Reduced turnover times make flexible optical reusable scope with EndoSheath ® Technology significantly cost-effective
Publication date: July 2012 Source:Journal of Biomedical Research, Volume 26, Issue 4 Author(s): Deepak Gupta, Arvind Srirajakalidindi, Hong Wang EndoSheath bronchoscopy (Vision Sciences, Inc.) uses a sterile, disposable microbial barrier that may meet the growing needs for safe, efficient, and cost effective flexible bronchoscopy. The purpose of this open-label com-parative study was to compare and calculate the costs-per-airway-procedure of the reusable fiberscope when used with and without EndoSheath® Technology; and to record the turnover time from the completion of the use of each scope until its readiness ...
Source: Journal of Biomedical Research - July 19, 2016 Category: Biochemistry Source Type: research
STAT3 mediates resistance of CD44+CD24 −/low breast cancer stem cells to tamoxifen in vitro
Publication date: September 2012 Source:Journal of Biomedical Research, Volume 26, Issue 5 Author(s): Xiaoyan Wang, Guozhu Wang, Yi Zhao, Xiaoan Liu, Qiang Ding, Jingping Shi, Yin Ding, Shui Wang We sought to determine whether STAT3 mediated tamoxifen resistance of breast cancer stem cells in vitro. The capacities for mammosphere formation and STAT3 expression of CD44+CD24−/low MCF-7 and MCF-7 were observed. The CD44+CD24−/low subpopulation ratio and its sensitivity to adriamycin were analyzed in MCF-7 and TAM resistant (TAM-R) cells. Cell cycle, apoptosis, STAT3 and phospho-STAT3 changes were obser...
Source: Journal of Biomedical Research - July 19, 2016 Category: Biochemistry Source Type: research
Sinomenine reduces iNOS expression via inhibiting the T-bet IFN- γ pathway in experimental autoimmune encephalomyelitis in rats
In conclusion, the anti-iNOS effect of sinomenine on EAE is mediated via the suppression of T-bet/IFN-γ pathway. (Source: Journal of Biomedical Research)
Source: Journal of Biomedical Research - July 19, 2016 Category: Biochemistry Source Type: research
Resveratrol inhibits angiotensin II-induced ERK1/2 activation by downregulating quinone reductase 2 in rat vascular smooth muscle cells
In conclusion, high concentration of resveratrol inhibits angiotensin II-induced ERK1/2 phosphorylation and subsequent proliferation by down-regulation of NQO2 in cultured rat VSMCs. (Source: Journal of Biomedical Research)
Source: Journal of Biomedical Research - May 17, 2015 Category: Biochemistry Source Type: research
Quercetin attenuates the progression of monocrotaline-induced pulmonary hypertension in rats
Publication date: March 2012 Source:Journal of Biomedical Research, Volume 26, Issue 2 Author(s): Hanhua Gao , Can Chen , Shi'an Huang , Bo Li Pulmonary arterial hypertension (PAH) is a progressive disease associated with increased constriction and remodeling of the pulmonary vasculature. Quercetin is a natural flavonoid and has a variety of pharmacological effects including improvement of endothelial cell function. However, its pharmacological effects on pulmonary hypertension have been rarely reported. We sought to observe the protective effect of quercetin in rats with monocrotaline induced PAH. We divided 30 ma...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Cynodon dactylon and Sida acuta extracts impact on the function of the cardiovascular system in zebrafish embryos
In conclusion, we developed an assay that can measure changes in cardiac function in response to herbal small molecules and determine the cardiogenic effects by microvideography. (Source: Journal of Biomedical Research)
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Prevalence of intestinal parasitic infections in certified food-handlers working in food establishments in the City of Nairobi, Kenya
Publication date: March 2012 Source:Journal of Biomedical Research, Volume 26, Issue 2 Author(s): Paul Kamau , Penina Aloo-Obudho , Ephantus Kabiru , Kepha Ombacho , Bernard Langat , Obadiah Mucheru , Laban Ireri Most intestinal parasites are cosmopolitan with the highest prevalence in the tropics and subtopics. Rural-to-urban migration rapidly increases the number of food eating places in towns and their environs. Some of these eating estabishments have poor sanitation and are overcrowded, facilitating disease transmission, especially through food-handling. Our investigations in Nairobi, therefore, were set to ...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
MTHFR C677T polymorphisms are associated with aberrant methylation of the IGF-2 gene in transitional cell carcinoma of the bladder
Publication date: March 2012 Source:Journal of Biomedical Research, Volume 26, Issue 2 Author(s): Huan Cheng , Zhonglei Deng , Zengjun Wang , Wei Zhang , Jiantang Su The purpose of this study was to determine the relationship between methylation status of the insulin-like growth factor 2 (IGF-2) gene and methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphisms in bladder transitional cell carcinoma tissues in a Chinese population. The polymorphisms of the folate metabolism enzyme gene MTHFR were studied by restrictive fragment length polymorphism (RFLP). PCR-based methods of DNA methylation analysis we...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
