T cell expressions of aberrant gene signatures and Co-inhibitory receptors (Co-IRs) as predictors of renal damage and lupus disease activity
Systemic lupus erythematosus (SLE) is distinguished by an extensive range of clinical heterogeneity with unpredictable disease flares and organ damage. This research investigates the potential of aberrant sign... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 22, 2024 Category: Biomedical Science Authors: Chin-Man Wang, Yeong-Jian Jan Wu, Jian-Wen Zheng, Li Yu Huang, Keng Poo Tan and Ji-Yih Chen Tags: Research Source Type: research
Targeting NLRP3 signaling reduces myocarditis-induced arrhythmogenesis and cardiac remodeling
Myocarditis substantially increases the risk of ventricular arrhythmia. Approximately 30% of all ventricular arrhythmia cases in patients with myocarditis originate from the right ventricular outflow tract (RV... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 22, 2024 Category: Biomedical Science Authors: Chye-Gen Chin, Yao-Chang Chen, Fong-Jhih Lin, Yung-Kuo Lin, Yen-Yu Lu, Tzu-Yu Cheng, Shih-Ann Chen and Yi-Jen Chen Tags: Research Source Type: research
Dengue virus pathogenesis and host molecular machineries
Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae family. DENV is the causative agent of dengue, the most rapidly spreading viral disease transmitted by mosquitoes. Each yea... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 22, 2024 Category: Biomedical Science Authors: Saumya Sinha, Kinjal Singh, Y. S. Ravi Kumar, Riya Roy, Sushant Phadnis, Varsha Meena, Sankar Bhattacharyya and Bhupendra Verma Tags: Review Source Type: research
Applications of peptides in nanosystems for diagnosing and managing bacterial sepsis
Sepsis represents a critical medical condition stemming from an imbalanced host immune response to infections, which is linked to a significant burden of disease. Despite substantial efforts in laboratory and ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 19, 2024 Category: Biomedical Science Authors: Mohammed A. Gafar, Calvin A. Omolo, Eman Elhassan, Usri H. Ibrahim and Thirumala Govender Tags: Review Source Type: research
Enhancement of NETosis by ACE2-cross-reactive anti-SARS-CoV-2 RBD antibodies in patients with COVID-19
High levels of neutrophil extracellular trap (NET) formation or NETosis and autoantibodies are related to poor prognosis and disease severity of COVID-19 patients. Human angiotensin-converting enzyme 2 (ACE2) ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 18, 2024 Category: Biomedical Science Authors: Kun-Han Hsieh, Chiao-Hsuan Chao, Yi-Ling Cheng, Yen-Chung Lai, Yung-Chun Chuang, Jen-Ren Wang, Sui-Yuan Chang, Yuan-Pin Hung, Yi-Ming Arthur Chen, Wei-Lun Liu, Woei-Jer Chuang and Trai-Ming Yeh Tags: Research Source Type: research
Attenuating mitochondrial dysfunction and morphological disruption with PT320 delays dopamine degeneration in MitoPark mice
Mitochondria are essential organelles involved in cellular energy production. Changes in mitochondrial function can lead to dysfunction and cell death in aging and age-related disorders. Recent research sugges... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 17, 2024 Category: Biomedical Science Authors: Vicki Wang, Kuan-Yin Tseng, Tung-Tai Kuo, Eagle Yi-Kung Huang, Kuo-Lun Lan, Zi-Rong Chen, Kuo-Hsing Ma, Nigel H. Greig, Jin Jung, Ho-II Choi, Lars Olson, Barry J. Hoffer and Yuan-Hao Chen Tags: Research Source Type: research
Longitudinal alterations in brain perfusion and vascular reactivity in the zQ175DN mouse model of Huntington ’s disease
Huntington ’s disease (HD) is marked by a CAG-repeat expansion in the huntingtin gene that causes neuronal dysfunction and loss, affecting mainly the striatum and the cortex. Alterations in the neurovascular co... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 16, 2024 Category: Biomedical Science Authors: Tamara Vasilkovska, Somaie Salajeghe, Verdi Vanreusel, Johan Van Audekerke, Marlies Verschuuren, Lydiane Hirschler, Jan Warnking, Isabel Pintelon, Dorian Pustina, Roger Cachope, Ladislav Mrzljak, Ignacio Mu ñoz-Sanjuan, Emmanuel L. Barbier, Winnok H. De Tags: Research Source Type: research
