma - April 18, 2024 Category: Respiratory Medicine Authors: Sainan Jiang Yiting Zhou Jianlong Gao Siyi Jin Genli Pan Yuan Jiang Source Type: research
Acoustic biomarkers in asthma: a systematic review
CONCLUSIONS: This systematic review establishes the promising role of acoustic biomarkers, particularly cough and wheeze, in supporting the diagnosis of asthma and monitoring. The evidence suggests the potential for clinical integration of acoustic biomarkers, emphasizing the need for further validation in larger, clinically-diverse populations.PMID:38634718 | DOI:10.1080/02770903.2024.2344156 (Source: Journal of Asthma)
Source: Journal of Asthma - April 18, 2024 Category: Respiratory Medicine Authors: Karolina Wieczorek Sachin Ananth Diana Valazquez-Pimentel Source Type: research
Functional analysis of airway remodeling is related with fibrotic mediators in asthmatic children
CONCLUSIONS: Impulse oscillometry is a sensitive method to detect airway resistance in persistent mild and moderate asthmatic children, an event followed by increased levels of pro-inflammatory and pro-fibrotic mediators.PMID:38577973 | DOI:10.1080/02770903.2024.2338862 (Source: Journal of Asthma)
Source: Journal of Asthma - April 5, 2024 Category: Respiratory Medicine Authors: Lucas P Salles-Dias Maysa A R Brandao-Rangel Amanda Cristina-Rosa Rayssa T Morais-Felix Simone Oliveira-Freitas Luis V F Oliveira Renilson Moraes-Ferreira Andre L L Bachi Elisa T Coutinho Claudio R Frison Asghar Abbasi Dobroslav Melamed Rodolfo P Vieira Source Type: research
Asthma management, focused on the use of oral corticosteroids: the opinions of Italian asthmatic patients
CONCLUSIONS: The survey results confirmed many problems related to mild-moderate and severe asthma management in Italy and highlighted the overuse of OCS rather than more effective and safe treatments, which had strong negative effects on HRQoL.PMID:38578082 | DOI:10.1080/02770903.2024.2338863 (Source: Journal of Asthma)
Source: Journal of Asthma - April 5, 2024 Category: Respiratory Medicine Authors: Manuela Latorre Angela Rizzi Pierluigi Paggiaro Ilaria Baiardini Diego Bagnasco Stefano DelGiacco Carlo Lombardi Vincenzo Patella Eleonora Nucera Roberta Parente Giovanni Paoletti Laura Pini Erminia Ridolo Gianenrico Senna Francesco Blasi Giorgio Walter C Source Type: research
Functional Analysis of Airway Remodeling is Related with Fibrotic Mediators in Asthmatic Children
CONCLUSIONS: Impulse oscillometry is a sensitive method to detect airway resistance in persistent mild and moderate asthmatic children, an event followed by increased levels of pro-inflammatory and pro-fibrotic mediators.PMID:38577973 | DOI:10.1080/02770903.2024.2338862 (Source: Journal of Asthma)
Source: Journal of Asthma - April 5, 2024 Category: Respiratory Medicine Authors: Lucas P Salles-Dias Maysa A R Brandao-Rangel Amanda Cristina-Rosa Rayssa T Morais-Felix Simone Oliveira-Freitas Luis V F Oliveira Renilson Moraes-Ferreira Andre L L Bachi Elisa T Coutinho Claudio R Frison Asghar Abbasi Dobroslav Melamed Rodolfo P Vieira Source Type: research
Asthma management, focused on the use of oral corticosteroids: the opinions of Italian asthmatic patients
CONCLUSIONS: The survey results confirmed many problems related to mild-moderate and severe asthma management in Italy and highlighted the overuse of OCS rather than more effective and safe treatments, which had strong negative effects on HRQoL.PMID:38578082 | DOI:10.1080/02770903.2024.2338863 (Source: Journal of Asthma)
Source: Journal of Asthma - April 5, 2024 Category: Respiratory Medicine Authors: Manuela Latorre Angela Rizzi Pierluigi Paggiaro Ilaria Baiardini Diego Bagnasco Stefano DelGiacco Carlo Lombardi Vincenzo Patella Eleonora Nucera Roberta Parente Giovanni Paoletti Laura Pini Erminia Ridolo Gianenrico Senna Francesco Blasi Giorgio Walter C Source Type: research
Functional Analysis of Airway Remodeling is Related with Fibrotic Mediators in Asthmatic Children
CONCLUSIONS: Impulse oscillometry is a sensitive method to detect airway resistance in persistent mild and moderate asthmatic children, an event followed by increased levels of pro-inflammatory and pro-fibrotic mediators.PMID:38577973 | DOI:10.1080/02770903.2024.2338862 (Source: Journal of Asthma)
Source: Journal of Asthma - April 5, 2024 Category: Respiratory Medicine Authors: Lucas P Salles-Dias Maysa A R Brandao-Rangel Amanda Cristina-Rosa Rayssa T Morais-Felix Simone Oliveira-Freitas Luis V F Oliveira Renilson Moraes-Ferreira Andre L L Bachi Elisa T Coutinho Claudio R Frison Asghar Abbasi Dobroslav Melamed Rodolfo P Vieira Source Type: research
Asthma management, focused on the use of oral corticosteroids: the opinions of Italian asthmatic patients
CONCLUSIONS: The survey results confirmed many problems related to mild-moderate and severe asthma management in Italy and highlighted the overuse of OCS rather than more effective and safe treatments, which had strong negative effects on HRQoL.PMID:38578082 | DOI:10.1080/02770903.2024.2338863 (Source: Journal of Asthma)
Source: Journal of Asthma - April 5, 2024 Category: Respiratory Medicine Authors: Manuela Latorre Angela Rizzi Pierluigi Paggiaro Ilaria Baiardini Diego Bagnasco Stefano DelGiacco Carlo Lombardi Vincenzo Patella Eleonora Nucera Roberta Parente Giovanni Paoletti Laura Pini Erminia Ridolo Gianenrico Senna Francesco Blasi Giorgio Walter C Source Type: research
Functional Analysis of Airway Remodeling is Related with Fibrotic Mediators in Asthmatic Children
CONCLUSIONS: Impulse oscillometry is a sensitive method to detect airway resistance in persistent mild and moderate asthmatic children, an event followed by increased levels of pro-inflammatory and pro-fibrotic mediators.PMID:38577973 | DOI:10.1080/02770903.2024.2338862 (Source: Journal of Asthma)
Source: Journal of Asthma - April 5, 2024 Category: Respiratory Medicine Authors: Lucas P Salles-Dias Maysa A R Brandao-Rangel Amanda Cristina-Rosa Rayssa T Morais-Felix Simone Oliveira-Freitas Luis V F Oliveira Renilson Moraes-Ferreira Andre L L Bachi Elisa T Coutinho Claudio R Frison Asghar Abbasi Dobroslav Melamed Rodolfo P Vieira Source Type: research