PET imaging for receptor occupancy: meditations on calculation and simplification
Publication date: March 2012 Source:Journal of Biomedical Research, Volume 26, Issue 2 Author(s): Yumin Zhang , Gerard B. Fox This invited mini-review briefly summarizes procedures and challenges of measuring receptor occupancy with positron emission tomography. Instead of describing the detailed analytic procedures of in vivo ligand-receptor imaging, the authors provide a pragmatic approach, along with personal perspectives, for conducting positron emission tomography imaging for receptor occupancy, and systematically elucidate the mathematics of receptor occupancy calculations in practical ways that can be understo...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Effects of lysed Enterococcus faecalis FK-23 on experimental allergic rhinitis in a murine model
Publication date: May 2012 Source:Journal of Biomedical Research, Volume 26, Issue 3 Author(s): Luping Zhu , Takashi Shimada , Ruoxi Chen , Meiping Lu , Qingzhao Zhang , Wenmin Lu , Min Yin , Tadao Enomoto , Lei Cheng In the current study, we sought to investigate whether lysed Enterococcus faecalis FK-23 (LFK), a heat-killed probiotic preparation, attenuated eosinophil influx into the upper airway and had immunomodulatory activity in a murine allergic rhinitis model. Eighteen BALB/c mice were divided into three groups; the ovalbumin (OVA)-sensitized/challenged group, which received saline orally for 6 weeks (...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Telmisartan prevents high-fat diet-induced hypertension and decreases perirenal fat in rats
Publication date: May 2012 Source:Journal of Biomedical Research, Volume 26, Issue 3 Author(s): Yaping Wang , Yan Song , Meng Suo , Xin Jin , Gang Tian We sought to investigate the effects of telmisartan on high-fat diet-induced hypertension and to explore the possible underlying mechanisms. Rats receiving high-fat diet were randomly divided into two groups, the tel-misartan group (n = 9) and the high-fat diet group (n = 10). The control group consisted of age-matched rats on a regular diet (n = 10). At the end of the treatment, the body weight, blood pressure, insulin sensitivity and serum adiponectin levels of a...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Preliminary feasibility and hemodynamic performance of a newly-developed self-expanding bioprosthesis and 16-F delivery system in transcatheter aortic valve implantation in sheep
Publication date: May 2012 Source:Journal of Biomedical Research, Volume 26, Issue 3 Author(s): Jing Cai , Yanhui Sheng , Shijiang Zhang , Wei Sun , Rong Yang , Liping Miao , Xiangqing Kong We sought to evaluate the feasibility and hemodynamic performance of a new self-expanding bioprosthesis and 16-F delivery system in sheep. A 23-mm new self-expanding aortic bioprosthesis was implanted in sheep (n = 10) with a 16-F catheter via the right common carotid artery. Each sheep underwent angiography and coronary angiography before intervention, immediately and 1 h after stent implantation. Electrocardiographic monito...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Sitagliptin, sitagliptin and metformin, or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats
In conclusion, treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain, but causes an increase in grip strength and pain sensitivity, exhibits neural protection, and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes. (Source: Journal of Biomedical Research)
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Antibacterial activity of calcium hydroxide combined with chitosan solutions and the outcomes on the bond strength of RealSeal sealer to radicular dentin
Publication date: May 2012 Source:Journal of Biomedical Research, Volume 26, Issue 3 Author(s): Shaymaa Elsayed Elsaka , Amr Mohamed Elnaghy The purpose of this study was to investigate the antibacterial activity of calcium hydroxide [Ca(OH)2] combined with chitosan solutions against Enterococcus faecalis-infected root canal dentin and the effect of this new intracanal medicament on the bond strength of RealSeal sealer to radicular dentin. An experimental intracanal medicament was prepared by mixing different concentrations of chitosan solution (25%, 50%, and 100%, W/V) to Ca(OH)2 powder. Antibacterial activity was e...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Influence of ozone on the rheological and electrical properties of stored human blood
Publication date: May 2012 Source:Journal of Biomedical Research, Volume 26, Issue 3 Author(s): Hoda El-Saied Abdel Baieth , Islam Shoukri Elashmawi Blood stored in a blood bank undergoes a series of chemical changes and storage lesions. The purpose of this study was to assess the effect of ozone on the rheological and electrical properties of stored human blood. Venous blood samples, obtained from three healthy humans, were treated with different concentrations of ozone (30, 50, 70 and 80 µg/mL) for three weeks in vitro. Ozone was generated from portable medical-grade oxygen using elec-trical corona arc discharge. ...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