Antimicrobial peptide thanatin fused endolysin PA90 (Tha-PA90) for the control of Acinetobacter baumannii infection in mouse model
This study addresses the urgent need for infection control agents driven by the rise of drug-resistant pathogens such as Acinetobacter baumannii. Our primary aim was to develop and assess a novel endolysin, Tha-P... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 15, 2024 Category: Biomedical Science Authors: Jeonghyun Lim, Heejoon Myung, Daejin Lim and Miryoung Song Tags: Research Source Type: research
Correction: A novel HIF1 α-STIL-FOXM1 axis regulates tumor metastasis
(Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 9, 2024 Category: Biomedical Science Authors: Yi-Wei Wang, Shu-Chuan Chen, De-Leung Gu, Yi-Chen Yeh, Jhih-Jie Tsai, Kuo-Tai Yang, Yuh-Shan Jou, Teh-Ying Chou and Tang K. Tang Tags: Correction Source Type: research
Significance of hepatitis B virus capsid dephosphorylation via polymerase
It is generally believed that hepatitis B virus (HBV) core protein (HBc) dephosphorylation (de-P) is important for viral DNA synthesis and virion secretion. HBV polymerase contains four domains for terminal pr... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 1, 2024 Category: Biomedical Science Authors: Chih-Hsu Chang and Chiaho Shih Tags: Research Source Type: research
Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck
T cell receptor (TCR) signaling and T cell activation are tightly regulated by gatekeepers to maintain immune tolerance and avoid autoimmunity. The TRAIL receptor (TRAIL-R) is a TNF-family death receptor that ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - March 27, 2024 Category: Biomedical Science Authors: I-Tsu Chyuan, Hsiu-Jung Liao, Tse-Hua Tan, Huai-Chia Chuang, Yu-Chuan Chu, Meng-Hsun Pan, Chien-Sheng Wu, Ching-Liang Chu, Bor-Ching Sheu and Ping-Ning Hsu Tags: Research Source Type: research
Improving CRISPR –Cas9 directed faithful transgene integration outcomes by reducing unwanted random DNA integration
The field of genome editing has been revolutionized by the development of an easily programmable editing tool, the CRISPR –Cas9. Despite its promise, off-target activity of Cas9 posed a great disadvantage for g... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - March 26, 2024 Category: Biomedical Science Authors: Rio Hermantara, Laura Richmond, Aqeel Faisal Taqi, Sabari Chilaka, Valentine Jeantet, Ileana Guerrini, Katherine West and Adam West Tags: Research Source Type: research
A matter of new life and cell death: programmed cell death in the mammalian ovary
The mammalian ovary is a unique organ that displays a distinctive feature of cyclic changes throughout the entire reproductive period. The estrous/menstrual cycles are associated with drastic functional and mo... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - March 20, 2024 Category: Biomedical Science Authors: Mikhail S. Chesnokov, Aygun R. Mamedova, Boris Zhivotovsky and Gelina S. Kopeina Tags: Review Source Type: research
Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury
Acute lung injury (ALI) is a life-threatening respiratory condition characterized by severe inflammation and lung tissue damage, frequently causing rapid respiratory failure and long-term complications. The mi... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - March 19, 2024 Category: Biomedical Science Authors: Sin-Yu Chen, Yi-Ling Chen, Po-Chen Li, Tai-Shan Cheng, Yeh-Shiu Chu, Yi-Shan Shen, Hsin-Tung Chen, Wei-Ni Tsai, Chien-Ling Huang, Martin Sieber, Yuan-Chieh Yeh, Hsiao-Sheng Liu, Chi-Ling Chiang, Chih-Hung Chang, Andrew S. Lee, Yen-Han Tseng & hellip; Tags: Research Source Type: research
The rise of big data: deep sequencing-driven computational methods are transforming the landscape of synthetic antibody design
Synthetic antibodies (Abs) represent a category of artificial proteins capable of closely emulating the functions of natural Abs. Their in vitro production eliminates the need for an immunological response, st... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - March 16, 2024 Category: Biomedical Science Authors: Eugenio Gallo Tags: Review Source Type: research
